公开(公告)号：US20060047313A1

公开(公告)日：2006-03-02

申请号：US10928744

申请日：2004-08-27

申请人： Puneet Khanna ,  Farhad Khosravi

发明人： Puneet Khanna ,  Farhad Khosravi

IPC分类号： A61B17/04

CPC分类号： A61B17/08 ,  A61B17/0057 ,  A61B17/10 ,  A61B2017/00004 ,  A61B2017/00575 ,  A61B2017/00601 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00659

摘要： Apparatus for sealing a puncture communicating with a blood vessel includes a bioabsorbable sealing member secured to one end of a filament or other retaining member. The sealing member is delivered through the puncture into the vessel, and retracted against the wall of the vessel to provide temporary hemostasis. The sealing member is rapidly absorbed after exposure within the vessel, e.g., to an aqueous or heated physiological environment (e.g., exposure to blood or body temperature), immediately or shortly after completing a medical procedure via the puncture, e.g., within the time period that the patient is ambulatory optionally, extravascular sealing material is delivered into the puncture proximal to the sealing member. The retaining member and/or extravascular material may be bioabsorbable, being absorbed at a slower rate than the sealing member. Alternatively, the filament is removed from the puncture after hemostasis is established.

摘要翻译： 用于密封与血管连通的穿刺的装置包括固定到细丝或其它保持构件的一端的生物可吸收密封构件。 密封构件通过穿刺输送到容器中，并且缩回到容器的壁上以提供临时止血。 在通过穿刺完成医疗程序之后立即或不久，例如在时间段内，密封构件在容器内暴露之后被快速吸收，例如水溶液或加热的生理环境（例如暴露于血液或体温） 患者任意行走，血管外密封材料被输送到靠近密封构件的穿刺部位。 保持构件和/或血管外材料可以是生物可吸收的，以比密封构件更慢的速度被吸收。 或者，在建立止血后，从穿刺中除去细丝。

公开(公告)号：US06632240B2

公开(公告)日：2003-10-14

申请号：US09932079

申请日：2001-08-17

申请人： Farhad Khosravi ,  Himanshu N. Patel ,  John Spiridigliozzi

发明人： Farhad Khosravi ,  Himanshu N. Patel ,  John Spiridigliozzi

IPC分类号： A61F206

CPC分类号： A61F2/07 ,  A61F2/848 ,  A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2/92 ,  A61F2/958 ,  A61F2002/065 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/8486 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0039

摘要： A stent-graft having an exo-skeleton attached to a tubular graft, the tubular graft having a peripheral wall defining a lumen therein extending between first and second ends. The exo-skeleton may assume contracted and enlarged conditions, and includes one or more serpentine elements, each extending both peripherally and axially along at least a portion of the peripheral wall. Coiled-sheet stents are provided on the ends of the tubular graft for anchoring the ends within a body passage. Each serpentine element is a zigzag structure extending peripherally about the peripheral wall, with a plurality of serpentine elements distributed axially along the peripheral wall. The serpentine elements are individually attached to the peripheral wall and/or connector elements may extend between adjacent serpentine elements. Alternatively, each serpentine element may define a generally sinusoidal shape extending axially along the peripheral wall. The tubular graft may have a bifurcated end from which a tubular graft extension segment may extend and to which a docking limb may be attached. A plurality of serpentine elements may also be attached to the extension segment and the docking limb.

摘要翻译： 具有附着到管状移植物上的外骨骼的支架移植物，所述管状移植物具有在第一和第二端之间限定内腔的周边壁。 外骨骼可以承担收缩和扩大的条件，并且包括一个或多个蛇形元件，每个沿着周壁的至少一部分周向和轴向地延伸。 螺旋片支架设置在管状移植物的端部上，用于将端部固定在体通道内。 每个蛇形元件是绕周边延伸的锯齿形结构，其中多个蛇形元件沿周壁轴向分布。 蛇形元件单独地附接到周壁，并且/或连接器元件可以在相邻的蛇形元件之间延伸。 或者，每个蛇形元件可以限定沿着周壁轴向延伸的大致正弦形状。 管状移植物可以具有分叉端，管状移植物延伸段可从该分叉端延伸并且对接肢可以附接到该端部。 多个蛇形元件也可以附接到延伸段和对接肢体。

公开(公告)号：US06613037B2

公开(公告)日：2003-09-02

申请号：US09827392

申请日：2001-04-04

申请人： Farhad Khosravi ,  Amir Abolfathi ,  Michael Hogendijk

发明人： Farhad Khosravi ,  Amir Abolfathi ,  Michael Hogendijk

IPC分类号： A61M3100

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/90 ,  A61F2002/077 ,  A61F2250/0003

摘要： Methods and apparatus are provided for temporarily excluding an aneurysm or an arterio-venous fistula from a flow path by transluminally disposing a hollow balloon catheter structure within the aneurysm so that its proximal and distal ends extend past the aneurysm while maintaining continuity of the flow path, and then injecting a synthetic molding material or a biological hardening agent into the aneurysm cavity to cause solidification of the volume within the cavity. Once the material within the excluded aneurysm has solidified, the balloon catheter structure is deflated and removed, so that the hardened mass forms a new lining for the organ or vessel, and relieves the weakened tissue of the aneurysm or fistula from further flow-induced stress.

公开(公告)号：US06361546B1

公开(公告)日：2002-03-26

申请号：US09483272

申请日：2000-01-13

申请人： Farhad Khosravi

发明人： Farhad Khosravi

IPC分类号： A61B1700

CPC分类号： A61F2/013 ,  A61F2/86 ,  A61F2/95 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/008

摘要： A vascular filter is provided that includes a tubular member having proximal and distal ends, and a guidewire lumen. An expandable frame is attached to the tubular member capable of assuming collapsed and enlarged conditions, and filter material is attached to the frame, the filter material having an open proximal end when the frame assumes its enlarged condition. An apparatus for recovering a vascular filter from a blood vessel is also provided that includes a sheath and a retrieval member deployable from the sheath. The retrieval member includes a connector on its distal end for securing the tubular member, such as an expandable member within a recess for receiving the tubular member. The vascular filter may be constrained in its collapsed condition in a sheath, and the tubular member advanced over a guidewire to a location downstream of a treatment site. The, vascular filter is deployed and expanded to its enlarged condition across the blood vessel, the guidewire remaining in place. A procedure is performed at the treatment site, the vascular filter capturing released emboli. The retrieval device is advanced over the guidewire, the vascular filter is secured to the retrieval member, and the vascular filter and retrieval device are withdrawn from the blood vessel.

摘要翻译： 提供血管过滤器，其包括具有近端和远端的管状构件和导丝管腔。 可膨胀框架连接到能够假设塌缩和扩大的条件的管状构件，并且过滤材料附接到框架，当框架呈现其放大状态时，过滤材料具有敞开的近端。 还提供了一种用于从血管中回收血管过滤器的装置，其包括护套和可从护套展开的取回构件。 回收构件包括在其远端上的连接器，用于将管状构件（例如可扩张构件）固定在用于容纳管状构件的凹部内。 血管过滤器可以在护套中以其折叠状态被约束，并且管状构件在导丝上前进到治疗部位下游的位置。 血管过滤器被部署并扩展到横跨血管的放大状态，导丝保持就位。 在治疗部位进行手术，血管过滤器捕获释放栓塞。 检索装置在导丝上前进，血管过滤器被固定到回收构件上，血管过滤器和取出装置从血管中取出。

公开(公告)号：US06231562B1

公开(公告)日：2001-05-15

申请号：US09095668

申请日：1998-06-10

申请人： Farhad Khosravi ,  Amir Abolfathi ,  Michael Hogendijk

发明人： Farhad Khosravi ,  Amir Abolfathi ,  Michael Hogendijk

IPC分类号： A61M3100

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/90 ,  A61F2002/077 ,  A61F2250/0003

摘要： Methods and apparatus are provided for temporarily excluding an aneurysm or an arterio-venous fistula from a flow path by transluminally disposing a hollow balloon catheter structure within the aneurysm so that its proximal and distal ends extend past the aneurysm while maintaining continuity of the flow path, and then injecting a synthetic molding material or a biological hardening agent into the aneurysm cavity to cause solidification of the volume within the cavity. Once the material within the excluded aneurysm has solidified, the balloon catheter structure is deflated and removed, so that the hardened mass forms a new lining for the organ or vessel, and relieves the weakened tissue of the aneurysm or fistula from further flow-induced stress.

摘要翻译： 提供的方法和装置用于通过在动脉瘤内部中空地设置中空球囊导管结构从流路中临时排除动脉瘤或动静脉瘘，使其近端和远端延伸超过动脉瘤，同时保持流路的连续性， 然后将合成成型材料或生物硬化剂注射到动脉瘤腔中，以使腔体内的体积凝固。 一旦排除的动脉瘤内的材料已经凝固，气囊导管结构就被放气和去除，使得硬化的质量形成器官或血管的新内衬，并且减轻动脉瘤或瘘的弱化组织进一步的流动应激 。

公开(公告)号：US06214026B1

公开(公告)日：2001-04-10

申请号：US09470682

申请日：1999-12-23

申请人： Jonah Lepak ,  Farhad Khosravi ,  Amr Salahieh

发明人： Jonah Lepak ,  Farhad Khosravi ,  Amr Salahieh

IPC分类号： A61B1722

CPC分类号： A61F2/01 ,  A61B2017/2212 ,  A61F2/013 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0008 ,  A61F2230/008 ,  A61M2025/09183 ,  A61M2025/1052 ,  A61M2025/109

摘要： Apparatus and methods are provided for use in deploying and retrieving a vascular device suited for filtering emboli from a vessel and performing thrombectomy and embolectomy. The vascular device comprises a support hoop having an articulation region connected near a distal end of a guide wire, and a blood permeable sac affixed to the support hoop so that the support hoop forms a mouth of the blood permeable sac. A specialized delivery system allows precise control over deployment and retrieval of the vascular device, and the introduction or withdrawal of fluids from an operative site.

摘要翻译： 提供装置和方法用于展开和取回适于从血管过滤栓塞并执行血栓切除术和止血切除术的血管装置。 血管装置包括支撑环，其具有连接在导丝的远端附近的关节运动区域，以及固定到支撑环的血液渗透囊，使得支撑环形成可渗透囊的口。 专门的输送系统允许精确控制血管装置的部署和恢复，以及从手术部位引入或取出流体。

公开(公告)号：US5824055A

公开(公告)日：1998-10-20

申请号：US824012

申请日：1997-03-25

申请人： John Spiridigliozzi ,  Amir Abolfathi ,  Farhad Khosravi ,  Michael R. Ross

发明人： John Spiridigliozzi ,  Amir Abolfathi ,  Farhad Khosravi ,  Michael R. Ross

IPC分类号： A61B17/00 ,  A61B17/32 ,  A61F2/00 ,  A61F2/06

CPC分类号： A61F2/966 ,  A61F2/954 ,  A61B17/32056 ,  A61B2017/00292 ,  A61F2/07 ,  A61F2002/065 ,  A61F2002/9511 ,  A61F2250/0098

摘要： A stent-graft delivery system and methods for use are provided for use in treating aneurysms occurring in single and bifurcated lumen hollow-body organs or vessels and for treating arterio-venous fistulas. A graft delivery component provides a clinician with complete control over the location of a graft at any time prior to implantation of stents, even when the graft is deployed from its introducer catheter. The graft delivery component includes a plurality of radially expandable fingers that releasably engage the graft, while the stent delivery component includes a small diameter introducer catheter and permits a wide range of conventional stent designs to be used to permanently fix the graft in position.

摘要翻译： 提供了支架移植物输送系统和使用方法，用于治疗单发和分叉腔腔体内器官或血管中发生的动脉瘤和用于治疗动静脉瘘。 移植物递送组件使临床医生在植入支架之前的任何时间都能完全控制移植物的位置，即使当移植物从其导引导管部署时。 移植物递送部件包括可释放地接合移植物的多个可径向扩张的指状物，而支架递送部件包括小直径导引器导管，并允许广泛范围的常规支架设计用于将移植物永久固定就位。

公开(公告)号：US5456667A

公开(公告)日：1995-10-10

申请号：US064966

申请日：1993-05-20

申请人： Kevin Ham ,  Michi E. Garrison ,  Farhad Khosravi

发明人： Kevin Ham ,  Michi E. Garrison ,  Farhad Khosravi

IPC分类号： A61M25/00 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M25/0074 ,  A61M25/0082 ,  A61M29/02 ,  A61M2025/0183 ,  A61M2025/1097

摘要： An intravascular catheter with an expandable region formed of a tubular material that continues the distal end of the catheter body in a one-piece configuration and is radially expanded and contracted by means of a control wire. The interior of the expandable region is in fluid communication with a lumen in the catheter body to allow the delivery of a fluid to the artery via openings in the surface of the expandable region. The catheter is particularly adapted to hold open an artery after a vascular procedure therein such as a balloon or other type of angioplasty, and if desired to introduce a therapeutic drug or other fluid to the site of the vascular procedure.

摘要翻译： 一种血管内导管，其具有由管状材料形成的可扩张区域，该管状材料以一体式构造将导管主体的远端延伸并且通过控制线径向膨胀和收缩。 可扩张区域的内部与导管主体中的内腔流体连通，以允许通过可扩张区域的表面中的开口将流体输送到动脉。 该导管特别适用于在其中血管手术（例如气囊或其它类型的血管成形术）之后保持动脉打开，并且如果需要将治疗药物或其它流体引入血管手术部位。

公开(公告)号：US20220390402A1

公开(公告)日：2022-12-08

申请号：US17856438

申请日：2022-07-01

申请人： Farhad Khosravi ,  David Bastable ,  Sergey A. Dryga

发明人： Farhad Khosravi ,  David Bastable ,  Sergey A. Dryga

IPC分类号： G01N27/04 ,  G01N33/487 ,  G01N27/403 ,  G01N27/414 ,  H01L29/06 ,  G01N27/327 ,  A61B5/1477

摘要： Sensors having an advantageous design and methods for fabricating such sensors are generally provided. Some sensors described herein comprise pairs of electrodes having radial symmetry, pairs of nested electrodes, and/or nanowires. Some embodiments relate to fabricating electrodes by methods in which nanowires are deposited from a fluid contacted with a substrate in a manner such that it evaporates and is replenished.

公开(公告)号：US08702777B2

公开(公告)日：2014-04-22

申请号：US11466445

申请日：2006-08-22

申请人： Jeffrey A. Krolik ,  Eliot Kim ,  James H. Dreher ,  Farhad Khosravi

发明人： Jeffrey A. Krolik ,  Eliot Kim ,  James H. Dreher ,  Farhad Khosravi

IPC分类号： A61F2/06

CPC分类号： A61F2/958 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/821 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0018 ,  A61F2250/0026 ,  A61F2250/0039 ,  A61M25/1002

摘要： A stent includes a first flaring portion including first and second sets of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second main portion connected to the first flaring portion. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The second portion resists expansion when the first portion is flared. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.

摘要翻译： 支架包括第一扩张部分，其包括当支架从收缩状态扩张到扩张状态时向外张开的第一组和第二组细胞，以及连接到第一扩张部分的第二主要部分。 在使用期间，支架在收缩状态下被引入主容器中，并且将第一部分定位成邻近口。 第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。 当第一部分展开时，第二部分抵抗扩张。 支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。