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31.发明授权Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators 有权三环杂芳基哌嗪，吡咯烷和氮杂环丁烷作为血清素受体调节剂公开(公告)号：US07423056B2
公开(公告)日：2008-09-09
申请号：US11217991
申请日：2005-09-01
IPC分类号： A61K31/40 , C07D209/56 , C07D495/02
CPC分类号： C07D491/04 , C07D495/04
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地说，本发明的化合物是六氢吖庚因吲哚和八氢吖辛因吲哚化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。
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32.发明授权Ring-labeled retinoids and intermediates, and methods for their synthesis and use 失效环标记的类视色素和中间体，以及它们的合成和使用方法
公开(公告)号：US5514821A
公开(公告)日：1996-05-07
申请号：US250368
申请日：1994-05-27
IPC分类号： C07C45/29 , C07C45/67 , C07C69/608 , C07C403/20 , C07D309/32 , C07C57/26
CPC分类号： C07C403/20 , C07C403/14 , C07C45/29 , C07C45/67 , C07C69/608 , C07D309/32 , C07B2200/05 , C07B2200/09 , C07C2101/16
摘要： Methods for the synthesis of dideuterium and/or ditritium ring-labeled retinoids and intermediates, and their use in the discovery of Retinoid X Receptor ligands are provided. In addition, dideuterium and/or ditritium ring-labeled retinoids and novel intermediates, as well as methods for their use in ligand binding and mass spectral studies are also provided.
摘要翻译： 提供了合成二氘和/或二铑环标记的类视黄醇和中间体的方法及其在发现维甲酸X受体配体中的用途。 此外，还提供了二氘和/或二铑环标记的类视黄醇和新型中间体，以及其用于配体结合和质谱研究的方法。
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公开(公告)号：US20130085150A1
公开(公告)日：2013-04-04
申请号：US13625151
申请日：2012-09-24
申请人： Oswy Z. Pereira , John Maxwell , Youssef L. Bennani , Sanjoy Kumar Das , Laval Chan Chun Kong , Jagadeeswar T. Reddy , Simon Giroux , Kevin M. Cottrell , Mark A. Morris
发明人： Oswy Z. Pereira , John Maxwell , Youssef L. Bennani , Sanjoy Kumar Das , Laval Chan Chun Kong , Jagadeeswar T. Reddy , Simon Giroux , Kevin M. Cottrell , Mark A. Morris
IPC分类号： A61K31/52 , A61K31/423 , C07D401/14 , A61K31/4184 , C07D471/04 , A61K31/437 , C07D473/00 , C07D403/14 , C07D413/14 , A61K31/454
CPC分类号： A61K31/52 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/454 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D487/04 , C07D495/04
摘要： Compounds represented by formula I or pharmaceutically acceptable salts thereof, wherein A, B, B′, X, Y, R1, R2, R2′, R3, R3′, R4, R4′, R5, R5′m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐，其中A，B，B'，X，Y，R 1，R 2，R 2'，R 3，R 3'，R 4，R 4'，R 5，R 5' 如本文所定义，可用于治疗黄病毒科病毒感染。
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34.发明授权Benzimidazole analogues for the treatment or prevention of flavivirus infections 失效苯并咪唑类似物用于治疗或预防黄病毒感染公开(公告)号：US08354419B2
公开(公告)日：2013-01-15
申请号：US12838350
申请日：2010-07-16
申请人： James A. Henderson , John Maxwell , Louis Vaillancourt , Mark Morris , Ronald Grey, Jr. , Simon Giroux , Laval Chan Chun Kong , Sanjoy Kumar Das , Bingcan Liu , Carl Poisson , Caroline Cadilhac , Monica Bubenik , T. Jagadeeswar Reddy , Guy Falardeau , Constantin Yannopoulos , Jian Wang , Oswy Z. Pereira , Youssef L. Bennani , Albert C. Pierce , Govinda Rao Bhisetti , Kevin M. Cottrell , Valerie Marone
发明人： James A. Henderson , John Maxwell , Louis Vaillancourt , Mark Morris , Ronald Grey, Jr. , Simon Giroux , Laval Chan Chun Kong , Sanjoy Kumar Das , Bingcan Liu , Carl Poisson , Caroline Cadilhac , Monica Bubenik , T. Jagadeeswar Reddy , Guy Falardeau , Constantin Yannopoulos , Jian Wang , Oswy Z. Pereira , Youssef L. Bennani , Albert C. Pierce , Govinda Rao Bhisetti , Kevin M. Cottrell , Valerie Marone
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4184 , C07D403/14 , C07D401/14
CPC分类号： C07K5/06052 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂化物，其中A，B，B'，X，Y，R1，R1'，R2，R2'，R3，R3'，R5，R5'，R6， n或p如本文所定义，可用于治疗黄病毒科病毒感染。
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公开(公告)号：US08273767B2
公开(公告)日：2012-09-25
申请号：US12849697
申请日：2010-08-03
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/506
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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36.发明授权公开(公告)号：US08232311B2
公开(公告)日：2012-07-31
申请号：US13071732
申请日：2011-03-25
CPC分类号： C07D209/90 , A61K31/403 , C07D209/70 , C07D409/04 , C07D491/04
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are tricyclic indeno-pyrrole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地说，本发明的化合物是三环茚并吡咯化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。
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37.发明申请公开(公告)号：US20110172283A1
公开(公告)日：2011-07-14
申请号：US13071732
申请日：2011-03-25
IPC分类号： A61K31/403 , C07D209/70 , A61P25/24 , A61P25/30 , A61P25/22 , A61P3/04 , C07D491/048 , A61K31/407
CPC分类号： C07D209/90 , A61K31/403 , C07D209/70 , C07D409/04 , C07D491/04
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are tricyclic indeno-pyrrole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地，本发明的化合物是三环茚并吡咯化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。
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公开(公告)号：US07932245B2
公开(公告)日：2011-04-26
申请号：US10691095
申请日：2003-10-22
申请人： Youssef L. Bennani , William H. Bunnelle , Sou-Jen Chang , Sanjay R. Chemburkar , Jinhua Chen , Michael J. Dart , Dilinie P. Fernando , Yi-Yin Ku , Mark Lockwood , Lei Wang
发明人： Youssef L. Bennani , William H. Bunnelle , Sou-Jen Chang , Sanjay R. Chemburkar , Jinhua Chen , Michael J. Dart , Dilinie P. Fernando , Yi-Yin Ku , Mark Lockwood , Lei Wang
IPC分类号： A61K31/397 , A61K31/535 , A61K31/4965 , A61K31/445
CPC分类号： C07C233/58 , A61K31/397 , A61K31/445 , A61K31/537 , A61K31/54 , C07C2602/50
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.
摘要翻译： 本发明涉及式（I）化合物用于治疗癫痫，双相情感障碍，精神障碍，偏头痛，疼痛或运动障碍的用途，并提供神经保护作用。
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39.发明申请INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS 有权作为组胺3受体抑制剂治疗认知障碍和睡眠障碍，肥胖和其他中枢神经系统疾病的吲哚衍生物公开(公告)号：US20110059966A1
公开(公告)日：2011-03-10
申请号：US12943659
申请日：2010-11-10
IPC分类号： A61K31/404 , C07D403/12 , C07D403/14 , C07D413/14 , A61K31/454 , A61K31/5377 , A61P29/00 , A61P25/06 , A61P25/16 , A61P25/08 , A61P9/00 , A61P9/12 , A61P9/10 , A61P1/00 , A61P25/00 , A61P25/28 , A61P25/24 , A61P25/18 , A61P3/04
CPC分类号： C07D209/08 , C07D209/12 , C07D209/42 , C07D403/12 , C07D413/12
摘要： This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain indole derivatives and their salts and solvates. These compounds have H3 histamine receptor antagonist activity. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H3 receptor blockade is beneficial.
摘要翻译： 本发明涉及具有药理活性的化合物，含有这些化合物的组合物以及使用该化合物和组合物的治疗方法。 更具体地说，本发明涉及某些吲哚衍生物及其盐和溶剂合物。 这些化合物具有H3组胺受体拮抗剂活性。 本发明还涉及含有这些化合物的药物组合物和治疗其中组胺H3受体阻断有益的病症的方法。
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公开(公告)号：US20090036446A1
公开(公告)日：2009-02-05
申请号：US12284574
申请日：2008-09-23
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/403
CPC分类号： C07D209/08 , C07D209/12 , C07D209/42 , C07D403/12 , C07D413/12
摘要： This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain indole derivatives and their salts and solvates. These compounds have H3 histamine receptor antagonist activity. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H3 receptor blockade is beneficial.
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