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    METHOD OF DETERMINING BRAIN ACTIVITY
    41.
    发明申请
    METHOD OF DETERMINING BRAIN ACTIVITY 有权

    公开(公告)号：US20210000367A1

    公开(公告)日：2021-01-07

    申请号：US16981065

    申请日：2019-03-18

    Applicant: Stichting VU

    Inventor： Klaus LINKENKAER-HANSEN ,  Richard Edward HARDSTONE

    IPC: A61B5/04 ,  A61B5/0476 ,  A61B5/00

    Abstract: A first aspect provides, in a device for processing biomedical data obtained from a body, a method of determining brain activity. The method comprises obtaining neuron oscillation signal data of a first part of a brain over a period of time. The oscillation signal data is apportioned in timeslots within the period and per time slot, based on the oscillation data for the timeslot, an amplitude value and variation value representing data values in the timeslot are obtained. A correlation value is determined between the amplitude values and the corresponding variation values over at least a substantial part of the first time period; and the correlation value is provided as an output. The correlation value may optionally be used for estimating a ratio between excitation and inhibition activity of the brain under scrutiny.

    METHOD AND SYSTEM FOR OPTICAL FORCE MEASUREMENT
    42.
    发明申请
    METHOD AND SYSTEM FOR OPTICAL FORCE MEASUREMENT 审中-公开

    公开(公告)号：US20200370974A1

    公开(公告)日：2020-11-26

    申请号：US16764275

    申请日：2018-11-19

    Applicant: STICHTING VU

    Inventor： Graeme Alan KING ,  Andreas Sebastian BIEBRICHER ,  Iddo HELLER ,  Erwin Johannes Gerard PETERMAN ,  Gijs Jan Lodewijk WUITE

    IPC: G01L1/24 ,  G01N15/14 ,  G02B21/00 ,  G02B21/06

    Abstract: One aspect of this disclosure relates to a computer-implemented method for determining a force acting on at least part of a structure, for example a biological structure, such as a DNA molecule. The method comprises controlling a light-sensitive system, e.g. of a microscope, to determine light information based on light from the structure. The light is incident on at least a part of the light sensitive system. The light-sensitive system may be said to capture the light from the structure. The at least part of the structure comprises one or more optically active entities, such as DNA intercalator molecules and donor/acceptor fluorophores. At least one of (i) an optical activity of the entities and (ii) a quantity of the entities depends on the force acting on the at least part of the structure. Furthermore, the light information defines a light property value associated with said at least part of the structure. The method further comprises determining the force acting on the at least part of the structure on the basis of said light property value and a reference light property value.

    Suture device
    43.
    发明授权
    Suture device 有权

    公开(公告)号：US10058324B2

    公开(公告)日：2018-08-28

    申请号：US14358136

    申请日：2012-11-16

    Applicant: Stichting VU-VUMC

    Inventor： Rianne Irene Van Loenen ,  Micha Ilan Paalman ,  Alexander Arnold Frederik Adriaan Veenhof

    IPC: A61B17/04 ,  A61B17/12

    CPC classification number: A61B17/0469 ,  A61B2017/047 ,  A61B2017/0472 ,  F04C2270/0421

    Abstract: A suture device includes a needle operating device movable longitudinally with respect to a housing between at least an insertion position and a needle transfer position. The needle operating device includes an elongate operating element arranged extending from a distal end of the housing to or near a housing proximal end. A needle holder connected at a distal end of the operating element holds two or more needles, with free ends directed in proximal direction. The holder is movable with respect to a protection device between at least a protecting position shielding the free ends, and a non-protecting position for the same. A needle receive device at a distal end of the housing receives the free ends when the operating device is moved to the transfer position. In at least the insertion position the holder and the protection device are spaced longitudinally from the housing to receive a tissue therebetween.

    RADIOLABELED QUINAZOLINE DERIVATIVES
    46.
    发明申请
    RADIOLABELED QUINAZOLINE DERIVATIVES 审中-公开
    放射性喹唑啉衍生物

    公开(公告)号：US20150368230A1

    公开(公告)日：2015-12-24

    申请号：US14765042

    申请日：2014-01-28

    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  STICHTING VU-VUMC

    Inventor： Paul SLOBBE ,  Alex Johannes POOT ,  Augustinus Antonius Maria Silvester VAN DONGEN ,  Heiko NIESSEN ,  Albert Dirk WINDHORST

    IPC: C07D405/12 ,  A61K51/04

    CPC classification number: C07D405/12 ,  A61K51/0459 ,  C07B2200/05

    Abstract: Novel radiotracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging are described. Specifically, the invention relates to 18F-labeled afatinib suitable as a PET or SPECT tracer for imaging epidermal growth factor receptor (EGFR, erbB1) and human epidermal growth factor receptor 2 (Her2, erbB2), to a precursor compound for use in its synthesis, to methods for the preparation 18F-labeled afatinib, as well as to the use thereof in in vivo diagnosis, tumor imaging or patient stratification on the basis of mutational status of EGFR (erbB1) and Her2 (erbB2).

    Abstract translation: 描述了用于正电子发射断层扫描（PET）或单光子发射计算机断层摄影（SPECT）成像的新型放射性示踪剂。 具体地说，本发明涉及适用于成像表皮生长因子受体（EGFR，erbB1）和人表皮生长因子受体2（Her2，erbB2）的PET或SPECT示踪剂的18F-标记的阿片碱，用于其合成中的前体化合物 ，用于制备18F标记的阿伐替尼的方法，以及其在体内诊断，肿瘤成像或患者分层中的用途，其基于EGFR（erbB1）和Her2（erbB2）的突变状态。

    BIOMARKERS
    49.
    发明申请
    BIOMARKERS 审中-公开
    生物标志

    公开(公告)号：US20150141273A1

    公开(公告)日：2015-05-21

    申请号：US14396522

    申请日：2013-04-26

    Applicant: STICHTING VU-VUMC

    Inventor： Linda Janna Willemien Bosch ,  Meike De Wit ,  Beatriz Pinto Morais de Carvalho ,  Remond Johnnes Adriaan Fijneman ,  Gerrit Albert Meijer ,  Comelia Ramona Jimenez ,  Sander Rogier Piersma ,  Viet Thang Pham ,  Gideon Oudgenoeg

    IPC: G01N33/68 ,  G01N33/574

    CPC classification number: G01N33/57419 ,  G01N33/6848 ,  G01N2500/10 ,  G01N2570/00 ,  G01N2800/7028

    Abstract: The invention provides a method for screening for colorectal cancer, the method comprising: screening a biological sample from an individual for one or more biomarkers selected from the group defined in Table 1 and/or Table 6, wherein the presence of or increased expression of the one or more biomarkers relative to a control sample is indicative that the individual is at risk of suffering from or is suffering from colorectal cancer. The invention also provides an array and kit suitable for use in the methods of the invention, methods of treating colorectal cancer and therapeutic agents for use in methods of treating cancer.

    Abstract translation: 本发明提供了筛选结肠直肠癌的方法，该方法包括：从个体中筛选一种或多种选自表1和/或表6中定义的组的生物标志物的生物样品，其中存在或增加表达 一个或多个相对于对照样品的生物标志物表明个体处于患有或正在患有结肠直肠癌的风险中。 本发明还提供适用于本发明方法的阵列和试剂盒，治疗结肠直肠癌的方法和用于治疗癌症的方法中的治疗剂。

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