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    PETAL-ARRAY SUPPORT FOR USE WITH MICROPLATES
    34.
    发明申请
    PETAL-ARRAY SUPPORT FOR USE WITH MICROPLATES 失效
    PETAL-ARRAY支持使用麦克风

    公开(公告)号：US20030129741A1

    公开(公告)日：2003-07-10

    申请号：US10038974

    申请日：2002-01-04

    申请人： PE Corporation (NY)

    发明人： Paul O. Ramstad

    IPC分类号： C12M001/34

    CPC分类号： B01L3/50853 ,  B01L2300/046 ,  B01L2300/0636 ,  B01L2300/0829

    摘要： The present invention provides, among other things, supports upon which one or more species can be adsorbed, captured, or immobilized for biochemical procedures. In various embodiments, the supports include a plurality of deformable petal-like members that provide binding sites for biochemical species. The invention provides an apparatus and method for the ready insertion of the petal-like members into respective wells of a multi-well microplate (e.g., a standard-format 96- or 384-well plate).

    摘要翻译： 本发明尤其提供了一种或多种物质可以被吸附，捕获或固定用于生化过程的载体。 在各种实施方案中，支持物包括提供用于生物化学物质的结合位点的多个可变形花瓣状构件。 本发明提供了一种用于将花瓣状构件准备好插入多孔微孔板（例如，标准格式的96孔或384孔板）的相应孔中的装置和方法。

    Sample handling system for a multi-channel capillary electrophoresis device
    36.
    发明申请
    Sample handling system for a multi-channel capillary electrophoresis device 有权
    多通道毛细管电泳装置的样品处理系统

    公开(公告)号：US20030062265A1

    公开(公告)日：2003-04-03

    申请号：US10288405

    申请日：2002-11-04

    申请人： PE Corporation (NY)

    发明人： Howard Gregg King ,  John Shigeura ,  Eric S. Nordman ,  Sean Matthew Desmond

    IPC分类号： G01N027/26 ,  G01N027/447

    CPC分类号： G01N27/44743

    摘要： A sample handling system in a multi-channel capillary electrophoresis apparatus is disclosed. The sample handling system includes a work surface for supporting a plurality of samples located at a plurality of work surface coordinates and a sample loading assembly comprising a plurality of loading wells. At least one of the loading wells includes a capillary fixedly positioned therein. The system further includes a programmable sample transfer device for automatically transferring a sample from a work surface coordinate to a loading well. The invention further includes methods for using the sample handling system.

    摘要翻译： 公开了一种多通道毛细管电泳装置中的样品处理系统。 样品处理系统包括用于支撑位于多个工作表面坐标处的多个样品的工作表面和包括多个加载孔的样品加载组件。 至少一个装载井包括固定地定位在其中的毛细管。 该系统还包括用于将样品从工作面坐标自动转移到装载井的可编程样品转移装置。 本发明还包括使用样品处理系统的方法。

    Methods for large scale protein matching
    37.
    发明申请
    Methods for large scale protein matching 审中-公开
    大规模蛋白质匹配方法

    公开(公告)号：US20030031350A1

    公开(公告)日：2003-02-13

    申请号：US10087541

    申请日：2002-03-01

    申请人： PE CORPORATION (NY)

    发明人： Benjamin R. Halpern

    IPC分类号： C12P021/06 ,  G06K009/00

    CPC分类号： H01J49/0036 ,  G16B30/00 ,  H01J49/0431

    摘要： The present invention provides methods for matching a sample of an unknown query peptide to a database of known peptides. The methods described herein allow for the rapid, sensitive, and selective identification of an unknown query peptide, which enables the development of high throughput protein identification. The methods described herein also allow for mass spectrometry data for a query peptide to be categorized and weighted according to its quality. Furthermore, the methods described herein provide robust identification of modified query proteins by either anticipating modifications or adjusting for modified peptide masses.

    摘要翻译： 本发明提供了将未知查询肽的样品与已知肽的数据库进行匹配的方法。 本文描述的方法允许对未知查询肽的快速，灵敏和选择性鉴定，其能够开发高通量蛋白质鉴定。 本文描述的方法还允许将查询肽的质谱数据根据其质量进行分类和加权。 此外，本文所述的方法通过预期修饰或调整修饰的肽质量来提供修饰的查询蛋白的强力鉴定。

    Nucleotide compounds including a rigid linker
    40.
    发明申请
    Nucleotide compounds including a rigid linker 有权
    包括刚性接头的核苷酸化合物

    公开(公告)号：US20020151711A1

    公开(公告)日：2002-10-17

    申请号：US10085561

    申请日：2002-02-26

    申请人： PE Corporation (NY)

    发明人： Shaheer H. Khan ,  Barnett B. Rosenblum ,  Weiguo Zhen ,  Steven M. Menchen

    IPC分类号： C07H021/04 ,  C12Q001/68

    CPC分类号： C07H21/00 ,  C07H19/04 ,  C07H19/06 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q2525/186 ,  C12Q2525/117 ,  C12Q2525/113

    摘要： A nucleoside/tide compound having the structure NUCnullLnullSnullLB/LG is described wherein NUC is a nucleoside/tide having a nucleobase portion B, L is a rigid linkage, S is a spacer; and LB/LG is a member of a linkage pair or a label. NUC is attached to L through B such that when B is a purine, L is attached to the 8-position of the purine, when B is 7-deazapurine, L is attached to the 7-position of the 7-deazapurine, and when B is pyrimidine, L is attached to the 5-position of the pyrimidine. In an important aspect of the invention, L has the structure 1 wherein each of n, o and p are integers ranging from 0 to 3, and the sum of n, o and p is at least 2, and each of W, X, Y and Z is selected from the group consisting of carbon and nitrogen. The invention further includes polynucleotide compounds comprising the nucleoside/tide, and primer extension methods utilizing the nucleoside/tide, particularly when used in combination with certain mutant polymerase enzymes.

    摘要翻译： 其中NUC是具有核碱基的核苷/潮汐的核苷/潮汐化合物，其具有结构<片段-inline-formula> NUC-LS-LB / LG 部分B，L是刚性连接，S是间隔物; 而LB / LG是连锁对或标签的成员。 N与B连接，B为嘌呤时，L为嘌呤8位时，B为7-脱氮嘌呤时，L为7-脱氮嘌呤的7-位， B是嘧啶，L连接到嘧啶的5位上。 在本发明的一个重要方面，L具有其中n，o和p各自为0〜3的整数，n，o和p的和为2以上的结构，W，X，Y Z选自碳和氮。 本发明还包括包含核苷/潮汐的多核苷酸化合物，以及利用核苷/潮汐的引物延伸方法，特别是当与某些突变型聚合酶组合使用时。