公开(公告)号：US4666633A

公开(公告)日：1987-05-19

申请号：US639969

申请日：1984-08-10

申请人： Yoichi Yuki ,  Ryoji Noyori ,  Masahiko Hayashi

发明人： Yoichi Yuki ,  Ryoji Noyori ,  Masahiko Hayashi

IPC分类号： C07C67/11 ,  C07C69/54 ,  C09B11/06 ,  C07C67/10

CPC分类号： C07C69/54

摘要： A triarylmethyl methacrylate is produced by reacting methacrylic acid with a triarylmethylating agent in an inert, organic solvent containing therein an excess amount of an amine or in the presence of an anion exchanger.

摘要翻译： 通过使甲基丙烯酸与三芳基甲基化试剂在含有过量胺的惰性有机溶剂中或在阴离子交换剂的存在下反应制备三芳基甲基丙烯酸甲酯。

公开(公告)号：US4315032A

公开(公告)日：1982-02-09

申请号：US149584

申请日：1980-05-14

申请人： Ryoji Noyori ,  Masaaki Suzuki ,  Seizi Kurozumi

发明人： Ryoji Noyori ,  Masaaki Suzuki ,  Seizi Kurozumi

IPC分类号： C07B37/02 ,  A61K31/557 ,  C07B31/00 ,  C07C45/00 ,  C07C45/69 ,  C07C45/70 ,  C07C45/72 ,  C07C45/75 ,  C07C49/493 ,  C07C49/517 ,  C07C49/743 ,  C07C49/747 ,  C07C49/753 ,  C07C67/00 ,  C07C225/20 ,  C07C401/00 ,  C07C405/00 ,  C07D309/12 ,  C07F7/18 ,  C07C177/00

CPC分类号： C07F7/1856 ,  A61K31/557 ,  C07C225/20 ,  C07C405/00 ,  C07C405/0025 ,  C07C45/70 ,  C07C45/72 ,  C07C45/75 ,  C07C49/493 ,  C07C49/743 ,  C07C49/747

摘要： A novel 7-hydroxyprostaglandin E.sub.1, or a stereoisomer thereof, or a protected derivative thereof, having the following formula: ##STR1## wherein R.sup.8 represents H, CH.sub.3 or C.sub.2 H.sub.5, R.sup.9 represents H or CH.sub.3, R.sup.10 and R.sup.11 are identical or different, and each represents H, tetrahydropyranyl or t-butyldimethylsilyl. Also provided is a process for producing an adjacently disubstituted ketone including the above compounds, i.e. 7-oxoprostaglandin, etc. which comprises reacting an .alpha.,.beta.-unsaturated carbonyl compound with a cuprous salt and an organolithium compound in an aprotic inert organic medium in the presence of trialkylphosphine, the amounts of said cuprous salt and said organolithium compound being substantially equimolar, and reacting the product with a protected acetal derivative of an organic carbonyl compound or an aldehyde in the presence of a Lewis acid, if necessary, followed by reacting the product with a proton donor.

摘要翻译： 具有下式的新颖的7-羟基前列腺素E1或其保护的衍生物：其中R 8表示H，CH 3或C 2 H 5，R 9表示H或CH 3，R 10和R 11相同或不同， 各自表示H，四氢吡喃基或叔丁基二甲基甲硅烷基。 还提供了制备包括上述化合物即7-氧代前列腺素等的相邻二取代的酮的方法，其包括使α，β-不饱和羰基化合物与亚硝酸盐和有机锂化合物在非质子惰性有机介质中反应 存在三烷基膦，所述亚铜盐和所述有机锂化合物的量基本上是等摩尔的，并且如果需要，在路易斯酸存在下，使产物与有机羰基化合物或醛的保护缩醛衍生物反应，然后使 产品与质子供体。

公开(公告)号：US4001249A

公开(公告)日：1977-01-04

申请号：US496579

申请日：1974-08-12

申请人： Ryoji Noyori ,  Yoshihiro Hayakawa ,  Yutaka Baba ,  Shinji Makino

发明人： Ryoji Noyori ,  Yoshihiro Hayakawa ,  Yutaka Baba ,  Shinji Makino

IPC分类号： B01J21/00 ,  C07B61/00 ,  C07D451/06 ,  C07D451/10 ,  C07D451/12

CPC分类号： C07D451/06

摘要： Process for the preparation of tropane alkaloids, more particularly of N-acyl-dehydronortropinones, dehydrotropine and tropine. The compounds can be prepared by cyclocoupling N-acyl-pyrrole with .alpha.,.alpha.'-halogenoketone in the presence of a reducing agent and, if necessary, subjecting the resulting N-acyl-dehydronortropinone to either partial reduction and then stereo-selective reduction, or stereo-selective reduction and then partial reduction.

公开(公告)号：US08013193B2

公开(公告)日：2011-09-06

申请号：US12594577

申请日：2008-04-02

申请人： Hirofumi Maeda ,  Kenji Inoue ,  Takaji Matsumoto ,  Izuru Nagasaki ,  Ryoji Noyori ,  Susumu Saito

发明人： Hirofumi Maeda ,  Kenji Inoue ,  Takaji Matsumoto ,  Izuru Nagasaki ,  Ryoji Noyori ,  Susumu Saito

IPC分类号： C07C29/149

CPC分类号： C07B53/00 ,  C07B2200/07 ,  C07C29/157 ,  C07C213/00 ,  C07C231/12 ,  C07C269/06 ,  C07C31/20 ,  C07C33/20 ,  C07C31/207 ,  C07C31/22 ,  C07C31/205 ,  C07C33/22 ,  C07C33/26 ,  C07C215/28 ,  C07C233/73 ,  C07C271/16

摘要： Disclosed is a method for producing an alcohol from a lactone or a carboxylic acid ester, which enables to produce an alcohol from a lactone or a carboxylic acid ester under relatively mild conditions with high yield and high catalytic efficiency. This method also enables to produce an optically active alcohol from an optically active lactone or an optically active carboxylic acid ester. Specifically disclosed is a method for producing an alcohol by hydrogen reducing a lactone or a carboxylic acid ester in the presence of a catalyst containing ruthenium and a phosphine compound represented by the following general formula (1): wherein R1 represents a spacer; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group; and R8, R9, R10, R11, R12 and R13 independently represent an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group.

摘要翻译： 公开了一种从内酯或羧酸酯制备醇的方法，其能够在相对温和的条件下以高产率和高催化效率从内酯或羧酸酯制备醇。 该方法还能够从光学活性的内酯或光学活性的羧酸酯制备光学活性的醇。 具体公开的是通过在含有钌的催化剂和由以下通式（1）表示的膦化合物的存在下氢还原内酯或羧酸酯来制备醇的方法：其中R1表示间隔基; R2，R3，R4，R5，R6和R7独立地表示氢原子，具有1-12个碳原子的烷基，芳基或杂环基; 并且R 8，R 9，R 10，R 11，R 12和R 13独立地表示具有1-12个碳原子的烷基，芳基或杂环基。

公开(公告)号：US20070249816A1

公开(公告)日：2007-10-25

申请号：US10582761

申请日：2004-12-13

申请人： Bengt Langstrom ,  Julien Barletta ,  Hisashi Doi ,  Masaaki Suzuki ,  Ryoji Noyori ,  Yasuyoshi Watanabe ,  Farhad Karimi

发明人： Bengt Langstrom ,  Julien Barletta ,  Hisashi Doi ,  Masaaki Suzuki ,  Ryoji Noyori ,  Yasuyoshi Watanabe ,  Farhad Karimi

IPC分类号： C07D213/84 ,  C07C233/02 ,  C07D205/04

CPC分类号： A61K51/04 ,  C07B59/00 ,  C07B2200/05 ,  C07C263/00 ,  C07C269/02 ,  C07C273/1827 ,  C07C265/12 ,  C07C271/28 ,  C07C275/28

摘要： Methods and reagents for rhodium-promoted carbonylation via isocyanate using carbon-isotope labeled carbon monoxide are provided. The resultant carbon isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.

摘要翻译： 提供了使用碳同位素标记的一氧化碳通过异氰酸酯进行铑促进羰基化的方法和试剂。 所得碳同位素标记的化合物可用作放射性药物，特别用于正电子发射断层扫描（PET）。 还提供了用于PET研究的相关工具包。

公开(公告)号：US06326512B1

公开(公告)日：2001-12-04

申请号：US09584747

申请日：2000-06-01

申请人： Masato Kitamura ,  Masahiro Yoshimura ,  Naoki Kanda ,  Ryoji Noyori

发明人： Masato Kitamura ,  Masahiro Yoshimura ,  Naoki Kanda ,  Ryoji Noyori

IPC分类号： C07C30900

CPC分类号： C07C303/22 ,  C07C303/32 ,  C07C309/24

摘要： Disclosed is a method of producing an optically active &bgr;-hydroxy sulfonic acid compound comprising hydrogenating a &bgr;-keto sulfonic acid compound represented by formula 1: where R1 represents an alkyl or a phenyl group, which may be substituted, and R2 represents sodium or an alkyl group, in an acidic solvent, in the presence of an asymmetric catalyst comprising a complex of bivalent Ru, having 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl as a ligand, to produce a compound represented by formula 2: where R1 and R2 are as defined above, and * designates an asymmetric carbon atom.

摘要翻译： 公开了一种制备光学活性β-羟基磺酸化合物的方法，包括氢化由式1表示的β-酮磺酸化合物：其中R 1表示可被取代的烷基或苯基，R 2表示钠或 烷基，在酸性溶剂中，在包含具有2,2'-双（二苯基膦基）-1,1'-联萘作为配体的二价Ru的络合物的不对称催化剂的存在下，制备由式 2：其中R1和R2如上所定义，*表示不对称碳原子。

公开(公告)号：US5532402A

公开(公告)日：1996-07-02

申请号：US402654

申请日：1995-03-13

申请人： Ryoji Noyori ,  Masato Kitamura ,  Makoto Tokunaga

发明人： Ryoji Noyori ,  Masato Kitamura ,  Makoto Tokunaga

IPC分类号： B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07F9/40

CPC分类号： C07F9/4006

摘要： Disclosed herein is a process for producing an optically active hydroxyalkylphosphonate represented by the formula (4), which comprises asymmetrically hydrogenating an oxoalkylphosphonate represented by the formula (1) using, as a catalyst, a ruthenium-optically active phosphine complex represented by the formula (2). ##STR1##

摘要翻译： 本文公开了一种制备由式（4）表示的光学活性羟烷基膦酸酯的方法，其包括使用由式（4）表示的钌光学活性膦配合物作为催化剂不对称地氢化由式（1）表示的氧代烷基膦酸酯， 2）。 + TR

公开(公告)号：US5329035A

公开(公告)日：1994-07-12

申请号：US38066

申请日：1993-03-29

申请人： Ryoji Noyori ,  Masaaki Suzuki ,  Toshio Tanaka ,  Seizi Kurozumi

发明人： Ryoji Noyori ,  Masaaki Suzuki ,  Toshio Tanaka ,  Seizi Kurozumi

IPC分类号： C07C405/00 ,  C07F7/18

CPC分类号： C07C405/0025 ,  C07C405/00 ,  C07F7/1856

摘要： A process for producing a 2,3-disubstituted-4-substituted cyclopentanone, an enantiomorph thereof, or a mixture of these in an arbitrary ratio.The process comprises (A) subjecting a 4-substituted-2-cyclopentenone, an enantiomorph thereof, or a mixture of these in an arbitrary ratio, and an organocopper compound to conjugate addition-reaction, and thereafter (B) reacting the resulting enolate intermediate with a halide in the presence of a phenyl organotin compound.

摘要翻译： 制备2,3-二取代-4-取代的环戊酮，其对映体或它们的混合物的任意比例的方法。 该方法包括（A）将4-取代-2-环戊烯酮，其对映体或它们的任意比例的混合物与有机聚合物化合物进行共轭加成反应，然后（B）使得到的烯醇化物中间体 在苯基有机锡化合物存在下用卤化物。

公开(公告)号：US4962230A

公开(公告)日：1990-10-09

申请号：US121247

申请日：1987-11-16

申请人： Hidemasa Takaya ,  Tetsuo Ohta ,  Ryoji Noyori ,  Noboru Sayo ,  Hidenori Kumobayashi ,  Susumu Akutagawa

发明人： Hidemasa Takaya ,  Tetsuo Ohta ,  Ryoji Noyori ,  Noboru Sayo ,  Hidenori Kumobayashi ,  Susumu Akutagawa

IPC分类号： C07C51/36 ,  C07F15/00

CPC分类号： C07F15/0053 ,  C07C51/36

摘要： A process for producing an optically active carboxylic acid represented by formula (I): ##STR1## wherein R.sup.1, and R.sup.2, and R.sup.3 each represents a hydrogen atom, an alkyl group, an alkenyl group, or a phenyl or naphthyl group which may have a substituent, provided that all of R.sup.1, R.sup.2, and R.sup.3 are not simultaneously a hydrogen atom; when R.sup.1 and R.sup.2 are simultaneously a hydrogen atom, then R.sup.3 is not a methyl group; and that when R.sup.3 is a hydrogen atom, then R.sup.1 and R.sup.2 are each a group other then a hydrogen atom,is disclosed, comprising asymmetrically hydrogenating an .alpha.,.beta.-unsaturated carboxylic acid represented by formula (II): ##STR2## wherein R.sup.1, R.sup.2, and R.sup.3 are the same as defined above, in the presence of a ruthenium-optically active phosphine complex as a catalyst.According to the process of the invention, the desired optically active carboxylic acids which can be widely used as raw materials for synthesizing various useful compounds, for example, as intermediates for synthesizing physiologically active substances of natural materials and also as liquid crystal materials can be industrially advantageously produced.

公开(公告)号：US4916252A

公开(公告)日：1990-04-10

申请号：US207428

申请日：1988-06-16

申请人： Noboru Sayo ,  Takao Saito ,  Hidenori Kumobayashi ,  Susumu Akutagawa ,  Ryoji Noyori ,  Hidemasa Takaya

发明人： Noboru Sayo ,  Takao Saito ,  Hidenori Kumobayashi ,  Susumu Akutagawa ,  Ryoji Noyori ,  Hidemasa Takaya

IPC分类号： B01J31/24 ,  C07B31/00 ,  C07B41/02 ,  C07B53/00 ,  C07B61/00 ,  C07C27/00 ,  C07C29/145 ,  C07C31/20 ,  C07C31/42 ,  C07C33/26 ,  C07C33/46 ,  C07C35/06 ,  C07C41/00 ,  C07C41/26 ,  C07C43/178 ,  C07C67/00 ,  C07C67/31 ,  C07C69/675 ,  C07C69/738 ,  C07C213/00 ,  C07C215/18 ,  C07F15/00

CPC分类号： C07C29/145 ,  C07C41/26 ,  C07B2200/07 ,  C07C2101/08 ,  C07C2101/14

摘要： A process for preparing an optically active alcohol is disclosed, which comprises asymmetrically hydrogenating a 1,3-diketone in the presence of a ruthenium-optically active phosphine complex as a catalyst. The resulting alcohol has high optical purity.