公开(公告)号：US20130023402A1

公开(公告)日：2013-01-24

申请号：US13630554

申请日：2012-09-28

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Omar M. Yaghi ,  Hideki Hayashi ,  Rahul Banerjee ,  Kyo Sung Park ,  Bo Wang ,  Adrien P. Cote

IPC: C07F3/06 ,  B01J29/04 ,  C07F15/06 ,  B01J20/22

CPC classification number: B01J20/226 ,  B01J20/30 ,  B01J31/1691 ,  B01J31/1815 ,  B01J31/183 ,  B01J2531/0216 ,  B01J2531/26 ,  B01J2531/33 ,  B01J2531/845 ,  C01B39/00 ,  C01B39/02 ,  C07F3/00 ,  C07F3/003 ,  C07F3/06 ,  C07F15/00 ,  C07F15/065 ,  C07F19/005 ,  F17C11/005 ,  Y02C10/08

Abstract: The disclosure provides zeolitic frameworks for gas separation, gas storage, catalysis and sensors. More particularly the disclosure provides zeolitic frameworks (ZIFs). The ZIF of the disclosure comprises any number of transition metals or a homogenous transition metal composition.

Abstract translation: 本公开提供了用于气体分离，气体储存，催化和传感器的沸石骨架。 更具体地，本公开提供沸石骨架（ZIF）。 本公开的ZIF包括任何数量的过渡金属或均匀的过渡金属组成。

公开(公告)号：US20040186049A1

公开(公告)日：2004-09-23

申请号：US10801985

申请日：2004-03-16

Applicant: Regents of the University of Colorado, A body Corporate, ,  The Board of Regents, The University of Texas System

Inventor： Carlin Long ,  Eric N. Olson ,  Michael Bristow ,  Timothy A. McKinsey

IPC: A61K038/12 ,  A61K031/4025 ,  A61K031/19

CPC classification number: A61K31/165 ,  A61K31/19 ,  A61K31/401 ,  A61K38/12 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac hypertrophy. Surprisingly, the present invention demonstrates that HDAC inhibitors inhibit cardiac hypertrophy by inhibiting fetal cardiac gene expression and interfering with sarcomeric organization.

公开(公告)号：US20250129118A1

公开(公告)日：2025-04-24

申请号：US18999693

申请日：2024-12-23

Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  INTEZYNE TECHNOLOGIES INC. ,  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Robert J. GILLIES ,  David L. MORSE ,  Natalie M. BARKEY ,  Kevin N. SILL ,  Josef VAGNER ,  Narges K. TAFRESHI ,  Jonathan L. SESSLER ,  Christian PREIHS ,  Victor J. HRUBY

IPC: C07K5/117 ,  A61K38/34 ,  A61K47/64 ,  A61K47/69 ,  A61K49/00 ,  A61K49/10 ,  A61K49/18 ,  C07K7/08 ,  C07K14/68 ,  C07K14/72

Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

公开(公告)号：US12255108B2

公开(公告)日：2025-03-18

申请号：US17843933

申请日：2022-06-17

Applicant: Regents of the University of Minnesota ,  Board of Regents, The University of Texas System

Inventor： Rhonda Franklin ,  Aditya Dave ,  Yali Zhang ,  Bethanie Joyce Hills Stadler ,  Allison Harpel ,  Rashaunda Henderson ,  Nikita Mahjabeen

IPC: G01R31/28 ,  H01L21/8238 ,  H01L23/66 ,  H01L29/06 ,  H01P11/00

Abstract: A device includes a substrate and at least one electrically conducting portion supported by the substrate, the at least one electrically conducting portion including a signal line and a ground plane electrically isolated from the signal line. The electrically conducting portion includes a layer of a first electrically conducting material and a layer of a metal oxide material including anodic aluminum oxide (AAO) and one or more nanowires (NW) of a second electrically conducting material each formed within a corresponding pore extending through the AAO from a first side of the layer to a second side of the layer of the metal oxide material opposite the first side.

公开(公告)号：US20250082743A1

公开(公告)日：2025-03-13

申请号：US18813246

申请日：2024-08-23

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Hiep Lai Xuan Vu ,  Hinh Ly ,  Yuying Liang

IPC: A61K39/145 ,  A61K39/00 ,  A61P37/04 ,  C12N15/86

Abstract: Provided herein are genetically engineered Pichinde viruses that include three ambisense genomic segments. Two of the genomic segments include an additional coding region that may encode one or more swine influenza virus (SIV) proteins, such as a SIV hemagglutinin (HA) protein. SIV HA proteins can be from different subtypes of SIV. Also provided herein is a reverse genetics system for making genetically engineered Pichinde virus, and a collection of vectors that can be used to produce genetically engineered Pichinde virus. Further provided are methods for using a reverse genetics system, and methods for treating a SIV infection in a subject.

公开(公告)号：US12161288B2

公开(公告)日：2024-12-10

申请号：US17258989

申请日：2019-07-22

Applicant: The Regents of the University of California ,  Arizona Board of Regents on Behalf of the University of Arizona

Inventor： Petra Beate Wilder Smith ,  Rongguang Liang

IPC: A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B1/05 ,  A61B1/06 ,  A61B1/24 ,  A61B5/00

Abstract: An oral and oropharyngeal cancer screening system and associated methods are disclosed. In at least one embodiment, the screening system provides an at least one oral and oropharyngeal cancer screening device configured for selectively capturing images of an oropharyngeal area of an at least one patient. The screening device provides an elongate, relatively compact housing, a distal end of the housing being selectively bendable. An imaging module is positioned within the housing, the imaging module providing a lens, an at least one light source, and an imaging sensor positioned in the distal end of the housing. A user application resides in memory on an at least one user device in selective communication with the at least one screening device. The user application is configured for receiving images captured by the at least one screening device and recording risk factors, automatically analyzing the captured images and potential health-risk factors to screen for OPML and oral and oropharyngeal risk.

公开(公告)号：US12116322B2

公开(公告)日：2024-10-15

申请号：US18222238

申请日：2023-07-14

Applicant: The Regents of the University of California ,  Arizona Board of Regents on Behalf of Arizona State University

Inventor： Gaurav Sant ,  Laurent G. Pilon ,  Bu Wang ,  Narayanan Neithalath ,  Zhenhua Wei ,  Benjamin Young ,  Gabriel D. Falzone ,  Dante Simonetti

IPC: C04B7/19 ,  B01J19/08 ,  B01J19/24 ,  C04B7/36 ,  C04B7/38 ,  C04B7/46 ,  C04B9/20 ,  C04B28/04 ,  C04B40/02 ,  C04B111/00

CPC classification number: C04B7/19 ,  C04B7/367 ,  C04B7/38 ,  C04B7/46 ,  C04B9/20 ,  C04B28/04 ,  C04B40/0231 ,  B01J19/087 ,  B01J19/245 ,  B01J2219/24 ,  C04B2111/00017 ,  C04B2111/00129 ,  C04B28/04 ,  C04B18/067

Abstract: A manufacturing process of a concrete product includes: (1) extracting calcium from solids as portlandite; (2) forming a cementitious slurry including the portlandite; (3) shaping the cementitious slurry into a structural component; and (4) exposing the structural component to carbon dioxide sourced from a flue gas stream, thereby forming the concrete product.

公开(公告)号：US20230411221A1

公开(公告)日：2023-12-21

申请号：US17843933

申请日：2022-06-17

Applicant: Regents of the University of Minnesota ,  Board of Regents, The University of Texas System

Inventor： Rhonda Franklin ,  Aditya Dave ,  Yali Zhang ,  Bethanie Joyce Hills Stadler ,  Allison Harpel ,  Rashaunda Henderson ,  Nikita Mahjabeen

IPC: H01L21/8238 ,  H01L23/66 ,  H01L29/06 ,  G01R31/28

CPC classification number: H01L21/823871 ,  H01L23/66 ,  H01L29/0669 ,  G01R31/2887 ,  H01L2221/1078

Abstract: A device includes a substrate and at least one electrically conducting portion supported by the substrate, the at least one electrically conducting portion including a signal line and a ground plane electrically isolated from the signal line. The electrically conducting portion includes a layer of a first electrically conducting material and a layer of a metal oxide material including anodic aluminum oxide (AAO) and one or more nanowires (NW) of a second electrically conducting material each formed within a corresponding pore extending through the AAO from a first side of the layer to a second side of the layer of the metal oxide material opposite the first side.

公开(公告)号：US20230346943A1

公开(公告)日：2023-11-02

申请号：US17793806

申请日：2021-01-20

Applicant: The Regents of the University of California ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Matthew Krummel ,  Seok Ki Choi ,  James R. Baker, JR.

IPC: A61K41/00 ,  A61K49/00 ,  A61K47/54

CPC classification number: A61K41/0042 ,  A61K47/545 ,  A61K47/549 ,  A61K49/0002

Abstract: Provided herein, inter alia, are methods and compositions useful for treating a disease.

公开(公告)号：US11786597B2

公开(公告)日：2023-10-17

申请号：US16448335

申请日：2019-06-21

Applicant: The Regents of the University of California ,  Triad National Security, LLC ,  Arizona Board of Regents

Inventor： Michael Zakrewsky ,  Samir Mitragotri ,  David T. Fox ,  Andrew Koppisch ,  Rico Del Sesto ,  Katherine Lovejoy

IPC: A01N3/00 ,  A61K31/215 ,  A01N37/12 ,  A01N37/44 ,  A61K31/24 ,  A01N25/00 ,  A61K47/24 ,  A61K9/00 ,  A61K47/12 ,  A01N33/12 ,  A01N43/36 ,  A61K31/047 ,  A61K31/545 ,  A61K31/66

CPC classification number: A61K47/24 ,  A01N33/12 ,  A01N43/36 ,  A61K9/0014 ,  A61K31/047 ,  A61K31/545 ,  A61K31/66 ,  A61K47/12 ,  A01N43/36 ,  A01N41/06 ,  A01N33/12 ,  A01N37/02 ,  A01N37/04 ,  A01N37/06 ,  A01N41/06 ,  A01N47/28 ,  A01N49/00

Abstract: The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders.