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公开(公告)号:US20150082317A1
公开(公告)日:2015-03-19
申请号:US14129921
申请日:2013-09-19
IPC分类号: G06F9/50
CPC分类号: G06F9/5094 , G06F9/5066 , G06F2209/5017 , Y02D10/22 , Y02D10/36
摘要: Various embodiments are generally directed to techniques for assigning portions of a task among individual cores of one or more processor components of each processing device of a distributed processing system. An apparatus to assign processor component cores to perform task portions includes a processor component; an interface to couple the processor component to a network to receive data that indicates available cores of base and subsystem processor components of processing devices of a distributed processing system, the subsystem processor components made accessible on the network through the base processor components; and a core selection component for execution by the processor component to select cores from among the available cores to execute instances of task portion routines of a task based on a selected balance point between compute time and power consumption needed to execute the instances of the task portion routines. Other embodiments are described and claimed.
摘要翻译: 各种实施例通常涉及用于在分布式处理系统的每个处理设备的一个或多个处理器组件的各个核心中分配任务的部分的技术。 分配处理器组件核来执行任务部分的装置包括处理器组件; 将处理器组件耦合到网络以接收指示分布式处理系统的处理设备的基础和子系统处理器组件的可用核心的数据的接口,所述子系统处理器组件通过所述基本处理器组件在所述网络上可访问; 以及核心选择组件,用于由处理器组件执行以从可用核心中选择核心,以基于执行任务部分的实例所需的计算时间和功耗之间的所选余额来执行任务的任务部分例程的实例 例程。 描述和要求保护其他实施例。
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公开(公告)号:US07714014B2
公开(公告)日:2010-05-11
申请号:US11608197
申请日:2006-12-07
申请人: Biao He , Naoaki Fujii , Liang You , Zhidong Xu , David M. Jablons
发明人: Biao He , Naoaki Fujii , Liang You , Zhidong Xu , David M. Jablons
IPC分类号: A61K31/415 , C07D231/06
CPC分类号: C07D231/06
摘要: This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3.
摘要翻译: 本发明提供了用于诊断和治疗表达GLI多肽,特别是GLI1,GLI2或GLI3多肽的癌症的组合物,方法和试剂盒。 本发明提供了模拟GLI多肽的转录激活结构域的小分子化合物。 本发明的小分子抑制剂特异性阻断GLI多肽的激活功能,而不是GLI3的阻遏物功能。
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公开(公告)号:US20090304695A1
公开(公告)日:2009-12-10
申请号:US12363569
申请日:2009-01-30
申请人: Biao He , Liang You , Zhidong Xu , David M. Jablons
发明人: Biao He , Liang You , Zhidong Xu , David M. Jablons
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: C07K16/30 , A61K2039/505 , C07K2317/56 , C07K2317/73
摘要: This invention relates to methods of inhibiting the growth of cancer cells that overexpress a Wnt protein. The methods comprise contacting the cell with an agent that inhibits binding of the Wnt protein to a Frizzled receptor.
摘要翻译: 本发明涉及抑制过表达Wnt蛋白的癌细胞生长的方法。 所述方法包括使细胞与抑制Wnt蛋白与卷曲毛发受体结合的试剂接触。
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公开(公告)号:US07141600B2
公开(公告)日:2006-11-28
申请号:US10826175
申请日:2004-04-15
申请人: R. Kiplin Guy , Irwin D. Kuntz , Jose Haresco , Naoaki Fujii , Kathleen P. Novak , David Stokoe , Biao He , Liang You , Zhidong Xu , David M. Jablons
发明人: R. Kiplin Guy , Irwin D. Kuntz , Jose Haresco , Naoaki Fujii , Kathleen P. Novak , David Stokoe , Biao He , Liang You , Zhidong Xu , David M. Jablons
IPC分类号: A61K31/404 , C07D209/12 , C07D209/30 , C07D209/04
CPC分类号: C07D209/12 , C07D209/18
摘要: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds.Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
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公开(公告)号:US08450062B2
公开(公告)日:2013-05-28
申请号:US12701432
申请日:2010-02-05
申请人: Biao He , Liang You , Zhidong Xu , David M. Jablons
发明人: Biao He , Liang You , Zhidong Xu , David M. Jablons
CPC分类号: C12Q1/6886 , C12Q1/6827 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , G01N33/5011 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/00 , G01N2800/52 , C12Q2523/125
摘要: This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression.
摘要翻译: 本发明提供了用于诊断和治疗SOCS-3表达降低的癌症的组合物和方法。
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公开(公告)号:US20120329097A1
公开(公告)日:2012-12-27
申请号:US13479001
申请日:2012-05-23
IPC分类号: C12P19/34
CPC分类号: C12P19/34 , C12N15/1096 , C12Q1/6846 , C12Q2525/179 , C12Q2525/143 , C12Q2521/107
摘要: The present invention provides improved methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mRNA, using oligonucleotides, DNA and RNA polymerases are provided. The invention further provides compositions and kits for practicing the methods, as well as methods which use the amplification products.
摘要翻译: 本发明提供了用于扩增核酸分子的改进方法。 提供了使用寡核苷酸,DNA和RNA聚合酶扩增靶多核苷酸(包括mRNA)的方法。 本发明还提供了用于实施该方法的组合物和试剂盒,以及使用扩增产物的方法。
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公开(公告)号:US07647836B2
公开(公告)日:2010-01-19
申请号:US11748803
申请日:2007-05-15
申请人: David O'Brien , Christophe Courcimault , Liang You , Mark Allen , Michael Fonseca , Florent Cros
发明人: David O'Brien , Christophe Courcimault , Liang You , Mark Allen , Michael Fonseca , Florent Cros
IPC分类号: G01L7/00
CPC分类号: G01L9/0075 , G01L9/0042 , G01L9/0055 , Y10T29/49002
摘要: A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.
摘要翻译: 压力腔是耐用的,稳定的和生物相容的并且被配置成使得其构成微微至纳升级体积的量。 压力腔与外部环境密封,同时保持与其他设备通信的能力。 微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力并返回信息。 设置在其中的压力腔和传感器部件与环境密封,以便减少传感器内的漂移和不稳定性。 传感器设计用于苛刻和生物环境,例如 体内植入和体内使用。 另外,采用新的制造方法构造传感器。
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公开(公告)号:US20080021082A1
公开(公告)日:2008-01-24
申请号:US11580001
申请日:2006-10-11
申请人: R. Guy , Irwin Kuntz , Jose Haresco , Naoaki Fujii , Kathleen Novak , David Stokoe , Biao He , Liang You , Zhidong Xu , David Jablons
发明人: R. Guy , Irwin Kuntz , Jose Haresco , Naoaki Fujii , Kathleen Novak , David Stokoe , Biao He , Liang You , Zhidong Xu , David Jablons
IPC分类号: A61K31/405 , A61K31/4184 , C07D209/18 , C07D235/04 , C07D403/02 , C07K14/47 , C12N5/06 , C12N5/08
CPC分类号: C07D209/12 , C07D209/18
摘要: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
摘要翻译: 已经发现已经发现有效抑制PDZ结构域相互作用的新型化合物,特别是MAGI中PDZ结构域与致癌(肿瘤抑制基因)蛋白PTEN的相互作用以及Dishedvelled(Dvl)蛋白质中的PDZ结构域和其它蛋白质之间的相互作用 (Fz)蛋白,具有通式本发明还包括用于筛选和研究使用这些化合物的蛋白质的组合文库,阵列和方法。 本发明化合物在过表达蛋白质(Dv1)的某些细胞系中产生凋亡; 抑制Wnt信号。
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公开(公告)号:US20070199385A1
公开(公告)日:2007-08-30
申请号:US11601597
申请日:2006-11-17
申请人: David O'Brien , Liang You
发明人: David O'Brien , Liang You
IPC分类号: G01L9/12
CPC分类号: G01L9/0075
摘要: A sensor has a sensor housing defining a cavity therein. A first wall partially defining the cavity is deflectable under a physiologically relevant range of pressures. An integrated circuit chip bearing electronics is fixedly mounted within the cavity. A capacitor comprises first and second capacitor plates in generally parallel, spaced-apart relation. The first capacitor plate is physically coupled to the deflectable wall so as to move as the wall deflects, and the second capacitor plate is carried by the chip. The second capacitor plate is in electrical communication with the input pad of the chip.
摘要翻译: 传感器具有在其中限定空腔的传感器外壳。 部分地限定空腔的第一壁在生理学上相关的压力范围内是可偏转的。 集成电路芯片轴承电子器件固定地安装在腔内。 电容器包括大致平行且间隔开的关系的第一和第二电容器板。 第一电容器板物理耦合到可偏转壁,以便当壁偏转时移动,并且第二电容器板由芯片承载。 第二电容器板与芯片的输入焊盘电连通。
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公开(公告)号:US20070037157A1
公开(公告)日:2007-02-15
申请号:US10570916
申请日:2004-09-03
申请人: Biao He , Liang You , Zhidong Xu , David Jablons
发明人: Biao He , Liang You , Zhidong Xu , David Jablons
IPC分类号: C12Q1/68 , G01N33/574
CPC分类号: C12Q1/6886 , C12Q1/6827 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , G01N33/5011 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/00 , G01N2800/52 , C12Q2523/125
摘要: This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression.
摘要翻译: 本发明提供了用于诊断和治疗SOCS-3表达降低的癌症的组合物和方法。
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