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公开(公告)号：US08050744B2
公开(公告)日：2011-11-01
申请号：US11037338
申请日：2005-01-19
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译： 在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置 在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。 光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在 信号一次。
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公开(公告)号：US20060184047A1
公开(公告)日：2006-08-17
申请号：US11371919
申请日：2006-03-10
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B6/03
摘要： An input instrument for a living body, using an optical measurement system for the living body, includes first and second light incident units arranged on a head of a living body, and first and second light detectors which are paired with the first and the second light incident units respectively, and which are provided to collect light which passes through the living body based on the light irradiated onto the head of the living body by the light incident means. Measurement signals are obtained by measuring a plurality of regions of the living body by the first and the second light incident units, the first and the second light detectors, and characteristic parameters of the signals of an arbitrary time interval of the measured signals are calculated.
摘要翻译： 使用生物体的光学测量系统的生物体的输入仪器具有设置在生物体的头部的第一和第二光入射单元，以及与第一和第二光线配对的第一和第二光检测器 入射单元，其被设置成基于通过光入射装置照射到生物体的头部上的光来收集穿过生物体的光。 通过第一和第二光入射单元，第一和第二光检测器测量生物体的多个区域以及测量信号的任意时间间隔的信号的特性参数来计算测量信号。
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公开(公告)号：US06947779B2
公开(公告)日：2005-09-20
申请号：US09873206
申请日：2001-06-05
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi
CPC分类号： A61B5/7475 , A61B5/1455
摘要： Optical measurement that is optimum for improving spatial resolution is accomplished by making it possible to estimate a physical quantity of an object substance to be measured at any point on a subject. When any position to be evaluated, in an image shown in a window 1-1, is pointed and selected a mouse pointer 1-4, the value of the concentration or its change of the object substance at the point is displayed in the display area 1-7 of a window 1-3. The drawings represents an example in which one position is specified and there are two object substances to be measured. The value of the concentration or its change of each object substance to be measured is separately displayed.
摘要翻译： 通过使得可以在对象的任何点估计待测物体的物理量来实现对于改善空间分辨率最佳的光学测量。 当要评估的任何位置在窗口1至1所示的图像中被指向并选择了鼠标指针1-4时，该点处的物体的浓度值或其变化的值被显示在显示区域中 1 - 7的窗口1 - 3。 附图表示其中指定了一个位置并且存在两个待测物体的示例。 分别显示要测量的每种物质的浓度值或其变化值。
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4.发明授权Amusement system using living body measurement by light, head setter for the amusement system, and program for use in the amusement system 有权娱乐系统使用活体测量的乐器，娱乐系统的头枕，以及娱乐系统中使用的节目公开(公告)号：US06657183B2
公开(公告)日：2003-12-02
申请号：US09939601
申请日：2001-08-28
申请人： Tsuyoshi Yamamoto , Kosuke Ohashi , Hironari Nakata , Atsushi Maki , Hideaki Koizumi , Mitsuru Oonuma
发明人： Tsuyoshi Yamamoto , Kosuke Ohashi , Hironari Nakata , Atsushi Maki , Hideaki Koizumi , Mitsuru Oonuma
IPC分类号： H01J4014
CPC分类号： A63F13/212 , A63F13/10 , A63F13/213 , A63F2300/1012 , A63F2300/807
摘要： Disclosed herein is an amusement system that can be used and enjoyed by different persons without using the brain continuously and with little feeling of fatigue and which permits setting a probe at any spot on the head of the subject. The amusement system includes irradiators for irradiating the subject with light, light detectors for detection of the light that has been emitted from said irradiator and which has propagated through the living body, signal processors for processing the signal of light intensity detected by said detector and display units that show the processing results from the signal processor. The range of display of a change in intensity of said transmitted light according to the results of a test task carried out on said living body.
摘要翻译： 本文公开了一种娱乐系统，其可以由不同的人使用和享用，而不用连续地使用大脑并且几乎没有疲劳的感觉，并且允许在受试者头部的任何位置设置探针。 娱乐系统包括用于用光照射对象的照射器，用于检测已经从所述照射器发射并已经通过生物体传播的光的光检测器，用于处理由所述检测器检测的光强度的信号的信号处理器和显示器 显示信号处理器处理结果的单位。 根据在所述活体上进行的测试任务的结果，显示所述透射光的强度变化的范围。
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公开(公告)号：US06188065B1
公开(公告)日：2001-02-13
申请号：US09260552
申请日：1999-03-02
IPC分类号： G01D5944
CPC分类号： H01J49/145 , H01J49/0431 , H01J49/049 , H01J49/165 , H01J49/168
摘要： A mass spectrometer includes a sample supplier which supplies a sample solution, the sample solution including a solvent, ions, and a solute, the solute being a sample to be analyzed, an ion converter, disposed after the sample supplier, which converts the ions in the sample solution into gaseous ions, an ion source, disposed after the ion converter, which ionizes the sample in the sample solution, thereby producing sample ions, a mass analyzer which analyzes masses of the sample ions produced by the ion source, and an ion blocking electrode which prevents the gaseous ions produced by the ion converter from reaching the ion source, thereby preventing the mass analyzer from analyzing masses of the gaseous ions produced by the ion converter.
摘要翻译： 质谱仪包括供样品溶液的样品供应商，包含溶剂的样品溶液，离子和溶质，作为待分析样品的溶质，设置在样品供应者之后的离子转化器，其将离子转化为 将样品溶液变成气态离子，离子源，设置在离子转换器之后，将样品溶液中的样品离子化，从而产生样品离子;分析质量分析器，其分析由离子源产生的样品离子的质量;以及离子 阻止由离子转换器产生的气体离子到达离子源的阻挡电极，从而防止质量分析器分析由离子转换器产生的气态离子的质量。
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公开(公告)号：US6121608A
公开(公告)日：2000-09-19
申请号：US968898
申请日：1997-11-06
CPC分类号： H01J49/165 , G01N30/7266 , H01J49/168
摘要： A mass spectrometric apparatus includes a device for supplying a sample solution to an outlet, the sample solution including a solvent and a solute, a first ionization device for receiving the sample solution from the outlet and electrospraying the received sample solution, thereby ionizing at least a portion of the received sample solution, a second ionization device for receiving at least a portion of the electrosprayed sample solution produced by the first ionization device and ionizing at least a portion of the received electrospayed sample solution, thereby producing ions, and a mass spectrometric device for receiving at least some of the ions produced by the second ionization device and analyzing masses of the received ions.
摘要翻译： 质谱装置包括用于将样品溶液供应到出口的装置，所述样品溶液包括溶剂和溶质，用于从所述出口接收样品溶液并对所接收的样品溶液进行电喷雾的第一离子化装置，从而将至少一种 接收样品溶液的一部分，第二电离装置，用于接收由第一离子化装置产生的电喷雾样品溶液的至少一部分，并且电离至少一部分接收的电喷雾样品溶液，从而产生离子，以及质谱仪 用于接收由第二电离装置产生的至少一些离子并分析所接收的离子的质量。
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7.发明授权Method and apparatus for ionizing a sample under atmospheric pressure and selectively introducing ions into a mass analysis region 失效用于在大气压下电离样品并选择性地将离子引入质量分析区域的方法和装置
公开(公告)号：US6005245A
公开(公告)日：1999-12-21
申请号：US919785
申请日：1997-08-29
CPC分类号： H01J49/061 , H01J49/044
摘要： A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.
摘要翻译： 将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为 大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。
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公开(公告)号：US5986259A
公开(公告)日：1999-11-16
申请号：US837216
申请日：1997-04-22
CPC分类号： H01J49/067 , H01J49/044 , H01J49/045
摘要： In a mass spectrometer using a sonic spray ion source, a technique of controlling the density of droplets in a nebulized sample solution which is passed into a mass spectrometer at high vacuum to an appropriate value to thereby reduce analysis noises is disclosed. A sample solution in a sample solution injection unit 1 is introduced into a capillary 2 disposed in an ion source 6. A gas is introduced from a gas supply unit 4 by way of a gas pipe 5 into the ion source 6 and is caused to flow along the outer circumferential surface at the top end of the capillary 2 and is jetted out from the orifice 3 as a gas flow into atmospheric air. The sample solution jetted from the top end of the capillary 2 is ionized by the gas flow in the atmospheric air. Fine droplets or ions formed by the sonic spray method are collide against a diffuser 7, droplets and ions reduced for the density by the diffusion pass through the holes 8 disposed in the diffuser 7, and pass from the sample orifice 10 into a mass spectrometer 11 and mass analyzed. Provision of the diffuser 7 can suppress generation of analysis noises caused by the clustering phenomenon resulting from introduction of droplets or ions at high density into the mass spectrometer 11, thereby enabling to conduct analysis at high S/N ratio.
摘要翻译： 在使用声波喷射离子源的质谱仪中，公开了一种在雾化样品溶液中控制液滴的密度的技术，其以高真空度进入质谱仪至适当的值，从而降低分析噪声。 将样品溶液注入单元1中的样品溶液引入设置在离子源6中的毛细管2.将气体从气体供给单元4通过气体管道5引入离子源6中并使其流动 沿着毛细管2的顶端的外周面，并且作为气流从孔3喷出到大气中。 从毛细管2的顶端喷出的样品溶液通过大气中的气流被离子化。 通过声波喷射法形成的细小液滴或离子与扩散器7碰撞，通过扩散通过设置在扩散器7中的孔8而使密度减小的液滴和离子，并从样品孔10通过到质谱仪11 并进行质量分析。 扩散器7的设置可以抑制由高密度地将液滴或离子引入质谱仪11而产生的聚集现象引起的分析噪声的产生，从而能够以高S / N比进行分析。
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公开(公告)号：US5877495A
公开(公告)日：1999-03-02
申请号：US511804
申请日：1995-08-07
IPC分类号： G01N27/62 , G01N27/447 , H01J49/04 , B01D59/44 , H01J49/00
CPC分类号： H01J49/145 , H01J49/0431 , H01J49/049 , H01J49/165 , H01J49/168
摘要： A mass spectrometer comprising a capillary electrophoresis region for separating a solution containing molecules of sample by capillary electrophoresis in a capillary, a nebulization region for nebulizing the solution containing molecules of the sample under an atmospheric pressure from the end of the capillary and forming liquid droplets of the solution containing the molecules of the sample, a vaporization region for vaporizing the liquid droplets under an atmospheric pressure to form gaseous molecules of the sample, a chemical ionization region for forming ions relevant to the molecules of the sample under the atmospheric pressure or the reduced pressure by a chemical reaction between the ions attributable to the gaseous molecules present in the atmosphere and the gaseous molecules of the sample, and a vacuum region having a sample aperture for introducing the ions formed by the chemical ionization means and incorporating a mass analysis region for mass analysis of ions introduced from the sample aperture. The mass spectrometer is combined with the capillary electrophoresis apparatus and is particularly suitable to formation and mass analysis of ions relevant to the neutral molecules of the sample.
摘要翻译： 一种质谱仪，其包括用于通过毛细管中的毛细管电泳分离含有样品分子的溶液的毛细管电泳区域，用于在大气压下从毛细管端部喷雾含有样品分子的溶液的雾化区域，并形成液滴 含有样品分子的溶液，用于在大气压下蒸发液滴的汽化区域以形成样品的气态分子;用于在大气压下形成与样品分子相关的离子的化学电离区域，或减少 存在于大气中的气体分子的离子和样品的气体分子之间的化学反应产生的压力，以及具有用于引入由化学电离装置形成的离子的样品孔的真空区域，并且包含用于 离子质量分析介绍f 取样孔。 质谱仪与毛细管电泳装置结合，特别适用于与样品中性分子相关的离子的形成和质量分析。
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公开(公告)号：US5803909A
公开(公告)日：1998-09-08
申请号：US539871
申请日：1995-10-06
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B2562/0219 , A61B2562/0233 , A61B2562/046 , A61B5/055 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface Changes in concentration values of absorbers are determined from the living body transmitting light intensity levels and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point to image a function of the living body. The measuring time is shortened by estimating fluctuation attributable to the living body, and a local change in hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by light detection at two different sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译： 以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平 波长和各个照射位置在表面上的不同位置被测量吸收体的浓度值的变化由生物体透射光强度水平确定，并且测量点设置在延伸穿过入射点和每个之间的中间点的垂直 检测点成像生物体的功能。 通过估计生物体的波动来缩短测量时间，并且可以通过在两个不同位置（等于光入射点的光检测）检测透射通过生物体内部的光线来测量血液动力学运动的局部变化 ），并且根据两个检测信号之间的对数差异仅分离血液动力学运动的局部变化与生物体中的血液动力学运动的总体变化。
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