公开(公告)号：US06657183B2

公开(公告)日：2003-12-02

申请号：US09939601

申请日：2001-08-28

申请人： Tsuyoshi Yamamoto ,  Kosuke Ohashi ,  Hironari Nakata ,  Atsushi Maki ,  Hideaki Koizumi ,  Mitsuru Oonuma

发明人： Tsuyoshi Yamamoto ,  Kosuke Ohashi ,  Hironari Nakata ,  Atsushi Maki ,  Hideaki Koizumi ,  Mitsuru Oonuma

IPC分类号： H01J4014

CPC分类号： A63F13/212 ,  A63F13/10 ,  A63F13/213 ,  A63F2300/1012 ,  A63F2300/807

摘要： Disclosed herein is an amusement system that can be used and enjoyed by different persons without using the brain continuously and with little feeling of fatigue and which permits setting a probe at any spot on the head of the subject. The amusement system includes irradiators for irradiating the subject with light, light detectors for detection of the light that has been emitted from said irradiator and which has propagated through the living body, signal processors for processing the signal of light intensity detected by said detector and display units that show the processing results from the signal processor. The range of display of a change in intensity of said transmitted light according to the results of a test task carried out on said living body.

摘要翻译： 本文公开了一种娱乐系统，其可以由不同的人使用和享用，而不用连续地使用大脑并且几乎没有疲劳的感觉，并且允许在受试者头部的任何位置设置探针。 娱乐系统包括用于用光照射对象的照射器，用于检测已经从所述照射器发射并已经通过生物体传播的光的光检测器，用于处理由所述检测器检测的光强度的信号的信号处理器和显示器 显示信号处理器处理结果的单位。 根据在所述活体上进行的测试任务的结果，显示所述透射光的强度变化的范围。

公开(公告)号：US5803909A

公开(公告)日：1998-09-08

申请号：US539871

申请日：1995-10-06

申请人： Atsushi Maki ,  Hideaki Koizumi ,  Fumio Kawaguchi ,  Yuichi Yamashita ,  Yoshitoshi Ito

发明人： Atsushi Maki ,  Hideaki Koizumi ,  Fumio Kawaguchi ,  Yuichi Yamashita ,  Yoshitoshi Ito

IPC分类号： A61B5/00 ,  A61B5/05 ,  A61B5/055 ,  A61B5/18 ,  A61B6/00 ,  A61B6/03

CPC分类号： A61B5/0059 ,  A61B5/0042 ,  A61B5/14552 ,  A61B5/14553 ,  A61B5/18 ,  A61B5/6814 ,  A61B2562/0219 ,  A61B2562/0233 ,  A61B2562/046 ,  A61B5/055 ,  A61B5/7207 ,  A61B5/7228 ,  A61B6/03 ,  A61B6/507

摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface Changes in concentration values of absorbers are determined from the living body transmitting light intensity levels and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point to image a function of the living body. The measuring time is shortened by estimating fluctuation attributable to the living body, and a local change in hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by light detection at two different sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.

摘要翻译： 以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平 波长和各个照射位置在表面上的不同位置被测量吸收体的浓度值的变化由生物体透射光强度水平确定，并且测量点设置在延伸穿过入射点和每个之间的中间点的垂直 检测点成像生物体的功能。 通过估计生物体的波动来缩短测量时间，并且可以通过在两个不同位置（等于光入射点的光检测）检测透射通过生物体内部的光线来测量血液动力学运动的局部变化 ），并且根据两个检测信号之间的对数差异仅分离血液动力学运动的局部变化与生物体中的血液动力学运动的总体变化。

公开(公告)号：US5042485A

公开(公告)日：1991-08-27

申请号：US358925

申请日：1989-05-31

申请人： Koichi Sano ,  Tetsuo Yokohama ,  Hideaki Koizumi

发明人： Koichi Sano ,  Tetsuo Yokohama ,  Hideaki Koizumi

IPC分类号： G01R33/44 ,  A61B5/055 ,  A61B10/00 ,  G01R33/48 ,  G01R33/561 ,  G01R33/563 ,  G01R33/567

CPC分类号： G01R33/5673 ,  G01R33/563 ,  G01R33/5617

摘要： In order to image on a time axis a moving object such as a coronary artery which changes in position dynamically along with the heart, the position to which the object has moved is measured and then the position of the object to be excited by a radio frequency field is changed in accordance with the measured position.

摘要翻译： 为了在时间轴上对与心脏动态地改变位置的移动物体（例如冠状动脉）进行成像，测量物体移动的位置，然后测量被射频激发的物体的位置 场根据测量位置而改变。

公开(公告)号：US5023553A

公开(公告)日：1991-06-11

申请号：US330835

申请日：1989-03-30

申请人： Koichi Sano ,  Tetsuo Yokoyama ,  Hideaki Koizumi

发明人： Koichi Sano ,  Tetsuo Yokoyama ,  Hideaki Koizumi

IPC分类号： G01R33/54 ,  A61B5/055 ,  A61B10/00 ,  G01R33/28 ,  G01R33/32 ,  G01R33/567

CPC分类号： G01R33/5676

摘要： In order to eliminate the degradation of NMR image caused by a body motion due to breathing or the like, one of measured image signals is selected as a reference, correlation is calculated between each measured image signal and the reference, and the image signal is modified on the basis of the value of correlation.

摘要翻译： 为了消除由于呼吸等引起的身体运动引起的NMR图像的劣化，选择测量图像信号之一作为参考，在每个测量的图像信号和参考之间计算相关性，并且图像信号被修改 在相关性的基础上。

公开(公告)号：US4948250A

公开(公告)日：1990-08-14

申请号：US621464

申请日：1984-06-18

申请人： Konosuke Oishi ,  Hideaki Koizumi ,  Masataka Koga

发明人： Konosuke Oishi ,  Hideaki Koizumi ,  Masataka Koga

IPC分类号： G01J3/42 ,  G01N21/31

CPC分类号： G01N21/3103 ,  G01N2021/3111

摘要： In atomic absorption spectrophotometers such as Zeeman atomic absorption spectrophotometer, the present invention is characterized in that the correction timing of background absorption in sample light is made to coincide with that of reference light so as to improve the accuracy of the output signals of the spectrophotometer. To accomplish this object, the present invention constitutes a calculation processing unit for storing and calculating signals by means for separating one signal consisting of sample signals and reference signals applied thereto from amplification means for amplifiying photoelectrically converted signals into sample and reference signals, and storing them, means for calculating respectively the mean values of two time adjacent signals of one of the sample and reference signals to prepare a signal of the mean values, and means for calculating the difference of the logarithmic converted values of the signals of the other of the sample and reference signals and those of the signals of the signal of the mean values at the same points of time, and obtaining correction signals of background absorption.

摘要翻译： 在诸如塞曼原子吸收分光光度计的原子吸收分光光度计中，本发明的特征在于使得样品光中的背景吸收的校正时间与参考光的校正时间一致，以提高分光光度计的输出信号的精度。 为了实现该目的，本发明构成了一种计算处理单元，用于通过用于将由采样信号和从其施加的参考信号组成的一个信号分离出来，用于存储和计算信号，该放大装置用于将光电转换的信号放大为采样和参考信号，并将它们存储 分别计算采样和参考信号之一的两个时间相邻信号的平均值以准备平均值的信号的装置，以及用于计算另一个样本的信号的对数转换值之差的装置 参考信号和相同时间点的平均值信号的信号，得到背景吸收的校正信号。

公开(公告)号：US4939462A

公开(公告)日：1990-07-03

申请号：US376216

申请日：1989-07-03

申请人： Akira Maeda ,  Koichi Sano ,  Tetsuo Yokoyama ,  Hideaki Koizumi

发明人： Akira Maeda ,  Koichi Sano ,  Tetsuo Yokoyama ,  Hideaki Koizumi

IPC分类号： A61B5/055 ,  G01R33/48 ,  G01R33/54

CPC分类号： G01R33/4833

摘要： In order to narrow the dynamic range of an NMR signal and to provide MRI of low cost and high image quality without inducing the distortions of an image other than distortion of phase which can be corrected or the degradations of the measurement accuracies of various parameters, a coil for generating an inhomogeneous magnetic field which varies slowly within region to-be-imaged is added to a coil for generating a static magnetic field of high homogeneity, and current to flow through the former coil is changed so as to control the inhomogeneous magnetic field.

公开(公告)号：US4724388A

公开(公告)日：1988-02-09

申请号：US869976

申请日：1986-06-02

申请人： Koichi Sano ,  Tetsuo Yokoyama ,  Hideaki Koizumi

发明人： Koichi Sano ,  Tetsuo Yokoyama ,  Hideaki Koizumi

IPC分类号： G01R33/565 ,  G01R33/20

CPC分类号： G01R33/56518 ,  G01R33/56563

摘要： In order to measure a static field distribution with one scanning operation and to make image distortion corrections with the static field distribution and a gradient field distribution simultaneously considered, an image is reconstructed using a spin echo signal produced under the condition that a time interval between a 90.degree. pulse and a 180.degree. pulse differs from an interval between the 180.degree. pulse and the time origin of the spin echo signal, the static field distribution is evaluated from the relation of distortions to phase errors free from a phase distortion attributed to the characteristic of a detecting part and a phase distortion attributed to the dynamic characteristic of the gradient field, a relations existing between the spatial distortion and phase distortion of the reconstructed image and a magnetic field distribution including the gradient field is obtained, and the distortion magnitude of the reconstructed image is evaluated from the measured magnetic field distribution.

摘要翻译： 为了通过一次扫描操作测量静态场分布，并且同时考虑静态场分布和梯度场分布进行图像失真校正，使用自旋回波信号来重构图像，该自旋回波信号是在 90°脉冲和180°脉冲与180°脉冲与自旋回波信号的时间原点之间的间隔不同，静态场分布从失真和相位误差的关系来评估，该相位误差不包括归因于特性的相位失真 得到归因于梯度场的动态特性的检测部分和相位失真，获得重建图像的空间失真和相位失真之间存在的关系以及包括梯度场的磁场分布，并且， 从测量的磁场分布评估重建图像 。

公开(公告)号：US4504145A

公开(公告)日：1985-03-12

申请号：US411370

申请日：1982-08-25

申请人： Hideaki Koizumi

发明人： Hideaki Koizumi

IPC分类号： G01N21/31 ,  G01J3/00 ,  G01J3/443

CPC分类号： G01J3/443

摘要： Light from a light source emitting a line spectrum is passed through an absorbing cell. A metal element is enclosed in the absorbing cell, and the temperature of the absorbing cell is controlled to maintain a predetermined atomic vapor pressure of the metal element. This absorbing cell is disposed in the gap between the poles of an electromagnet. A linear polarizer is disposed between the light source and the absorbing cell. Light passed through the absorbing cell is led via a spectroscope toward a light sensor. While the light is being directed from the light source toward the absorbing cell, the value of current supplied to the electromagnet is changed to vary the intensity of the magnetic field. With the field intensity variation, the wavelength of a component split from the absorption line of the atomic vapor in the absorbing cell is shifted. This wavelength-shifted component is scanned along the wavelength of the line spectrum emitted from the light source, whereby the profile of the emission line spectrum can be measured.

摘要翻译： 来自发射线谱的光源的光通过吸收单元。 将金属元件封装在吸收单元中，并且控制吸收单元的温度以保持金属元件的预定的原子蒸气压。 该吸收单元设置在电磁体的极之间的间隙中。 线性偏振器设置在光源和吸收单元之间。 通过吸收单元的光通过分光镜被引导到光传感器。 当光从光源引向吸收单元时，改变提供给电磁体的电流值以改变磁场的强度。 随着场强变化，从吸收单元中的原子蒸气的吸收线分离的分量的波长发生偏移。 沿着从光源发射的线谱的波长扫描该波长偏移分量，由此可以测量发射谱谱的轮廓。

公开(公告)号：US20150192604A1

公开(公告)日：2015-07-09

申请号：US14417407

申请日：2012-07-27

申请人： Tsuyoshi Yamamoto ,  Seiji Heike ,  Akira Nambu ,  Tomihiro Hashizume ,  Hideaki Koizumi

发明人： Tsuyoshi Yamamoto ,  Seiji Heike ,  Akira Nambu ,  Tomihiro Hashizume ,  Hideaki Koizumi

IPC分类号： G01Q30/20 ,  G01Q60/24

CPC分类号： G01Q30/20 ,  G01Q30/02 ,  G01Q30/10 ,  G01Q30/14 ,  G01Q60/24

摘要： At the time of carrying out measurement of a biological tissue with a probe microscope, measurement is to be realized while maintain survival conditions for a cell.As a holder for the probe microscope, a measurement holder including: a container in which a measurement object is housed; a first cover section which covers at least a part of the measurement object and has an aperture for inserting a measurement probe; and a second cover section which is connected to the first cover section, covers the container, and has an aperture for inserting the measurement probe, is used.

摘要翻译： 在用探针显微镜进行生物体组织的测定时，要保持细胞的生存条件，进行测定。 作为探针显微镜的保持器，测量保持器包括：容纳测量对象的容器; 第一覆盖部分，其覆盖所述测量对象的至少一部分并且具有用于插入测量探针的孔; 并且连接到第一盖部分的第二盖部分覆盖容器，并且具有用于插入测量探针的孔。

公开(公告)号：US08795175B2

公开(公告)日：2014-08-05

申请号：US12252809

申请日：2008-10-16

申请人： Tsukasa Funane ,  Naoki Tanaka ,  Hideaki Koizumi ,  Atsushi Maki

发明人： Tsukasa Funane ,  Naoki Tanaka ,  Hideaki Koizumi ,  Atsushi Maki

IPC分类号： A61B5/00 ,  A61B5/02

CPC分类号： A61B5/14553 ,  A61B5/02416

摘要： Cerebral blood volume changes are measured to evaluate, from properties of low-frequency components of such changes and heart rate changes calculated by analysis, a distribution of cerebral blood vessel hardness and its change over time to thereby estimate and display diseased and dangerous portions based on the evaluation. This is attainable by a biological measurement system having a cerebral blood volume measurement unit which measures a regional cerebral blood volume of a body under test, an analyzer unit that analyzes a signal measured by the cerebral blood volume measurement unit, an extraction unit for extracting, based on an output of the analysis unit, information concerning a regional cerebral blood vessel state of the test body, and a display unit which displays a measurement result of the cerebral blood volume measurement unit, an analysis result of the analyzer unit or an extraction result of the extraction unit.

摘要翻译： 测量脑血容量变化，从这些变化的低频成分的特性和通过分析计算出的心率变化的性质来评估脑血管硬度的分布及其随时间的变化，从而基于以下方式估计和显示患病和危险部分： 评估。 这是通过具有测量被检测体的局部脑血容量的脑血容量测量单元的生物测量系统，分析由脑血容量测量单元测量的信号的分析单元，提取单元， 基于分析单元的输出，关于测试体的区域性脑血管状态的信息和显示脑血容量测量单元的测量结果的显示单元，分析器单元的分析结果或提取结果 的提取单位。