公开(公告)号：US20180218118A1

公开(公告)日：2018-08-02

申请号：US15742622

申请日：2016-07-06

Applicant: St. Jude Children's Research Hospital

Inventor： Xin Zhou ,  Jinghui Zhang

IPC: G06F19/26 ,  G06F19/22

CPC classification number: G16B45/00 ,  G16B30/00

Abstract: Methods and systems for visually representing genomic mutations are disclosed. An example method can comprise receiving, at a computer, mutation information regarding one or more mutations of a protein. The computer can determine one or more mutations in the amino acid sequence, and can sort the one or more mutations according to a position of the one or more mutations in the amino acid sequence. For each of the one or more mutations, one or more mutation characteristics are determined and a display position can be set. The display position can comprise a horizontal position and a vertical position. A graphical representation of all of the one or more mutations is displayed. All of the one or more mutations are arranged based on the selected display positions, and an alignment position marker connects the display position to a marker indicating the position of the mutated amino acid.

公开(公告)号：US20180126006A1

公开(公告)日：2018-05-10

申请号：US15573684

申请日：2016-05-13

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： John T. GRAY

IPC: A61K48/00 ,  C12N15/861 ,  A61K35/76 ,  C12N7/00

CPC classification number: A61K48/0058 ,  A61K35/76 ,  A61K48/0091 ,  C12N7/00 ,  C12N15/86 ,  C12N15/8616 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2750/14143 ,  C12N2830/38

Abstract: The present invention relates to nucleic acid molecules containing spacers that can be packaged into viral particles and methods of producing them. In a first aspect, the invention features a nucleic acid molecule including a first spacer (SSI); a first inverted terminal repeat (ITR1); a cloning site (CS); a second inverted terminal repeat (ITR2); and a second spacer (SS2), such as a eukaryotic spacer; operably linked to each other in a 5′-to-3′ direction as: SS1-ITR1-CS-ITR2-SS2. In an embodiment, the invention features a vector comprising any of the above-described nucleic acid molecules. In another aspect, the invention features a plurality of viral particles including the nucleic acid molecule. The invention further includes a host cell including any of the above-described vectors.

公开(公告)号：US09953418B2

公开(公告)日：2018-04-24

申请号：US15166440

申请日：2016-05-27

Applicant: St. Jude Children's Research Hospital

Inventor： Junyu Guo ,  Wilburn E. Reddick

IPC: G06K9/00 ,  G06T7/00 ,  G06T5/00 ,  G01R33/50 ,  A61B5/055 ,  A61B5/00 ,  G01R33/483

CPC classification number: G06T7/0012 ,  A61B5/055 ,  A61B5/7225 ,  A61B5/7271 ,  G01R33/4835 ,  G01R33/50 ,  G06T5/00 ,  G06T5/002 ,  G06T2207/10088 ,  G06T2207/20024

Abstract: Apparatus, methods, and other embodiments associated with the spectral analysis of T2 spectral data are described. One example magnetic resonance imaging (MRI) method includes accessing a data set comprising T2 spectral data associated with a magnetic resonance imaging (MRI) signal received from an object. The method also includes decomposing the T2 spectral data with multi-exponential functions to determine T2 spectra corresponding to the T2 spectral data. The T2 spectra are portioned into a plurality of intervals defined by the T2 spectral data acquired in a predetermined time period.

公开(公告)号：US20180078633A1

公开(公告)日：2018-03-22

申请号：US15812361

申请日：2017-11-14

Applicant: St. Jude Children's Research Hospital

Inventor： Elaine Tuomanen ,  Elizabeth R. Mann

IPC: A61K39/09 ,  C07K14/47 ,  C07K14/315 ,  A61K39/00

CPC classification number: A61K39/092 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55544 ,  A61K2039/55583 ,  A61K2039/575 ,  A61K2039/6068 ,  A61K2039/645 ,  C07K14/3156 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/40

Abstract: Compositions and methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections. Compositions provided herein comprise a variety of immunogenic fusion proteins, wherein at least one polypeptide component of a given fusion protein comprises a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof. Methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections by employing the various immunogenic fusion proteins having at least one polypeptide component comprising a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof.

公开(公告)号：US20180030453A1

公开(公告)日：2018-02-01

申请号：US15551659

申请日：2016-02-18

Applicant: St. Jude Children's Research Hospital, Inc.

Inventor： Stanislav S. ZAKHARENKO ,  Jay A. BLUNDON

IPC: C12N15/113 ,  G09B5/00 ,  G09B19/00 ,  A61K31/4545 ,  A61K31/416

Abstract: The invention is directed to a method for improving learning and/or memory (e.g., auditory, visual, somatosensory or motor) in adults and children of an age which is beyond the early critical period for learning, said method comprising inhibiting (i) ecto-5′-nucleotidase (Nt5e, aka CD73) or (ii) A1 adenosine receptor (A1R, aka Adora1) expression or function in the brain. The invention is also directed to a method for treating learning and memory defects and neurological diseases associated with an abnormal auditory, visual, or somatosensory perception by inhibiting Nt5e or A1R expression or function in the brain.

公开(公告)号：US09822100B2

公开(公告)日：2017-11-21

申请号：US14991744

申请日：2016-01-08

Applicant: St. Jude Children's Research Hospital

Inventor： R. Kiplin Guy ,  Yiqun Zhang ,  Brandon Young ,  Michael Dyer ,  Kristin Finch ,  Donald Bashford ,  Nagakumar Bharatham ,  Richard Kriwacki ,  Grace Roy-Appa ,  Lie Min ,  Jaeki Min ,  Antonio Ferreira

IPC: C07D403/06 ,  C07D403/14 ,  C07D233/22

CPC classification number: C07D403/06 ,  C07D233/22 ,  C07D403/14

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20170189477A1

公开(公告)日：2017-07-06

申请号：US15394375

申请日：2016-12-29

Applicant: St. Jude Children's Research Hospital

Inventor： Jian Zuo ,  Taosheng Chen ,  Brandon Walters ,  Bryan Kuo ,  Bradley Walters

IPC: A61K38/17 ,  C12N5/0793 ,  A61K35/12 ,  A61K9/00 ,  A61K31/55 ,  A61K45/06

CPC classification number: A61K38/1703 ,  A61K9/0046 ,  A61K31/05 ,  A61K31/222 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/55 ,  A61K35/12 ,  A61K38/17 ,  A61K45/06 ,  C12N5/0602 ,  C12N5/062

Abstract: In one aspect, the invention relates to pharmaceutical compositions comprising agents that activate the expression of Atoh1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof and agents that inhibit the expression of p27Kip1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof, which are useful for inducing the formation of cochlear hair cells; and methods of treating hearing impairments or disorders using the compositions. In one aspect, the invention relates to pharmaceutical compositions comprising β-catenin; and agents that activate the expression of Atoh1, or pharmaceutically acceptable salts, solvates, or polymorphs thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20170173021A1

公开(公告)日：2017-06-22

申请号：US15301683

申请日：2015-04-02

Applicant: Memorial Sloan-Kettering Cancer Center ,  St. Jude Children's Research Hospital

Inventor： Scott William LOWE ,  Charles J. SHERR ,  Chun-Hao HUANG ,  Amaia LUJAMBIO

IPC: A61K31/519 ,  A61K31/655 ,  G01N33/574 ,  A61K31/4745 ,  C12N15/113 ,  C12Q1/68 ,  A61K31/7048 ,  A61K31/4545

CPC classification number: A61K31/519 ,  A61K31/40 ,  A61K31/404 ,  A61K31/44 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/4745 ,  A61K31/655 ,  A61K31/7048 ,  A61K31/7068 ,  A61K45/06 ,  C12N15/1137 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Y207/11022 ,  C12Y207/11023 ,  G01N33/57423 ,  G01N33/57426 ,  G01N33/57438 ,  G01N2333/91205 ,  G01N2800/52 ,  A61K2300/00

Abstract: A method of determining sensitivity to cancer treatment includes the step of determining the presence of overexpression of MYC in a biological sample from a patient suffering from cancer, wherein the presence of overexpression of MYC indicates a sensitivity to a treatment by a CDK9 inhibitor and wherein the cancer is selected from the group consisting of carcinoma, leukemia, and lymphoma.

公开(公告)号：US20170137524A1

公开(公告)日：2017-05-18

申请号：US15361839

申请日：2016-11-28

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Dario A. A. Vignali ,  Seng-ryong Woo ,  Greg M. Delgoffe

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0387 ,  A61K31/713 ,  A61K38/1709 ,  A61K39/0011 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/5158 ,  C07K16/2803 ,  C07K2317/32 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C12N5/0637 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2501/165

Abstract: The invention is directed to treatment of cancer, infections and various inflammatory and autoimmune conditions by affecting regulatory T cell stability and function via a Neuropilin-1:Semaphorin axis.

公开(公告)号：US20170107491A1

公开(公告)日：2017-04-20

申请号：US15337854

申请日：2016-10-28

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  NATIONAL UNIVERSITY OF SINGAPORE

Inventor： Dario Campana ,  Yu-Hsiang Chang

IPC: C12N5/0783 ,  A61K35/17 ,  C07K14/725 ,  C12N5/00 ,  C07K14/705

CPC classification number: C12N5/0646 ,  A61K35/17 ,  A61K38/00 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/7056 ,  C07K2319/00 ,  C07K2319/70 ,  C12N5/0087 ,  C12N2510/00

Abstract: The invention provides a chimeric receptor comprising NKG2D, DAP10 and CD3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of NK cells. The invention also encompansses methods for use of NKG2D-DAP10-CD3 zeta polypeptides, vectors and cells in methods for treating cancer and other proliferative disorders, as well as infectious diseases.