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公开(公告)号：US09956397B2
公开(公告)日：2018-05-01
申请号：US15700935
申请日：2017-09-11
Applicant: Oculeve, Inc.
Inventor： James Donald Loudin , Amitava Gupta , Marie Dvorak Christ , F. Richard Christ
IPC: A61N1/05 , A61N1/04 , C08F220/54 , H01B1/12 , C08F230/08 , A61N1/36
CPC classification number: A61N1/0546 , A61N1/0456 , A61N1/0496 , A61N1/36014 , C08F220/54 , C08F230/08 , H01B1/125 , Y10T29/49826 , Y10T29/49885 , C08F226/10 , C08F220/20 , C08F2222/1013 , C08F2230/085
Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
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公开(公告)号：US20170368333A1
公开(公告)日：2017-12-28
申请号：US15700935
申请日：2017-09-11
Applicant: Oculeve, Inc.
Inventor： James Donald LOUDIN , Amitava GUPTA , John WARDLE , Christopher William STIVERS , Anand DORAISWAMY , Marie Dvorak CHRIST , F. Richard CHRIST
IPC: A61N1/05 , C08F230/08 , H01B1/12 , C08F220/54 , A61N1/04 , A61N1/36
CPC classification number: A61N1/0546 , A61N1/0456 , A61N1/0496 , A61N1/36014 , C08F220/54 , C08F230/08 , H01B1/125 , Y10T29/49826 , Y10T29/49885 , C08F226/10 , C08F220/20 , C08F2222/1013 , C08F2230/085
Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
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公开(公告)号：US20170312521A1
公开(公告)日：2017-11-02
申请号：US15584956
申请日：2017-05-02
Applicant: Oculeve, Inc.
Inventor： Manfred FRANKE , Diane Michelle SENCHYNA , Daniel N. HAMILTON
Abstract: Described here are devices, systems, and methods for treating meibomian gland disease and/or blepharitis by providing intranasal stimulation. Generally, the devices may deliver electrical stimulation to the nasal mucosa. Intranasal stimulation may unblock obstructed meibomian glands and increase the lipid content of tears, both acutely during stimulation and subsequent to intranasal stimulation. The methods may include an initial round of stimulation to unblock obstructed meibomian glands, and subsequent shorter rounds of stimulation to cause meibum secretion and maintain the open glands.
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公开(公告)号：US09737712B2
公开(公告)日：2017-08-22
申请号：US14920860
申请日：2015-10-22
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin , John Wardle , Mark Jeffrey Holdbrook
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/37205 , A61N1/37247 , A61N1/3756 , A61N1/3758
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
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公开(公告)号：US09737702B2
公开(公告)日：2017-08-22
申请号：US15256392
申请日：2016-09-02
Applicant: Oculeve, Inc.
Inventor： Douglas Michael Ackermann , James Donald Loudin , John Wardle , Jarren Armond Baldwin , Daniel N. Hamilton , Janusz Kuzma
IPC: A61N1/05 , A61N1/36 , A61H1/00 , A61F7/12 , A61N1/378 , A61H9/00 , A61H21/00 , A61H23/02 , H02J7/00 , A61N1/04 , A61M31/00 , A61N7/00
CPC classification number: A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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Patent Agency Ranking
公开(公告)号：US09687652B2
公开(公告)日：2017-06-27
申请号：US14809109
申请日：2015-07-24
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin , Jarren Armond Baldwin
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/3756
Abstract: Described herein are electrical stimulation patterns and methods of use thereof for treating dry eye disease, tired eye, or other forms of ocular discomfort. The methods generally include applying patterned stimulation to an anatomical structure located in an ocular region or a nasal region to increase tear production.
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公开(公告)号：US20160114172A1
公开(公告)日：2016-04-28
申请号：US14920847
申请日：2015-10-22
Applicant: Oculeve, Inc.
Inventor： James Donald LOUDIN , Manfred FRANKE , Daniel N. HAMILTON , Anand DORAISWAMY , Douglas Michael ACKERMANN
CPC classification number: A61N1/3787 , A61N1/36046 , A61N1/36121 , B29D11/00038 , B29D11/00826
Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.
Abstract translation: 这里描述了通过刺激角膜，结膜和/或结膜下增加泪液产生的装置，系统和方法。 在一些变型中，装置可以是隐形眼镜的形式。 隐形眼镜可以包括透镜体和刺激器芯片，其中刺激器芯片嵌入在透镜体中。 外部电源将能量无线地传输到刺激器芯片，其中刺激器芯片可以将能量转换成电波形以刺激角膜，结膜和/或结膜下。 刺激可以激活泪液反射以增加泪液产生。 用于增加泪液生产的装置和系统可以用于治疗干眼症，减少疲劳眼睛的症状，增加隐形眼镜佩戴者的舒适度以及延长隐形眼镜用户可佩戴接触的年数的方法。 还描述了制造隐形眼镜的方法。
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公开(公告)号：US09265956B2
公开(公告)日：2016-02-23
申请号：US14201753
申请日：2014-03-07
Applicant: Oculeve, Inc.
Inventor： Douglas Michael Ackermann , James Donald Loudin
CPC classification number: A61N1/37217 , A61N1/0526 , A61N1/36046
Abstract: Described here are devices, systems, and methods for treating a condition in an animal. Generally the systems include a stimulator that is implantable in the animal and a controller system configured to transmit one or more signals to the implanted stimulator. The controller system may have a controller configured to generate the one or more signals. The controller system may include one or more collars, bridles, horse hoods, cages, animal beds, and/or food bowls. The systems may be used to treat one or more conditions such as dry eye, and may treat the conditions in an animal such as a horse, dog, or cat.
Abstract translation: 这里描述了用于治疗动物状况的装置，系统和方法。 通常，系统包括可植入动物的刺激器和被配置为将一个或多个信号传输到植入的刺激器的控制器系统。 控制器系统可以具有被配置为产生一个或多个信号的控制器。 控制器系统可以包括一个或多个衣领，绷腿，马罩，笼子，动物床和/或食物碗。 该系统可用于治疗一种或多种病症如干眼症，并且可以治疗动物如马，狗或猫的病症。
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公开(公告)号：US20210031040A1
公开(公告)日：2021-02-04
申请号：US16995520
申请日：2020-08-17
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin , John Wardle , Mark Jeffrey Holdbrook
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
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公开(公告)号：US10780273B2
公开(公告)日：2020-09-22
申请号：US16137464
申请日：2018-09-20
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin , John Wardle , Mark Jeffrey Holdbrook
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
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