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82 条记录 (耗时 0.016 秒)

    Therapeutic and prophylactic agents for peptic ulcer
    43.
    发明授权
    Therapeutic and prophylactic agents for peptic ulcer 失效
    消化性溃疡的治疗和预防剂

    公开(公告)号：US4888417A

    公开(公告)日：1989-12-19

    申请号：US867169

    申请日：1986-05-27

    申请人： Yusei Shiraga ,  Chikara Fukaya ,  Toshiaki Akira ,  Masakazu Iwai ,  Kazumasa Yokoyama ,  Mamoru Tabata ,  Hiroshi Fukui ,  Shigeo Tanaka ,  Yoshiro Iga ,  Tadakazu Suyama ,  Kanemichi Okano

    发明人： Yusei Shiraga ,  Chikara Fukaya ,  Toshiaki Akira ,  Masakazu Iwai ,  Kazumasa Yokoyama ,  Mamoru Tabata ,  Hiroshi Fukui ,  Shigeo Tanaka ,  Yoshiro Iga ,  Tadakazu Suyama ,  Kanemichi Okano

    IPC分类号： A61K31/12 ,  A61K31/70 ,  A61K36/54 ,  C07C49/242 ,  C07C49/255 ,  C07C49/647 ,  C07C49/743 ,  C07H15/18 ,  C07H15/203 ,  C07H15/207

    CPC分类号： C07C403/08 ,  C07C403/10 ,  C07C403/12 ,  C07H15/18 ,  C07H15/203 ,  C07C2101/16 ,  Y10S514/927

    摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or =O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.6 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;X represents group (A):.dbd.C.dbd.CH--COR.sub.8 (A) or group (B): ##STR2## wherein R.sub.8 represents alkyl, and R.sub.9 and R.sub.10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R.sub.1 and R.sub.3 both represent hydrogen, R.sub.2 represents --OR.sub.5 ; R.sub.4 represents OR.sub.7 and the bond between the carbon atoms to which X is attached and the carbon atom to which R.sub.4 is attached is a single bond, and when X represents group (B), then R.sub.1 represents .dbd.O, R.sub.2 represents hydrogen, R.sub.3 represents --OR.sub.6 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II): ##STR3## wherein R.sub.11 represents hydrogen or an organic residue, and R.sub.12, R.sub.13 and R.sub.14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.

    摘要翻译： 含有作为活性成分的通式（I）的化合物的消化性溃疡的治疗和预防剂：其中R1表示氢或= O; R2代表氢或-OR5; R3表示氢或-OR6; 在不存在双键的情况下，R4代表-OR7; R5，R6和R7各自表示氢或有机残基; X表示基团（A）：= C = CH-COR 8（A）或基团（B）：其中R 8表示烷基，R 9和R 10各自表示氢或有机残基; 条件是当X表示基团（A）时，则R1和R3都表示氢，R2表示-OR5; R4表示OR7，X所连接的碳原子和与R4连接的碳原子之间的键为单键，当X表示基团（B）时，则R 1表示= O，R 2表示氢，R 3表示 -OR 6和X所连接的碳原子和与R 4连接的碳原子之间的键是双键，或其药学上可接受的盐或通式（II）的化合物：（ II）其中R 11表示氢或有机残基，R 12，R 13和R 14各自表示有机残基或其药学上可接受的盐。 通式（I）和（II）的化合物可以衍生自肉桂热水提取物中所含的化合物。

    Water soluble drug complex and method for production of same
    45.
    发明授权
    Water soluble drug complex and method for production of same 失效
    水溶性药物复合物及其制备方法

    公开(公告)号：US4687762A

    公开(公告)日：1987-08-18

    申请号：US716436

    申请日：1985-03-27

    申请人： Tsunekazu Fukushima ,  Hiroshi Emoto ,  Yoshio Kagitani ,  Kazumasa Yokoyama ,  Masayuki Nishida ,  Tadakazu Suyama

    发明人： Tsunekazu Fukushima ,  Hiroshi Emoto ,  Yoshio Kagitani ,  Kazumasa Yokoyama ,  Masayuki Nishida ,  Tadakazu Suyama

    IPC分类号： B01J13/02 ,  A61K9/00 ,  A61K9/127 ,  A61K9/50 ,  A61K31/70 ,  A61K31/545 ,  A61K31/685

    CPC分类号： A61K47/48053 ,  A61K9/1277

    摘要： The invention provides a method of producing a water-soluble complex comprising a water-insoluble drug and a phospholipid, comprising the steps of (1) dissolving a water-insoluble drug and a phospholipid in an organic solvent, (2) removing the solvent to leave behind a drug-containing phospholipid film, (3) suspending the resulting film in an aqueous solution, (4) ultrasonicating the film, (5) centrifuging the resulting suspension, and (6) recovering the lowermost layer of the resulting sediment to yield the water-soluble complex. The above complex can be administered parenterally as well as by the oral and other routes, and is so rich in the drug component that a remarkably increased drug activity can be realized.

    摘要翻译： 本发明提供一种生产包含水不溶性药物和磷脂的水溶性络合物的方法，包括以下步骤：（1）将水不溶性药物和磷脂溶于有机溶剂中，（2）除去溶剂至 留下含药磷脂膜，（3）将所得膜悬浮在水溶液中，（4）使膜超声波化，（5）离心所得悬浮液，（6）回收所得沉淀物的最下层，得到 水溶性复合物。 上述复合物可以肠胃外给药，口服给药或其他途径给药，药物成分丰富，药物活性显着提高。

    Prostaglandin I.sub.2 ester and fat emulsion containing the same
    46.
    发明授权
    Prostaglandin I.sub.2 ester and fat emulsion containing the same 失效
    前列腺素I2酯和脂肪乳剂含有相同的

    公开(公告)号：US4613614A

    公开(公告)日：1986-09-23

    申请号：US626422

    申请日：1984-06-29

    申请人： Chikara Fukaya ,  Youichiro Naito ,  Kazumasa Yokoyama

    发明人： Chikara Fukaya ,  Youichiro Naito ,  Kazumasa Yokoyama

    IPC分类号： C07D307/935 ,  A61K9/107 ,  A61K31/557 ,  A61P43/00 ,  C07D307/937 ,  A61K31/74 ,  C07D307/93

    CPC分类号： C07D307/937

    摘要： There is provided a new ester of prostaglandin of the formula ##STR1## wherein R.sub.1 denotes an alkyl group having 1 to 20 carbon atoms; R.sub.2 denotes a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; and X denotes a group represented by the formula ##STR2## The new ester dissolves in oil easier than prostaglandin I.sub.2 itself and can easily be emulsified in the form of particles of solution in a vegetable oil. The ester in the fat emulsion is more stable than prostaglandin I.sub.2 and its physiological acts which are the same as prostaglandin I.sub.2 are prolonged.

    摘要翻译： 提供了一种新型的具有式“IMAGE”的前列腺素酯，其中R 1表示具有1至20个碳原子的烷基; R2表示氢原子或碳原子数1〜4的低级烷基， 并且X表示由下式表示的基团。新的酯比前列腺素I2本身容易溶于油中，并且可以容易地以植物油中的溶液颗粒的形式乳化。 脂肪乳剂中的酯比前列腺素I2更稳定，其与前列腺素I2相同的生理作用延长。

    Perfusate for preserving organ to be transplanted and preserving method
    48.
    发明授权
    Perfusate for preserving organ to be transplanted and preserving method 失效
    用于保存器官的移植和保存方法

    公开(公告)号：US4186253A

    公开(公告)日：1980-01-29

    申请号：US950071

    申请日：1978-10-10

    申请人： Kazumasa Yokoyama ,  Masakazu Iwai ,  Hiroyuki Okamoto ,  Noboru Yamada

    发明人： Kazumasa Yokoyama ,  Masakazu Iwai ,  Hiroyuki Okamoto ,  Noboru Yamada

    IPC分类号： A01N1/00 ,  A01N1/02 ,  C12B3/00 ,  A61K31/025

    CPC分类号： A01N1/02 ,  A01N1/0226

    摘要： An organ to be transplanted, such as kidney, can effectively be preserved by perfusion for a considerably long time by the use of a perfusate which is made by mixing a Ringer's solution modified by increasing potassium ion to 8-20 meq/l, a stable perfluorocarbon compound emulsion and albumin, so that the concentration of the perfluorocarbon compound is 7.5 to 12.5% (W/V) and that of albumin is 1-8% (W/V) based on the perfusate.

    摘要翻译： 通过使用通过将通过增加钾离子修饰的林格氏溶液混合至8-20meq / l而制成的灌注液，可以通过灌注相当长的时间来有效地保存要移植的器官，例如肾脏，稳定的 全氟化碳化合物乳液和白蛋白，使得全氟化碳化合物的浓度为7.5至12.5％（W / V），而白蛋白的浓度为基于灌注液的1-8％（W / V）。

    Process for preparing stable oxygen transferable emulsion
    49.
    发明授权
    Process for preparing stable oxygen transferable emulsion 失效
    制备稳定的可转印乳液的方法

    公开(公告)号：US3993581A

    公开(公告)日：1976-11-23

    申请号：US485318

    申请日：1974-07-02

    申请人： Kazumasa Yokoyama ,  Koichi Yamanouchi ,  Ryoichiro Murashima ,  Ryozo Watanabe

    发明人： Kazumasa Yokoyama ,  Koichi Yamanouchi ,  Ryoichiro Murashima ,  Ryozo Watanabe

    IPC分类号： A61K9/00 ,  A61K31/02 ,  B01J13/00

    CPC分类号： A61K9/0026 ,  A61K31/02 ,  Y10S516/06

    摘要： Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3.sub.-5 -alkylcyclohexanes), perfluoro(C.sub.4.sub.-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5.sub.-7 -alkyltetrahydrofurans), perfluoro(C.sub.5.sub.-7 -alkylmorpholins) and perfluoro(C.sub.9.sub.-11 -trialkylamines) are emulsified in a physiologically acceptable aqueous solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfurate for preservation of the internal organs.

    摘要翻译： 可全氟（C 5-8 - 烷基环己烷），全氟（C 5-6 - 烷基四氢吡喃），全氟（C 5-7 - 烷基四氢呋喃），全氟（C 5-7 - 烷基四氢呋喃），全氟 ）和全氟（C9-11-三烷基胺）在生理学上可接受的水溶液如林格氏溶液中借助于磷脂作为乳化剂和8-22个碳原子的脂肪酸，其碱金属盐或其单甘油酯作为乳化助剂乳化 。 该乳液在相当长的一段时间内是稳定的并且含有粒度范围为0.05-0.3μm的颗粒。 它可用作血液替代物或用于保存内脏的胃酸。

    Infusion preparation and two compartment container containing the preparation
    50.
    发明授权
    Infusion preparation and two compartment container containing the preparation 失效
    输液制剂和含有制剂的两室容器

    公开(公告)号：US5728681A

    公开(公告)日：1998-03-17

    申请号：US564237

    申请日：1995-12-20

    申请人： Takae Kido ,  Hideto Kodaira ,  Koji Munechika ,  Shigeo Ii ,  Shunichi Abe ,  Kazumasa Yokoyama

    发明人： Takae Kido ,  Hideto Kodaira ,  Koji Munechika ,  Shigeo Ii ,  Shunichi Abe ,  Kazumasa Yokoyama

    IPC分类号： A61J1/00 ,  A61J1/10 ,  A61J1/20 ,  A61K9/00 ,  A61K45/06 ,  A61K31/70 ,  A61K31/205 ,  A61K31/34 ,  A61K31/355 ,  A61K31/51 ,  A61K31/525 ,  A61K31/59 ,  A61K31/685

    CPC分类号： A61K9/0029 ,  A61J1/2093 ,  A61K45/06 ,  A61J1/10 ,  A61J1/2034

    摘要： A container filled with infusion liquids useful for preparation of an infusion liquid containing sugars, amino acids, electrolytes, a fat emulsion and vitamins. A container having two compartments which are separated from each other by a separation means, which contains an infusion liquid comprising a fat emulsion, sugars and specific vitamins in the first compartment and an infusion liquid comprising amino acids, electrolytes and other specific vitamins in the second compartment. An infusion preparation containing sugars, amino acids, electrolytes, a fat emulsion and vitamins can be obtained easily and aseptically upon use, by simply removing a separation means and mixing the infusion liquids included in the first and second compartments.

    摘要翻译： PCT No.PCT / JP95 / 00778 Sec。 371 1995年12月20日第 102（e）1995年12月20日日期PCT提交1995年4月20日PCT公布。 WO95 / 28906 PCT公开号 日期1995年11月2日一种装有输液的容器，其用于制备含有糖，氨基酸，电解质，脂肪乳剂和维生素的输液。 一种容器，其具有通过分离装置彼此分离的两个隔室，所述分离装置包含第一隔室中包含脂肪乳剂，糖和特定维生素的输液，以及在第二隔室中包含氨基酸，电解质和其它特定维生素的输液 隔间 通过简单地除去分离装置并混合包含在第一和第二隔室中的输液，可以容易地和无菌地获得含有糖，氨基酸，电解质，脂肪乳剂和维生素的输注制剂。