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41.发明申请公开(公告)号：US20200262847A1
公开(公告)日：2020-08-20
申请号：US16867835
申请日：2020-05-06
发明人： Michael BADER , Edgar SPECKER , Susann MATTHES , Anja SCHÜTZ , Keven MALLOW , Maik GROHMANN , Marc NAZARÉ
IPC分类号： C07D519/00
摘要： The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation comprising the xanthine derivative. The novel xanthine compounds are capable of inhibiting tryptophan hydroxylases (TPH) involved in the biosynthesis of serotonin and are effective in influencing the serotonin level in the body.
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42.发明授权公开(公告)号：US10690877B2
公开(公告)日：2020-06-23
申请号：US15500643
申请日：2015-07-24
摘要： The present invention relates to an to an optical device comprising a micro-optical system and a retainer, and to a method for producing an optical device. In the case of the device according to the invention, the micro-optical system (10) is fastened in such a way that the micro-optical system is oriented in relation to a surface (50) of the retainer (60). The device is characterized in that the retainer (60) has a round, tapered recess (40) and the micro-optical system (10) is fastened on a spherical cap (20) and the spherical cap (20) is fastened to the retainer (60), wherein the spherical cap (20) at least partially protrudes into the recess (40) and lies against a partial surface (30) of the recess (40) or an edge (41) in the recess (40), wherein the spherical cap (20) is fastened to the retainer (60) in the recess (40), but is not fastened where the spherical cap lies in contact. Because the spherical cap lies in contact, shrinking of a fasting means cannot cause a shift or rotation of the spherical cap and thus cannot cause a misadjustment.
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43.发明申请公开(公告)号：US20190307907A1
公开(公告)日：2019-10-10
申请号：US16315368
申请日：2017-07-28
发明人： GIL GREGOR WESTMEYER , DONG-JIUNN JEFFERY TRUONG , LEIF SCHRÖDER , FEDERICA ROSSELLA , CHRISTOPHER WITTE
摘要： The present invention relates to a precursor of a molecular sensor for determining analyte concentrations and/or measuring analyte concentration changes comprising a host for an active nucleus, an NMR-modulating moiety and an interacting moiety, wherein said NMR-modulating moiety changes the resonance frequency or the chemical exchange saturation transfer (CEST) signal of the active nucleus-host complex, and wherein said interacting moiety specifically responds to an environmental parameter, to an analyte or to a target molecule that binds the analyte or said interacting moiety specifically binds to a target molecule in an analyte-dependent manner. The present invention further relates to a molecular sensor comprising an active nucleus and said precursor. The present invention further relates to a molecular sensor for determining analyte concentrations and/or measuring analyte concentration changes inside a cell, wherein moiety/ies of the sensor are expressed in said cells and then assembled inside said cell. The present invention further relates to uses of the molecular sensors as well as to an in vitro method for determining metal concentration and/or measuring metal concentration changes and a method for diagnosing and/or monitoring treatment of diseases causing changes in metal concentrations.
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公开(公告)号：US10348056B2
公开(公告)日：2019-07-09
申请号：US15736631
申请日：2016-03-09
发明人： Jörg Fricke , Götz Erbert , Paul Crump , Jonathan Decker
摘要： Laser diode comprises an active layer; a waveguiding region at least partially surrounding the active layer; a rear facet; a front facet designed for outcoupling laser radiation, wherein the active layer extends at least partially along a first axis (X) between the rear facet and the front facet; and a grating operatively connected to the waveguiding region, wherein the grating comprises a plurality of bridges and trenches designed such that an average increase of a coupling parameter P for the plurality of trenches along the grating is non-zero, wherein the coupling parameter P of a trench is defined by the equation, wherein dres is a distance of the trench to the active layer, w is a width of the trench and Δn is the refractive index difference between a refractive index of the trench and a refractive index of a material surrounding the trench.
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公开(公告)号：US20190131999A1
公开(公告)日：2019-05-02
申请号：US16092883
申请日：2017-04-12
发明人： Florian HÜHN
CPC分类号： H03M3/404 , H03F3/189 , H03F3/217 , H03F3/38 , H03F3/387 , H03F2200/339 , H04L27/2092
摘要： The present invention relates to a modulator for a digital amplifier and a device comprising such a modulator and a digital amplifier.The modulator (100) comprises a pulse shaper (110) and a control unit (120) for controlling the pulse shaper (110) to convert an input signal into a bit stream (130) configured for a digital amplifier which encodes an amplitude value per clock of a carrier signal. The pulse shaper (110) can represent a respective amplitude value of the input signal with different bit patterns. The bit pattern respectively used by the pulse shaper is determined by the control unit (120) by means of a corresponding, associated control command. The modulator (100) is characterized in that in the control unit (120) an assignment (160) of the control commands to associated amplitude values resulting from amplification of the associated bit patterns with the digital amplifier (400) is stored or at least is provided in that the control unit (120) selects a control command per clock by means of the assignment (160) and the amplitude value of the input signal and drives the pulse shaper (110) accordingly.
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公开(公告)号：US20180095040A1
公开(公告)日：2018-04-05
申请号：US15725448
申请日：2017-10-05
发明人： Bernd Sumpf , Martin Maiwald
CPC分类号： G01N21/65 , G01N15/1434 , G01N15/1459 , G01N21/53 , G01N2015/1006 , G01N2015/1452 , G01N2201/0612
摘要： Optical systems and methods for spectroscopy are described. The optical system may be particularly suitable for Raman spectroscopy and includes a multispectral excitation source, designed to emit monochromatic excitation radiation successively at at least two different excitation wavelengths along a common beam axis; an elongated flow volume with a longitudinal axis, designed to direct a particle flow along the longitudinal axis; an excitation beam path, designed to irradiate the monochromatic excitation radiation into the flow volume at a first position and the second position that are located in the flow volume and the first position is spaced apart from the second position; and a detection device, designed to wavelength-selectively filter and detect a portion of a radiation scattered from the first position at a first filter wavelength and to wavelength-selectively filter and detect a portion of a radiation scattered from the second position at a second filter wavelength.
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47.发明授权公开(公告)号：US09927423B2
公开(公告)日：2018-03-27
申请号：US14642776
申请日：2015-03-10
发明人： Thomas Jentsch , Tobias Stauber , Felizia K. Voss
IPC分类号： G01N33/50 , G01N33/68 , C07K14/705
CPC分类号： G01N33/502 , C07K14/705 , G01N33/6872 , G01N2500/10
摘要： The invention relates to a method for the identification of a channel modulator, such as an agonist or antagonist, that interacts with one or more or LRRC8A, LRRC8B, LRRC8C, LRRC8D and/or LRRC8E and/or protein complexes thereof. The invention further relates to an isolated heteromeric protein complex comprising one or more or LRRC8A, LRRC8B, LRRC8C, LRRC8D and/or LRRC8E for use in such methods, in addition to kits suitable for carrying out such methods. The invention therefore relate preferably to the use of LRRC8 proteins and complexes thereof for the identification of VRAC (VSOAC) modulators.
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公开(公告)号：US20170320910A1
公开(公告)日：2017-11-09
申请号：US15535002
申请日：2015-12-11
发明人： Ronald KÜHNE , Hans-Günther SCHMALZ , Matthias MÜLLER , Cedric REUTER , Arne SOICKE , Robert OPITZ , Matthias BARONE , Hartmut OSCHKINAT
CPC分类号： C07K7/06 , A61K38/00 , C07D519/00
摘要： The present invention relates to chemical compounds that can in particular be used as structural mimetics of proline-rich peptides. The compounds of the present invention are capable of selectively inhibiting ena/VASP-EVH1-mediated protein-protein interactions. The invention further relates to the use of said compounds as pharmaceutical agents and to the use of the pharmaceutical agents to treat tumor diseases. The chemical compounds of the present invention can significantly inhibit the chemotaxis and motility of invasive tumor cells and can therefore be used in the treatment and/or prevention of tumor metastases.
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49.发明授权公开(公告)号：US09768356B2
公开(公告)日：2017-09-19
申请号：US15105541
申请日：2014-12-17
发明人： Sven Einfeldt , Luca Redaelli , Michael Kneissl
IPC分类号： H01L33/40 , H01L21/285 , H01L29/45 , H01S5/22 , H01L33/36 , H01S5/323 , H01L33/32 , H01L33/38 , H01L33/58 , H01L29/20 , H01S5/042 , H01L33/00
CPC分类号： H01L33/40 , H01L21/28575 , H01L29/2003 , H01L29/452 , H01L33/0075 , H01L33/32 , H01L33/36 , H01L33/38 , H01L33/58 , H01L2933/0016 , H01S5/0425 , H01S5/22 , H01S5/32341
摘要： A method is described for forming at least one metal contact on a surface of a semiconductor and a device with at least one metal contact. The method is used for forming at least one metal contact (60) on a surface (11) of a semiconductor (10) and has the steps of: applying a metal layer (20) of palladium onto the semiconductor surface (11), applying a mask (40, 50) onto the metal layer (20), and structuring the palladium of the metal layer (20) using the mask (40, 50), wherein lateral deposits (21) of the metal are formed on sidewalls of the mask by the structuring so that the mask is embedded between the deposits (21) and the structured metal layer (20′) after the structuring. Since the mask is conductive, it can remain embedded in the metal. The deposits and the mask form a part of the contact.
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公开(公告)号：US20160024023A1
公开(公告)日：2016-01-28
申请号：US14869318
申请日：2015-09-29
申请人： The Government of the United States of America as represented by the Secretary of the Department of , Forschungsverbund Berlin E.V.
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wei Zheng , Wenwei Huang , Gerd Krause , Gunnar Kleinau
IPC分类号： C07D239/91 , A61K31/517 , A61K51/00
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
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