公开(公告)号：US20180236056A1

公开(公告)日：2018-08-23

申请号：US15499072

申请日：2017-04-27

Applicant: MERIAL INC. ,  CHULALONGKORN UNIVERSITY

Inventor： Sanipa Suradhat ,  Jean-Christophe Audonnet ,  Catherine Charreyre

IPC: A61K39/12 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/552 ,  C12N2770/10034

Abstract: The invention provides novel methods and compositions for the vaccination of porcine animals against porcine reproductive and respiratory syndrome virus (PRRSV). Described herein are immunological and/or vaccine compositions comprising a DNA vector encoding a PRRSV protein, particularly a truncated ORF7 protein, which are administered to porcines using needle-free delivery. The plasmid can include more than one nucleic acid molecule such that the plasmid can express more than one antigen. Also disclosed are methods for using and kits employing such compositions.

公开(公告)号：US10045979B2

公开(公告)日：2018-08-14

申请号：US15311848

申请日：2015-05-19

Applicant: MERIAL INC.

Inventor： Alan Long ,  Srinivas Reddy Gurrala

IPC: A61K31/496 ,  A61K31/4468 ,  A61K31/495 ,  A61K45/06 ,  A61K31/06 ,  A61K31/423 ,  A61K31/454

Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X6, X8, Q1, Q2, Q3, Q4, Q5, Q6, Ring A, Ring B, W, W′, R2, R3, R, R′, m, n and q are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

公开(公告)号：US20180201906A1

公开(公告)日：2018-07-19

申请号：US15914420

申请日：2018-03-07

Applicant: MERIAL INC.

Inventor： Paulraj Lawrence ,  Frederic Dumas

IPC: C12N7/00 ,  A61K39/12 ,  A61K39/00

CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  C12N2750/10034 ,  C12N2750/10051

Abstract: This invention relates to a method for rapid production of PCV2 such that an optimum yield of the virus can be obtained. This invention also relates to the vaccine useful against PCV2 which includes the PCV2 propagated using such a method.

公开(公告)号：US10006050B2

公开(公告)日：2018-06-26

申请号：US15410588

申请日：2017-01-19

Applicant: MERIAL, INC.

Inventor： Teshome Mebatsion ,  Jules Maarten Minke ,  Frederic David

IPC: C12N15/63 ,  C12N15/86 ,  C12N15/863 ,  A61K39/008 ,  A61K39/12 ,  A61K39/39 ,  A61K39/205 ,  A61K39/00

CPC classification number: C12N15/86 ,  A61K39/008 ,  A61K39/12 ,  A61K39/205 ,  A61K39/39 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/55516 ,  C12N15/8633 ,  C12N2710/24043 ,  C12N2760/20134

Abstract: The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the OX40L polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. In a particular example, the invention provides vectors encoding a Rabies G immunogenic polypeptide and a canine OX40L genetic adjuvant, which vectors elicit strong immune responses in canine against rabies virus.

公开(公告)号：US20180110852A1

公开(公告)日：2018-04-26

申请号：US15789936

申请日：2017-10-20

Applicant: MERIAL, INC. ,  The United States of America, as represented by the Secretary of Agriculture

Inventor： Teshome Mebatsion ,  Joyce Pritchard ,  David Swayne

IPC: A61K39/145 ,  C12N7/00

CPC classification number: A61K39/145 ,  A61K2039/5256 ,  A61K2039/552 ,  C12N7/00 ,  C12N2710/16343 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: The present invention provides recombinant viral vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant viral vectors, polyvalent vaccines comprising the recombinant viral vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant viral vectors.

公开(公告)号：US09913891B2

公开(公告)日：2018-03-13

申请号：US15353727

申请日：2016-11-16

Applicant: MERIAL INC.

Inventor： Jean-Christophe Audonnet ,  Frédéric Reynard ,  Natalia Bomchil ,  Cécile Sigoillot-Claude

IPC: A61K48/00 ,  C12N15/85 ,  A61K38/19 ,  C07K14/535 ,  A61K38/18 ,  A61K39/135 ,  A61K39/385 ,  C07K14/005 ,  C12N7/00 ,  C07K14/32 ,  A61K39/00

CPC classification number: A61K39/135 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K14/005 ,  C07K14/32 ,  C07K2319/40 ,  C07K2319/735 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/32171

Abstract: The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV. The invention further encompasses methods of making or producing antigenic polypeptides or antigens.

公开(公告)号：US20170363622A1

公开(公告)日：2017-12-21

申请号：US15533345

申请日：2015-12-07

Applicant: MERIAL INC.

Inventor： Paulraj Lawrence ,  Russell F. Bey ,  Mike Stoll ,  Eric Bumgardner ,  Douglas Stine

IPC: G01N33/569 ,  C07K14/30

CPC classification number: G01N33/56933 ,  C07K14/30

Abstract: This disclosure presents an Enzyme-Linked Immunosorbent Assay (ELISA) for the selective detection of anti-Mycoplasma hyorhinis IgG in porcine serum, which may contain antibodies specific to multiple other Mycoplasma spp.

公开(公告)号：US20170224807A1

公开(公告)日：2017-08-10

申请号：US15434353

申请日：2017-02-16

Applicant: Merial Inc.

Inventor： Michel Bublot ,  Frederic REYNARD ,  François-Xavier LE GROS

IPC: A61K39/145 ,  C12N15/86 ,  A61K39/275 ,  A61K39/17 ,  C12N7/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/17 ,  A61K39/275 ,  A61K2039/5256 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/24034 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2760/18034 ,  C12N2760/18134 ,  C12N2760/18143 ,  C12N2760/18171

Abstract: The present invention encompasses engineered Newcastle Disease Virus (NDV) vaccines or compositions. The vaccine or composition may be a recombinant vaccine. The invention also encompasses recombinant vectors encoding and expressing avian pathogen antigens, more specifically avian influenza proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals, in particular avian, against disease.

公开(公告)号：US20170157232A1

公开(公告)日：2017-06-08

申请号：US15419568

申请日：2017-01-30

Applicant: MERIAL, INC.

Inventor： Tammy (Kolander) Bremer ,  Paulraj Lawrence ,  Russell Bey

IPC: A61K39/02

CPC classification number: A61K39/102 ,  A61K45/06 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C12N1/36 ,  C12N1/38

Abstract: This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.

公开(公告)号：US20170100394A1

公开(公告)日：2017-04-13

申请号：US15311848

申请日：2015-05-19

Applicant: MERIAL INC.

Inventor： Alan Long ,  Srinivas Reddy Gurrala

IPC: A61K31/496 ,  A61K31/495 ,  A61K31/454 ,  A61K31/06 ,  A61K31/423 ,  A61K31/4468 ,  A61K45/06

CPC classification number: A61K31/496 ,  A61K31/06 ,  A61K31/423 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/495 ,  A61K45/06 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D487/06 ,  H05B41/06

Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X6, X8, Q1, Q2, Q3, Q4, Q5, Q6, Ring A, Ring B, W, W′, R2, R3, R, R′, m, n and q are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.