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公开(公告)号：US07674775B2
公开(公告)日：2010-03-09
申请号：US11419651
申请日：2006-05-22
申请人： Philip John Hogg , Neil Donoghue
发明人： Philip John Hogg , Neil Donoghue
摘要： The present invention relates to a compound according to Formula (I): A-(L-Y)p, wherein A comprises at least one substantially cell-membrane impermeable pendant group; L comprises any suitable linker and/or spacer group; Y comprises at least one arsenoxide or arsenoxide equivalent; p is an integer from 1 to 10; and the sum total of carbon atoms in A and L together, is greater than 6.
摘要翻译： 本发明涉及式（I）的化合物：A-（L-Y）p，其中A包含至少一个基本上为细胞膜不可渗透的侧基; L包含任何合适的接头和/或间隔基团; Y包含至少一种等同的砷或砷; p是1至10的整数; 并且A和L中的碳原子总数在一起，大于6。
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公开(公告)号：US07498406B2
公开(公告)日：2009-03-03
申请号：US11419644
申请日：2006-05-22
申请人： Philip John Hogg , Neil Donoghue
发明人： Philip John Hogg , Neil Donoghue
摘要： The present invention relates to a compound according to Formula (I): A-(L-Y)p, wherein A comprises at least one substantially cell- membrane impermeable pendant group; L comprises any suitable linker and/or spacer group; Y comprises at least one arsenoxide or arsenoxide equivalent; p is an integer from 1 to 10; and the sum total of carbon atoms in A and L together, is greater than 6.
摘要翻译： 本发明涉及式（I）化合物：A-（L-Y）p，其中A包含至少一个基本上为细胞膜不可渗透的侧基; L包含任何合适的接头和/或间隔基团; Y包含至少一种等同的砷或砷; p是1至10的整数; 并且A和L中的碳原子总数在一起，大于6。
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公开(公告)号：US20080090793A1
公开(公告)日：2008-04-17
申请号：US11894766
申请日：2007-08-20
申请人： Ralph Zingaro , Hatice Duzkale , Emil Freireich , Hagop Kantarjian , Merida Sotelo-Lerma , Srdan Verstovsek , Mingzhang Gao
发明人： Ralph Zingaro , Hatice Duzkale , Emil Freireich , Hagop Kantarjian , Merida Sotelo-Lerma , Srdan Verstovsek , Mingzhang Gao
IPC分类号： A61K31/285 , A61K31/555 , A61P35/00 , C07F9/00 , C07F9/80
摘要： The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.
摘要翻译： 本发明提供有机砷。 许多这些化合物对许多人类肿瘤细胞系（包括固体和血液来源）以及来自患有白血病的患者的恶性血细胞具有有效的体外细胞毒活性。
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公开(公告)号：US07321048B2
公开(公告)日：2008-01-22
申请号：US11600998
申请日：2006-11-17
IPC分类号： C07F5/06 , C07C395/00 , C07C5/02
CPC分类号： C07F3/06 , C07B63/04 , C07C241/02 , C07F5/00 , C07F5/062 , C07F7/00 , C07F7/10 , C07F7/20 , C07F7/30 , C07F9/72 , C07F9/902 , C07F9/94 , C07C243/14
摘要： A method of purifying an organometallic compound by heating the organometallic compound in the presence of a trialkyl aluminum compound and a catalyst.
摘要翻译： 一种通过在三烷基铝化合物和催化剂的存在下加热有机金属化合物来纯化有机金属化合物的方法。
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公开(公告)号：US20070037995A1
公开(公告)日：2007-02-15
申请号：US11419644
申请日：2006-05-22
申请人： Philip Hogg , Neil Donoghue
发明人： Philip Hogg , Neil Donoghue
摘要： The present invention relates to a compound according to Formula (I): A-(L-Y)p, wherein A comprises at least one substantially cell-membrane impermeable pendant group; L comprises any suitable linker and/or spacer group; Y comprises at least one arsenoxide or arsenoxide equivalent; p is an integer from 1 to 10; and the sum total of carbon atoms in A and L together, is greater than 6.
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公开(公告)号：US06956127B2
公开(公告)日：2005-10-18
申请号：US10346275
申请日：2003-01-17
申请人： Deodatta Vinayak Shenai-Khatkhate , Michael Brendan Power , Artashes Amamchyan , Ronald L. DiCarlo, Jr.
发明人： Deodatta Vinayak Shenai-Khatkhate , Michael Brendan Power , Artashes Amamchyan , Ronald L. DiCarlo, Jr.
CPC分类号： C07F9/72 , C07F9/5068 , C07F9/52 , C23C16/301
摘要： Disclosed are methods of preparing monoalkyl Group VA metal dihalide compounds in high yield and high purity by the reaction of a Group VA metal trihalide with an organo lithium reagent or a compound of the formula RnM1X3−n, where R is an alkyl, M1 is a Group IIIA metal, X is a halogen and n is an integer fro 1 to 3. Such monoalkyl Group VA metal dihalide compounds are substantially free of oxygenated impurities, ethereal solvents and metallic impurities. Monoalkyl Group VA metal dihydride compounds can be easily produced in high yield and high purity by reducing such monoalkyl Group VA metal dihalide compounds.
摘要翻译： 公开了通过VA族金属三卤化物与有机锂试剂或式R a的化合物的反应制备高产率和高纯度的单烷基基团VA金属二卤化物化合物的方法， 1 X 3-n N，其中R是烷基，M 1是IIIA族金属，X是卤素，n是1至 这样的单烷基VA族金属二卤化物基本上不含氧杂质，醚类溶剂和金属杂质。 通过还原这种单烷基VA族金属二卤化物化合物，可以容易地以高产率和高纯度制备单烷基基团VA金属二氢化合物。
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公开(公告)号：US20050131062A1
公开(公告)日：2005-06-16
申请号：US11035178
申请日：2005-01-13
申请人： Ralph Zingaro , Emil Freireich , Hatice Duzkale , Hagop Kantarjian , Srdan Verstovsek , Merida Sotelo-Lerma
发明人： Ralph Zingaro , Emil Freireich , Hatice Duzkale , Hagop Kantarjian , Srdan Verstovsek , Merida Sotelo-Lerma
IPC分类号： A61K38/00 , A61K31/203 , A61K31/285 , A61P35/00 , A61P35/02 , C07F9/72 , C07F9/74 , C07F9/78 , C07F9/70
CPC分类号： C07F9/72
摘要： Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.
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公开(公告)号：US06875886B2
公开(公告)日：2005-04-05
申请号：US10071890
申请日：2002-02-07
申请人： John V. Frangioni
发明人： John V. Frangioni
IPC分类号： C12N9/00 , A61K31/66 , A61K45/00 , A61K51/00 , A61P13/08 , A61P13/12 , A61P15/08 , A61P25/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07F5/02 , C07F9/00 , C07F9/22 , C07F9/28 , C07F9/30 , C07F9/32 , C07F9/572 , C07F9/6596 , C07F9/70 , C07F9/72 , C07H15/252 , C07K14/415 , C07K14/46 , C12N9/10 , C12N9/16 , C12Q1/04 , G01N33/574 , C07C229/00
CPC分类号： G01N33/57492 , C07F5/025 , C07F9/005 , C07F9/301 , C07F9/3211 , C07F9/5728 , C07F9/6596 , C07F9/72 , C07H15/252 , G01N33/57426 , G01N33/57434
摘要： The instant invention provides reagents and methods for diagnosis, detection and treatment of cancers (for example, prostate cancers). In particular, the invention provides methods to generate various functionalized PSMA ligands, and their uses in diagnosis, detection, imaging, and treatment of prostate cancers, especially those overexpressing PSMA.
摘要翻译： 本发明提供用于癌症（例如前列腺癌）的诊断，检测和治疗的试剂和方法。 特别地，本发明提供了生成各种官能化PSMA配体的方法及其在诊断，检测，成像和治疗前列腺癌，特别是过表达PSMA的那些中的用途。
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39.发明申请Novel lipophilic compounds having affinity with nucleic acids and therapeutical uses thereof 审中-公开与核酸具有亲和力的新型亲脂性化合物及其治疗用途公开(公告)号：US20010056074A1
公开(公告)日：2001-12-27
申请号：US09754814
申请日：2001-01-04
发明人： Jean-Jacques Yaouanc , Erwann Guenin , Jean-Claude Clement , Anne-Cecile Herve , Claude Ferec , Virginie Floch , Herve des Abbayes
IPC分类号： A61K048/00 , C07J051/00 , C07F009/70 , C07F009/28
CPC分类号： C12N15/88 , A61K9/1272 , C07F9/4006 , C07F9/5407 , C07F9/5421 , C07F9/72 , C07J51/00
摘要： The invention consists of a compound of the general formula (I) below: 1 Wherein A, R1, R2, R3, R4 and X are as disclosed in the specification. The invention also relates to the therapeutical uses of this compound, particularly for gene therapy.
摘要翻译： 本发明由以下通式（I）的化合物组成：其中A，R1，R2，R3，R4和X如说明书中所公开的。 本发明还涉及该化合物的治疗用途，特别是用于基因治疗。
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