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公开(公告)号:US20190194184A1
公开(公告)日:2019-06-27
申请号:US16289212
申请日:2019-02-28
发明人: Jean-Christophe Andrez , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , James Philip Johnson, JR. , Alla Yurevna Zenova
IPC分类号: C07D451/06 , C07D285/08 , C07D277/52 , C07D493/10 , C07D261/16 , C07D417/12 , C07D401/12 , C07D239/69 , C07D237/20 , C07D213/76 , C07D403/12 , C07D417/14 , C07D413/12
摘要: This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
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公开(公告)号:US10246453B2
公开(公告)日:2019-04-02
申请号:US15600490
申请日:2017-05-19
发明人: Jean-Christophe Andrez , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , James Philip Johnson, Jr. , Alla Yurevna Zenova
IPC分类号: A61K31/4025 , A61K31/426 , A61K31/427 , A61K31/444 , C07D417/12 , C07D417/14 , C07D401/12 , C07D401/14 , C07D451/06 , C07D403/12 , C07D213/76 , C07D237/20 , C07D239/69 , C07D413/12 , C07D261/16 , C07D493/10 , C07D277/52 , C07D285/08
摘要: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
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公开(公告)号:US10179767B2
公开(公告)日:2019-01-15
申请号:US15161085
申请日:2016-05-20
发明人: Sultan Chowdhury , Christoph Martin Dehnhardt , Abid Hasan , Ivan William Hemeon , Qi Jia , Jun Li , Zhiguo Liu , Daniel F. Ortwine , Brian Safina , Daniel Sutherlin , Shaoyi Sun , Andrew D. White , Wei Gong , Alla Yurevna Zenova , Jiuxiang Zhu
IPC分类号: A01N43/00 , A61K31/00 , C07D211/22 , C07D211/48 , C07D211/34 , C07D405/08 , C07D401/12 , C07D401/08 , C07D211/42 , C07D221/20 , C07D401/04 , C07D211/38 , C07D211/62
摘要: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号:US10100060B2
公开(公告)日:2018-10-16
申请号:US15625173
申请日:2017-06-16
发明人: Ronen Ben-David , Jian Chen , Michael A. Christie , Mina Gadelrab Dimitri , Graciela Noemi Gershon , Linli He , Nelson G. Landmesser , Daniel V. Levy , Orel Yosef Mizrahi , Partha S. Mudipalli , Harlan F. Reese , Joseph A. Sclafani , Yi Wang
IPC分类号: C07D491/20 , C07D405/10 , C07D209/34 , B01J31/02
摘要: This invention is directed to asymmetric synthesis of funapide, which is useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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公开(公告)号:US20180265465A1
公开(公告)日:2018-09-20
申请号:US15988956
申请日:2018-05-24
发明人: Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC分类号: C07D207/16 , C07D277/06 , C07D413/14 , C07D413/12 , C07D401/10 , C07D471/08 , C07D401/12 , C07C235/54 , C07D405/10 , C07D403/14
CPC分类号: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2103/74 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
摘要: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号:US20170334902A1
公开(公告)日:2017-11-23
申请号:US15600490
申请日:2017-05-19
发明人: Jean-Christophe Andrez , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , James Philip Johnson, JR. , Alla Yurevna Zenova
IPC分类号: C07D451/06 , C07D401/12 , C07D417/12 , C07D417/14
CPC分类号: C07D451/06 , C07D213/76 , C07D237/20 , C07D239/69 , C07D261/16 , C07D277/52 , C07D285/08 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D493/10
摘要: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
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公开(公告)号:US20170114075A1
公开(公告)日:2017-04-27
申请号:US15253369
申请日:2016-08-31
发明人: Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Alexandre Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC分类号: C07D513/22 , C07D491/20 , C07D495/20 , C07D498/20 , C07D491/22 , C07D513/20 , C07D491/107
CPC分类号: C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
摘要: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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公开(公告)号:US09630929B2
公开(公告)日:2017-04-25
申请号:US14355552
申请日:2012-10-30
发明人: Shaoyi Sun , Alla Yurevna Zenova , Mikhail Chafeev , Qi Jia , Zaihui Zhang , Renata Marcella Oballa
IPC分类号: C07D417/12 , C07D239/42 , C07D285/08 , C07D401/12 , C07D413/12 , C07D211/22 , C07D257/06 , C07D261/14 , C07D277/52 , C07D285/135
CPC分类号: C07D239/42 , C07D211/22 , C07D257/06 , C07D261/14 , C07D277/52 , C07D285/08 , C07D285/135 , C07D401/12 , C07D413/12 , C07D417/12
摘要: This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.
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公开(公告)号:US20170002017A1
公开(公告)日:2017-01-05
申请号:US15017282
申请日:2016-02-05
发明人: Jean-Christophe Andrez , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Daniel F. Ortwine , Brian Safina , Tao Sheng , Shaoyi Sun , Daniel P. Sutherlin , Michael Scott Wilson , Alla Yurevna Zenova
IPC分类号: C07D491/107 , C07C311/51 , C07D307/12 , C07D213/82 , C07D205/04 , C07D207/48 , C07D295/26 , C07D257/04 , C07D311/58 , C07D209/52 , C07D307/18 , C07D211/22 , C07D233/84
CPC分类号: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
摘要: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
摘要翻译: 和其药学上可接受的盐,其中变量RA,下标n,环A,X2,L,下标m,X1,B,R1,R2,R3,R4,R5和RN具有本文所述的含义, 化合物和使用这些化合物和组合物的方法。
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公开(公告)号:US20160297754A1
公开(公告)日:2016-10-13
申请号:US15133030
申请日:2016-04-19
发明人: Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Daniel Ortwine , Brian Safina , Shaoyi Sun , Daniel P. Sutherlin , Alla Yurevna Zenova
IPC分类号: C07C311/51 , C07D213/82 , C07D213/64 , C07D205/04 , C07D471/08 , C07D405/12 , C07D295/26 , C07D233/84 , C07D257/04 , C07D207/46 , C07C307/06 , C07D311/58
CPC分类号: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
摘要: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
摘要翻译: 和其药学上可接受的盐,其中变量RA,下标n,环A,X2,L,下标m,X1,B,R1,R2,R3,R4,R5和RN具有本文所述的含义, 化合物和使用这些化合物和组合物的方法。
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