公开(公告)号：US07908018B2

公开(公告)日：2011-03-15

申请号：US11516172

申请日：2006-09-06

申请人： David O'Brien

发明人： David O'Brien

IPC分类号： A61N1/00 ,  A61B5/04

CPC分类号： A61N1/05

摘要： An electrode array has a flexible body supporting a plurality of electrodes. Each electrode comprises an exposed connector pad at the upper end of the body, an exposed recording/stimulating pad at the lower end of the body, and a conductor located within the body and electrically connecting the connector pad and the recording/stimulating pad. In one embodiment the electrode array has an elongated recording/stimulating portion coiled or folded to distribute the exposed recording/stimulating pads in three dimensions. An implantation method employs an introducer with a helical portion to which an end of the flexible electrode is attached. The helical portion straightens to pass through a small-diameter cannula and then resumes its helical configuration to place the recording/stimulating portion of the attached electrode in a helix within the patient's tissues.

摘要翻译： 电极阵列具有支撑多个电极的柔性主体。 每个电极包括在本体的上端处的暴露的连接器垫，在主体的下端的暴露的记录/刺激垫，以及位于主体内的导体，并且电连接连接器垫和记录/刺激垫。 在一个实施例中，电极阵列具有螺旋或折叠的细长记录/刺激部分，以在三个维度上分布曝光的记录/刺激垫。 植入方法采用具有螺旋部分的导引器，柔性电极的端部附接到螺旋部分。 螺旋部分伸直通过小直径套管，然后恢复其螺旋构造，以将附着的电极的记录/刺激部分置于患者组织内的螺旋内。

公开(公告)号：US07854172B2

公开(公告)日：2010-12-21

申请号：US12372274

申请日：2009-02-17

申请人： David O'Brien ,  Florent Cros ,  Jin Woo Park ,  Michael Fonseca ,  Liang You ,  Mark Allen

发明人： David O'Brien ,  Florent Cros ,  Jin Woo Park ,  Michael Fonseca ,  Liang You ,  Mark Allen

IPC分类号： G01L7/00

CPC分类号： G01L9/0075 ,  A61B5/03 ,  A61B2562/0247 ,  B81B7/007 ,  B81B2201/0264 ,  B81B2201/06 ,  B81B2207/096 ,  B81C1/00301 ,  G01L9/0073

摘要： A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

公开(公告)号：US07829363B2

公开(公告)日：2010-11-09

申请号：US11801586

申请日：2007-05-10

申请人： Liang You

发明人： Liang You

IPC分类号： H01L21/00

CPC分类号： B81C1/00301 ,  B81B2201/0264 ,  B81B2207/096

摘要： Disclosed are apparatus and methods that provide for electrical contacts in a substrate. For example, the apparatus may comprise a trench formed in a substrate, with an electrical contact pad formed on interior walls of the trench that comprises a narrowed opening. A conductive wire is squeezed into the trench that is secured by mechanical stress resulting from material deformation. One exemplary method comprises depositing metal on walls of the trench such that a narrowed opening is provided, and disposing a conductive wire in the trench so that it contacts the deposited metal and is secured by mechanical stress resulting from material deformation. Another exemplary method comprises providing a substrate having a trench formed therein, placing a conductive wire in the trench, and depositing metal atoms into the trench to bury the wire and provide exposed metal on a surface of the substrate.

摘要翻译： 公开了提供衬底中的电接触的装置和方法。 例如，该装置可以包括形成在衬底中的沟槽，其中形成在沟槽的内壁上的电接触垫包括狭窄的开口。 导线被挤压到沟槽中，该沟槽由于材料变形引起的机械应力而被固定。 一种示例性方法包括在沟槽的壁上沉积金属，使得提供变窄的开口，并且将导线布置在沟槽中，使得其接触沉积的金属并且由材料变形引起的机械应力来固定。 另一示例性方法包括提供其中形成有沟槽的衬底，将导线放置在沟槽中，并且将金属原子沉积到沟槽中以埋入线并且在衬底的表面上提供暴露的金属。

公开(公告)号：US07812416B2

公开(公告)日：2010-10-12

申请号：US11803578

申请日：2007-05-15

申请人： Christophe Courcimault

发明人： Christophe Courcimault

IPC分类号： H01L27/14

CPC分类号： H01L24/32 ,  B81B2207/096 ,  B81C1/00301 ,  H01L24/29 ,  H01L24/48 ,  H01L24/83 ,  H01L2224/04026 ,  H01L2224/29101 ,  H01L2224/29111 ,  H01L2224/29144 ,  H01L2224/32225 ,  H01L2224/32506 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73265 ,  H01L2224/83101 ,  H01L2224/838 ,  H01L2924/00014 ,  H01L2924/01006 ,  H01L2924/01019 ,  H01L2924/01024 ,  H01L2924/01033 ,  H01L2924/01041 ,  H01L2924/01042 ,  H01L2924/01047 ,  H01L2924/0105 ,  H01L2924/01072 ,  H01L2924/01073 ,  H01L2924/01074 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/0132 ,  H01L2924/01322 ,  H01L2924/01327 ,  H01L2924/0133 ,  H01L2924/014 ,  H01L2924/09701 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/1433 ,  H01L2924/15153 ,  H01L2924/15165 ,  H01L2924/15787 ,  H01L2924/15788 ,  H01L2924/16788 ,  H01L2924/19041 ,  H01L2924/19043 ,  H01L2924/30105 ,  H01L2924/00 ,  H01L2924/00012 ,  H01L2224/45099 ,  H01L2224/45015 ,  H01L2924/207

摘要： Disclosed are methods for attaching an integrated circuit to a substrate, and in particular, a fused silica substrate, along with apparatus fabricated using the methods. Exemplary apparatus comprises a glass substrate, a metallic layer disposed on the substrate, and an integrated circuit eutectically bonded to the glass substrate via the metallic layer. The integrated circuit and fused silica substrate form part of a hermetic sensor. In an exemplary sensor, a first trench is formed in a first substrate. A second trench that is deeper than the first trench is formed in the first substrate. A first plurality of electrodes are formed in the first trench. An integrated circuit is attached to the first substrate within the second trench using a solder preform. The integrated circuit may be attached to the first substrate by depositing a Cr/Au film onto either the integrated circuit or first substrate, depositing a Cr/Ni/Au film onto either the first substrate or integrated circuit, placing the an Au/Sn solder preform onto the Cr/Ni/Au film, positioning the integrated circuit on top of the soldered preform so that it contacts the Cr/Au film, and heating the assembly.

摘要翻译： 公开了将集成电路连接到基板，特别是熔凝石英基板，以及使用该方法制造的装置的方法。 示例性装置包括玻璃基板，设置在基板上的金属层，以及通过金属层与玻璃基板共晶地结合的集成电路。 集成电路和熔融石英衬底形成气密传感器的一部分。 在示例性传感器中，第一沟槽形成在第一衬底中。 在第一衬底中形成比第一沟槽更深的第二沟槽。 在第一沟槽中形成第一多个电极。 使用焊料预制件将集成电路附接到第二沟槽内的第一衬底。 集成电路可以通过在集成电路或第一衬底上沉积Cr / Au膜而将Cr / Ni / Au膜沉积到第一衬底或集成电路上，将Au / Sn焊料放置在第一衬底上 预成型到Cr / Ni / Au膜上，将集成电路定位在焊料预制件的顶部，使其接触Cr / Au膜，并加热组件。

公开(公告)号：US20100026318A1

公开(公告)日：2010-02-04

申请号：US12545166

申请日：2009-08-21

申请人： Jason Kroh ,  Michael Ellis ,  Donald Miller

发明人： Jason Kroh ,  Michael Ellis ,  Donald Miller

IPC分类号： G01R27/28

CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/064 ,  A61B5/07 ,  A61B2560/0219 ,  H01B11/20 ,  H04B5/0043 ,  Y10S128/903

摘要： A coupling loop or antenna is provided that can be used with a system that determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. In one embodiment multiple energizing loops energize an implanted sensor and a sensor coupling loop connected to an input impedance that is at least two times greater than the inductance of the sensor coupling loop receives the sensor signal.

摘要翻译： 提供耦合环路或天线，其可以与通过调节激励信号的相位和频率来确定传感器的谐振频率的系统一起使用，直到通电信号的频率与传感器的谐振频率匹配。 在一个实施例中，多个激励环路激励植入的传感器，并且连接到至少比传感器耦合回路的电感大两倍的输入阻抗的传感器耦合回路接收传感器信号。

公开(公告)号：US07618363B2

公开(公告)日：2009-11-17

申请号：US10636293

申请日：2003-08-06

申请人： Jay Yadav ,  Mark Allen ,  David O'Brien ,  David Stern ,  Jason White ,  Michael A. Fonseca

发明人： Jay Yadav ,  Mark Allen ,  David O'Brien ,  David Stern ,  Jason White ,  Michael A. Fonseca

IPC分类号： A61M1/12

CPC分类号： A61M1/106 ,  A61M1/1008 ,  A61M1/1068 ,  A61M1/12

摘要： A ventricular assist device comprises a sheet of hydraulically actuated material that can be affixed to prescribed locations on the surface of the heart to assist areas of the heart that do not contract normally. The material is comprised of a network of contractible unit cells that individually contract when fluid is pumped into them. These unit cells are connected together in a network that causes the sheet to contract radially inward. This contraction causes the sheet to transmit forces to the heart to assist in its natural contraction. A sensing function coordinates the contraction of the sheet with the contraction of the heart. The change in shape of the device is accomplished by distributing pressurized fluid throughout the spaces of the device by way of a network of channels. When pressure is removed from the fluid system, it assumes a deenergized “rest” position in which it does not transmit any forces to the surface of the heart. This property of the device prevents the device from inhibiting the heart's natural contractions in the event of a failure of the device or a loss of hydraulic power.

摘要翻译： 心室辅助装置包括一片液压致动材料片，该片材可以固定在心脏表面上的规定位置，以帮助心脏不能正常收缩的区域。 该材料由可收缩的单体电池网络组成，当将流体泵入其中时单独收缩。 这些单电池在网络中连接在一起，导致片材向内径向收缩。 这种收缩导致片材将力传递到心脏以帮助其自然收缩。 检测功能可以协调纸张与心脏收缩的收缩。 设备形状的变化通过通过通道网络将加压流体分配到设备的整个空间中来实现。 当压力从流体系统移除时，它承受断电的“静止”位置，在该位置，它不会将任何力传递到心脏表面。 该装置的这种特性防止装置在装置发生故障或液压动力损失的情况下抑制心脏的自然收缩。

公开(公告)号：US20090224773A1

公开(公告)日：2009-09-10

申请号：US12466541

申请日：2009-05-15

申请人： James Joy ,  Jason Kroh ,  Michael Ellis ,  Mark Allen ,  Wilton Pyle

发明人： James Joy ,  Jason Kroh ,  Michael Ellis ,  Mark Allen ,  Wilton Pyle

IPC分类号： G01R23/12

CPC分类号： G01R23/12 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/05 ,  A61B5/076 ,  A61B2560/0219 ,  A61B2560/0223 ,  G01D21/00 ,  G01F15/066 ,  G01R23/145

摘要： The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal.

摘要翻译： 本发明通过调节激励信号的相位和频率直到激励信号的频率与传感器的谐振频率相匹配来确定传感器的谐振频率。 该系统以低占空比激励传感器，具有预定频率或一组频率和预定幅度的RF能量门控突发。 激励信号通过磁耦合耦合到传感器，并且感应传感器中的电流，其以传感器的谐振频率振荡。 系统通过磁耦合接收传感器的响铃响应，并确定传感器的谐振频率，用于计算测量的物理参数。 该系统使用一对锁相环来调节激励信号的相位和频率。

公开(公告)号：US20090030291A1

公开(公告)日：2009-01-29

申请号：US12175803

申请日：2008-07-18

申请人： David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

发明人： David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

IPC分类号： A61B5/00

CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/076 ,  Y10T29/49016 ,  Y10T29/49069 ,  Y10T29/49071 ,  Y10T29/49073

摘要： A wireless sensor for indicating a physical state within an environment includes a unitary housing defining a cavity. A structure located within the cavity of the housing has elements providing capacitance, the elements being arranged such that the distance and thereby the capacitance of the structure changes when a physical state of the environment changes. The structure has a resonant frequency based at least in part on the capacitance of the structure when in the presence of a fluctuating electromagnetic field. When the sensor is positioned within an environment and is subjected to a fluctuating electromagnetic field, the resonant frequency indicates the physical state of the environment.

摘要翻译： 用于指示环境中的物理状态的无线传感器包括限定空腔的整体壳体。 位于壳体的腔内的结构具有提供电容的元件，该元件被布置成使得当环境的物理状态改变时，结构的距离以及由此的结构的电容改变。 当存在波动的电磁场时，该结构至少部分地基于结构的电容。 当传感器位于环境中并且经受波动的电磁场时，谐振频率表示环境的物理状态。

公开(公告)号：US07466120B2

公开(公告)日：2008-12-16

申请号：US11717967

申请日：2007-03-14

申请人： Donald J. Miller ,  Michael G. Ellis ,  Mark G. Allen

发明人： Donald J. Miller ,  Michael G. Ellis ,  Mark G. Allen

IPC分类号： G01R23/12 ,  G01R35/00

CPC分类号： A61B5/0031 ,  A61B5/02014 ,  A61B5/073 ,  A61B5/076 ,  A61B2560/0219

摘要： Aspects of the present invention determine the resonant frequency of a sensor by obtaining sensor signals in response to three energizing signals, measuring the phase of each sensor signal, and using a group phase delay to determine the resonant frequency. The phase difference between the first and second signal is determined as a first group phase delay. The phase difference between the second and third signal is determined as a second group phase delay. The first group phase delay and second group phase delay are compared. Based on the comparison, the system may lock on the resonant frequency of the sensor or adjust a subsequent set of three energizing signals.

摘要翻译： 本发明的方面通过响应于三个激励信号获得传感器信号，测量每个传感器信号的相位以及使用组相位延迟来确定谐振频率来确定传感器的谐振频率。 第一和第二信号之间的相位差被确定为第一组相位延迟。 第二和第三信号之间的相位差被确定为第二组相位延迟。 比较第一组相位延迟和第二组相位延迟。 基于比较，系统可以锁定传感器的谐振频率或调整后续的一组三个通电信号。

公开(公告)号：US20070261497A1

公开(公告)日：2007-11-15

申请号：US11748803

申请日：2007-05-15

申请人： David O'Brien ,  Christophe Courcimault ,  Liang You

发明人： David O'Brien ,  Christophe Courcimault ,  Liang You

IPC分类号： G01L9/12 ,  G01L7/00

CPC分类号： G01L9/0075 ,  G01L9/0042 ,  G01L9/0055 ,  Y10T29/49002

摘要： A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Mi cromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

摘要翻译： 压力腔是耐用的，稳定的和生物相容的并且被配置成使得其构成微微至纳升级体积的量。 压力腔与外部环境密封，同时保持与其他设备通信的能力。 密封的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力和返回信息。 设置在其中的压力腔和传感器部件与环境密封，以便减少传感器内的漂移和不稳定性。 传感器设计用于苛刻和生物环境，例如 体内植入和体内使用。 另外，采用新的制造方法构造传感器。