公开(公告)号：US20070148739A1

公开(公告)日：2007-06-28

申请号：US10546112

申请日：2004-02-18

Applicant: Tim Jones ,  Matthew Baker ,  Marian Hanlon ,  Francis Carr

Inventor： Tim Jones ,  Matthew Baker ,  Marian Hanlon ,  Francis Carr

IPC: A61K38/21 ,  C07H21/04 ,  C12P21/04 ,  C07K14/56

CPC classification number: A61K38/212 ,  C07K14/56 ,  C07K2319/30

Abstract: The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.

Abstract translation: 本发明涉及人类干扰素α，特别涉及具有改进性质的干扰素α2的修饰形式。 改进的蛋白质在特定位置含有氨基酸取代，其在生物测定中赋予增加的相对活性。 本发明还提供修饰的干扰素α，其具有改善的生物活性，伴随蛋白质中的免疫原性潜力降低。 改进的蛋白质用于治疗人类疾病的治疗用途。

公开(公告)号：US20050171587A1

公开(公告)日：2005-08-04

申请号：US10996803

申请日：2004-11-24

Applicant: Terry Daglow ,  Brian Franz ,  John Erickson ,  Sandy Hooper ,  Tim Jones

Inventor： Terry Daglow ,  Brian Franz ,  John Erickson ,  Sandy Hooper ,  Tim Jones

IPC: A61N1/05

CPC classification number: A61N1/0551 ,  A61N1/0529

Abstract: A lead, method of manufacturing same, and system for stimulation is provided. The lead includes an insulative member or layer that masks a portion of the electrode(s) to effectively generate a directional lead that focuses or directs the stimulation to desired location(s). In another embodiment, the lead further includes a marking system to allow a clinician to orient the directional lead, as desired, while the lead is within a body.

Abstract translation: 提供铅，制造方法和刺激系统。 引线包括掩蔽电极的一部分的绝缘构件或层，以有效地产生将刺激聚焦或引导到所需位置的方向引线。 在另一个实施例中，引线还包括标记系统，以允许临床医生在引线位于身体内时根据需要定向方向引线。

公开(公告)号：US10095367B1

公开(公告)日：2018-10-09

申请号：US12905520

申请日：2010-10-15

Applicant: Matthew G. Berry ,  Tim Jones ,  Isaac Kunkel

Inventor： Matthew G. Berry ,  Tim Jones ,  Isaac Kunkel

IPC: G06F3/048

Abstract: Managing metadata associated with a digital media asset includes selecting the digital media asset, displaying the digital media asset in a filmstrip format that presents one or more scenes from the digital media asset along a timeline, wherein each scene corresponds with an underlying point in time along the timeline, and wherein the digital media asset has a start time and an end time that define the timeline, displaying at least one track in timeline alignment with the film strip format wherein the at least one track corresponds with a type of metadata associated with the digital media asset, and displaying on the at least one track, one or more segments, wherein each segment has a start point and an end point along the timeline and wherein each respective segment represents a span of time in which the type of metadata occurs within the digital media asset.

公开(公告)号：US20140239472A1

公开(公告)日：2014-08-28

申请号：US13780070

申请日：2013-02-28

Applicant: Frank Tim Jones ,  Phillip Celaya

Inventor： Frank Tim Jones ,  Phillip Celaya

IPC: H01L23/495 ,  H01L21/82

CPC classification number: H01L23/49551 ,  H01L23/295 ,  H01L23/3107 ,  H01L23/49562 ,  H01L23/49575 ,  H01L24/06 ,  H01L24/29 ,  H01L24/32 ,  H01L24/45 ,  H01L24/48 ,  H01L24/49 ,  H01L24/73 ,  H01L2224/04042 ,  H01L2224/05554 ,  H01L2224/05624 ,  H01L2224/0603 ,  H01L2224/29101 ,  H01L2224/2929 ,  H01L2224/32245 ,  H01L2224/45014 ,  H01L2224/45124 ,  H01L2224/45144 ,  H01L2224/45147 ,  H01L2224/48111 ,  H01L2224/48137 ,  H01L2224/48145 ,  H01L2224/48247 ,  H01L2224/48465 ,  H01L2224/48624 ,  H01L2224/48724 ,  H01L2224/48824 ,  H01L2224/4903 ,  H01L2224/49111 ,  H01L2224/73265 ,  H01L2225/06562 ,  H01L2924/0781 ,  H01L2924/13091 ,  H01L2924/181 ,  H01L2924/00 ,  H01L2924/00014 ,  H01L2924/0665 ,  H01L2924/014 ,  H01L2924/00012 ,  H01L2224/32145 ,  H01L2224/00

Abstract: In one embodiment, a semiconductor package includes a first and a second die flag, wherein the first and second die flags are separated by a gap. First and second metal oxide semiconductor field effect transistor (MOSFET) die are on the first and the second die flags, respectively. A power control integrated circuit (IC) is stacked on top of at least one of the first or the second MOSFET die. A mold compound is encapsulating the power control IC, the first and second MOSFET die, and the first and second die flags.

Abstract translation: 在一个实施例中，半导体封装包括第一和第二管芯标记，其中第一和第二管芯标记由间隙分开。 第一和第二金属氧化物半导体场效应晶体管（MOSFET）管芯分别在第一和第二管芯标记上。 功率控制集成电路（IC）堆叠在第一或第二MOSFET管芯中的至少一个的顶部上。 模具化合物封装了功率控制IC，第一和第二MOSFET管芯以及第一和第二管芯标记。

公开(公告)号：US08224456B2

公开(公告)日：2012-07-17

申请号：US10996803

申请日：2004-11-24

Applicant: Terry Daglow ,  Brian Franz ,  John H. Erickson ,  Sandy Hooper ,  Tim Jones

Inventor： Terry Daglow ,  Brian Franz ,  John H. Erickson ,  Sandy Hooper ,  Tim Jones

IPC: A61N1/00

CPC classification number: A61N1/0551 ,  A61N1/0529

Abstract: A lead, method of manufacturing same, and system for stimulation is provided. The lead includes an insulative member or layer that masks a portion of the electrode(s) to effectively generate a directional lead that focuses or directs the stimulation to desired location(s). In another embodiment, the lead further includes a marking system to allow a clinician to orient the directional lead, as desired, while the lead is within a body.

Abstract translation: 提供铅，制造方法和刺激系统。 引线包括掩蔽电极的一部分的绝缘构件或层，以有效地产生将刺激聚焦或引导到所需位置的方向引线。 在另一个实施例中，引线还包括标记系统，以允许临床医生在引线位于身体内时根据需要定向方向引线。

公开(公告)号：US07392141B2

公开(公告)日：2008-06-24

申请号：US10467396

申请日：2002-02-05

Applicant: Francis J. Carr ,  Graham Carter ,  Tim Jones ,  Stephen Williams

Inventor： Francis J. Carr ,  Graham Carter ,  Tim Jones ,  Stephen Williams

IPC: G06F19/00 ,  G06F17/00 ,  G06G7/58 ,  C12P21/06 ,  G01N33/53 ,  G01N33/00 ,  A61K39/00

CPC classification number: C07K14/535 ,  A61K9/7015 ,  A61K38/00 ,  A61K47/02 ,  A61K47/12 ,  C07K14/54 ,  C07K16/18 ,  C07K16/2866 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3046 ,  C07K16/464 ,  C07K2319/00 ,  G06F19/16 ,  G06F19/18 ,  Y10S707/99943

Abstract: A method of preparing a modified granulocyte colony stimulating factor (G-CSF) protein having reduced immunogenicity relative to human G-CSF comprises the steps of (i) identifying one or more potential T-cell epitopes within the amino acid sequence of human G-CSF (SEQ ID NO: 1); (ii) designing at least one sequence variant of at least one potential T-cell epitope identified in step (i), wherein the sequence variant eliminates or substantially reduces the MHC class II binding activity of the potential T-cell epitope; (iii) preparing, by recombinant DNA techniques, at least one modified G-CSF protein including a sequence variant designed in step (ii); (iv) evaluating at least one modified G-CSF protein prepared in step (iii) for G-CSF activity and immunogenicity; and (v) selecting a modified G-CSF protein evaluated in step (iv) that has substantially the same therapeutic G-CSF biological activity as, but substantially less immunogenicity than, human G-CSF.

Abstract translation: 制备相对于人G-CSF具有降低的免疫原性的修饰的粒细胞集落刺激因子（G-CSF）蛋白质的方法包括以下步骤：（i）鉴定人G-蛋白的氨基酸序列内的一个或多个潜在T细胞表位， CSF（SEQ ID NO：1）; （ii）设计步骤（i）中鉴定的至少一个潜在T细胞表位的至少一个序列变体，其中所述序列变体消除或显着降低潜在T细胞表位的MHC II类结合活性; （iii）通过重组DNA技术制备至少一种修饰的G-CSF蛋白，包括在步骤（ii）中设计的序列变体; （iv）评估在步骤（iii）中制备的至少一种修饰的G-CSF蛋白质的G-CSF活性和免疫原性; 和（v）选择在步骤（iv）中评估的与人G-CSF具有基本上相同的治疗性G-CSF生物学活性但显着更低的免疫原性的修饰的G-CSF蛋白质。

公开(公告)号：US07381795B2

公开(公告)日：2008-06-03

申请号：US10471894

申请日：2002-03-15

Applicant: Francis J. Carr ,  Graham Carter ,  Tim Jones ,  John Watkins ,  Matthew Baker

Inventor： Francis J. Carr ,  Graham Carter ,  Tim Jones ,  John Watkins ,  Matthew Baker

IPC: C07K14/00 ,  C12N15/24

CPC classification number: C07K14/565

Abstract: A modified interferon beta (INFβ) is provided, which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered to a human in vivo. The modified INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by a substitution at one or more residues of SEQ ID NO: 1. Preferred substitutions are at residues selected from the group consisting of residue 50, 59, 60, 62, 63, 66, 67, 69, 70, 125, 126, 129, 130, 132, 133, and 138. Examples of suitable substitutions include F50A, L57A, I59A, Y60N, M62A, L63A, I66T, F67H, I69A, F70A, Y125A, Y126A, I129A, L130A, Y132S, L133A, Y138H, and Y138A.

Abstract translation: 提供了经修饰的干扰素β（INFbeta），当其在体内施用于人时，其比人INFbeta（SEQ ID NO：1）的免疫原性较低。 修饰的INFbeta包含通过在SEQ ID NO：1的一个或多个残基处的取代而与SEQ ID NO：1不同的氨基酸残基序列。优选的取代是选自残基50,59,60， 合适的取代的实例包括F50A，L57A，I59A，Y60N，M62A，L63A，I66T，F67H，I69A，SEQ ID NO：6,62,63,66,67,69,70,125,126,129,130​​,132,133,138。 F70A，Y125A，Y126A，I129A，L130A，Y132S，L133A，Y138H和Y138A。

公开(公告)号：US20050256304A1

公开(公告)日：2005-11-17

申请号：US10511559

申请日：2003-04-17

Applicant: Tim Jones ,  Matthew Baker ,  Francis Carr

Inventor： Tim Jones ,  Matthew Baker ,  Francis Carr

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/10 ,  A61K38/36 ,  A61K38/37 ,  A61K39/00 ,  A61P7/00 ,  A61P7/04 ,  A61P37/06 ,  C07K7/08 ,  C07K14/755 ,  C12N15/12 ,  C12P21/02

CPC classification number: C07K14/755 ,  A61K38/37 ,  A61K39/00

Abstract: The invention relates to the modification of human Factor VIII (FVIII) to result in FVIII proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo. The invention relates furthermore to T-cell epitope peptides derived from said non-modified protein by means of which it is possible to create modified FVIII variants with reduced immunogenicity.

Abstract translation: 本发明涉及人因子VIII（FVIII）的修饰，以产生当在体内使用时与任何未修饰的对应物基本上不具有免疫原性或较少免疫原性的FVIII蛋白。 本发明进一步涉及衍生自所述非修饰蛋白质的T细胞表位肽，借此可以产生具有降低的免疫原性的修饰的FVIII变体。

公开(公告)号：US06432074B1

公开(公告)日：2002-08-13

申请号：US09423449

申请日：2000-06-30

Applicant: Colin Ager ,  Alaric Naiman ,  Mark Priest ,  Tim Jones ,  Julian Scarfe ,  Edward Colby

Inventor： Colin Ager ,  Alaric Naiman ,  Mark Priest ,  Tim Jones ,  Julian Scarfe ,  Edward Colby

IPC: A61F1300

CPC classification number: A61F13/00059 ,  A61F2013/00123 ,  A61F2013/00182 ,  A61F2013/00846

Abstract: An extension indicator is provided for determining a predetermined extension applied to an extensibly deformable article such as medical bandage used in compression therapy. The indicator includes first (420) and second (430) co-operating members, each adapted to be secured to an extensibly deformable article (440). One of the members is more extensible than the other and each member (420, 430) bears visual indicia (450, 460, 470) which upon extension of the more extensible member, are adapted to align with each other to indicate a predetermined extension of the more extensible member.

Abstract translation: 提供延伸指示器用于确定应用于可压缩变形制品的预定延伸部，例如在压缩治疗中使用的医用绷带。 所述指示器包括第一（420）和第二（430）配合构件，每个配合构件适于固定到可延展变形的制品（440）上。 其中一个构件比另一个构件更可伸展，并且每个构件（420,430）具有视觉标记（450,460,470），其在更可延伸构件的延伸部分上适于彼此对齐以指示预定的延伸部 更可扩展的成员。