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公开(公告)号：US07304789B2
公开(公告)日：2007-12-04
申请号：US11057165
申请日：2005-02-15
IPC分类号： G02B21/00
CPC分类号： G02B21/0004 , G02B21/02
摘要： A microscope system includes a light source and an objective unit. The objective unit includes an objective optical system, including a small-diameter distal optical system arranged at an end brought near to or into contact with a specimen, for focusing light from the light source onto the specimen; a threaded mount at a coupling position; and an outer cylinder enclosing the small-diameter distal optical system. The microscope system further includes an imaging optical system for forming an image of light from the specimen through the objective optical system and a microscope main body for housing the imaging optical system. The objective unit is detachable from and attachable to the microscope main body with the threaded mount. Conditional expression Df/Da≦0.3 is satisfied, where Df represents the outer diameter of the outer cylinder and Da represents the outer diameter of the threaded mount.
摘要翻译： 显微镜系统包括光源和目标单元。 目标单元包括物镜光学系统，其包括设置在靠近或与样本接触的端部的小直径远端光学系统，用于将来自光源的光聚焦到样本上; 在联接位置的螺纹安装座; 以及包围小直径远端光学系统的外筒。 显微镜系统还包括用于通过物镜光学系统形成来自样本的光的图像的成像光学系统和用于容纳成像光学系统的显微镜主体。 目标单元可与螺纹安装座分离并附接到显微镜主体。 条件表达式Df / Da <= 0.3，其中Df表示外筒的外径，Da表示螺纹安装座的外径。
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公开(公告)号：US20070091425A1
公开(公告)日：2007-04-26
申请号：US11583057
申请日：2006-10-19
申请人： Yoshihiro Kawano
发明人： Yoshihiro Kawano
IPC分类号： G02B21/06
CPC分类号： G02B21/0076 , G02B21/0032 , G02B21/16
摘要： Multiple fluorescences are produced even though a comparatively small light source is used, and a clear, high-resolution fluorescence image is obtained. The invention provides a microscope examination apparatus comprising a light-source unit for emitting a line-shaped excitation beam, and an observation optical system having an observation optical axis aligned in a direction orthogonal to the excitation beam from the light-source unit. A focal position of the observation optical system is disposed in the path of the excitation beam from the light-source unit.
摘要翻译： 即使使用比较小的光源也产生多种荧光，并且获得清晰的高分辨率荧光图像。 本发明提供了一种显微镜检查装置，其包括用于发射线状激发光束的光源单元和具有在与来自光源单元的激励光束正交的方向上对准的观察光轴的观察光学系统。 观察光学系统的焦点位置设置在来自光源单元的激励光束的路径中。
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公开(公告)号：US20050279950A1
公开(公告)日：2005-12-22
申请号：US11070191
申请日：2005-03-03
CPC分类号： G01N21/6486 , G01N21/6456
摘要： The invention provides a multiphoton-excitation-type examination apparatus that efficiently generates a multiphoton-excitation effect, that makes the measurement head compact, and that can be easily adjusted when the measurement head is replaced. The multiphoton-excitation-type examination apparatus comprises a laser light source that oscillates ultrashort pulsed laser light; an optical fiber that transmits the ultrashort pulsed laser light from the laser light source; a support member; a measurement head supported on the support member so as to be movable upwards and downwards and at an angle, and having an optical system that irradiates a specimen with the ultrashort pulsed laser light transmitted by the optical fiber that measures fluorescence or reflected light coming from the specimen; and a dispersion-compensating member, in the measurement head, that compensates for group velocity dispersion of the ultrashort pulsed laser light irradiated onto the specimen.
摘要翻译： 本发明提供了一种多光子激发型检查装置，其有效地产生使得测量头紧凑，并且在更换测量头时可以容易地调节的多光子激发效果。 多光子激发型检查装置包括：振荡超短脉冲激光的激光光源; 从激光光源发射超短脉冲激光的光纤; 支撑构件; 测量头支撑在支撑构件上，以便可上下移动一定角度，并且具有光学系统，该光学系统用由光纤透射的超短脉冲激光照射样本，该光纤测量荧光或来自 标本; 以及在测量头中补偿照射到样本上的超短脉冲激光的组速度色散的色散补偿部件。
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34.发明申请Observation window member and experimental animal having observation window 审中-公开观察窗口成员和具有观察窗口的实验动物公开(公告)号：US20050107675A1
公开(公告)日：2005-05-19
申请号：US10984238
申请日：2004-11-09
申请人： Kazunari Tokuda , Yoshihiro Kawano
发明人： Kazunari Tokuda , Yoshihiro Kawano
CPC分类号： A61L31/048
摘要： In order to enable observation of an experimental animal over a long term, keeping it without stress and in a healthy condition, an observation window member is provided which is made from an optically transparent and biocompatible material formed in a plate or membrane shape to be in close contact with internal tissue of an experimental animal in an area where the epidermis has been removed.
摘要翻译： 为了能够长期观察实验动物，在没有压力的情况下保持健康状态，提供了观察窗构件，其由以板或膜形状形成的光学透明和生物相容性材料制成， 在表皮被去除的区域内与实验动物的内部组织紧密接触。
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公开(公告)号：US5461516A
公开(公告)日：1995-10-24
申请号：US118241
申请日：1993-09-09
摘要： A multilayer film structure includes a light absorption layer and a transparent layer so that a phase in the light absorption layer and a phase in the transparent layer have substantially constant values, irrespective of wavelengths of light transmitted through both the layers.
摘要翻译： 多层膜结构包括光吸收层和透明层，使得光透射层中的相位和透明层中的相位具有基本恒定的值，而不管透过两层的光的波长如何。
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36.发明申请Processor for Pathologic Diagnosis and Processing System for Pathologic Diagnosis 审中-公开病理诊断和处理系统用于病理诊断的处理器公开(公告)号：US20110052017A1
公开(公告)日：2011-03-03
申请号：US12859584
申请日：2010-08-19
IPC分类号： G06K9/00
CPC分类号： A61B5/002 , G06F19/321 , G16H40/20
摘要： The object is to enable a pathologist to appropriately conduct a diagnosis as well as enabling the pathologist to quickly proceed with the pathologic diagnosis. A processor for pathologic diagnosis comprises: a diagnosis receiver unit which receives identification information of a patient and diagnosis request information; a pathologist information storage unit which stores information of pathologists; a pathologist selection unit which makes an inquiry to the pathologist information storage unit based on the diagnosis request information received by the diagnosis receiver unit, and selects a pathologist suitable for the diagnosis request information; an image transmission, commander unit which issues a command to send digital image data of the patient stored in an image storage server, to a local server connected to a second network belonged to by a pathologist terminal used by the pathologist selected by the pathologist selection unit; and a diagnosis requesting unit which sends a request for diagnosis of the specimen of the patient, to the pathologist selected by the pathologist selection unit, after the digital image data has been sent to the local server by the image transmission commander unit.
摘要翻译： 目的是使病理学家适当进行诊断，并使病理学家能够快速进行病理诊断。 用于病理诊断的处理器包括：诊断接收器单元，其接收患者的识别信息和诊断请求信息; 病理学家信息存储单元，其存储病理学家的信息; 病理学家选择单元，其基于由诊断接收单元接收到的诊断请求信息向病理学家信息存储单元进行查询，并选择适合于诊断请求信息的病理学家; 命令单元，发送命令，将存储在图像存储服务器中的患者的数字图像数据发送到由病理学家选择单元选择的病理学家所使用的病理学家终端所连接的第二网络的本地服务器 ; 以及诊断请求单元，其在由图像传输指令单元将数字图像数据发送到本地服务器之后，向病理学家选择单元选择的病理学家发送患者的标本的诊断请求。
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公开(公告)号：US20070167842A1
公开(公告)日：2007-07-19
申请号：US11640921
申请日：2006-12-19
IPC分类号： A61B6/00
CPC分类号： A61B1/045 , A61B1/043 , A61B5/0068 , A61B5/0071 , A61B5/0084
摘要： An object is to easily and reliably reach an examination site. The present invention provides an examination method of carrying out in-vivo examination using an in-vivo examination apparatus capable of fluorescence examination and reflected-light examination and includes the steps of setting a reference position so as to set an examination site by carrying out reflected-light examination, switching from reflected-light examination to fluorescence examination, and moving from the reference position to the examination site.
摘要翻译： 目的是轻松可靠地到达考场。 本发明提供使用能够进行荧光检查和反射光检查的体内检查装置进行体内检查的检查方法，包括以下步骤：设定参考位置，以便通过进行反射 光线检查，从反射光检查切换到荧光检查，从参考位置移动到检查点。
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公开(公告)号：US20070120070A1
公开(公告)日：2007-05-31
申请号：US11647031
申请日：2006-12-27
IPC分类号： G01J1/58
CPC分类号： G01N21/6486 , G01N21/6456
摘要： The invention provides a multiphoton-excitation-type examination apparatus that efficiently generates a multiphoton-excitation effect, that makes the measurement head compact, and that can be easily adjusted when the measurement head is replaced. The multiphoton-excitation-type examination apparatus comprises a laser light source that oscillates ultrashort pulsed laser light; an optical fiber that transmits the ultrashort pulsed laser light from the laser light source; a support member; a measurement head supported on the support member so as to be movable upwards and downwards and at an angle, and having an optical system that irradiates a specimen with the ultrashort pulsed laser light transmitted by the optical fiber that measures fluorescence or reflected light coming from the specimen; and a dispersion-compensating member, in the measurement head, that compensates for group velocity dispersion of the ultrashort pulsed laser light irradiated onto the specimen.
摘要翻译： 本发明提供了一种多光子激发型检查装置，其有效地产生使得测量头紧凑，并且在更换测量头时可以容易地调节的多光子激发效果。 多光子激发型检查装置包括：振荡超短脉冲激光的激光光源; 从激光光源发射超短脉冲激光的光纤; 支撑构件; 测量头支撑在支撑构件上，以便可上下移动一定角度，并且具有光学系统，该光学系统用由光纤透射的超短脉冲激光照射样本，该光纤测量荧光或来自 标本; 以及在测量头中补偿照射到样本上的超短脉冲激光的组速度色散的色散补偿部件。
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公开(公告)号：US20060187499A1
公开(公告)日：2006-08-24
申请号：US11338578
申请日：2006-01-23
申请人： Yasuaki Natori , Kenji Kawasaki , Kenji Karaki , Yoshihiro Kawano
发明人： Yasuaki Natori , Kenji Kawasaki , Kenji Karaki , Yoshihiro Kawano
IPC分类号： H04N1/04
CPC分类号： G02B21/0064 , G02B21/0032 , G02B21/0076 , G02B21/16
摘要： When exchanging a dichroic mirror to detect fluorescence of a different wavelength, it is unnecessary to carry out precise positional adjustment, particularly in a compact examination apparatus, and the dichroic mirror can be easily exchanged. The invention provides a connection unit including a light-source optical fiber, removably connected to the light source, for conveying the excitation light from the light source; a collimator lens for collimating the excitation light emitted from the light-source optical fiber to introduce the excitation light to the optical scanning section; and a dichroic mirror for splitting off fluorescence, which is generated in the sample and which returns via the objective lens and the optical scanning section, from a light path of the excitation light and for directing the fluorescence to a photodetector. The light-source optical fiber, the collimator lens, and the dichroic mirror are secured to each other such that optical axes thereof are aligned.
摘要翻译： 当更换分色镜以检测不同波长的荧光时，不需要进行精确的位置调整，特别是在小型检查装置中，并且可以容易地更换分色镜。 本发明提供了一种连接单元，包括可移除地连接到光源的用于传送来自光源的激发光的光源光纤; 准直透镜，用于准直从光源光纤发射的激发光，以将激发光引入光学扫描部分; 以及用于分离荧光的二向色镜，其在样品中产生，并且经由物镜和光学扫描部分从激发光的光路返回，并将荧光引导到光电检测器。 光源光纤，准直透镜和分色镜彼此固定，使得其光轴对齐。
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公开(公告)号：US20060044556A1
公开(公告)日：2006-03-02
申请号：US11209693
申请日：2005-08-24
申请人： Yoshihiro Kawano
发明人： Yoshihiro Kawano
CPC分类号： G01N21/6456 , G01J3/021 , G01J3/0229 , G01J3/10 , G01J3/1256 , G01J3/4406 , G01J2003/1221 , G01J2003/1286 , G01N21/6486 , G01N2021/6419 , G01N2021/6421 , G01N2021/6463
摘要： Fluorescence emitted from a tissue can be detected efficiently, and excitation light with a plurality of wavelengths can be simultaneously emitted to simultaneously detect fluorescence with a plurality of wavelengths. A laser-scanning fluoroscopy apparatus includes a laser light source of a plurality of wavelengths; a spectroscopic device for splitting laser beams according to wavelength; a focusing lens for focusing the split laser beams; and a wavelength-selecting reflection device which includes a plurality of reflection sections disposed near the focal positions, spaced out at predetermined intervals in a split direction to reflect the laser beams with different wavelengths and a transmission section arranged adjacent to the reflection sections. The laser-scanning fluoroscopy apparatus further includes a diffraction grating for combining the reflected laser beams; a scanning section for two-dimensionally scanning the combined laser beams; an objective optical system for focusing the scanned laser beams onto a tissue; and a photodetector for detecting fluorescence emitted from the tissue. A width dimension, as measured along the split direction, of each reflection section of the wavelength-selecting reflection device is smaller than a width dimension of the transmission section.
摘要翻译： 可以有效地检测从组织发出的荧光，并且可以同时发射具有多个波长的激发光，以同时检测多个波长的荧光。 激光扫描透视设备包括多个波长的激光光源; 用于根据波长分割激光束的分光装置; 用于聚焦分束激光束的聚焦透镜; 以及波长选择反射装置，其包括设置在聚焦位置附近的多个反射部分，以分割方向以预定间隔隔开以反射具有不同波长的激光束，以及布置在反射部分附近的透射部分。 激光扫描透视装置还包括用于组合反射的激光束的衍射光栅; 用于二维扫描组合的激光束的扫描部分; 用于将扫描的激光束聚焦到组织上的物镜光学系统; 以及用于检测从组织发出的荧光的光电检测器。 波长选择反射装置的每个反射部分沿分割方向测量的宽度尺寸小于透射部分的宽度尺寸。
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