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公开(公告)号：US08539037B2
公开(公告)日：2013-09-17
申请号：US11852685
申请日：2007-09-10
Applicant: Seok-Hyun Yoon , Won-ho Ryu , Sung-ho Ryu
Inventor： Seok-Hyun Yoon , Won-ho Ryu , Sung-ho Ryu
IPC: G06F15/16
CPC classification number: H04L67/1095 , G06Q10/10 , H04L67/04
Abstract: A method and apparatus for synchronizing feed information are provided. A podcasting client includes a synchronization-processing unit which synchronizes first feed information acquired from a connected device with pre-stored second feed information, and a communication interface which transmits feed information of content that is podcast based on the synchronized feed information to the connected device.
Abstract translation: 提供了一种用于同步馈送信息的方法和装置。 播客客户端包括同步处理单元，其将从连接的设备获取的第一馈送信息与预先存储的第二馈送信息同步，以及通信接口，其将基于同步的馈送信息的播客的内容的馈送信息发送到所连接的设备 。
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公开(公告)号：US08247493B2
公开(公告)日：2012-08-21
申请号：US12422950
申请日：2009-04-13
Applicant: Sei-Kwang Hahn , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
Inventor： Sei-Kwang Hahn , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC: A61K47/48
CPC classification number: C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
Abstract: The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
Abstract translation: 本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。 通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。
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43.发明授权Method of preparing 5′-amino-linker oligonucleotides derivatives and analogous 5′-labeled-linker oligonucleotides therefrom 有权从其中制备5'-氨基 - 连接寡核苷酸衍生物和类似的5'-标记 - 接头寡核苷酸的方法公开(公告)号：US08124756B2
公开(公告)日：2012-02-28
申请号：US12559666
申请日：2009-09-15
Applicant: Jung-Hwan Lee , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang
Inventor： Jung-Hwan Lee , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang
IPC: C07H21/00
Abstract: A method for preparing amino linker oligonucleotides is provided. More specifically, a method of preparing 5′-amino-linker oligonucleotides comprising the steps of: introducing an amino linker having a protecting group into the 5′ terminus of an oligonucleotide; and removing the protecting group from the amino linker oligonucleotide by contacting with acetic acid and 2,2,2-trifluoroethanol is provided. The amino protecting group is efficiently removed from the amino linker oligonucleotides, and thereby achieving a high yield of the amino linker oligonucleotides.
Abstract translation: 提供了制备氨基接头寡核苷酸的方法。 更具体地说，制备5'-氨基连接寡核苷酸的方法包括以下步骤：将具有保护基的氨基接头引入寡核苷酸的5'末端; 并通过与乙酸和2,2,2-三氟乙醇接触，从氨基接头寡核苷酸中除去保护基。 从氨基接头寡核苷酸有效地除去氨基保护基，从而达到高产量的氨基接头寡核苷酸。
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公开(公告)号：US08017572B2
公开(公告)日：2011-09-13
申请号：US12246229
申请日：2008-10-06
Applicant: Sung-Ho Ryu , Pann-Ghill Suh , Yoe-Sik Bae , Ji-Young Song
Inventor： Sung-Ho Ryu , Pann-Ghill Suh , Yoe-Sik Bae , Ji-Young Song
Abstract: Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.
Abstract translation: 公开了具有SEQ ID NO：1至24的肽，其诱导人单核细胞或嗜中性粒细胞产生超氧化物; 其诱导人外周血单核细胞或嗜中性粒细胞的细胞内钙增加; 结合甲酰肽受体或甲酰肽受体样1; 在体外诱导人单核细胞或嗜中性粒细胞趋化迁移; 其在表达甲酰基肽受体的细胞或甲酰肽受体样1表达细胞中诱导脱颗粒; 通过激活甲酰肽受体或甲酰肽受体样1刺激细胞外信号调节蛋白激酶磷酸化; 或通过激活甲酰肽受体或甲酰肽受体样1来刺激Akt磷酸化。
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45.发明授权Method of protecting cells against damage and pharmaceutical composition comprising leumorphin 有权保护细胞免受损伤的方法和包含leumorphin的药物组合物公开(公告)号：US07951779B2
公开(公告)日：2011-05-31
申请号：US11482480
申请日：2006-07-06
Applicant: Byoung Dae Lee , SooMi Kim , Eun-Mi Hur , Yong-Soo Park , Yun-Hee Kim , Taehoon Lee , Kyong-Tai Kim , Pann-Ghill Suh , Sung Ho Ryu
Inventor： Byoung Dae Lee , SooMi Kim , Eun-Mi Hur , Yong-Soo Park , Yun-Hee Kim , Taehoon Lee , Kyong-Tai Kim , Pann-Ghill Suh , Sung Ho Ryu
IPC: A61K38/33
CPC classification number: A61K38/33
Abstract: The present invention relates to a method of protecting cells against damage caused at least in part by apoptosis, comprising administering to subjects a therapeutic dose of leumorphin having cytoprotective activity, and a pharmaceutical composition comprising an effective amount of leumorphin having a cytoprotective activity.
Abstract translation: 本发明涉及一种保护细胞免受至少部分通过细胞凋亡引起的损伤的方法，包括向受试者施用具有细胞保护活性的治疗剂量的亮氨酸，以及包含有效量的具有细胞保护活性的亮氨酸的药物组合物。
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Patent Agency Ranking
公开(公告)号：US20100210509A1
公开(公告)日：2010-08-19
申请号：US12680955
申请日：2008-10-09
Applicant: Eun-Ju Oh , Jung-Wook Kim , Sung-Ho Ryu , Sei-Kwang Hahn
Inventor： Eun-Ju Oh , Jung-Wook Kim , Sung-Ho Ryu , Sei-Kwang Hahn
Abstract: The invention relates to a novel bioconjugation protocol for peptide suitable for in vivo applications. Bioconjugation of the peptide to HA derivative increases its half life in circulation contributing for a high efficacy. More over, conjugate of HA derivative and peptide which is treated with hyaluronidase shows increased bioactivity. And also, in contrast to PEGylation, HA derivative can be conjugated with many numbers of peptide molecules per single HA derivative chain, which enables multiple action of peptide drugs.
Abstract translation: 本发明涉及适用于体内应用的肽的新型生物缀合方案。 肽与HA衍生物的生物共轭增加其循环的半衰期有助于高效力。 更具体地，HA衍生物和用透明质酸酶处理的肽的缀合物显示增加的生物活性。 而且，与聚乙二醇化相反，HA衍生物可以与单个HA衍生物链中的许多肽分子缀合，这使得肽药物能够多次作用。
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47.发明申请Glucose uptake modulator and method for treating diabetes or diabetic complications 审中-公开葡萄糖摄取调节剂和治疗糖尿病或糖尿病并发症的方法公开(公告)号：US20100120662A1
公开(公告)日：2010-05-13
申请号：US12657083
申请日：2010-01-13
Applicant: Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
Inventor： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
IPC: A61K38/28 , A61K31/661 , A61K38/16 , A61P3/10
CPC classification number: A61K31/7032 , A61K38/2228 , A61K38/28 , A61K2300/00
Abstract: The present invention relates to an glucose uptake modulator, a pharmaceutical composition comprising the glucose uptake modulator, and a method of treating a diabetes or diabetic complications in a mammal in need thereof, which comprises administering to said mammal an effecting amount of a glucose uptake modulator.
Abstract translation: 本发明涉及葡萄糖摄取调节剂，包含葡萄糖摄取调节剂的药物组合物和治疗有此需要的哺乳动物的糖尿病或糖尿病并发症的方法，其包括对所述哺乳动物施用有效量的葡萄糖摄取调节剂 。
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48.发明申请EPIDERMAL GROWTH FACTOR INCREASING INSULIN SECRETION AND LOWERING BLOOD GLUCOSE 审中-公开生长因子增加胰岛素分泌和降低血糖公开(公告)号：US20090312250A1
公开(公告)日：2009-12-17
申请号：US12373691
申请日：2007-07-16
Applicant: Sung-Ho Ryu , Hye-Young Lee , Kyung-Moo Yea , Byoung-Dae Lee , Young-Chan Chae , Hyeon-Soo Kim , Seon-Hee Kim , Pann-Ghill Suh
Inventor： Sung-Ho Ryu , Hye-Young Lee , Kyung-Moo Yea , Byoung-Dae Lee , Young-Chan Chae , Hyeon-Soo Kim , Seon-Hee Kim , Pann-Ghill Suh
IPC: A61K38/18
CPC classification number: A61K38/1808
Abstract: The present inventors show that a brief exposure to EGF stimulates insulin secretion glucose-independently via a Ca2+ influx- and PLD2-dependent mechanism. Furthermore, the present invention shows that EGF is a novel secretagogue that lowers plasma glucose levels in normal and diabetic mice, suggesting the potential for EGF treatment in diabetes.
Abstract translation: 本发明人表明，EGF的短暂暴露通过Ca2 +流入和PLD2依赖性机制独立地刺激胰岛素分泌葡萄糖。 此外，本发明显示EGF是降低正常糖尿病小鼠血浆葡萄糖水平的新型促分泌素，表明在糖尿病中EGF治疗的潜力。
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49.发明申请Method of Regulating Mammalian Target-of-Rapamycin Activity by Interaction Between Phospholipase D and RHEB 失效通过磷脂酶D和RHEB之间的相互作用调节哺乳动物雷帕霉素目标的方法公开(公告)号：US20090304667A1
公开(公告)日：2009-12-10
申请号：US12374239
申请日：2007-08-03
Applicant: Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , II-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
Inventor： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , II-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
IPC: A61K38/46 , A61K38/16 , G01N33/567 , G01N33/574
CPC classification number: C12Q1/485 , A61K38/00 , C12N9/16 , C12Q1/34 , G01N2333/9121 , G01N2333/916
Abstract: The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibitin mTOR.
Abstract translation: 本发明涉及基于由磷脂酶D（PLD）和富含脑（Rheb）的Ras同源物的mTOR调节机制的新发现调节哺乳动物雷帕霉素靶（mTOR）的方法。 此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR治疗mTOR相关代谢疾病的方法和组合物。
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公开(公告)号：US07622551B2
公开(公告)日：2009-11-24
申请号：US11277343
申请日：2006-03-23
Applicant: Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
Inventor： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
Abstract: The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release. The application also discloses methods of using the disclosed peptides.
Abstract translation: 本申请描述了刺激靶细胞中花生四烯酸释放的肽。 本申请还公开了引起细胞内钙释放的肽。 本申请还公开了使用所公开的肽的方法。
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