公开(公告)号：US3917719A

公开(公告)日：1975-11-04

申请号：US36829573

申请日：1973-06-08

申请人： KERR MC GEE CHEM CORP

发明人： BALDWIN ROGER ALLEN ,  HAWTHORNE MARION FREDERICK ,  CHENG MING TZU

IPC分类号： C07C205/22 ,  C07C207/04 ,  C07C79/26

CPC分类号： C07C201/06 ,  C07C201/00 ,  C07C205/22 ,  C07C207/04

摘要： The invention provides a process for the preparation of 4-nitrom-cresol which includes nitrosating m-cresol by simultaneously introducing separate streams of m-cresol and a nitrosating agent into a quantity of cold aqueous acid to form 4-nitroso-m-cresol and thereafter introducing both sodium nitrate and nitric acid to effect the oxidation of the nitroso compound to form 4-nitro-mcresol.

摘要翻译： 本发明提供了一种制备4-硝基间甲酚的方法，该方法包括通过同时将间甲苯和亚硝基化剂流引入一定量的含水酸中，使间甲酚亚硝化形成4-亚硝基间甲酚， 甲酚，然后引入硝酸钠和硝酸，以使亚硝基化合物氧化形成4-硝基间甲酚。

公开(公告)号：US3689576A

公开(公告)日：1972-09-05

申请号：US3689576D

申请日：1969-12-05

申请人： PURDUE RESEARCH FOUNDATION

发明人： BACHMAN GUSTAVE BRYANT ,  BIERMANN THEODORE F

IPC分类号： C07C201/06 ,  C07C201/12 ,  C07C205/02 ,  C07C205/05 ,  C07C205/06 ,  C07C205/08 ,  C07C79/04

CPC分类号： C07C201/06 ,  C07C2601/14 ,  C07C205/02 ,  C07C205/08 ,  C07C205/05 ,  C07C205/06

摘要： A process for the production of nitroalkanes and nitroaromatics having from one to 19 carbon atoms by the thermal decomposition of an acyl nitrate having from one to 20 carbon atoms.

摘要翻译： 通过热分解具有1至20个碳原子的酰基硝酸盐来生产具有1至19个碳原子的硝基烷烃和硝基芳族化合物的方法。

公开(公告)号：US3649665A

公开(公告)日：1972-03-14

申请号：US3649665D

申请日：1969-04-23

申请人： TEXACO INC

发明人： CHAFETZ HARRY ,  BLACKLEY WILLIAM D ,  KREUZ KENNETH L

IPC分类号： C07C45/33 ,  C07C45/36 ,  C07C51/31 ,  C07C201/02 ,  C07C201/04 ,  C07C203/00 ,  C07C205/02 ,  C07C205/06 ,  C07C77/00 ,  C07C77/02 ,  C07C79/02

CPC分类号： C07C201/02 ,  C07C45/33 ,  C07C45/36 ,  C07C51/316 ,  C07C201/04 ,  C07C201/06 ,  C07C2601/14 ,  C07C203/02 ,  C07C203/00 ,  C07C205/06 ,  C07C205/02

摘要： THIS INVENTION RELATES TO THE RELATIVELY LOW TEMPERATURE TREATMENT OF HYDROCARBONS WITH NITRIC OIDE (NO) AND OXYGEN TO RPODUCE NITRATES, NITRITES AND KETONES AND OTHER OXIDATION PRODUCTS. THROUGH THE USE OF ALKALINE INHIBITORS SUCH AS ALKALI METAL BICARBONATES, THE PRODUCTION OF KETONES AND OTHER NON-NITROGEN CONTAINING OXIDATION PRODUCTS CAN BE MINIMIZED WHILE THE PRODUCTION OF ITRATES AND NITRIES ARE MAXIMIZED.

公开(公告)号：US3377387A

公开(公告)日：1968-04-09

申请号：US59820466

申请日：1966-12-01

申请人： PURDUE RESEARCH FOUNDATION

发明人： BRYANT BACHMAN GUSTAVE ,  STRAWN KENNETH G

IPC分类号： C07C45/40 ,  C07C201/06 ,  C07C205/02 ,  C07C205/06 ,  C07C205/15

CPC分类号： C07C201/06 ,  C07C45/40 ,  C07C49/04 ,  C07C205/02 ,  C07C205/06 ,  C07C205/15

公开(公告)号：US09340486B2

公开(公告)日：2016-05-17

申请号：US13854491

申请日：2013-04-01

申请人： ANGUS Chemical Company

发明人： Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, Jr.

IPC分类号： B01J19/00 ,  C07C201/08 ,  C07C201/16 ,  C07C201/06 ,  B01J10/00

CPC分类号： C07C201/06 ,  B01J10/00 ,  B01J19/00 ,  C07C201/08 ,  C07C201/16 ,  C07C205/02

摘要： Disclosed are a process and an apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. Energy and capital costs may be reduced by recycling a majority of the aqueous phase back to the reactor.

公开(公告)号：US20160130295A1

公开(公告)日：2016-05-12

申请号：US14941164

申请日：2015-11-13

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

IPC分类号： C07H19/16 ,  C07C201/06 ,  B01J19/00 ,  C07D207/46 ,  C07B59/00 ,  C07H19/06 ,  C07H5/02

CPC分类号： C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

摘要： A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

公开(公告)号：US20150218194A1

公开(公告)日：2015-08-06

申请号：US14683910

申请日：2015-04-10

申请人： AbbVie Inc.

发明人： Mary E. Bellizzi ,  David A. Betebenner ,  Jean C. Califano ,  Daniel D. Caspi ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Yi Gao ,  Charles W. Hutchins ,  Douglas K. Hutchinson ,  Tammie K. Jinkerson ,  Warren M. Kati ,  Ryan G. Keddy ,  Allan C. Krueger ,  Wenke Li ,  Dachun Liu ,  Clarence J. Maring ,  Mark A. Matulenko ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kathy Sarris ,  Michael D. Tufano ,  Seble H. Wagaw ,  Rolf Wagner ,  Kevin R. Woller

IPC分类号： C07F9/6558 ,  C07D405/14 ,  C07D403/14 ,  C07D401/14 ,  C07D207/09 ,  C07D491/113 ,  C07D413/14 ,  C07D471/04 ,  C07C201/06 ,  C07D207/08 ,  C07D207/16 ,  C07D417/14

CPC分类号： C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

摘要翻译： 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：US09006477B2

公开(公告)日：2015-04-14

申请号：US14131106

申请日：2012-07-04

申请人： Shinki Tani ,  Nami Yadomatsu ,  Akiko Ikumi ,  Yuuki Hirano ,  Takuya Ido

发明人： Shinki Tani ,  Nami Yadomatsu ,  Akiko Ikumi ,  Yuuki Hirano ,  Takuya Ido

IPC分类号： C07C205/06 ,  C07C201/06

CPC分类号： C07C201/06 ,  C07C205/06 ,  C07C205/58

摘要： A method for producing a nitrobenzene compound represented by general formula (2),wherein R1 and R5 are the same or different, and each is a halogen atom or another functional group, and R2, R3, and R4 are the same or different, and each is a hydrogen atom or another functional group, comprises oxidizing an aniline compound represented by general formula (1), wherein R1, R2, R3, R4, and R5 are the same as described above, with hydrogen peroxide in the presence of a tungsten compound under an acidic condition, followed by oxidation with hydrogen peroxide under a neutral to alkaline condition.

摘要翻译： 一种制备由通式（2）表示的硝基苯化合物的方法，其中R1和R5相同或不同，并且各自为卤素原子或其它官能团，R2，R3和R4相同或不同， 各自为氢原子或另一官能团，包括将氧化由通式（1）表示的苯胺化合物，其中R1，R2，R3，R4和R5与上述相同，与过氧化氢在钨存在下 在酸性条件下，然后在中性至碱性条件下用过氧化氢氧化。

公开(公告)号：US09006387B2

公开(公告)日：2015-04-14

申请号：US14180886

申请日：2014-02-14

申请人： AbbVie, Inc.

发明人： Rolf Wagner ,  John K. Pratt ,  Dachun Liu ,  Michael D. Tufano ,  David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi ,  Yi Gao ,  Allan C. Krueger

IPC分类号： C07K16/00 ,  A61K38/00 ,  C07K5/06 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  C07C33/26 ,  C07C205/19

CPC分类号： C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US08692036B2

公开(公告)日：2014-04-08

申请号：US13823831

申请日：2011-09-05

申请人： Shengjian Zhang ,  Yingxian Zhao ,  Hong Zhang

发明人： Shengjian Zhang ,  Yingxian Zhao ,  Hong Zhang

IPC分类号： C07C205/00

CPC分类号： C07C201/14 ,  C07C201/06 ,  C07C205/02

摘要： The present invention relates to a method for preparing 2,3-dimethyl-2,3-dinitrobutane (DMNB), which includes the following steps: (1) making titanium-silicate molecular sieve catalyst, acetone, hydrogen peroxide and ammonia contact and react at 65-80° C. to obtain a modified titanium-silicate molecular sieve catalyst; and (2-1) making acetone oxime and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof; or (2-2) making acetone, ammonia and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof. By the method provided by the present invention, DMNB can be prepared without having to use dangerous chemicals, such as 2-nitropropane, NaH and the like.

摘要翻译： 本发明涉及一种制备2,3-二甲基-2,3-二硝基丁烷（DMNB）的方法，其包括以下步骤：（1）使钛硅酸盐分子筛催化剂，丙酮，过氧化氢和氨接触并反应 在65-80℃下，得到改性钛酸酯分子筛催化剂; 和（2-1）使丙酮肟和过氧化氢接触并在改性的钛酸硅酸盐分子筛催化剂和水的存在下在60-90℃的温度和pH为8-10的条件下反应，并分离 DMNB反应产物; 或（2-2）使丙酮，氨和过氧化氢接触并在改性钛硅酸盐分子筛催化剂和水的存在下在60-90℃的温度和pH为8-10的条件下反应，和 从其反应产物中分离DMNB。 通过本发明提供的方法，可以制备DMNB，而不必使用危险化学品，例如2-硝基丙烷，NaH等。