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公开(公告)号：US11827687B2
公开(公告)日：2023-11-28
申请号：US17591620
申请日：2022-02-03
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Genady Kostenich , Mor Oron-Herman , Arie Orenstein , Talia Shekhter Zahavi , Ehud Gazit , Yoseph Salitra , Ludmilla Buzhansky
CPC classification number: C07K14/655 , A61K38/08 , A61K38/12 , A61K47/62 , A61K47/6923 , A61K47/6933 , A61K47/6937 , A61K49/0043 , A61K49/0056 , A61K49/0093
Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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公开(公告)号：US20230310204A1
公开(公告)日：2023-10-05
申请号：US17927987
申请日：2021-05-27
Inventor： Shlomi COHEN , Tamir BEN DAVID , Tovy SIVAN
IPC: A61F6/22
CPC classification number: A61F6/225
Abstract: A contraceptive device is provided including an occluding component for deployment in a tubal lumen of a reproductive organ. The device includes an expandable frame reversibly expandable from a collapsed state to an expanded state and a barrier supported by the expandable frame. In the expanded state the barrier is disposed between the expandable frame and walls of the lumen to inhibit in-growth of cellular material into and onto the occluding component, and additionally the barrier is urged against walls of the tubal lumen to define at least two tube lumen sealing areas, disposed perpendicular to a longitudinal axis of the walls of the tube lumen such that (i) the expandable frame is disposed between the two tubal lumen sealing surface, and (ii) passage of reproductive cells through the expandable frame, and through the tube lumen is blocked, therefore, creating a the complete blockage for liquids from a first part of the tube to a second part of the tube, downstream the first part. Other applications are also described.
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公开(公告)号：US11712248B2
公开(公告)日：2023-08-01
申请号：US16706986
申请日：2019-12-09
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , The Trendlines Group Ltd.
Inventor： Abraham Tsur , Sharon Farber , Roy Mashiach , Yosef Hazan , David Shashar , Avshalom Shenhav
CPC classification number: A61B17/122 , A61B5/4356 , A61B5/6846 , A61B5/6847 , A61B5/6882 , A61B5/6885 , A61B17/1227 , A61B17/42 , A61F6/08 , A61M31/00 , A61B5/435 , A61B2017/00221 , A61B2017/00535 , A61B2017/00734 , A61B2017/00893 , A61B2017/4225 , A61B2090/065 , A61B2090/0811
Abstract: A device for retarding birth including an upper ring for surrounding a cervix, an anchoring component for anchoring the device, and an elastic component for attaching the upper ring to the anchoring component, wherein the elastic component pushes the upper ring and the anchoring component apart. A device for retarding birth including a sleeve for surrounding a cervix along a greater portion of a length of the cervix, a support strip on the sleeve directed along an axis of the sleeve, and a ring at least partially around the sleeve, in which when a top of the sleeve is pushed to expand radially, the support strip pivots on the ring, such that an end of the support strip near the top of the sleeve moves radially outward, and an end of the support strip near the bottom of the sleeve moves radially inward. Related apparatus and methods are also described.
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公开(公告)号：US20230140799A1
公开(公告)日：2023-05-04
申请号：US17910293
申请日：2021-04-11
Inventor： Eitan GIAT , Yahel GIAT , Itamar GOLDSTEIN
IPC: A61K31/7105 , C12N15/86 , A61P31/14
Abstract: There is provided a decoy transcript derived from a ssRNA virus (WV), the transcript comprising at least one of a 5′UTR of the WV, a genomic packaging signal (GPS) of the WV, a 3′UTR of the WV, and an exogenous stop codon.
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公开(公告)号：US11564836B2
公开(公告)日：2023-01-31
申请号：US16420194
申请日：2019-05-23
Applicant: Ramot at Tel Aviv University Ltd. , Tel Hashomer Medical Research Infrastructure and Services Ltd.
Inventor： Michael Belkin , Mordechai Goldenfeld
Abstract: An apparatus includes a laser source and a scanner. The laser source is configured to generate electromagnetic radiation. The scanner scans at least part of a limbal area of an eye with the electromagnetic radiation generated by the laser source, thereby directing the electromagnetic radiation through an entire thickness of the limbal area of the eye without any contact with the eye and irradiating one or more regions of a trabecular meshwork of the eye with the electromagnetic radiation.
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Patent Agency Ranking
公开(公告)号：US20220135979A1
公开(公告)日：2022-05-05
申请号：US17430072
申请日：2020-02-27
Inventor： Ruty SHAI , Shany FREEDMAN PICCIOTTO , Amos TOREN
IPC: C12N15/113 , C12Q1/6806 , C12Q1/6851 , C12Q1/6886 , A61K31/713 , A61P35/00
Abstract: Methods for classifying, identifying and monitoring of a medulloblastoma tumor in a subject are provided, based on lincRNA expression in the tumor and/or in a biological sample of the subject. Compositions and methods for treating medulloblastoma using inhibitors of the specific lincRNAs disclosed herein. Additionally, novel inhibitory nucleic acids targeting the specific lincRNAs are provided.
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公开(公告)号：US20220080093A1
公开(公告)日：2022-03-17
申请号：US17416508
申请日：2019-12-26
Inventor： Alexander KOGAN
Abstract: A controller for controlling an apparatus comprising a blood pump, oxygenator, and blood filtering system connected together by blood flow tubing and to a patient to circulate blood from the patient through the apparatus and back to the patient, to oxygenate and filter the blood, the controller comprising at least one communication interface operable to receive signals generated responsive to monitored parameters characterizing blood flow and/or quality of blood from the patient circulating through the apparatus and configured to: determine values for the monitored parameters based on the monitoring signals; determine whether or not a value determined for a given monitored parameter for blood circulating through the apparatus is within a normative range for the parameter; and generate an alarm to alert an operator of the system if the value is not within the normative range.
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公开(公告)号：US11076757B2
公开(公告)日：2021-08-03
申请号：US16068994
申请日：2017-01-12
Inventor： Ygal Rotenstreich , Ifat Sher
Abstract: A system and method for determining a state of health of an eye using a pupillometer is provided comprising an ocular fixture, a testing compartment, a camera, and a controller. The testing compartment comprises a plurality of chromatic beam emitters arranged about a visual field. The ocular fixture is positioned to facilitate exposure of light sensitive ocular structures of the eye to a chromatic stimuli. The camera is positioned to record temporal pupil responses of the eye. The controller controls emission wavelength, intensity, and duration of the chromatic beam emitters. The controller processes temporal pupil response data to generate signals representative of the eye positioned at the ocular fixture in response to the chromatic stimuli at a plurality of locations in the visual field. The method comprises driving the chromatic beam emitters with the controller to generate signals using chromatic stimuli and determining the state of health of the eye.
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公开(公告)号：US20210186478A1
公开(公告)日：2021-06-24
申请号：US17271189
申请日：2019-08-29
Inventor： Ari LESHNO
Abstract: Apparatus for performing an ocular surgery, the apparatus comprising: a support housing having a bottom configured to be positioned on the sclera of an eye during performance of an ocular surgery; a muscle hook holder connected to the support housing and configured to hold an ocular muscle hook so that the ocular muscle hook is translatable to elevate an ocular muscle away from the eye during performance of the surgery; and a set of graduation markings on the support housing useable to determine a distance that the ocular muscle hook is translated to elevate the ocular muscle.
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公开(公告)号：US20210163591A1
公开(公告)日：2021-06-03
申请号：US17263251
申请日：2019-07-25
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Tageza Biopharmaceuticals Ltd.
Inventor： Benjamin DEKEL , Orit HARARI-STEINBERG
IPC: C07K16/28 , G01N33/574 , A61K35/17 , C12Q1/6886 , A61K47/68
Abstract: Methods of treating cancer are provided. Accordingly, there is provided a method of treating cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an agent capable of (i) specifically binding GABRA2, the agent comprising a therapeutic moiety; and/or (ii) downregulating activity and/or expression of said GABRA2. Also provided are compositions, article of manufactures and methods of diagnosing cancer and monitoring cancer treatment.
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