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31.发明授权
公开(公告)号：US5221671A
公开(公告)日：1993-06-22
申请号：US778563
申请日：1991-10-17
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22
CPC分类号： C07D495/14
摘要： A triazolo-1,4-di-azepine compound of the below given formulas and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译： 公开了以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐，特别适用于过敏性疾病。 和其中R 1和R 2为氢或烷基，R 3为氢或卤素，R 4为氢或烷基，X为-OCO - ， - NHCO - ， - CO-或其它物质的
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公开(公告)号：US06281214B1
公开(公告)日：2001-08-28
申请号：US09166229
申请日：1998-10-05
申请人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
发明人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
IPC分类号： A61K31495
CPC分类号： C07D213/30 , C07C2601/02 , C07D213/26 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/1804
摘要： A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: wherein R1, R2, R3, R4, and R5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.
摘要翻译： 由下式（I）表示的联苯衍生物或其药理学上可接受的盐：其中R1，R2，R3，R4和R5在说明书中定义，在临床上可用于治疗和改善精神障碍如脑血管障碍，侵袭性 老年性痴呆，精神激素，por妄症，del妄，幻觉，运动过度，精神分裂症，情绪障碍，抑郁症，神经症，心理生理障碍和焦虑神经症的行为。 该化合物表现出多巴胺2受体拮抗作用和/或5-羟色胺2受体拮抗作用。
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公开(公告)号：US5849912A
公开(公告)日：1998-12-15
申请号：US855790
申请日：1997-05-12
申请人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
发明人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
IPC分类号： C07D295/03 , A61K31/495 , A61P25/18 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/04 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/18 , C07D401/06
CPC分类号： C07D213/30 , C07D213/26 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/1856 , C07C2101/02
摘要： A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.
摘要翻译： 由下式（I）表示的联苯衍生物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4和R 5在本说明书中定义，其在临床上可用于治疗和改善精神障碍 脑血管障碍，老年性痴呆，精神激动，心脏虚弱，del妄，幻觉，运动过度，精神分裂症，情绪障碍，抑郁，神经症，心理生理障碍和焦虑神经症引起的侵略行为。 该化合物表现出多巴胺2受体拮抗作用和/或5-羟色胺2受体拮抗作用。
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公开(公告)号：US5476863A
公开(公告)日：1995-12-19
申请号：US129301
申请日：1993-09-30
申请人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , A61K31/44 , A61K31/495 , C07D213/72
CPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12
摘要： A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
摘要翻译： 具有下式（I）或（I'）的甘油衍生物及其药理学上可接受的盐可用于治疗血小板活化因子引起的疾病。 （I）
（I） -
公开(公告)号：US5409909A
公开(公告)日：1995-04-25
申请号：US214850
申请日：1994-03-18
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Kimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Kimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , A61K31/55
CPC分类号： C07D495/14
摘要： A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to treat allergic diseases: ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译： 公开了以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐，其可用于药物领域，特别是治疗过敏性疾病：其中R 1和R 2为氢或烷基 ，R 3为氢或卤素，R 4为氢或烷基，X为-OCO - ， - NHCO - ， - CO-等，Y为环烷基，环烷基烷基，炔基等。
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公开(公告)号：US5273985A
公开(公告)日：1993-12-28
申请号：US710089
申请日：1991-06-04
申请人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , A61K31/44 , C07D213/72
CPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12
摘要： A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
摘要翻译： 具有下式（I）或（I'）的甘油衍生物及其药理学上可接受的盐可用于治疗血小板活化因子引起的疾病。 （I）
（I） -
公开(公告)号：US5438045A
公开(公告)日：1995-08-01
申请号：US52721
申请日：1993-04-27
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , A61K31/55
CPC分类号： C07D495/14
摘要： A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OOO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译： 公开了以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐，尤其适用于过敏性疾病。 其中R 1和R 2是氢或烷基，R 3是氢或卤素，R 4是氢或烷基，X是-O-，-NHCO-，-CO-或其它，Y是环烷基， 环烷基烷基，炔基等。
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公开(公告)号：US5482937A
公开(公告)日：1996-01-09
申请号：US318971
申请日：1994-10-06
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , C07F9/6561 , A61K31/55
CPC分类号： C07D495/14 , C07F9/6561
摘要： A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are useful in the pharmaceutical field, especially in treating allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译： 以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐可用于制药领域，特别是用于治疗过敏性疾病。 其中R1和R2是氢或烷基，R3是氢或卤素，R4是氢或烷基，X是-OCO-，Y是环烷基，环烷基烷基，炔基等。
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公开(公告)号：US5476864A
公开(公告)日：1995-12-19
申请号：US129302
申请日：1993-11-10
申请人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , A61K31/44 , C07D213/02
CPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12
摘要： A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
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公开(公告)号：US5468740A
公开(公告)日：1995-11-21
申请号：US386533
申请日：1995-02-10
申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07D495/14 , C07D495/22 , C07F9/6561 , A61K31/675 , C07F9/00
CPC分类号： C07D495/14 , C07F9/6561
摘要： A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.
摘要翻译： 公开了以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐，尤其适用于过敏性疾病。 其中R 1和R 2是氢或烷基，R 3是氢或卤素，R 4是氢或烷基，X是-OCO - ， - NHCO-，-CO-或其它，Y是环烷基， 环烷基烷基，炔基等。
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