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公开(公告)号：US5814477A
公开(公告)日：1998-09-29
申请号：US457048
申请日：1995-06-01
IPC分类号： A61K38/00 , A61K39/00 , C07K14/33 , C07K16/02 , C07K16/06 , C07K16/12 , C07K16/18 , C07K17/08 , C12N15/31 , C12N15/00 , C12N15/09
CPC分类号： C07K16/065 , C07K14/33 , C07K16/02 , C07K16/1282 , C07K16/18 , C07K17/08 , A61K38/00 , A61K39/00 , C07K2317/34
摘要： The present invention includes methods for the production and purification of recombinant clostridial toxin proteins.
摘要翻译： 本发明包括生产和纯化重组梭菌毒素蛋白质的方法。
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32.发明授权Method of treating parasitosis by the enteral administration of hyperimmune hen egg yolk antibodies 失效通过肠内施用超免疫鸡蛋黄抗体治疗寄生虫的方法
公开(公告)号：US5753228A
公开(公告)日：1998-05-19
申请号：US349840
申请日：1994-12-05
摘要： Egg yolks and egg yolk fractions containing effective therapeutic concentrations of avian antibodies against parasitic antigen, and a method of providing passive immunization for the prevention or treatment of intestinal parasitosis by enteral administration of egg yolk antibodies harvested from hyperimmunized avian hens. Also provided are pharmaceutical formulations comprising the egg yolk antibodies.
摘要翻译： 含有有效治疗浓度的针对寄生虫抗原的禽类抗体的蛋黄和蛋黄级分，以及通过肠内施用从超免疫禽鸟收获的蛋黄抗体来提供被动免疫以预防或治疗肠寄生虫的方法。 还提供了包含蛋黄抗体的药物制剂。
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公开(公告)号：US5601823A
公开(公告)日：1997-02-11
申请号：US161907
申请日：1993-12-02
IPC分类号： A61K38/00 , A61K39/00 , C07K14/33 , C07K16/02 , C07K16/06 , C07K16/12 , C07K16/18 , C07K17/08 , C12N15/31 , A61K39/395
CPC分类号： C07K16/065 , C07K14/33 , C07K16/02 , C07K16/1282 , C07K16/18 , C07K17/08 , A61K38/00 , A61K39/00 , C07K2317/34
摘要： The present invention includes methods and compositions for treating humans and other animals intoxicated with at least one Clostridial toxin by administration of antitoxin. In particular, the antitoxin directed against these toxins is produced in avian species. This avian antitoxin is designed so as to be orally administerable in therapeutic amounts and may be in any form (i.e., as a solid or in aqueous solution).
摘要翻译： 本发明包括通过施用抗毒素治疗人和其它被至少一种梭菌毒素中毒的动物的方法和组合物。 特别地，针对这些毒素的抗毒素在鸟类中产生。 这种禽抗毒素被设计成以治疗量口服给药并且可以是任何形式（即作为固体或在水溶液中）。
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公开(公告)号：US5420253A
公开(公告)日：1995-05-30
申请号：US118514
申请日：1993-09-09
申请人： Daryll A. Emery , Darren E. Straub
发明人： Daryll A. Emery , Darren E. Straub
CPC分类号： C07K16/065 , A23J1/08 , C07K16/02 , A61K39/00 , Y10S530/853 , Y10S530/861
摘要： The present invention provides a method for purifying high yields of IgG immunoglobulins from an egg yolk by a single phase separation step using a nonionic detergent.
摘要翻译： 本发明提供了通过使用非离子洗涤剂的单相分离步骤从蛋黄纯化高产量IgG免疫球蛋白的方法。
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公开(公告)号：US4748018A
公开(公告)日：1988-05-31
申请号：US622130
申请日：1984-06-19
申请人： Ralph J. Stolle , Lee R. Beck
发明人： Ralph J. Stolle , Lee R. Beck
IPC分类号： A23C23/00 , A23L1/30 , A23L1/305 , A61K35/54 , A61K38/00 , A61K39/395 , A61K39/40 , A61K39/42 , A61P31/04 , A61P37/00 , C07K16/02 , C07K16/04 , C12Q1/00 , G01N33/531
CPC分类号： C07K16/04 , C07K16/02 , C07K16/1275 , A61K2039/505 , A61K2039/507 , A61K2039/542 , C07K2317/23
摘要： A method of passively immunizing a mammal against a condition caused by an antigen comprising: administering to the mammal immunizing amounts of an antibody obtained from a domesticated fowl which has been immunized against the antigen; the mammal being tolerant to the antibody by virtue of having a history of consumption of antibody containing material derived from the egg of a fowl.
摘要翻译： 一种针对由抗原引起的病症被动免疫哺乳动物的方法，包括：给哺乳动物免疫一定量的已经针对抗原免疫的驯养的家禽获得的抗体; 哺乳动物由于具有从家禽卵衍生的含抗体的物质的消费史，对抗体是耐受的。
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公开(公告)号：US20240299463A1
公开(公告)日：2024-09-12
申请号：US18666591
申请日：2024-05-16
申请人： Camas Incorporated
发明人： Bradley M. Mitteness
摘要： Compositions for reducing the emission of methane by ruminant animals are disclosed. The compositions include avian antibodies against methanogens generally found in the rumen of the animals. Egg contents of eggs from female birds inoculated with immunogenic compositions containing one or more methanogens or antigens derived from methanogens are used. The antibodies in the egg contents may be used directly without further purification, may be partially purified or purified. The compositions may be administered in drinking water or in animal feed. Administering of the anti-methanogenic composition reduces the emission of methane and increases the efficiency of feed conversion.
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公开(公告)号：US11866492B2
公开(公告)日：2024-01-09
申请号：US16980074
申请日：2019-03-13
申请人： ALTEOGEN, INC.
发明人： Soon Jae Park , Hye-Shin Chung , Sunbae Lee
IPC分类号： C07K16/28 , A61K47/68 , G01N33/574 , C07K16/02
CPC分类号： C07K16/02 , A61K47/6849 , G01N33/57492 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N2333/705
摘要： A modified antibody that binds specifically to folate receptor alpha (FOLR1) and blocks the activity of FOLR1 with an increased binding affinity, an antigen-binding fragment thereof, a composition containing the antibody or fragment, and their uses are disclosed. The modified antibody or antigen-binding fragment thereof may be used for the prevention or treatment of cancer proliferative disorder associated with an increased FOR1 expression, and may also be used for diagnosis of the disease. The proliferative disorder may be cancer.
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公开(公告)号：US11753439B2
公开(公告)日：2023-09-12
申请号：US16619719
申请日：2017-12-18
发明人： Ángela Liliana Albarracín Cárdenas , Adriana Arévalo Jamaica , Sofía Duque Beltrán , Fabio Leonardo Quintero Vargas , Cesar Augusto Ramírez Segura
IPC分类号： C07K1/22 , C07K16/02 , G01N33/569
CPC分类号： C07K1/22 , C07K16/02 , G01N33/569
摘要： The present invention relates to a stationary phase for the purification of polyclonal anti-Giardia IgG and IgY antibodies, as well as a method for purifying polyclonal anti-Giardia IgG and IgY antibodies by affinity chromatography. The invention also relates to the polyclonal anti-Giardia IgG and IgY antibodies purified by affinity chromatography, which specifically bind to the antigenic proteins CWP1, alpha-giardin 7.3 and kinesin 3.
In an additional aspect, the invention relates to a method for diagnosing giardiasis by detection of Giardia in a specific sample, and a kit for diagnosing giardiasis in biological and environmental samples.-
39.发明授权公开(公告)号：US10017569B2
公开(公告)日：2018-07-10
申请号：US15334542
申请日：2016-10-26
IPC分类号： C07K16/24 , A61K39/395 , A61K38/20 , C07K16/02 , C07K14/54 , A23K20/147 , A23K50/75 , A61K39/00 , A61K38/00
CPC分类号： C07K16/244 , A23K20/147 , A23K50/75 , A61K38/00 , A61K38/2066 , A61K39/3955 , A61K2039/505 , C07K14/5428 , C07K16/02 , C07K2317/11 , C07K2317/23 , C07K2317/34
摘要： The present disclosure is directed to interleukin-10 (IL-10) peptides and isolated antibodies that specifically bind to the IL-10 peptides. The IL-10 peptides and the isolated antibodies may be administered alone or as an animal feed additive to treat gastrointestinal protozoan infection in animals.
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公开(公告)号：US20180155410A1
公开(公告)日：2018-06-07
申请号：US15828260
申请日：2017-11-30
申请人： Thomas Julius Borody
发明人： Thomas Julius Borody
CPC分类号： C07K16/02 , A61K35/74 , A61K2039/505 , C07K16/1282 , C07K2317/11 , Y02A50/489 , Y02A50/49 , A61K2300/00
摘要： A method and composition for treating enteric pathogen infections in animals suffering from such infections or displaying diseases or conditions consistent with such infections or for preventing or reducing the likelihood of enteric pathogen infections in animals at risk for developing such infections.
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