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    Subcutaneous Glucose Electrode
    41.
    发明申请
    Subcutaneous Glucose Electrode 审中-公开
    皮下葡萄糖电极

    公开(公告)号：US20100059372A1

    公开(公告)日：2010-03-11

    申请号：US12551497

    申请日：2009-08-31

    申请人： Adam Heller ,  Michael V. Pishko

    发明人： Adam Heller ,  Michael V. Pishko

    IPC分类号： G01N27/26

    CPC分类号： C12Q1/54 ,  C12Q1/006 ,  Y10S435/817 ,  Y10S435/917 ,  Y10S435/962

    摘要： A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

    摘要翻译： 描述了设计用于皮下体内电导率监测葡萄糖的小直径柔性电极。 电极被设计成允许“一点”体内校准，即即使在血清或血液的其它电反应物质的存在下也能在零葡萄糖浓度下具有零输出电流。 电极优选为三层或四层，其中层叠在聚酰胺绝缘金线的尖端上的凹槽内。 第一葡萄糖浓度 - 电流转导层用电绝缘和葡萄糖通量限制层（第二层）涂覆，其上任选地沉积固定的干扰消除辣根过氧化物酶基膜（第三层）。 外（第四）层是生物相容的。

    Subcutaneous Glucose Electrode
    42.
    发明申请
    Subcutaneous Glucose Electrode 审中-公开

    公开(公告)号：US20100059370A1

    公开(公告)日：2010-03-11

    申请号：US12551480

    申请日：2009-08-31

    申请人： Adam Heller ,  Michael V. Pishko

    发明人： Adam Heller ,  Michael V. Pishko

    IPC分类号： C12Q1/00

    CPC分类号： C12Q1/54 ,  C12Q1/006 ,  Y10S435/817 ,  Y10S435/917 ,  Y10S435/962

    摘要： A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

    Electrodes with multilayer membranes and methods of using and making the electrodes
    43.
    发明授权
    Electrodes with multilayer membranes and methods of using and making the electrodes 有权
    具有多层膜的电极和使用和制造电极的方法

    公开(公告)号：US07666284B2

    公开(公告)日：2010-02-23

    申请号：US10862932

    申请日：2004-06-07

    申请人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

    发明人： Adam Heller ,  Ting Chen ,  Keith A. Friedman

    IPC分类号： G01N27/327

    CPC分类号： G01N27/3271

    摘要： A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.

    摘要翻译： 包括感测层的传感器设置在电极或光栅上，以及设置在感测层上的逐层组装的质量传输限制膜。 膜包括至少一层聚阴离子或聚阳离子材料。 膜的组装层通常以交替的方式设置。 传感器还可选地包括生物相容膜。

    Subcutaneous Glucose Electrode
    45.
    发明申请
    Subcutaneous Glucose Electrode 审中-公开
    皮下葡萄糖电极

    公开(公告)号：US20100030050A1

    公开(公告)日：2010-02-04

    申请号：US12551439

    申请日：2009-08-31

    申请人： Adam Heller ,  Michael V. Pishko

    发明人： Adam Heller ,  Michael V. Pishko

    IPC分类号： A61B5/1473

    CPC分类号： C12Q1/54 ,  C12Q1/006 ,  Y10S435/817 ,  Y10S435/917 ,  Y10S435/962

    摘要： A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

    摘要翻译： 描述了设计用于皮下体内电导率监测葡萄糖的小直径柔性电极。 电极被设计成允许“一点”体内校准，即即使在血清或血液的其它电反应物质的存在下也能在零葡萄糖浓度下具有零输出电流。 电极优选为三层或四层，其中层叠在聚酰胺绝缘金线的尖端上的凹槽内。 第一葡萄糖浓度 - 电流转导层用电绝缘和葡萄糖通量限制层（第二层）涂覆，其上任选地沉积固定的干扰消除辣根过氧化物酶基膜（第三层）。 外（第四）层是生物相容的。