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    Method for characterizing polypeptides
    31.
    发明授权
    Method for characterizing polypeptides 失效
    表征多肽的方法

    公开(公告)号：US07163803B2

    公开(公告)日：2007-01-16

    申请号：US10479843

    申请日：2002-06-07

    申请人： Christian Hamon ,  Andrew Thompson ,  Thomas Neumann ,  Robert Johnstone ,  Abdul Karim Abed Mohammed

    发明人： Christian Hamon ,  Andrew Thompson ,  Thomas Neumann ,  Robert Johnstone ,  Abdul Karim Abed Mohammed

    IPC分类号： C12Q1/37

    CPC分类号： G01N33/6848 ,  C07K1/12 ,  G01N33/6821

    摘要： Provided is a method for characterizing a polypeptide, which method comprises the steps of: (a) optionally reducing cysteine disulphide bridges in the polypeptide to form free thiols, and capping the free thiols; (b) cleaving the polypeptide with a sequence specific cleavage reagent to form peptide fragments; (c) optionally deactivating the cleavage reagent; (d) capping one or more ε-amino groups that are present with a lysine reactive agent; (e) analyzing peptide fragments by mass spectrometry to form a mass fingerprint for the polypeptide; and (f) determining the identity of the polypeptide from the mass fingerprint.

    摘要翻译： 提供了表征多肽的方法，该方法包括以下步骤：（a）任选地减少多肽中的半胱氨酸二硫键形成游离硫醇，并封端游离硫醇; （b）用序列特异性切割试剂切割多肽以形成肽片段; （c）任选地使切割试剂失活; （d）封端与赖氨酸反应剂一起存在的一个或多个ε-氨基; （e）通过质谱分析肽片段以形成多肽的质量指纹图谱; 和（f）从质量指纹图谱确定多肽的身份。

    ALS CAMERA SYSTEM
    34.
    发明申请
    ALS CAMERA SYSTEM 有权

    公开(公告)号：US20220294947A1

    公开(公告)日：2022-09-15

    申请号：US17691534

    申请日：2022-03-10

    申请人： Kevin Thomas ,  Andrew Thompson

    发明人： Kevin Thomas ,  Andrew Thompson

    IPC分类号： H04N5/225 ,  G06T7/00 ,  G02B7/00

    摘要： A system for detecting foreign materials comprising an alternative light source (ALS), one or more filters operationally associated with the ALS, one or more camera lenses operationally associated with the ALS and the filters, one or more processors, a computer readable memory, and a computer readable storage medium operatively associated with a computing device operatively associated with the ALS, one or more sensors operationally associated with the computing device and the ALS, wherein the sensors detect the presence of the filter and a camera operationally associated with the lens and the computing device.

    Sock
    37.
    发明授权
    Sock 失效
    袜子

    公开(公告)号：US07213420B2

    公开(公告)日：2007-05-08

    申请号：US10290369

    申请日：2002-11-08

    申请人： Justin Lynch ,  Maria Bourke ,  Andrew Thompson

    发明人： Justin Lynch ,  Maria Bourke ,  Andrew Thompson

    IPC分类号： D04B9/46

    CPC分类号： D04B1/108 ,  A41B11/005 ,  A41B17/005 ,  A41B2400/34 ,  D04B1/16 ,  D04B1/26 ,  D04B9/40 ,  D04B15/02 ,  D10B2321/042 ,  D10B2401/021 ,  D10B2401/022 ,  D10B2401/13 ,  D10B2403/023

    摘要： A knitted sock has an inner layer 2 comprising a toe end 4 and an outer layer 3 comprising a toe end 7. The inner and outer toe ends are aligned and joined wale stitch to wale stitch to form a composite toe end, which is closed to provide a flat toe seam 10. The layered sock is manufactured complete in a single process being knit continuously from the inner toe end to the outer toe end. It comprises reciprocated heel and toe portions. The foot portion of the inner layer is knit from a yarn with properties such as a low coefficient of friction and/or antifungal/antibacterial properties. The low friction fiber is a fluoropolymer such as polytetrafluroethylene. The outer layer may comprise a cushion structure.

    摘要翻译： 针织袜具有包括趾端4的内层2和包括趾端7的外层3。 内端和外脚趾端部对齐并连接起来，将纵向线迹连接到纵向线迹以形成复合脚趾端，该端部被封闭以提供平坦的趾部接缝10。 分层的袜子在一个单一的过程中被制造成完整的，从内趾端连续地编织到外趾端。 它包括往复运动的跟部和脚趾部分。 内层的脚部由具有低摩擦系数和/或抗真菌/抗菌性能的纱线编织而成。 低摩擦纤维是聚四氟乙烯等含氟聚合物。 外层可以包括缓冲结构。

    Method for characterising analytes
    38.
    发明申请
    Method for characterising analytes 失效
    表征分析物的方法

    公开(公告)号：US20060040334A1

    公开(公告)日：2006-02-23

    申请号：US10510246

    申请日：2003-04-04

    申请人： Andrew Thompson

    发明人： Andrew Thompson

    IPC分类号： C12Q1/37 ,  G01N33/00

    CPC分类号： G01N33/6848 ,  C07K1/13 ,  G01N33/6851

    摘要： Provided is a method for characterising an analyte by matrix assisted laser desorption ionisation (MALDI) mass spectrometry, which method comprises: (a) labelling the analyte with a light-absorbing label that absorbs light at a pre-determined frequency, to form a labelled analyte; (b) embedding the labelled analyte in a matrix formed from at least one compound that absorbs light, to form an embedded labelled analyte; (c) desorbing the embedded labelled analyte by exposing it to light having the pre-determined frequency, to form a desorbed analyte; and (d) detecting the desorbed analyte by mass spectrometry to characterise the analyte.

    摘要翻译： 提供了一种通过基质辅助激光解吸电离（MALDI）质谱鉴定分析物的方法，该方法包括：（a）用预吸收光的光吸收标记物以预定的频率标记分析物，形成标记的 分析物; （b）将标记的分析物包埋在由吸收光的至少一种化合物形成的基质中，以形成嵌入的标记分析物; （c）通过将嵌入的标记分析物暴露于具有预定频率的光来解吸，形成解吸附的分析物; 和（d）通过质谱检测解吸附的分析物来表征分析物。