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公开(公告)号：US08147350B2
公开(公告)日：2012-04-03
申请号：US13077825
申请日：2011-03-31
申请人： Todd P. Beach , Mark V. Greaney , Ian C. Wright , Kraig A. Willett , Nathan T. Sargent , Matthew D. Johnson , Gery M. Zimmerman
发明人： Todd P. Beach , Mark V. Greaney , Ian C. Wright , Kraig A. Willett , Nathan T. Sargent , Matthew D. Johnson , Gery M. Zimmerman
IPC分类号： A63B53/02
CPC分类号： A63B60/00 , A63B53/02 , A63B53/0466 , A63B53/047 , A63B53/0487 , A63B53/06 , A63B2053/023 , A63B2053/026 , A63B2053/0416 , A63B2053/0425 , A63B2053/0433 , A63B2053/045 , A63B2053/0454 , A63B2053/0458 , A63B2053/0491 , A63B2209/00 , A63B2209/02
摘要： A golf club comprises a shaft, a club head, and a connection assembly that allows the shaft to be easily disconnected from the club head. In particular embodiments, the connection assembly includes a removable hosel sleeve that allows a shaft to be supported a desired predetermined orientation relative to the club head. In this manner, the shaft loft and/or lie angle of the club can be adjusted without resorting to traditional bending of the shaft. In another embodiment, the club head has an adjustable sole that can be adjusted upwardly and downwardly relative to the strike face of the club head, which is effective to adjust the face angle of the club head.
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公开(公告)号：US07572887B2
公开(公告)日：2009-08-11
申请号：US10552515
申请日：2004-04-05
申请人： Ira Pastan , Tapan K. Bera , Byungkook Lee
发明人： Ira Pastan , Tapan K. Bera , Byungkook Lee
CPC分类号： A61K38/168 , A61K38/164 , A61K47/64 , C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , G01N33/57434 , G01N2500/00
摘要： A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugages are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection of prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NEGP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.
摘要翻译： 公开了在前列腺细胞中特异性检测到的多肽，称为前列腺中表达的剪接变体 - 新型基因（SV-NGEP）。 还公开了编码SV-NGEP的多核苷酸，以及包括这些多核苷酸的载体。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合SV-NGEP的抗体和免疫结合物。 公开了使用NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。 公开了检测前列腺癌的测定。 还公开了包含SV-NGEP多肽，特异性结合SV-NEGP的抗体或编码SV-NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。
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公开(公告)号：US10588744B2
公开(公告)日：2020-03-17
申请号：US15252110
申请日：2016-08-30
发明人： Kevin D. Rupp , Tung T. Le , Thanh Huy Le , Brian C. Gray , Alejandro J. Froimovich Rosenberg , Jeff Lindstrom , Kim D. Nguyen , Sonny Tran
摘要： A delivery apparatus for implanting a radially compressible and expandable prosthetic heart valve in a native heart valve of the heart includes a handle portion and an elongated shaft extending from and movable relative to the handle portion. The shaft includes a proximal end portion coupled to the handle portion and a distal end portion configured to mount a prosthetic heart valve in a radially compressed state. The handle portion includes a control member movable longitudinally with respect to the handle portion, the control member engaging a gear assembly operable to convert longitudinal motion of the control member to rotational motion of the gear assembly. The gear assembly engages the elongated shaft such that rotational motion of the gear assembly causes corresponding longitudinal motion of the elongated shaft relative to the handle portion.
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公开(公告)号：US10584403B2
公开(公告)日：2020-03-10
申请号：US15650743
申请日：2017-07-14
申请人： UT-Battelle, LLC , University of Tennessee Research Foundation , Iowa State University Research Foundation, Inc. , Eck Industries Incorporated
发明人： Orlando Rios , Sudarsanam Suresh Babu , Ryan R. Dehoff , Ryan Ott , Alex J. Plotkowski , Zachary C. Sims , Niyanth Sridharan , David Weiss , Hunter B. Henderson
IPC分类号： C22C23/06 , C22C21/08 , C22C21/06 , B33Y10/00 , B33Y80/00 , B23K26/354 , B22D21/00 , C22C1/03 , C22C28/00 , C22C30/06 , C21D1/10 , C22C21/00 , C22F1/04 , B22F3/105 , C22C1/04
摘要： Embodiments of surface-hardened aluminum-rare earth alloys and methods of making the alloys are disclosed. In some embodiments, the alloy comprises aluminum and 4 wt % to 60 wt % of a rare earth component X having a maximum solid solubility of ≤0.5 wt % in aluminum. The surface-hardened alloy component has an alloy bulk portion and a hardened alloy surface portion. At least a portion of the hardened alloy surface portion has a Vickers hardness that is at least 30% greater than a Vickers hardness of the alloy bulk portion.
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公开(公告)号：US10568732B2
公开(公告)日：2020-02-25
申请号：US15934850
申请日：2018-03-23
IPC分类号： A61F2/06 , A61B17/15 , A61F2/07 , A61B17/072 , A61F2/954 , A61F2/958 , A61F2/966 , A61F2/848 , A61F2/89 , A61B17/115 , A61F2/90 , A61F2/95
摘要： An implantable vascular device comprises an expandable and compressible implant body, a housing, a rotatable member, and a locking member. The housing is coupled to a first end portion of the implant body. The rotatable member is coupled to the housing and to a second end portion of the implant body such that rotating the rotatable member relative to the housing and the implant body expands or contracts the implant body. The locking member is coupled to the rotatable member and configured to move between an unlocked state and a locked state. In the unlocked state, the locking member allows the rotatable member to be rotated relative to the housing and the implant body. In the locked state, the locking member prevents the rotatable member from being rotated relative to the housing and the implant body.
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公开(公告)号：US10478294B2
公开(公告)日：2019-11-19
申请号：US16200458
申请日：2018-11-26
发明人： David M. Taylor
摘要： An assembly for delivering a prosthetic heart valve to a native heart valve is disclosed. The assembly includes a self-expanding prosthetic heart valve formed with an expandable metallic stent and a flexible valvular structure. The assembly also includes a delivery apparatus having a delivery sleeve. The delivery sleeve includes a selectively steerable section and a distal portion for retaining the prosthetic heart valve in a compressed state. A handle is coupled to a proximal end of the delivery sleeve and a pull wire extends from the handle to the steerable section of the delivery sleeve. The handle preferably includes a rotatable portion for actuating the pull wire and thereby selectively controlling a curvature of the steerable section during advancement through the patient's vasculature. In preferred embodiments, the steerable section includes a flexible metallic tubular portion formed with a plurality of circumferentially extending openings.
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公开(公告)号：US10328244B2
公开(公告)日：2019-06-25
申请号：US14907241
申请日：2015-06-24
摘要： This disclosure relates generally to systems and methods for occluding vessels of the heart and inducing cardioplegic arrest to facilitate the performance of cardiac procedures. An aortic occlusion and perfusion device includes an expandable member configured to expand within the aorta to secure the device within the aorta, and a catheter extending proximally from the expandable member and in fluid communication with the expandable member. The catheter can define a plurality of openings along its length through which blood can pass with one or more of the openings located proximal to the expandable member and one or more of the openings located within the expandable member. The device can also include a flow control sheath disposed around the catheter member such that axial movement of the flow control sheath relative to the catheter selectively occludes or uncovers one or more of the openings located proximal to the expandable member.
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公开(公告)号：US10232564B2
公开(公告)日：2019-03-19
申请号：US15140387
申请日：2016-04-27
发明人： Itai Pelled , Elena Sherman , Eran Goldberg , Kevin D. Rupp , Noam Nir
摘要： The present disclosure relates to laminated sealing members for prosthetic valves and methods of making the same. In a representative embodiment, an implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration comprises an annular frame having an inflow end and an outflow end, a leaflet structure positioned within the frame and secured thereto, and a laminate sealing member comprising an encapsulating material. The laminate sealing member has a main portion that encapsulates at least a portion of the frame and an end portion extending from the inflow end of the frame, and the end portion of the laminate sealing member is folded to form a cuff adjacent the inflow end of the frame and secured to the main portion of the laminate sealing member.
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公开(公告)号：US10179048B2
公开(公告)日：2019-01-15
申请号：US15042049
申请日：2016-02-11
发明人： Philippe Marchand , David M. Taylor , Robert Milich , David J. Evans , Christopher Chia , Ronaldo C. Cayabyab , Robert Bowes
摘要： Embodiments of the present disclosure provide a delivery apparatus for delivering a prosthetic heart valve to a native valve site via the human vasculature without the need for a separate introducer sheath. The delivery apparatus is particularly well-suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a stenotic aortic valve.
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公开(公告)号：US10179046B2
公开(公告)日：2019-01-15
申请号：US15232722
申请日：2016-08-09
发明人： Tamir S. Levi
摘要： In one representative embodiment, a gripping and pushing device for a medical instrument comprises an elongated main body defining a lumen. The elongated main body comprises one or more deflectable portions that can be pressed radially inwardly toward a shaft of the medical instrument extending through the lumen. One or more elastomeric gripping layers can be secured to the inner surface of a respective deflectable portion at axially spaced apart attachment locations. The one or more gripping layers are axially deformable relative to the one or more deflectable portions between the attachment locations when manual pressure is applied to the one or more deflectable portions to press the one or more gripping layers against the shaft and move the shaft longitudinally into a patient's body.
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