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    Crystal structure of soluble glutaminyl cyclase
    442.
    发明授权
    Crystal structure of soluble glutaminyl cyclase 有权
    可溶性谷氨酰胺环化酶的晶体结构

    公开(公告)号：US07572614B2

    公开(公告)日：2009-08-11

    申请号：US11362051

    申请日：2006-02-24

    Applicant: Andrew H.-J. Wang ,  Kai-Fa Huang

    Inventor： Andrew H.-J. Wang ,  Kai-Fa Huang

    IPC: C12N9/00 ,  C12N9/10 ,  C12N9/86 ,  C12P21/06

    CPC classification number: C12N9/104 ,  C07K2299/00 ,  G01N2333/9108 ,  Y02A90/26

    Abstract: A crystalline structure of glutaminyl cyclase (QC). is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of QC. In addition, a structural basis for the rational design or identification of new inhibitors that may be used to treat QC-associated disorders is also described.

    Abstract translation: 谷氨酰胺环化酶（QC）的晶体结构。 被描述。 还描述了制备QC的晶体结构的方法和用于鉴定QC候选抑制剂的方法。 此外，还描述了可用于治疗QC相关疾病的合理设计或鉴定新抑制剂的结构基础。

    DISACCHARIDE COMPOUNDS
    444.
    发明申请
    DISACCHARIDE COMPOUNDS 审中-公开
    异氰酸酯化合物

    公开(公告)号：US20090137793A1

    公开(公告)日：2009-05-28

    申请号：US12273768

    申请日：2008-11-19

    Applicant: Shang-cheng Hung

    Inventor： Shang-cheng Hung

    IPC: C07H3/04 ,  C07H1/00

    CPC classification number: C07H3/04 ,  C07H1/00

    Abstract: Disaccharide compounds used as building blocks for making heparin and heparan sulfate oligosaccharides. Also disclosed are methods for making these disaccharide compounds.

    Abstract translation: 用作制备肝素和硫酸乙酰肝素寡糖的结构单元的二糖化合物。 还公开了制备这些二糖化合物的方法。

    Single-atom tip and preparation method thereof
    445.
    发明授权
    Single-atom tip and preparation method thereof 有权
    单原子尖端及其制备方法

    公开(公告)号：US07507320B2

    公开(公告)日：2009-03-24

    申请号：US10985717

    申请日：2004-10-09

    Applicant: Ing-Shouh Hwang ,  Hong-Shi Kuo ,  Tien T. Tsong ,  Tsu-Yi Fu

    Inventor： Ing-Shouh Hwang ,  Hong-Shi Kuo ,  Tien T. Tsong ,  Tsu-Yi Fu

    IPC: C25D5/34

    CPC classification number: C25F1/00 ,  C25D3/48 ,  C25D3/50 ,  C25D5/003 ,  C25D5/022 ,  C25D5/38 ,  C25D5/48 ,  C25D5/50 ,  G01Q70/16 ,  H01J9/025 ,  H01J37/073 ,  H01J37/08 ,  H01J2237/06341 ,  H01J2237/0807 ,  Y10T29/49002

    Abstract: This invention discloses an electrochemical method for the preparation of single atom tips to replace the traditional vacuum evaporation method. The invented method for preparation of single atom tips includes the following steps: A substrate single crystal metal wire etched electrochemically to form a tip. The surface of the metal tip is cleaned. A small quantity of noble metal is plated on the apex of the tip in low concentration noble metal electrolyte. Annealing in vacuum or in inert gas ambient to diffuse the additional electroplated noble metal atoms and thus a single atom tip is formed on the surface of the substrate. The present invention also discloses the single atom tip so prepared. The single atom tip of this invention has only a very small number of atoms, usually only one atom, at its apex.

    Abstract translation: 本发明公开了一种用于制备单原子尖端以取代传统真空蒸发方法的电化学方法。 本发明制备单原子尖端的方法包括以下步骤：电化学蚀刻形成尖端的基片单晶金属线。 清洁金属尖端的表面。 在低浓度贵金属电解质中，尖端的顶点上镀有少量贵金属。 在真空中或在惰性气体环境中退火以扩散附加的电镀的贵金属原子，因此在衬底的表面上形成单个原子尖端。 本发明还公开了如此制备的单个原子尖端。 本发明的单个原子尖端在其顶点仅具有非常少数量的原子，通常仅有一个原子。

    RECONSTRUCTION OF GENE NETWORKS FROM TIME-SERIES MICROARRAY DATA
    446.
    发明申请
    RECONSTRUCTION OF GENE NETWORKS FROM TIME-SERIES MICROARRAY DATA 有权
    从时间序列微观数据重建基因网络

    公开(公告)号：US20090063376A1

    公开(公告)日：2009-03-05

    申请号：US12131162

    申请日：2008-06-02

    Applicant: Sai-Ping Li ,  Sun-Chong Wang

    Inventor： Sai-Ping Li ,  Sun-Chong Wang

    IPC: G06F15/18 ,  G06N3/12

    CPC classification number: G06F19/12 ,  G06F19/20 ,  G06F19/24

    Abstract: Gene regulation network is reconstructed using time series microarray data under the method of the Bayesian network. Particular power-law function is used to calculate the joint probabilities among genes across time points. This invention discloses the use of the downhill simplex algorithm to find global maxima of interrelational likelihood. Arcs with higher frequencies are selected to establish the gene regulation network. Prior knowledge may be included into candidate gene networks to accelerate search for best networks.

    Abstract translation: 基于贝叶斯网络的方法，使用时序微阵列数据重建基因调控网络。 特定的幂律函数用于计算时间点之间基因的联合概率。 本发明公开了使用下坡单纯形算法来找到相关似然性的全局最大值。 选择具有较高频率的弧以建立基因调控网络。 可能将先验知识纳入候选基因网络，以加速搜索最佳网络。

    RECOMBINANT CANDIDA RUGOSA LIPASES
    447.
    发明申请
    RECOMBINANT CANDIDA RUGOSA LIPASES 失效
    重组甘地达葛根药

    公开(公告)号：US20090053795A1

    公开(公告)日：2009-02-26

    申请号：US11841492

    申请日：2007-08-20

    Applicant: Jei-Fu Shaw ,  Guan-chiun Lee ,  Shye-Jye Tang

    Inventor： Jei-Fu Shaw ,  Guan-chiun Lee ,  Shye-Jye Tang

    IPC: C12N15/55 ,  C12N1/21 ,  C12N1/19

    CPC classification number: C12N9/20 ,  C07K2319/00

    Abstract: The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, 17, or all) universal serine codons corresponding to CTG codons in the wild-type DNA. Each of the universal serine codons, independently, is TCT, TCC, TCA, TCG, AGT, or AGC. The Candida rugosa lipase can be Candida rugosa lipase 1, 2, 3, 4, 5, or 8.

    Abstract translation: 本发明的特征在于分离的核酸，其包含编码假丝酵母假单胞菌脂肪酶的突变DNA，其中突变DNA与编码假丝酵母脂肪酶的野生型DNA具有80％同一性，并且包括至少12个（例如13,15 ，17或全部）对应于野生型DNA中的CTG密码子的通用丝氨酸密码子。 每个通用丝氨酸密码子独立地是TCT，TCC，TCA，TCG，AGT或AGC。 假丝酵母粗脂肪酶可以是1号，2号，3号，4号，5号或8号念珠菌。

    XML document editor
    450.
    发明授权
    XML document editor 有权
    XML文档编辑器

    公开(公告)号：US07409673B2

    公开(公告)日：2008-08-05

    申请号：US10601521

    申请日：2003-06-24

    Applicant: Yue-Sun Kuo ,  Jaspher Wang ,  Nai-Cheng Shih

    Inventor： Yue-Sun Kuo ,  Jaspher Wang ,  Nai-Cheng Shih

    IPC: G06F9/44 ,  G06F17/00 ,  G06F17/10

    CPC classification number: G06F17/218 ,  G06F8/33 ,  G06F17/2247 ,  G06F17/243

    Abstract: A DTD-compliant XML document editor is disclosed. The XML document editor generates hints for required elements and required element slots automatically in the process of document creation and edition so as to guide the user to produce a valid document, while syntactic violations are avoided at the same time. The editor also suggests optional elements that may be added into the document to be edited. The user requires no knowledge about XML and DTD to edit DTD-compliant XML documents. The editing process is user-interface-neutral, being able to support user interfaces based on tree views, presentation views and forms. By combining the DTD-compliant editing process with the simplicity of forms, a simple XML document editor with forms as its user interface is developed.

    Abstract translation: 公开了符合DTD的XML文档编辑器。 XML文档编辑器在文档创建和编辑过程中自动生成所需元素和所需元素插槽的提示，以引导用户生成有效的文档，同时避免语法违规。 编辑器还提出可以添加到要编辑的文档中的可选元素。 用户不需要知道XML和DTD来编辑符合DTD的XML文档。 编辑过程是用户界面中立的，能够支持基于树视图，演示视图和表单的用户界面。 通过将符合DTD的编辑过程与表单的简单结合，开发了一种具有表单作为其用户界面的简单XML文档编辑器。

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