公开(公告)号：US4604615A

公开(公告)日：1986-08-05

申请号：US546424

申请日：1983-10-28

Applicant: Yasuhiro Funahashi

Inventor： Yasuhiro Funahashi

IPC: G06F3/153 ,  G09G1/16 ,  G09G5/00 ,  G09G5/22 ,  G09G1/24

CPC classification number: G09G5/001 ,  G09G5/393 ,  G09G5/222

Abstract: An image reproduction interface disposed between a CPU, and a display device for reproducing an image based on code signals from the CPU corresponding to multiple image elements. The interface comprises a random-access memory for temporarily storing the code signals, and a multiplexor for selecting, for a first period, an address bus for the CPU to address the memory for storing therein the code signals, and for a second period, a refresh address bus for a controller of the display device to address the memory for reading out therefrom the code signals to reproduce the image. A sum of said first and second periods is equal to an interval at which the image elements are reproduced, whereby both storage and retrieval of the code signals into and from the memory may be effected within each reproduction interval in a time-sharing manner, thus reducing an idle or waiting time of the CPU and increasing a rate of updating the image on the display device.

Abstract translation: 一种图像再现界面，设置在CPU和用于基于与多个图像元素对应的来自CPU的代码信号再现图像的显示装置之间。 接口包括用于临时存储代码信号的随机存取存储器，以及多路复用器，用于在第一周期中选择用于CPU的地址总线以寻址存储器以存储代码信号，并且在第二周期中， 刷新地址总线，用于显示设备的控制器，以寻址存储器，用于从中读出代码信号以再现图像。 所述第一和第二周期的总和等于图像元素再现的间隔，从而可以以每个再现间隔以分时方式在代码信号中存储和从存储器检索代码信号，因此 减少CPU的空闲或等待时间，并增加显示设备上的图像更新速率。

公开(公告)号：US20150329615A1

公开(公告)日：2015-11-19

申请号：US14668525

申请日：2015-03-25

Applicant: Jan Kitajewski ,  Carrie Shawber ,  Yasuhiro Funahashi

Inventor： Jan Kitajewski ,  Carrie Shawber ,  Yasuhiro Funahashi

IPC: C07K14/705

CPC classification number: A61K48/00 ,  A61K9/0019 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/30 ,  C07K2319/32

Abstract: This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.

Abstract translation: 本发明提供了治疗患有肿瘤的受试者的方法和用于抑制受试者血管生成的方法，所述方法包括向受试者施用有效量的包含Notch受体蛋白的细胞外结构域的物质组合物， 生命增加部分。 本发明还提供了包含Notch4受体蛋白的细胞外结构域的物质组合物，其可操作地附着于半衰期增加的部分。 本发明还提供了一种制造品。 最后，本发明提供了可复制载体，其编码包含可操作地附着于半衰期增加部分的Notch受体蛋白的细胞外结构域的多肽，包含该可复制载体的宿主载体系统和产生该多肽的方法。

公开(公告)号：US07612092B2

公开(公告)日：2009-11-03

申请号：US11293785

申请日：2005-12-02

Applicant: Yasuhiro Funahashi ,  Akihiko Tsuruoka ,  Masayuki Matsukura ,  Toru Haneda ,  Yoshio Fukuda ,  Junichi Kamata ,  Keiko Takahashi ,  Tomohiro Matsushima ,  Kazuki Miyazaki ,  Ken-ichi Nomoto ,  Tatsuo Watanabe ,  Hiroshi Obaishi ,  Atsumi Yamaguchi ,  Sachi Suzuki ,  Katsuji Nakamura ,  Fusayo Mimura ,  Yuji Yamamoto ,  Junji Matsui

Inventor： Yasuhiro Funahashi ,  Akihiko Tsuruoka ,  Masayuki Matsukura ,  Toru Haneda ,  Yoshio Fukuda ,  Junichi Kamata ,  Keiko Takahashi ,  Tomohiro Matsushima ,  Kazuki Miyazaki ,  Ken-ichi Nomoto ,  Tatsuo Watanabe ,  Hiroshi Obaishi ,  Atsumi Yamaguchi ,  Sachi Suzuki ,  Katsuji Nakamura ,  Fusayo Mimura ,  Yuji Yamamoto ,  Junji Matsui

IPC: A61K31/47

CPC classification number: C07D213/73 ,  A61K31/4706 ,  A61K31/4745 ,  A61K31/517 ,  A61K31/519 ,  C07D207/34 ,  C07D213/26 ,  C07D213/68 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/18 ,  C07D215/233 ,  C07D215/36 ,  C07D215/38 ,  C07D215/48 ,  C07D239/34 ,  C07D239/42 ,  C07D239/47 ,  C07D239/88 ,  C07D249/04 ,  C07D261/14 ,  C07D277/48 ,  C07D307/68 ,  C07D319/06 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—, Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.

Abstract translation: 由以下通式表示的化合物：其中Ag是任选取代的5至14元杂环基等; Xg为-O-，-S-等; Yg是任选取代的C 6-14芳基，任选取代的5至14元杂环基等; Tg1为下列通式表示的基团：（其中Eg为单键或-N（Rg2） - ，Rg1和Rg2各自独立地表示氢原子，可以具有取代基的C1-6烷基等，Zg 表示C 1-8烷基，C 3-8脂环族烃基，C 6-14芳基等）]，其盐或前述的水合物。

公开(公告)号：US07122318B2

公开(公告)日：2006-10-17

申请号：US10468615

申请日：2002-02-21

Applicant: Naoto Ono ,  Taro Senba ,  Naoko Hata ,  Yasuhiro Funahashi ,  Toshiaki Wakabayashi

Inventor： Naoto Ono ,  Taro Senba ,  Naoko Hata ,  Yasuhiro Funahashi ,  Toshiaki Wakabayashi

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/566 ,  C07D209/42 ,  C07K14/70546 ,  G01N2333/70546 ,  G01N2500/00

Abstract: The present invention provides a system for testing the influence of a drug on integrin expression, which comprises measuring an integrin expression level in platelets of an individual to which the drug is administered and, based on the measured expression amount, determining what effect the drug has on integrin expression in cells other than platelets.

Abstract translation: 本发明提供了一种用于测试药物对整合素表达的影响的系统，其包括测量施用药物的个体的血小板中的整联蛋白表达水平，并且基于测量的表达量，确定药物具有的作用 对血小板以外的细胞中的整合素表达。

公开(公告)号：US20050176712A1

公开(公告)日：2005-08-11

申请号：US11097218

申请日：2005-04-04

Applicant: Toshiaki Wakabayashi ,  Yasuhiro Funahashi ,  Naoko Hata ,  Taro Semba ,  Yuji Yamamoto ,  Toru Haneda ,  Takashi Owa ,  Akihiko Tsuruoka ,  Junichi Kamata ,  Tadashi Okabe ,  Keiko Takahashi ,  Kazumasa Nara ,  Shinichi Hamaoka ,  Norihiro Ueda

Inventor： Toshiaki Wakabayashi ,  Yasuhiro Funahashi ,  Naoko Hata ,  Taro Semba ,  Yuji Yamamoto ,  Toru Haneda ,  Takashi Owa ,  Akihiko Tsuruoka ,  Junichi Kamata ,  Tadashi Okabe ,  Keiko Takahashi ,  Kazumasa Nara ,  Shinichi Hamaoka ,  Norihiro Ueda

IPC: A61K45/06 ,  A61K31/00 ,  A61K31/145 ,  A61K31/18 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/506 ,  A61P7/02 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P35/00 ,  A61P35/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D215/38 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D311/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D411/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/53 ,  A61K31/47 ,  A61K31/517 ,  A61K31/519

CPC classification number: C07D471/04 ,  A61K31/00 ,  A61K31/18 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/4439 ,  A61K31/506 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D215/38 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D311/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D411/12 ,  C07D417/12

Abstract: The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them, wherein in the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, —CH═CH— or —(CR4bR5b)mb— (wherein R4b and R5b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mb means an integer of 1 or 2); R1 means hydrogen atom or a C1-C6 alkyl group; Z means a single bond or —CO—NH—; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.

Abstract translation: 本发明提供一种整联蛋白表达抑制剂，以及基于整联蛋白抑制作用的治疗动脉硬化，银屑病，癌症，视网膜血管生成，糖尿病性视网膜病变或炎性疾病，抗凝血剂或癌转移抑制剂的药剂。 即，提供一种整联蛋白表达抑制剂，其包含作为活性成分的下式（I）表示的磺酰胺化合物，其药理学上可接受的盐或其水合物，其中，式中，B表示C6〜C10芳基 环或6至10元杂芳基环，其可以具有取代基，并且其中一部分环可以饱和; K表示单键，-CH-CH-或 - （CR 4b）R b） （其中R 4b和R 5b彼此相同或不同，并且各自表示氢原子或C 1 -C 4烷基;且m b， / SUP>表示1或2的整数）; R 1表示氢原子或C 1 -C 6烷基; Z表示单键或-CO-NH-; 并且R表示可以分别具有取代基并且其中一部分环可以饱和的C 6 -C 10芳基环或6至10元杂芳基环。

公开(公告)号：US06787534B2

公开(公告)日：2004-09-07

申请号：US10149253

申请日：2002-06-10

Applicant: Toru Haneda ,  Akihiko Tsuruoka ,  Junichi Kamata ,  Tadashi Okabe ,  Keiko Takahashi ,  Kazumasa Nara ,  Shinichi Hamaoka ,  Norihiro Ueda ,  Toshiaki Wakabayashi ,  Yasuhiro Funahashi ,  Taro Semba ,  Naoko Hata ,  Yuji Yamamoto ,  Yoichi Ozawa ,  Naoko Tsukahara ,  Takashi Owa

Inventor： Toru Haneda ,  Akihiko Tsuruoka ,  Junichi Kamata ,  Tadashi Okabe ,  Keiko Takahashi ,  Kazumasa Nara ,  Shinichi Hamaoka ,  Norihiro Ueda ,  Toshiaki Wakabayashi ,  Yasuhiro Funahashi ,  Taro Semba ,  Naoko Hata ,  Yuji Yamamoto ,  Yoichi Ozawa ,  Naoko Tsukahara ,  Takashi Owa

IPC: A61K3133

CPC classification number: C07D215/38 ,  C07D215/48 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D217/26 ,  C07D311/16 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention provides a sulfonamide- or sulfonylurea-containing heterocyclic compounds. Specifically, it provides a heterocyclic compound represented by the formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, A is hydrogen atom, a halogen atom, a C1-C4 alkyl or alkoxy group which may be substituted with a halogen atom, or cyano group; B is an optionally substituted aryl group or monocyclic heteroaryl group, or: (wherein, the ring Q is an aromatic ring which may have nitrogen atom; and the ring M is a ring sharing a double bond with the ring Q, which ring may have a heteroatom; and the rings Q and M may share nitrogen atom); K is a single bond; T, W, X and Y are the same as or different from each other and each is ═C(D)— (wherein, D is hydrogen or a halogen atom) or nitrogen atom; U and V are the same as or different from each other and each is ═C(D)—, nitrogen atom, —CH2—, oxygen atom or —CO—; Z is a single bond or —CO—NH—; and R1 is hydrogen atom, etc.

Abstract translation: 本发明提供了含磺酰胺或磺酰脲的杂环化合物。 具体地说，它提供由式（I）表示的杂环化合物，其药理学上可接受的盐或它们的水合物。在该式中，A是氢原子，卤素原子，可以是C 1 -C 4烷基或烷氧基的 被卤素原子或氰基取代; B是任选取代的芳基或单环杂芳基，或者：（其中，环Q是可以具有氮原子的芳环;环M是与环Q共享双键的环，该环可以具有 杂原子;并且环Q和M可以共享氮原子）; K是单键; T，W，X和Y彼此相同或不同，并且各自为= C（D） - （其中，D为氢或卤素原子）或氮原子; U和V彼此相同或不同，并且各自为= C（D） - ，氮原子，-CH 2 - ，氧原子或-CO-; Z是单键或-CO-NH-; R1为氢原子等

公开(公告)号：US06649367B2

公开(公告)日：2003-11-18

申请号：US10084686

申请日：2002-02-26

Applicant: Yuji Yamamoto ,  Yasuhiro Funahashi ,  Kenichi Nomoto ,  Tatsuo Watanabe

Inventor： Yuji Yamamoto ,  Yasuhiro Funahashi ,  Kenichi Nomoto ,  Tatsuo Watanabe

IPC: C12Q102

CPC classification number: G01N33/5011 ,  G01N2500/20

Abstract: A method for producing a cell to which angiogenesis-inducing ability has been imparted, comprising the steps of introducing a gene of an angiogenic factor into a human or animal cell having low angiogenesis-inducing ability, and selecting a cell that overexpresses the angiogenic factor; and a method for screening for an angiogenesis inhibitor or a substance having anticancer activity by using the produced cell.

Abstract translation: 一种生产具有血管发生诱导能力的细胞的方法，包括以下步骤：将血管生成因子的基因导入具有低血管发生诱导能力的人或动物细胞中，并选择过表达血管生成因子的细胞; 以及通过使用所制造的细胞筛选血管生成抑制剂或具有抗癌活性的物质的方法。

公开(公告)号：US06469043B1

公开(公告)日：2002-10-22

申请号：US09647215

申请日：2000-09-28

Applicant: Toru Haneda ,  Akihiko Tsuruoka ,  Junichi Kamata ,  Tadashi Okabe ,  Keiko Takahashi ,  Kazumasa Nara ,  Shinichi Hamaoka ,  Norihiro Ueda ,  Takashi Owa ,  Toshiaki Wakabayashi ,  Yasuhiro Funahashi ,  Taro Semba ,  Naoko Hata ,  Yuji Yamamoto ,  Yoichi Ozawa ,  Noako Tsukahara

Inventor： Toru Haneda ,  Akihiko Tsuruoka ,  Junichi Kamata ,  Tadashi Okabe ,  Keiko Takahashi ,  Kazumasa Nara ,  Shinichi Hamaoka ,  Norihiro Ueda ,  Takashi Owa ,  Toshiaki Wakabayashi ,  Yasuhiro Funahashi ,  Taro Semba ,  Naoko Hata ,  Yuji Yamamoto ,  Yoichi Ozawa ,  Noako Tsukahara

IPC: A61K31404

CPC classification number: C07D401/12 ,  C07D209/04 ,  C07D209/30 ,  C07D209/42 ,  C07D403/12 ,  C07D409/12

Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof. In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1˜C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1˜C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded. Further, when the ring A is cyanophenyl group, 2-amino-5-pyridyl group or a 2-halo-5-pyridyl group and R1 is cyano group or a halogen atom, at least one of R2 and R3 should not be a hydrogen atom.

Abstract translation: 本发明创造出一种新型抗血管生成剂，并提供与常规抗肿瘤剂相比显示出高安全性的抗肿瘤剂，具有确定的作用并且能够长时间施用。 也就是说，其提供由下式（I）表示的吲哚化合物，其药理学上可接受的盐或其水合物。在该式中，R1表示氢原子，卤素原子或氰基; R2和R3相同或不同，各自表示氢原子，C1〜C4低级烷基或卤原子; R4表示氢原子或C1〜C4低级烷基; 并且环A表示氰基苯基，氨基磺酰基苯基，氨基吡啶基，氨基嘧啶基，卤代吡啶基或氰基噻吩基，条件是所有的R 1，R 2和R 3均为氢原子，其中R 2和R 3均为氢原子或 环A为氨基磺酰基，R1和R2均为卤素原子。 此外，当环A为氰基苯基，2-氨基-5-吡啶基或2-卤代-5-吡啶基并且R 1为氰基或卤素原子时，R 2和R 3中的至少一个不应为氢 原子。

公开(公告)号：US06321383B1

公开(公告)日：2001-11-20

申请号：US08688295

申请日：1996-07-29

Applicant: Yasuhiro Funahashi ,  Takuma Kuno

Inventor： Yasuhiro Funahashi ,  Takuma Kuno

IPC: H04N7173

CPC classification number: H04N21/4307 ,  G10H1/0058 ,  G10H1/365 ,  G10H1/368 ,  G10H2220/011 ,  H04N7/17336 ,  H04N21/23106 ,  H04N21/2368 ,  H04N21/4341 ,  H04N21/44016 ,  H04N21/472 ,  H04N21/47202 ,  H04N21/8106 ,  H04N21/8113 ,  H04N21/8153

Abstract: The first auxiliary memory 11a stores background image information in the form of digital data, and the second auxiliary memory 11b stores sound information in the form of digital data. When a request is transmitted from the terminal 36 to the information supplying device 28, a background image information of a genre, to which the requested song belongs, is retrieved from the first auxiliary memory 11a, packetized by the video packetizer 5, and outputted to the multiplexer 9. A sound information for the requested song is retrieved from the second auxiliary memory 11b, packetized by the audio packetizer 6, and outputted to the multiplexer 9. The background image information and the sound information are combined into a single packet data train and outputted to the terminal 36.

Abstract translation: 第一辅助存储器11a存储数字数据形式的背景图像信息，第二辅助存储器11b存储数字数据形式的声音信息。 当从终端36向信息提供装置28发送请求时，从第一辅助存储器11a检索所请求的歌曲所属的类型的背景图像信息，由视频打包器5分组，并输出到 多路复用器9.从第二辅助存储器11b检索所请求的歌曲的声音信息，由音频分组器6分组，并输出到多路复用器9.背景图像信息和声音信息被组合成单个分组数据串 并输出到端子36。

公开(公告)号：US5931679A

公开(公告)日：1999-08-03

申请号：US612065

申请日：1996-03-07

Applicant: Yasuhiro Funahashi

Inventor： Yasuhiro Funahashi

IPC: G06F13/00 ,  G06Q50/00 ,  G06Q50/10 ,  G10H1/36 ,  G10K15/02 ,  G10K15/04 ,  H04L12/00 ,  H04N7/173 ,  H04N21/258 ,  G09B5/00

CPC classification number: G10H1/365 ,  G10H2220/011

Abstract: An information provision system including: a plurality of information provision devices, each information provision device including: a memory for storing data; and an information processor for using the data stored in the memory to prepare external-output information; a transmission unit for conveying external-output information provided by the information provision devices; a plurality of output terminals in a number greater than the plurality of information provision devices, each output terminal including: a keyboard by which requests are inputted; request transmission unit for transmitting, according to commands inputted via the keyboard, requests; and output device for outputting information based on external-output information; and a central control device including: request receiver for receiving requests transmitted from the request transmitter; a priority storage unit for storing, for each output terminal, a priority level at which external-output information is to be provided; and command unit for commanding, according to requests and according to priority level stored for requesting output terminals, an information provision device to provide external-output information requested in a request received by the request receiver.

Abstract translation: 一种信息提供系统，包括：多个信息提供装置，每个信息提供装置包括：用于存储数据的存储器; 以及信息处理器，用于使用存储在存储器中的数据来准备外部输出信息; 传送单元，用于传送由信息提供装置提供的外部输出信息; 多个输出端子，其数量大于所述多个信息提供装置，每个输出端子包括：输入请求的键盘; 请求发送单元根据通过键盘输入的命令发送请求; 以及用于基于外部输出信息输出信息的输出装置; 以及中央控制装置，包括：请求接收器，用于接收从请求发送器发送的请求; 优先级存储单元，用于为每个输出终端存储要提供外部输出信息的优先级; 以及命令单元，根据请求，根据存储的请求输出终端的优先级，提供信息提供装置，用于提供在请求接收者接收到的请求中请求的外部输出信息。