公开(公告)号：US20050214850A1

公开(公告)日：2005-09-29

申请号：US11128026

申请日：2005-05-11

申请人： Hui Tian ,  Joshua Schultz ,  Bei Shan

发明人： Hui Tian ,  Joshua Schultz ,  Bei Shan

IPC分类号： C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/10 ,  C12N15/09

CPC分类号： C07K14/705

摘要： The present invention provides polypeptides of a novel ABC family cholesterol transporter, SSG. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the activity of SSG.

摘要翻译： 本发明提供新型ABC家族胆固醇转运蛋白SSG的多肽。 本文所公开的序列可用于许多目的中的任何一种，包括用于诊断和治疗胆固醇相关疾病，包括静脉麻醉，以及鉴定与SSG的活性相关和/或调节的分子。

公开(公告)号：US5695963A

公开(公告)日：1997-12-09

申请号：US785241

申请日：1997-01-17

申请人： Steven L. McKnight ,  David W. Russell ,  Hui Tian

发明人： Steven L. McKnight ,  David W. Russell ,  Hui Tian

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N1/21 ,  C12P21/00 ,  C07H21/04 ,  G01N33/53

CPC分类号： C07K14/4702 ,  A61K38/00

摘要： The invention provides methods and compositions relating to endothelial PAS domain protein 1 (EPAS1) and related nucleic acids. The proteins may be produced recombinantly from transformed host cells from the disclosed EPAS1 encoding nucleic acids or purified from human cells. The invention provides isolated EPAS1 hybridization probes and primers capable of specifically hybridizing with the disclosed EPAS1 gene, EPAS1-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

摘要翻译： 本发明提供了与内皮PAS结构域蛋白1（EPAS1）和相关核酸相关的方法和组合物。 可以从编码核酸的公开的EPAS1的转化的宿主细胞中重组产生蛋白质，或从人细胞中纯化。 本发明提供了能够与所公开的EPAS1基因，EPAS1特异性结合剂如特异性抗体特异性杂交的分离的EPAS1杂交探针和引物，以及在诊断，治疗和生物制药工业中制备和使用该主题组合物的方法。

公开(公告)号：US08822897B2

公开(公告)日：2014-09-02

申请号：US13051320

申请日：2011-03-18

申请人： Hui Tian ,  Igor Constantin Ivanov ,  Edward Hartley Sargent

发明人： Hui Tian ,  Igor Constantin Ivanov ,  Edward Hartley Sargent

IPC分类号： H01L27/148 ,  H01L31/0232 ,  H01L27/146 ,  H04N9/04

CPC分类号： H01L27/14643 ,  H01L27/14603 ,  H01L27/14609 ,  H01L27/14621 ,  H01L27/14632 ,  H01L27/14636 ,  H04N9/045

摘要： In various example embodiments, the inventive subject matter is an image sensor and methods of formation of image sensors. In an embodiment, the image sensor comprises a semiconductor substrate and a plurality of pixel regions. Each of the pixel regions includes an optically sensitive material over the substrate with the optically sensitive material positioned to receive light. A pixel circuit for each pixel region is also included in the sensor. Each pixel circuit comprises a charge store formed on the semiconductor substrate and a read out circuit. A non-metallic contact region is between the charge store and the optically sensitive material of the respective pixel region, the charge store being in electrical communication with the optically sensitive material of the respective pixel region through the non-metallic contact region.

摘要翻译： 在各种示例性实施例中，本发明主题是图像传感器和形成图像传感器的方法。 在一个实施例中，图像传感器包括半导体衬底和多个像素区域。 每个像素区域包括在基底上的光敏材料，光敏材料定位成接收光。 每个像素区域的像素电路也包括在传感器中。 每个像素电路包括形成在半导体衬底上的电荷存储器和读出电路。 非金属接触区域位于电荷存储器和相应像素区域的光敏材料之间，电荷存储器通过非金属接触区域与相应像素区域的光敏材料电连通。

公开(公告)号：US08736733B2

公开(公告)日：2014-05-27

申请号：US13051983

申请日：2011-03-18

申请人： Hui Tian ,  Pierre Henri Rene Della Nave

发明人： Hui Tian ,  Pierre Henri Rene Della Nave

IPC分类号： H04N5/335 ,  H04N3/14

CPC分类号： H04N5/378 ,  H04N5/2253 ,  H04N5/3575 ,  H04N5/361 ,  H04N5/363 ,  H04N5/3698 ,  H04N5/3745 ,  H04N5/3765 ,  H04N9/045 ,  H04N2209/047

摘要： In various embodiments, an image sensor and method of using an image sensor are described. In an example embodiment, the image sensor comprises a semiconductor substrate and a plurality of pixel regions with each pixel region comprising an optically sensitive material over the substrate and positioned to receive light. There is a bias electrode for each pixel region, with the bias electrode configured to provide a bias voltage to the optically sensitive material of the respective pixel region. Also included is a pixel circuit for each pixel region with each pixel circuit comprising a charge store formed on the semiconductor substrate and a read out circuit, the charge store being in electrical communication with the optically sensitive material of the respective pixel region. The pixel circuit is configured to reset the voltage on the charge store to a reset voltage during a reset period, to integrate charge from the optically sensitive material to the charge store during an integration period, and to read out a signal from the charge store during a read out period. The pixel circuit includes a reference voltage node to be coupled to the charge store during the reset period and the read out circuit during the read out period where a reference voltage is applied to the reference voltage node and is configured to be varied during the operation of the pixel circuit.

摘要翻译： 在各种实施例中，描述了使用图像传感器的图像传感器和方法。 在示例性实施例中，图像传感器包括半导体衬底和多个像素区域，每个像素区域在衬底上包括光敏材料并被定位成接收光。 对于每个像素区域存在偏置电极，其中偏置电极被配置为向相应像素区域的光敏材料提供偏置电压。 还包括每个像素区域的像素电路，每个像素电路包括形成在半导体衬底上的电荷存储器和读出电路，电荷存储器与相应像素区域的光敏材料电连通。 像素电路被配置为在复位周期期间将电荷存储器上的电压复位为复位电压，以在积分期间将来自光敏材料的电荷集成到电荷存储器，并且在电荷存储期间读出来自电荷存储器的信号 读出期。 像素电路包括在复位周期期间耦合到电荷存储器的参考电压节点和在读出周期期间的读出电路，其中参考电压被施加到参考电压节点，并且被配置为在操作期间变化 像素电路。

公开(公告)号：US20130250150A1

公开(公告)日：2013-09-26

申请号：US13894184

申请日：2013-05-14

申请人： Michael R. Malone ,  Pierre Henri Rene Della Nave ,  Michael Charles Brading ,  Jess Jan Young Lee ,  Hui Tian ,  Igor Constantin Ivanov ,  Edward Hartley Sargent

发明人： Michael R. Malone ,  Pierre Henri Rene Della Nave ,  Michael Charles Brading ,  Jess Jan Young Lee ,  Hui Tian ,  Igor Constantin Ivanov ,  Edward Hartley Sargent

IPC分类号： G02B15/00

CPC分类号： G02B15/00 ,  H01L27/14609 ,  H01L27/14625 ,  H04N5/2258 ,  H04N5/23232 ,  H04N5/23296 ,  H04N5/37452

摘要： In various example embodiments, an imaging system and method are provided. In an embodiment, the system comprises a first image sensor array, a first optical system to project a first image on the first image sensor array, the first optical system having a first zoom level. A second optical system is to project a second image on a second image sensor array, the second optical system having a second zoom level. The second image sensor array and the second optical system are pointed in the same direction as the first image sensor array and the first optical system. The second zoom level is greater than the first zoom level such that the second image projected onto the second image sensor array is a zoomed in on portion of the first image projected on the first image sensor array. The first image sensor array may include at least four megapixels and the second image sensor array may include one-half or less than the number of pixels in the first image sensor array.

摘要翻译： 在各种示例性实施例中，提供了一种成像系统和方法。 在一个实施例中，系统包括第一图像传感器阵列，第一光学系统，用于投影第一图像传感器阵列上的第一图像，第一光学系统具有第一缩放级别。 第二光学系统是在第二图像传感器阵列上投影第二图像，第二光学系统具有第二缩放水平。 第二图像传感器阵列和第二光学系统指向与第一图像传感器阵列和第一光学系统相同的方向。 第二缩放级别大于第一缩放级别，使得投影到第二图像传感器阵列上的第二图像放大在投影在第一图像传感器阵列上的第一图像的一部分上。 第一图像传感器阵列可以包括至少四百万像素，并且第二图像传感器阵列可以包括第一图像传感器阵列中的像素数量的一半或更小。

公开(公告)号：US08525287B2

公开(公告)日：2013-09-03

申请号：US13217103

申请日：2011-08-24

申请人： Hui Tian ,  Edward Sargent

发明人： Hui Tian ,  Edward Sargent

IPC分类号： H01L31/00

CPC分类号： H01L27/14625 ,  H01L27/14603 ,  H01L27/14623 ,  H01L27/14632 ,  H01L27/14638 ,  H01L27/14687 ,  H01L31/0224 ,  H01L31/022475 ,  H01L31/0324 ,  H01L31/035218 ,  H01L31/072 ,  H01L31/09 ,  H01L31/1013 ,  H01L31/1085 ,  Y02E10/50

摘要： A photodetector is described along with corresponding materials, systems, and methods. The photodetector comprises an integrated circuit and at least two optically sensitive layers. A first optically sensitive layer is over at least a portion of the integrated circuit, and a second optically sensitive layer is over the first optically sensitive layer. Each optically sensitive layer is interposed between two electrodes. The two electrodes include a respective first electrode and a respective second electrode. The integrated circuit selectively applies a bias to the electrodes and reads signals from the optically sensitive layers. The signal is related to the number of photons received by the respective optically sensitive layer.

公开(公告)号：US08441090B2

公开(公告)日：2013-05-14

申请号：US13218802

申请日：2011-08-26

申请人： Hui Tian ,  Edward Sargent

发明人： Hui Tian ,  Edward Sargent

IPC分类号： H01L27/146

CPC分类号： H01L31/1013 ,  H01L27/14601 ,  H01L27/14603 ,  H01L27/14609 ,  H01L27/14641 ,  H01L27/14647 ,  H01L27/14652 ,  H01L27/14687 ,  H01L27/14692 ,  H01L31/036

摘要： A photodetector is described along with corresponding materials, systems, and methods. The photodetector comprises an integrated circuit and at least two optically sensitive layers. A first optically sensitive layer is over at least a portion of the integrated circuit, and a second optically sensitive layer is over the first optically sensitive layer. Each optically sensitive layer is interposed between two electrodes. The two electrodes include a respective first electrode and a respective second electrode. The integrated circuit selectively applies a bias to the electrodes and reads signals from the optically sensitive layers. The signal is related to the number of photons received by the respective optically sensitive layer.

公开(公告)号：US08274126B2

公开(公告)日：2012-09-25

申请号：US13213932

申请日：2011-08-19

申请人： Hui Tian ,  Edward Sargent

发明人： Hui Tian ,  Edward Sargent

IPC分类号： H01L33/00

CPC分类号： H01L31/1013 ,  H01L27/14601 ,  H01L27/14603 ,  H01L27/14609 ,  H01L27/14641 ,  H01L27/14647 ,  H01L27/14652 ,  H01L27/14687 ,  H01L27/14692 ,  H01L31/036

摘要： A photodetector is described along with corresponding materials, systems, and methods. The photodetector comprises an integrated circuit and at least two optically sensitive layers. A first optically sensitive layer is over at least a portion of the integrated circuit, and a second optically sensitive layer is over the first optically sensitive layer. Each optically sensitive layer is interposed between two electrodes. The two electrodes include a respective first electrode and a respective second electrode. The integrated circuit selectively applies a bias to the electrodes and reads signals from the optically sensitive layers. The signal is related to the number of photons received by the respective optically sensitive layer.

公开(公告)号：US08269260B2

公开(公告)日：2012-09-18

申请号：US13214711

申请日：2011-08-22

申请人： Hui Tian ,  Edward Sargent

发明人： Hui Tian ,  Edward Sargent

IPC分类号： H01L27/148

CPC分类号： H01L31/1013 ,  H01L27/14601 ,  H01L27/14603 ,  H01L27/14609 ,  H01L27/14641 ,  H01L27/14647 ,  H01L27/14652 ,  H01L27/14687 ,  H01L27/14692 ,  H01L31/036

摘要： A photodetector is described along with corresponding materials, systems, and methods. The photodetector comprises an integrated circuit and at least two optically sensitive layers. A first optically sensitive layer is over at least a portion of the integrated circuit, and a second optically sensitive layer is over the first optically sensitive layer. Each optically sensitive layer is interposed between two electrodes. The two electrodes include a respective first electrode and a respective second electrode. The integrated circuit selectively applies a bias to the electrodes and reads signals from the optically sensitive layers. The signal is related to the number of photons received by the respective optically sensitive layer.

摘要翻译： 描述光电探测器以及相应的材料，系统和方法。 光电检测器包括集成电路和至少两个光敏层。 第一光敏层在集成电路的至少一部分之上，第二光敏层位于第一光敏层之上。 每个光敏层插在两个电极之间。 两个电极包括相应的第一电极和相应的第二电极。 集成电路选择性地向电极施加偏压并从光敏层读取信号。 该信号与相应的光敏层所接收的光子的数量有关。

公开(公告)号：US08257934B2

公开(公告)日：2012-09-04

申请号：US12705169

申请日：2010-02-12

申请人： Hui Tian ,  Joshua Schultz ,  Bei Shan

发明人： Hui Tian ,  Joshua Schultz ,  Bei Shan

IPC分类号： G01N33/53 ,  G01N33/566 ,  C07K14/00

CPC分类号： C07K14/705

摘要： The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, SSG. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the activity of SSG.

摘要翻译： 本发明提供编码新型ABC家族胆固醇转运蛋白SSG的核酸。 本文所公开的序列可用于许多目的中的任何一种，包括用于诊断和治疗胆固醇相关疾病，包括静脉麻醉，以及鉴定与SSG的活性相关和/或调节的分子。