Medical devices and methods of making the same
    32.
    发明授权
    Medical devices and methods of making the same 失效
    医疗器械和制造方法

    公开(公告)号:US08071155B2

    公开(公告)日:2011-12-06

    申请号:US11122583

    申请日:2005-05-05

    CPC classification number: C03C8/00 A61L31/082

    Abstract: Medical devices, such as stents, and methods of making the devices are disclosed. In some embodiments, a method includes diffusing a first element into a first portion of the medical device. The first element includes carbon, hydrogen, nitrogen, oxygen, or combinations thereof. The first portion includes a refractory material.

    Abstract translation: 公开了诸如支架的医疗装置和制造装置的方法。 在一些实施例中,一种方法包括将第一元件扩散到医疗装置的第一部分中。 第一元素包括碳,氢,氮,氧或它们的组合。 第一部分包括耐火材料。

    POROUS FIBER ELECTRODE COATING AND RELATED METHODS
    34.
    发明申请
    POROUS FIBER ELECTRODE COATING AND RELATED METHODS 有权
    多孔纤维电极涂层及相关方法

    公开(公告)号:US20100241204A1

    公开(公告)日:2010-09-23

    申请号:US12703544

    申请日:2010-02-10

    CPC classification number: A61N1/056 A61B5/042 A61B2562/0209

    Abstract: The embodiments herein relate to an electrode having a porous coating including a fiber mesh, a multi-layer coating, and an outer coating, and a method of making the same. The various electrode coating embodiments include pores in the coating that prevent access by protein or cells while allowing for ion and/or liquid access.

    Abstract translation: 本文的实施方案涉及具有包括纤维网,多层涂层和外涂层的多孔涂层的电极及其制造方法。 各种电极涂覆实施方案包括涂层中的孔,其阻止蛋白质或细胞进入,同时允许离子和/或液体进入。

    Primarily niobium stent
    36.
    发明授权
    Primarily niobium stent 失效
    主要是铌支架

    公开(公告)号:US07604703B2

    公开(公告)日:2009-10-20

    申请号:US11417856

    申请日:2006-05-03

    Abstract: In a process of fabricating a stent composed primarily of niobium alloyed with a trace amount of zirconium, tantalum, or titanium for hardening, the stent is annealed under vacuum in a substantially oxygen-free environment. The vacuum is preferably maintained at pressure less than 10−4 millibars, oxygen-content less than about 80 parts per million, and the annealing temperature exceeds 400° C. for at least one hour, and is preferably kept in a range from about 1100-1200° C. for several hours. This may be followed by applying a surface layer of oxide, such as iridium oxide, with a thickness of 299-300 nm to the stent.

    Abstract translation: 在制造主要由铌合金化的用于硬化的锆,钽或钛的支架的制造过程中,支架在基本上无氧的环境中在真空下退火。 真空优选保持在小于10-4毫巴的压力,含氧量小于约百万分之八十,退火温度超过400℃至少一小时,优选保持在约1100 -1200℃几个小时。 然后可以向支架施加厚度为299-300nm的氧化物表面层,例如氧化铱。

    Metal Stent with Surface Layer of Noble Metal Oxide and Method of Fabrication
    39.
    发明申请
    Metal Stent with Surface Layer of Noble Metal Oxide and Method of Fabrication 失效
    金属支架与贵金属氧化物表面层及其制作方法

    公开(公告)号:US20080147167A1

    公开(公告)日:2008-06-19

    申请号:US11952624

    申请日:2007-12-07

    Abstract: In a process for producing a biocompatible stent, a tubular substrate of the stent adapted for diametric expansion has a layer of a noble metal oxide formed over at least the outer surface of greater diameter of the substrate, the substrate being composed of a metal or an alloy thereof that is non-noble or less-noble than the layer's noble metal. An interface region adapted to prevent corrosion and to provide a firm bond between the surface of the substrate and the noble metal oxide layer is established, at least in part, by forming the noble metal oxide layer with a progressively varying concentration of noble metal-to-oxide with depth of the layer such that a surface of pure noble metal and negligible oxide of the layer is in closest proximity to the surface of the substrate. In one embodiment of the process, the interface region is established by forming the surface of pure noble metal and negligible oxide thereof in direct contact with the metal or alloy of the substrate surface. In another, the interface region is established by first creating an oxide of the substrate metal or alloy thereof at the substrate surface, and then forming the noble metal oxide layer as above, but in contact with the substrate metal or alloy oxide. Alternatively, the noble metal oxide layer has no progressively varying concentration but simply overlies an oxide of the substrate metal or alloy.

    Abstract translation: 在制造生物相容性支架的方法中,适用于直径膨胀的支架的管状基底具有至少在基底的较大直径的外表面上形成的贵金属氧化物层,该基底由金属或 它的合金是非贵重的或比贵金属低贵的贵金属。 至少部分地通过以逐渐变化的贵金属浓度形成贵金属氧化物层,从而建立适于防止腐蚀并提供衬底的表面与贵金属氧化物层之间牢固结合的界面区域 - 至少 氧化物,其层的深度使得纯贵金属的表面和该层的可忽略的氧化物最接近衬底的表面。 在该方法的一个实施方案中,通过形成纯金属的表面和与基底表面的金属或合金直接接触的可忽略的氧化物的表面来建立界面区域。 另一方面,通过首先在基板表面产生基板金属或其合金的氧化物,然后如上所述形成贵金属氧化物层,但与基板金属或合金氧化物接触来建立界面区域。 或者,贵金属氧化物层的浓度没有逐渐变化,而是简单地覆盖基板金属或合金的氧化物。

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