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公开(公告)号：US11802821B2
公开(公告)日：2023-10-31
申请号：US16338860
申请日：2017-09-29
申请人： The USA as represented by the Secretary, Department of Health and Human Services , Michael Oshetski
CPC分类号： G01N1/36 , B01L3/508 , G01N1/42 , B01L2300/041 , B01L2300/0609 , G01N2001/315 , G01N2001/366
摘要： An article comprising:
a planar base having a first surface and an opposing second surface and an outer peripheral edge, wherein the second surface includes an area comprising a plurality of protuberances and configured to attach and maintain orientation of a frozen tissue specimen block; and
a removable lid having a first side and a second side, wherein the first side defines a continuous planar surface and the second side defines a recessed portion configured to cover a frozen tissue specimen block and an outer rim configured to engage with the outer peripheral edge of the base, wherein the outer rim does not form part of the recessed portion,
wherein the area of the base and the recessed portion of the lid are aligned.-
公开(公告)号：US11801153B2
公开(公告)日：2023-10-31
申请号：US16321565
申请日：2017-07-31
发明人： Thomas Bulea , Zachary Lerner , Diane Damiano , Andrew Gravunder
IPC分类号： A61F2/70 , A63F13/212 , A61H1/02 , A61H3/00
CPC分类号： A61F2/70 , A61H1/024 , A61H3/00 , A63F13/212 , A61H2201/1642 , A61H2201/5012 , A61H2201/5061 , A61H2201/5069 , A61H2201/5097 , A61H2230/605
摘要： Disclosed are powered gait assistance systems that include a controller, sensors, and a motor coupled to a patient's thigh and lower leg and operable to apply assistive torque to the patient's knee joint to assist the patient's volitional knee pivoting muscle output during selected stages of the patient's gait cycle, such that the assistive torque applied by the motor improves the patient's leg posture, muscle output, range of motion, and/or other parameters over the gait cycle. The sensors can include a torque sensor that measures torque applied by the motor, a knee angle sensor, a foot sensor that measures ground contact of the patient's foot, and/or other sensors. The controller can determine what stage of the patient's gait cycle the patient's leg is in based on sensor signals and cause the motor to apply corresponding assistive torque to the knee based on the gait cycle stage, sensor inputs, and known patient characteristics.
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公开(公告)号：US11786589B2
公开(公告)日：2023-10-17
申请号：US17349639
申请日：2021-06-16
发明人： Baoming Jiang , Roger I. Glass , Yuhuan Wang , Jon Gentsch
CPC分类号： A61K39/15 , A61K39/12 , C07K14/005 , C07K16/10 , C12N7/00 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , C12N2720/12334 , C12N2720/12361
摘要： A vaccine composition and method of vaccination are provided useful for immunizing a subject against a rotavirus. The vaccines include rotavirus strains CDC-9 and CDC-66, fragments thereof, homologues thereof, or combinations thereof. Inventive vaccines may include a fragment of CDC-9, CDC-66, homologues thereof, or combinations thereof. Methods of inducing an immunological response are provided by administering an inventive vaccine.
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公开(公告)号：US11771737B2
公开(公告)日：2023-10-03
申请号：US16756926
申请日：2018-10-29
发明人： Tim F. Greten , Chi Ma
IPC分类号： A61K38/14 , A61P1/16 , A61P35/00 , A61K31/4985 , A61K31/575 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： A61K38/14 , A61K31/4985 , A61K31/575 , A61K39/39541 , A61P1/16 , A61P35/00 , C07K16/2818 , A61K2039/505 , C07K2317/76
摘要： In embodiments, the invention provides a method of treating or preventing an adverse condition of the liver of a mammal, the method comprising administering to the mammal an effective amount of vancomycin and a checkpoint inhibitor. In embodiments, the invention provides a method of treating or preventing an adverse condition of the liver of a mammal, the method comprising administering to the mammal an effective amount of a primary bile acid.
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45.发明公开公开(公告)号：US20230303976A1
公开(公告)日：2023-09-28
申请号：US18174928
申请日：2023-02-27
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Alena Gros , Steven A. Rosenberg
IPC分类号： C12N5/0783 , A61P35/00 , A61K38/17 , C12N15/63
CPC分类号： C12N5/0636 , A61P35/00 , A61K38/1703 , C12N15/63
摘要： Disclosed are methods of isolating T cells and TCRs having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Also disclosed are related methods of preparing a population of cells, populations of cells, TCRs, pharmaceutical compositions, and methods of treating or preventing cancer.
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公开(公告)号：US20230295550A1
公开(公告)日：2023-09-21
申请号：US18018762
申请日：2021-07-30
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Ralph E. Parchment , Thu A. Nguyen
IPC分类号： C12M1/12
CPC分类号： C12M25/14
摘要： Provided are inserts (100) for preparing a cell culture chamber(s), or array of chambers, inside of histology cassettes that are suitable for three-dimensional multicellular growth of a cell or cells into spheroids, organoids, or other 3D structures, such that the resulting 3D multi-cellular structures are ready and suitable for histology processing without transfer to a different receptacle or container. Further embodiments of the invention provide methods of preparing at least one cell culture chamber using the inserts, systems for growing three-dimensional multicellular spheroids comprising culturing cells within a cell culture chamber prepared using the inserts, and systems for analyzing at least one cultured cell in vitro comprising culturing cells within a cell culture chamber prepared using the inserts.
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公开(公告)号：US20230287067A1
公开(公告)日：2023-09-14
申请号：US17793753
申请日：2021-01-21
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
摘要： The invention provides human immunogenic epitopes of HEMO and HHLA2 human endogenous retroviruses (HERVs), which can be used as a peptide, polypeptide (protein), and/or in a vaccine or other composition for the prevention or therapy of cancer. The invention further provides a nucleic acid encoding the peptide or polypeptide (protein), a vector comprising the nucleic acid, a cell comprising the peptide, polypeptide (protein), nucleic acid, or vector, and compositions thereof.
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公开(公告)号：US20230285143A1
公开(公告)日：2023-09-14
申请号：US18006331
申请日：2021-07-20
发明人： Robert J. Lederman , Toby Rogers
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2457 , A61F2/2415
摘要： Systems and methods of atrioventricular valve replacement are provided. In various embodiments, an arch-like support structure is provided that is insertable and implantable into a heart and is positioned in the mitral annulus to replace a native mitral valve. The support structure is operable to support, and various systems comprise leaflet and chord structures operable to control and regular blood flow between chambers of the heart.
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公开(公告)号：US20230272038A1
公开(公告)日：2023-08-31
申请号：US18015776
申请日：2021-07-13
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Noam Levin , Rami Yoseph , Gal Cafri , Steven A. Rosenberg
IPC分类号： C07K14/725 , G01N33/574 , A61K39/00
CPC分类号： C07K14/7051 , G01N33/5748 , A61K39/4611 , A61K39/4632 , A61K39/464464
摘要： Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glycine at position 12 with aspartic acid. The TCRs may recognize G12D RAS presented by an HLA-DR heterodimer. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US20230257756A1
公开(公告)日：2023-08-17
申请号：US18020843
申请日：2021-08-09
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Mark J. Henderson , Michael H. Ronzetti , Bolormaa Baljinnyam , Tino W. Sanchez , Samuel G. Michael , Ashley E. Owens , Anton Simeonov
IPC分类号： C12N15/62 , C12N9/06 , C07K14/705 , C12N15/86 , G01N33/68
CPC分类号： C12N15/625 , C12Y101/01027 , C12Y105/01003 , C12N9/003 , C07K14/70596 , C07K14/70521 , C12N15/86 , G01N33/6845 , C12N2330/51
摘要： The disclosure provides methods for carrying out Real Time Cellular Thermal Shift Assays (RT-CETSA). Also provided are molecular constructs and protein constructs for use in such assays and devices suitable for carrying out such assays.
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