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135 条记录 (耗时 0.035 秒)

    Method for exclusion of ectopic events from heart rate variability metrics
    31.
    发明授权
    Method for exclusion of ectopic events from heart rate variability metrics 有权
    排除异位事件与心律变异性指标的方法

    公开(公告)号：US07970467B2

    公开(公告)日：2011-06-28

    申请号：US12235868

    申请日：2008-09-23

    申请人： John A. Dyjach ,  Gerrard M. Carlson

    发明人： John A. Dyjach ,  Gerrard M. Carlson

    IPC分类号： A61N1/00

    CPC分类号： A61B5/0468 ,  A61B5/4035 ,  A61N1/3622

    摘要： Heart rate variability metrics are derived from the intervals between successive heart beats, referred to as BB intervals. A method implementable by an implantable cardiac device for excluding BB intervals due to ectopic beats based on a function of preceding BB intervals is presented. It is desirable to remove such BB intervals from a BB interval time series used to calculate a heart rate variability metric.

    摘要翻译： 心率变异性度量是从连续的心跳之间的间隔导出的，称为BB间隔。 提出了一种可植入心脏装置的方法，用于根据先前的BB间隔的功能排除由于异位搏动造成的BB间隔。 期望从用于计算心率变异性度量的BB间隔时间序列中去除这样的BB间隔。

    Maximum pacing rate limiter implemented using the evoked response—T-wave interval
    32.
    发明授权
    Maximum pacing rate limiter implemented using the evoked response—T-wave interval 失效
    使用诱发响应T波间隔实现最大起搏速率限制器

    公开(公告)号：US07953486B2

    公开(公告)日：2011-05-31

    申请号：US11225712

    申请日：2005-09-13

    申请人： Douglas R. Daum ,  Geng Zhang ,  Qingsheng Zhu ,  Gerrard M. Carlson ,  Julio Spinelli

    发明人： Douglas R. Daum ,  Geng Zhang ,  Qingsheng Zhu ,  Gerrard M. Carlson ,  Julio Spinelli

    IPC分类号： A61N1/365

    CPC分类号： A61N1/365

    摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.

    摘要翻译： 与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。 最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。 最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。 在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率 到起搏器。

    Sensing rate of change of pressure in the left ventricle with an implanted device
    33.
    发明授权
    Sensing rate of change of pressure in the left ventricle with an implanted device 有权
    用植入装置感测左心室压力变化率

    公开(公告)号：US07670298B2

    公开(公告)日：2010-03-02

    申请号：US11142851

    申请日：2005-06-01

    申请人： Gerrard M. Carlson ,  Krzysztof Z. Siejko ,  Ramesh Wariar ,  Marina Brockway

    发明人： Gerrard M. Carlson ,  Krzysztof Z. Siejko ,  Ramesh Wariar ,  Marina Brockway

    IPC分类号： A61B5/02 ,  A61B1/00

    CPC分类号： A61B5/021 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/375

    摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.

    摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。

    Tracking progression of congestive heart failure via a force-frequency relationship
    34.
    发明授权
    Tracking progression of congestive heart failure via a force-frequency relationship 有权
    通过力 - 频率关系跟踪充血性心力衰竭的进展

    公开(公告)号：US07634309B2

    公开(公告)日：2009-12-15

    申请号：US11208281

    申请日：2005-08-19

    申请人： Ramesh Wariar ,  Gerrard M. Carlson

    发明人： Ramesh Wariar ,  Gerrard M. Carlson

    IPC分类号： A61B5/021 ,  A61B5/0225

    CPC分类号： A61B7/023 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/0456 ,  A61B5/11 ,  A61N1/3627

    摘要： A system, method, or device monitor a force-frequency relationship exhibited by a patient's heart. A contractility characteristic, such as a heart sound characteristic of an S1 heart sound, is measured. The contractility characteristic indicates the forcefulness of a contraction of the heart. The frequency at which the heart is contracting is determined. A group of (contractility characteristic, heart rate) pairs is stored in a memory device. The group of pairs defines a force-frequency relationship for the heart. The method may be implemented by an implantable device, or by a system including a implantable device.

    摘要翻译： 系统，方法或设备监测患者心脏展示的力 - 频率关系。 测量S1心音的心音特征的收缩特性。 收缩性特征表明心脏收缩的强度。 确定心脏收缩的频率。 一组（收缩特性，心率）对存储在存储器件中。 一组对定义了心脏的力 - 频率关系。 该方法可以由可植入装置或包括可植入装置的系统来实现。

    Managing preload reserve by tracking the ventricular operating point with heart sounds
    35.
    发明授权
    Managing preload reserve by tracking the ventricular operating point with heart sounds 有权
    通过用心脏声音跟踪心室手术点来管理预负荷储备

    公开(公告)号：US07585279B2

    公开(公告)日：2009-09-08

    申请号：US11189462

    申请日：2005-07-26

    申请人： Gerrard M. Carlson ,  Ramesh Wariar ,  Krzysztof Z. Siejko

    发明人： Gerrard M. Carlson ,  Ramesh Wariar ,  Krzysztof Z. Siejko

    IPC分类号： A61B5/021 ,  A61B5/0225

    CPC分类号： A61N1/36585 ,  A61B5/021 ,  A61B5/0452 ,  A61B7/04 ,  A61M5/1723 ,  A61N1/37

    摘要： A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.

    摘要翻译： 一种用于管理预负荷储备并跟踪患者心脏的变力状态的系统和方法。 测量S1心音作为直接测量行程体积的代理。 可以将S3心音测量为用于直接测量预载水平的代理。 S1-S3对在Frank Starling曲线上产生一个点，并显示关于患者的心室手术点和变力状态的信息。 作为S3心音的测量或除了测量S3心音之外，也可以测量S4心音，或者为了确定患者的预压水平可以进行直接的压力测量。 上述测量可以由诸如起搏器或可植入除颤器的心律管理装置进行。

    Statistical method for assessing autonomic balance
    36.
    发明授权
    Statistical method for assessing autonomic balance 有权
    评估自主神经平衡的统计方法

    公开(公告)号：US07499744B2

    公开(公告)日：2009-03-03

    申请号：US11382568

    申请日：2006-05-10

    申请人： Gerrard M. Carlson ,  Ronald D. Berger

    发明人： Gerrard M. Carlson ,  Ronald D. Berger

    IPC分类号： A61B5/0452

    CPC分类号： A61B5/02405 ,  A61B5/4035 ,  A61N1/3622

    摘要： A computationally efficient method for assessing a subject's autonomic balance by measurement of heart rate variability is disclosed which is particularly suitable for implementation by an implantable medical device. Statistical surrogates are used to represent frequency components of an RR time series. A ratio of the low frequency component to the high frequency component may then be estimated to assess the subject's autonomic balance.

    摘要翻译： 公开了一种通过测量心率变异性来评估受试者的自主平衡的计算上有效的方法，其特别适用于可植入医疗装置的实现。 统计代理用于表示RR时间序列的频率分量。 然后可以估计低频分量与高频分量的比率以评估受试者的自主平衡。

    NEURAL STIMULATION WITH RESPIRATORY RHYTHM MANAGEMENT
    37.
    发明申请
    NEURAL STIMULATION WITH RESPIRATORY RHYTHM MANAGEMENT 有权
    神经刺激与呼吸环境管理

    公开(公告)号：US20080319513A1

    公开(公告)日：2008-12-25

    申请号：US11767901

    申请日：2007-06-25

    申请人： Yachuan Pu ,  Anthony V. Caparso ,  Gerrard M. Carlson ,  Joseph M. Pastore

    发明人： Yachuan Pu ,  Anthony V. Caparso ,  Gerrard M. Carlson ,  Joseph M. Pastore

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36139 ,  A61B5/0816 ,  A61B5/4035 ,  A61N1/3601 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36117

    摘要： A system embodiment comprises at least one respiration sensor, a neural stimulation therapy delivery module, and a controller. The respiration sensor is adapted for use in monitoring respiration of the patient. The neural stimulation therapy delivery module is adapted to generate a neural stimulation signal for use in stimulating the autonomic neural target of the patient for the chronic neural stimulation therapy. The controller is adapted to receive a respiration signal from the at least one respiration sensor indicative of the patient's respiration, and adapted to control the neural stimulation therapy delivery module using a respiratory variability measurement derived using the respiration signal.

    摘要翻译： 系统实施例包括至少一个呼吸传感器，神经刺激治疗传递模块和控制器。 呼吸传感器适用于监测患者的呼吸。 神经刺激治疗递送模块适于产生用于刺激患者的自主神经靶标用于慢性神经刺激治疗的神经刺激信号。 控制器适于接收来自指示患者呼吸的至少一个呼吸传感器的呼吸信号，并且适于使用使用呼吸信号导出的呼吸变异性测量来控制神经刺激治疗递送模块。

    Systems and methods for multi-axis cardiac vibration measurements
    39.
    发明授权
    Systems and methods for multi-axis cardiac vibration measurements 有权
    用于多轴心脏振动测量的系统和方法

    公开(公告)号：US07424321B2

    公开(公告)日：2008-09-09

    申请号：US11135985

    申请日：2005-05-24

    申请人： Ramesh Wariar ,  Krzysztof Z. Siejko ,  Gerrard M. Carlson ,  Jeffrey E. Stahmann

    发明人： Ramesh Wariar ,  Krzysztof Z. Siejko ,  Gerrard M. Carlson ,  Jeffrey E. Stahmann

    IPC分类号： A61B5/04 ,  A61B5/025 ,  A61B5/0225

    CPC分类号： A61B7/00 ,  A61N1/08

    摘要： A system to monitor heart sounds, such as to detect a worsening condition of heart failure decompensation. The system comprises a medical device that includes an implantable multi-axis heart sound sensor, operable to produce, for each of at least two nonparallel axes, an electrical signal representative of at least one heart sound, the heart sound associated with mechanical activity of a patient's heart. The device further includes a controller circuit coupled to the heart sound sensor. The controller circuit measures components of the heart sound that respectively correspond to each of the axes.

    摘要翻译： 监测心脏声音的系统，例如检测心力衰竭代偿失调的恶化情况。 该系统包括医疗装置，其包括可植入的多轴心音传感器，可操作以针对至少两个不平行的轴中的每一个产生代表至少一个心脏声音的电信号，所述心脏声音与 病人的心。 该装置还包括耦合到心脏声音传感器的控制器电路。 控制器电路测量分别对应于每个轴的心音的分量。