摘要:
This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
摘要:
The present invention provides recombinant polypeptides comprising an N-terminal fragment of an ActA protein or LLO protein fused to an antigen or a fragment thereof, nucleotides encoding same, recombinant vectors comprising same, and immunogenic and therapeutic methods utilizing same.
摘要:
Compositions and methods for enhancing the immunogenicity of an antigen via fusion to a non-hemolytic truncated form of listeriolysin or a PEST-like amino acid sequence derived from a prokaryotic organism are provided.
摘要:
The present invention includes compositions, methods and kits for enhancing the immunogenicity of an antigen via fusion to a Listerial protein. The present invention further encompasses Listeria vaccine strains for enhancing the immunogenicity of an antigen.
摘要:
This invention provides recombinant polypeptides comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA), recombinant Listeria strains comprising same, and methods of inducing an anti-HMW-MAA and anti HER-2/neu immune response thus treating and impeding the growth of tumors, comprising administering same.
摘要:
The present invention provides methods of treating, protecting against, and inducing immune response against cervical cancer, comprising the step of administering to a sub recombinant Listeria strain, comprising a fusion peptide that comprises an LLO fragment a E7 and/or E6 antigen. The present invention also provides methods for inducing an anti-E7 response in a human subject and treating HPV-mediated diseases, disorders, and symp comprising administration of the recombinant Listeria strain.
摘要:
This invention provides recombinant peptides comprising a fragment of an IgE constant region, nucleotide molecules encoding same, recombinant vaccine vectors comprising same, and methods for inducing immune response and treating allergy, asthma and IgE mediated disease comprising same.
摘要:
The present invention provides methods of inducing an immune response in a subject against a protein of interest and treating and suppressing a formation of a tumor comprising a tumor-associated protein, comprising sequential administration of fragments of the protein. The present invention also provides Her-2 protein fragments, recombinant peptides comprising same, nucleotide molecules encoding same, recombinant vaccine vectors and immunogenic compositions comprising same, and methods for inducing immune response and treating cancer, comprising same.