摘要:
The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein.
摘要:
A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as immunodeficiencies, cancers, cardiovascular diseases, endocrine disorders, Parkinson's disease, metabolic diseases, tumorigenesis, Alzheimer's disease, heart disease, diabetes, neurodegeneration, inflammation, kidney disease, atherosclerosis and airway disease.
摘要:
Disclosed is a compound of the formula: and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating protein kinase mediated diseases using the compound of formula 1.0. Also disclosed are methods of treating cancer using a compound of formula 1.0. The disclosed methods also include combination therapies wherein the compound of formula 1.0 is administered in combination with at least one addition pharmaceutically active ingredient.
摘要:
A water purification device is provided in the form of a hydrogel matrix containing immobilized nanoparticles that are directly synthesized in-situ in the hydrogel matrix. The hydrogel matrix is temperature sensitive, such that swelling draws in pollutants that are captured by the nanoparticles, while deswelling releases purified water. A related method of decontaminating the water supply contaminated with a target pollutant is also disclosed.
摘要:
A time synchronization method and system for a multi-core system are provided. The time synchronization method comprises: establishing at least one clock synchronization domain, and respectively allocating each core to each clock synchronization domain; selecting a core with a lowest load in each clock synchronization domain as a master clock synchronization source in the clock synchronization domain, and selecting the clock synchronization domain having the master clock synchronization source with a lowest load as a master clock synchronization domain, while other clock synchronization domains as slave clock synchronization domains; the master clock synchronization domain sending a synchronization deviation detection message to each slave clock synchronization domain, and calculating a time deviation value; when the time deviation value is greater than a permitted deviation value, the master clock synchronization domain calculating a time adjustment quantity and releasing to each slave clock synchronization domain, making adjustment based on its time adjustment quantity.
摘要:
Methods, systems, and apparatus, including computer programs encoded on computer storage media, for identifying web hosting entities. In one aspect, a system includes one or more computers programmed to perform operations including maintaining an Internet Protocol (IP) address history for each hostname in a plurality of hostnames. Each IP address history is a time series of IP addresses. The operations further include organizing the hostnames into a collection of groups so that each hostname of the plurality of hostnames is a member of exactly one group in the collection of groups. Each group has a kernel calculated from the IP address histories of the members of the group, and the IP address history of each member of the group is within a threshold distance of the kernel of the group.
摘要:
A water purification device is provided in the form of a hydrogel matrix containing immobilized nanoparticles that are directly synthesized in-situ in the hydrogel matrix. A related method of decontaminating the water supply contaminated with a target pollutant is also disclosed.
摘要:
The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein.
摘要:
A method of making a device includes forming at least one anodizable metal layer over at least one of an electrode or a semiconductor device, forming a plurality of pores in the anodizable metal layer by anodization of the anodizable metal layer to expose a portion of the electrode or semiconductor device, and filling at least one pore with a rewritable material such that at least some of the rewritable material is in electrical contact with the electrode or semiconductor device.
摘要:
The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.