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53 条记录 (耗时 0.036 秒)

    Novel drug delivery device
    41.
    发明授权
    Novel drug delivery device 失效
    新型药物输送装置

    公开(公告)号：US3948254A

    公开(公告)日：1976-04-06

    申请号：US501207

    申请日：1974-08-28

    申请人： Alejandro Zaffaroni

    发明人： Alejandro Zaffaroni

    IPC分类号： A61K9/00 ,  A61M31/00 ,  A61F5/46

    CPC分类号： A61K9/0004 ,  A61M31/002

    摘要： A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a solid drug carrier permeable to the passage of the drug. The wall is formed in at least a part of a microporous material the pores of which contain a drug release rate controlling medium also permeable to the passage of the drug, but the rate of passage of the drug through the medium is lower than the rate passage of the drug through the solid drug carrier so that drug release by the medium in the microporous wall is the drug release rate controlling step for releasing drug from the drug delivery device.

    摘要翻译： 用于以受控的速率长时间施用药物以产生局部或全身的生理或药理作用的药物递送装置由围绕包含药物的储器的壁组成。 储存器由可通过药物通过的固体药物载体形成。 该壁形成在微孔材料的至少一部分中，微孔材料的孔含有药物释放速率控制介质，其也可以通过药物通过，但药物通过培养基的速率低于速率通道 的药物通过固体药物载体使得通过介质在微孔壁中的药物释放是用于从药物递送装置释放药物的药物释放速率控制步骤。

    Drug condensation aerosols and kits
    42.
    发明申请
    Drug condensation aerosols and kits 审中-公开
    药物冷凝气溶胶和试剂盒

    公开(公告)号：US20070122353A1

    公开(公告)日：2007-05-31

    申请号：US11504419

    申请日：2006-08-15

    申请人： Ron Hale ,  Craig Hodges ,  Peter Lloyd ,  Amy Lu ,  Daniel Myers ,  Joshua Rabinowitz ,  Martin Wensley ,  Jeffrey McKinney ,  Alejandro Zaffaroni

    发明人： Ron Hale ,  Craig Hodges ,  Peter Lloyd ,  Amy Lu ,  Daniel Myers ,  Joshua Rabinowitz ,  Martin Wensley ,  Jeffrey McKinney ,  Alejandro Zaffaroni

    IPC分类号： A61K9/14

    CPC分类号： A61K9/0004 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/12 ,  A61K31/4468 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/5517 ,  A61K31/553 ,  A61M11/002 ,  A61M11/005 ,  A61M11/04 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047 ,  A61M15/00 ,  A61M2207/00

    摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

    摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气雾剂的装置的试剂盒。典型地，试剂盒中所含的装置具有用于加热药物的元件，其在基底上以薄膜形式包被，并含有治疗有效剂量的药物 药物以气溶胶形式施用，并且允许蒸气冷却以形成气溶胶的元素。 还公开了使用这些气溶胶和试剂盒的方法。