公开(公告)号：US20230340055A1

公开(公告)日：2023-10-26

申请号：US18043319

申请日：2021-08-27

申请人： ASCENDIS PHARMA ONCOLOGY DIVISION A/S

发明人： Sigurd OKKELS ,  David B. ROSEN ,  Burkhardt LAUFER ,  Thomas KNAPPE

IPC分类号： A61P35/00 ,  C07K14/55

CPC分类号： C07K14/55 ,  A61P35/00 ,  C07K2319/91

摘要： The present invention relates to an IL-2 protein sequence of the formula (Tag1)y - (Ala)x - SEQA - SEQ B - SEQ C -(Tag2)z (I), wherein SEQ A has at least 89% sequence identity with SEQ ID NO:1; SEQ B has at least 76% sequence identity to SEQ ID NO:2 and comprises at least one glycosylation motif; SEQ C has at least 91% sequence identity with SEQ ID NO:4; Tag 1 and Tag2 are independently a tag moiety; Ala is an alanine residue; x is 0 or 1; y is 0 or 1; and z is 0 or 1; to conjugates thereof and their uses in the treatment of cell-proliferation disorders.

公开(公告)号：US11795203B2

公开(公告)日：2023-10-24

申请号：US17264193

申请日：2019-07-30

申请人： Jinyu Zhang

发明人： Jinyu Zhang

IPC分类号： C07K14/475 ,  C07K14/535 ,  C07K14/54 ,  C07K14/55 ,  A61P35/00 ,  A61K38/00

CPC分类号： C07K14/475 ,  A61P35/00 ,  C07K14/535 ,  C07K14/5418 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/55 ,  A61K38/00

摘要： Disclosed are a protein heterodimer and the use thereof. The protein heterodimer comprises a first polypeptide chain and a second polypeptide chain different from the first polypeptide chain, wherein the first polypeptide chain comprises IL(interleukin)12a and a first factor fused to IL12a, the second polypeptide chain comprises IL12b and a second factor fused to IL12b, and the first factor and the second factor are each independently selected from a group consisting of: IL2, GMCSF(granulocyte-macrophage colony-stimulating factor), IL7, IL15, IL21 and FLT3L(FMS-like tyrosine kinase 3 ligand). The protein heterodimer can be used for treating tumors.

公开(公告)号：US20230303714A1

公开(公告)日：2023-09-28

申请号：US17991775

申请日：2022-11-21

申请人： AskGene Pharma Inc. ,  Jiangsu AoSaiKang Pharmaceutical Co., Ltd.

发明人： Yuefeng Lu ,  Kurt Shanebeck ,  Lu Li ,  Lei Liu ,  Shiwen Zhang ,  Lan Yang ,  Jian-Feng Lu

IPC分类号： C07K16/30 ,  A61P35/00 ,  A61K47/68 ,  C07K14/765 ,  C07K14/55 ,  C07K14/54 ,  C07K16/28 ,  A61K31/282 ,  A61K31/337 ,  A61K39/395

CPC分类号： C07K16/3046 ,  A61P35/00 ,  A61K47/6863 ,  C07K14/765 ,  C07K14/55 ,  C07K14/5443 ,  C07K16/2809 ,  A61K31/282 ,  A61K31/337 ,  A61K39/39558 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  A61K2039/505

摘要： Described and provided herein are novel antibodies for Claudin 18.2. Also described and provided are pharmaceutical compositions of the antibodies and methods of use for the treatment of cancer.

公开(公告)号：US20230302089A1

公开(公告)日：2023-09-28

申请号：US18179198

申请日：2023-03-06

申请人： Synthorx, Inc.

发明人： Carolina E. CAFFARO ,  Marcos MILLA ,  Jerod PTACIN

IPC分类号： A61K38/20 ,  A61K47/54 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64 ,  A61K47/65 ,  A61K47/68 ,  C07K14/55 ,  C07K14/715

CPC分类号： A61K38/2013 ,  A61K47/542 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61K47/68 ,  A61K47/644 ,  C07K14/55 ,  C07K14/7155 ,  A61K38/00

摘要： Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).

公开(公告)号：US20230295287A1

公开(公告)日：2023-09-21

申请号：US18134095

申请日：2023-04-13

申请人： Akouos, Inc.

发明人： Emmanuel John Simons ,  Robert Ng ,  Michael McKenna

IPC分类号： C07K16/22 ,  C12N15/86 ,  C07K14/55 ,  C07K14/005 ,  A61K48/00 ,  A61P27/16

CPC分类号： C07K16/22 ,  C12N15/86 ,  C07K14/55 ,  C07K14/005 ,  A61K48/0066 ,  A61P27/16 ,  C12N2750/14143 ,  C12N2750/14152 ,  C07K2317/55 ,  C07K2317/24 ,  C07K2317/76

摘要： The present disclosure provides a construct comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a vascular endothelial growth factor (VEGF) binding agent or a portion thereof. In some embodiments, a construct is an AAV construct. In some embodiments, an AAV construct is a part of an AAV particle. Compositions comprising constructs and AAV particles described herein can be useful in treating hearing loss, for example, hearing loss associated with vestibular schwannoma.

公开(公告)号：US20230279424A1

公开(公告)日：2023-09-07

申请号：US17927637

申请日：2021-05-26

申请人： UNIVERSITY HEALTH NETWORK

发明人： Christopher J. Paige

IPC分类号： C12N15/86 ,  C07K14/54 ,  C07K14/55 ,  A61K39/39 ,  C12N5/0783 ,  A61P35/00

CPC分类号： C12N15/86 ,  C07K14/5434 ,  C07K14/55 ,  A61K39/39 ,  C12N5/0636 ,  A61P35/00 ,  A61K2039/55538

摘要： Methods and compositions of whole cell vaccines for delivering immune modulatory molecules IL-12 and at least one of IL-21 and/or IL-18 to result in a therapeutic effect are disclosed. The methods and compositions use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia.

公开(公告)号：US20230272042A1

公开(公告)日：2023-08-31

申请号：US18179995

申请日：2023-03-07

申请人： ImmunityBio, Inc.

发明人： Laurent H. Boissel ,  Hans G. Klingemann ,  Abhijit Dandapat ,  Himani Chinnapen

IPC分类号： C07K14/735 ,  A61P35/00 ,  A61K35/17 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  A61K45/06 ,  C07K14/54 ,  C07K14/55 ,  C07K14/705 ,  C07K16/28 ,  C07K16/32 ,  C12N5/0783

CPC分类号： C07K14/70535 ,  A61P35/00 ,  A61K35/17 ,  A61K38/1774 ,  A61K38/2013 ,  A61K38/2086 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07K14/5443 ,  C07K14/55 ,  C07K14/70517 ,  C07K14/70521 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2878 ,  C07K16/32 ,  C12N5/0646 ,  A61K2039/505

摘要： Recombinant NK cells, and especially recombinant NK-92 cells express a chimeric antigen receptor (CAR) having an intracellular domain of FcεRIγ. Notably, CAR constructs with an intracellular domain of FcεRIγ had a substantially prolonged duration of expression and significantly extended cytotoxicity over time. The CAR may be expressed from RNA and DNA, preferably as a tricistronic construct that further encodes CD16 and a cytokine to confer autocrine growth support. Advantageously, such constructs also enable high levels of transfection and expression of the recombinant proteins and provide a convenient selection marker to facilitate rapid production of recombinant NK/NK-92 cells.

公开(公告)号：US20230270856A1

公开(公告)日：2023-08-31

申请号：US18006591

申请日：2021-05-19

申请人： SUPERMAB (BEIJING) BIOTECH CO., LTD.

发明人： Yu LIU

IPC分类号： A61K39/00 ,  C07K14/55 ,  C07K16/00 ,  C07K7/06

CPC分类号： A61K39/4611 ,  C07K14/55 ,  C07K16/00 ,  C07K7/06 ,  A61K39/4613 ,  A61K39/4633 ,  A61K39/4635 ,  C07K2319/30 ,  C07K2317/622

摘要： The present invention relates to a fusion protein and the use thereof. The fusion protein includes, from N to C terminals, a first moiety, an Fc segment, a linking moiety comprising a moiety selected from a linker and a protein or polypeptide selected from IL2 or scFv, and a substrate moiety of transpeptidase A; the linker includes a sequence selected from the group consisting of (1) (GGGGS)n, wherein when the linking moiety includes the protein or polypeptide and the linker, n≥1; when the linking moiety only includes the linker, n≥3; and (2) (EAAAK)n, n≥1; the substrate moiety includes LPXTG. The fusion protein can be directly connected to cells to enable the cells to have a targeting property, is more simple than an existing method for preparing targeting cells by means of cell transfection, and can also reduce the risk possibly generated by an effector cell genome operation.

公开(公告)号：US11723932B2

公开(公告)日：2023-08-15

申请号：US16069220

申请日：2017-01-11

申请人： Synlogic Operating Company, Inc.

发明人： Dean Falb ,  Jonathan W. Kotula ,  Vincent M. Isabella ,  Paul F. Miller ,  Suman Machinani ,  Saurabh Saha ,  Adam B. Fisher ,  Yves Millet ,  Ning Li

IPC分类号： A01N63/00 ,  A61K35/74 ,  C07K16/28 ,  A61P35/00 ,  C07K14/54 ,  C12N15/70 ,  C12P13/22 ,  A61K38/20 ,  C12N15/00 ,  C12N5/00 ,  C07K14/34 ,  A61K31/00 ,  C07K14/335 ,  C07K14/245 ,  A61K39/395 ,  C07K14/535 ,  C07K14/55 ,  A61K48/00 ,  A61K38/19 ,  C12P21/02 ,  A61K39/00

CPC分类号： A61K35/74 ,  A61K31/00 ,  A61K38/193 ,  A61K38/20 ,  A61K39/3955 ,  A61K39/39541 ,  A61K48/00 ,  A61P35/00 ,  C07K14/245 ,  C07K14/335 ,  C07K14/34 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/55 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/2827 ,  C12N5/00 ,  C12N15/00 ,  C12N15/70 ,  C12P13/227 ,  C12P21/02 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/03 ,  C07K2319/036 ,  C07K2319/40 ,  A61K39/39541 ,  A61K2300/00 ,  A61K39/3955 ,  A61K2300/00

摘要： Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.

公开(公告)号：US20230250156A1

公开(公告)日：2023-08-10

申请号：US17909621

申请日：2021-03-15

申请人： Quadrucept Bio Limited

发明人： Hanif ALI ,  Jasper CLUBE

IPC分类号： C07K16/10 ,  G01N33/569 ,  A61K9/00 ,  A61K39/42 ,  A61K45/06 ,  A61P31/14 ,  C07K14/725 ,  A61K38/17 ,  C07K14/55 ,  A61K38/20 ,  C07K16/28 ,  A61K39/395 ,  C07K16/24

CPC分类号： C07K16/10 ,  A61K9/0078 ,  A61K38/1774 ,  A61K38/2013 ,  A61K39/42 ,  A61K39/3955 ,  A61K45/06 ,  A61P31/14 ,  C07K14/55 ,  C07K14/7051 ,  C07K16/244 ,  C07K16/2827 ,  C07K16/2875 ,  C07K16/2878 ,  C07K16/2887 ,  G01N33/56983 ,  A61K2039/505 ,  C07K2317/569

摘要： The invention relates to multimers such as multimers comprising 4 copies of a binding site or peptide; tetramers of polypeptides; and tetramers, octamers, dodecamers and hexadecamers of epitopes or effector domains, such as antigen binding sites (eg, antibody or TCR binding sites that specifically bind to antigen or pMHC, or variable domains thereof) or peptides such as incretin, insulin or hormone peptides. The invention also relates to methods and uses to expand antigen specificity of binding sites, as well as vaccines, methods of vaccination and assay methods and reagents.