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公开(公告)号：US20220390402A1
公开(公告)日：2022-12-08
申请号：US17856438
申请日：2022-07-01
申请人： Farhad Khosravi , David Bastable , Sergey A. Dryga
发明人： Farhad Khosravi , David Bastable , Sergey A. Dryga
IPC分类号： G01N27/04 , G01N33/487 , G01N27/403 , G01N27/414 , H01L29/06 , G01N27/327 , A61B5/1477
摘要： Sensors having an advantageous design and methods for fabricating such sensors are generally provided. Some sensors described herein comprise pairs of electrodes having radial symmetry, pairs of nested electrodes, and/or nanowires. Some embodiments relate to fabricating electrodes by methods in which nanowires are deposited from a fluid contacted with a substrate in a manner such that it evaporates and is replenished.
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公开(公告)号：US09562896B2
公开(公告)日：2017-02-07
申请号：US13091534
申请日：2011-04-21
IPC分类号： G01N33/00 , G01N33/543 , G01N33/569 , C07K1/22 , C07K16/12 , C12N13/00 , C12Q1/68 , G01N24/08 , G01R33/465 , A61B5/055
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to conducting an assay on a sample that isolates a bacterium from the sample, in which the assay isolates as low as about 1 CFU/ml of bacteria in the sample.
摘要翻译： 本发明一般涉及对从样品中分离出细菌的样品进行测定，其中测定分离出样品中低至约1CFU / ml的细菌。
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公开(公告)号：US09389225B2
公开(公告)日：2016-07-12
申请号：US12855147
申请日：2010-08-12
IPC分类号： G01N33/543 , G01N33/569 , C12Q1/68 , A61B5/055 , G01R33/465 , G01N24/08 , C07K1/22 , C07K16/12 , C12N13/00
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to using magnetic particles and alternating magnet fields to separate a target analyte from a sample. In certain embodiments, methods of the invention involve contacting a sample with magnetic particles including first moieties specific for a target analyte, thereby forming target/particle complexes in the sample, flowing the sample through a channel including second moieties attached to at least one surface of the channel, applying alternating magnetic fields to the flowing sample to result in target/particle complexes being brought into proximity of the surface to bind the second moieties and unbound particles remaining free in the sample, binding the target/particle complexes to the second moieties, and washing away unbound particles and unbound analytes of the sample.
摘要翻译： 本发明一般涉及使用磁性颗粒和交替磁场将目标分析物与样品分离。 在某些实施方案中，本发明的方法包括将样品与包括对于目标分析物特异性的第一部分的磁性颗粒接触，从而在样品中形成靶/颗粒复合物，使样品流过包含连接至至少一个表面的第二部分的通道 通道，向流动的样品施加交变磁场以导致靶/颗粒复合物接近表面以结合样品中残留的第二部分和未结合的颗粒，将靶/颗粒复合物结合到第二部分， 并清洗样品中未结合的颗粒和未结合的分析物。
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公开(公告)号：US20130109590A1
公开(公告)日：2013-05-02
申请号：US13720771
申请日：2012-12-19
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , C07K1/22 , C07K16/1267 , C07K2317/33 , C12N13/00 , C12Q1/6806 , G01N33/54333 , G01N33/56905 , G01N2333/4724 , G01N2400/00 , G01N2446/80 , C12Q2563/131 , C12Q2563/143 , C12Q2565/629
摘要： The invention generally relates to using magnetic particles and magnets to isolate a target analyte from a sample. In certain embodiments, methods of the invention involve introducing to a sample at least one set of magnetic particles having at least one type of lectin in order to create a mixture, incubating the mixture such that the lectin binds to a carbohydrate on a surface of a target in the sample to thereby form target/particle complexes, in which the incubating is performed in the presence of a buffer that influences binding, and applying a magnetic field to separate target/particle complexes from remaining components of the sample, thereby isolating target/magnetic particle complexes.
摘要翻译： 本发明一般涉及使用磁性颗粒和磁体从样品中分离出目标分析物。 在某些实施方案中，本发明的方法包括向样品中引入至少一组具有至少一种类型的凝集素的磁性颗粒，以产生混合物，将混合物孵育，使得凝集素结合到表面上的碳水化合物 以形成目标/颗粒复合物，其中在存在影响结合的缓冲液的情况下进行孵育，并施加磁场以将样品的剩余组分与目标/颗粒复合物分离，由此分离靶/ 磁性颗粒复合物。
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5.发明申请RECOMBINANT ALPHAVIRUS-BASED VECTORS WITH REDUCED INHIBITION OF CELLULAR MACRO-MOLECULAR SYNTHESIS 审中-公开基于重组腺病毒的载体，具有减少细胞宏观分子合成的抑制作用公开(公告)号：US20100330121A1
公开(公告)日：2010-12-30
申请号：US12845516
申请日：2010-07-28
申请人： Thomas W. Dubensky, JR. , John M. Polo , Barbara A. Belli , Sergey A. Dryga , Sondra Schlessinger , Ilya Frolov
发明人： Thomas W. Dubensky, JR. , John M. Polo , Barbara A. Belli , Sergey A. Dryga , Sondra Schlessinger , Ilya Frolov
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/79 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
摘要翻译： 公开了分离的核酸分子，其包含甲病毒非结构蛋白基因，当可操作地并入重组甲病毒颗粒中时，与野生型相比，真核分子载体启动系统或RNA载体复制子具有降低的载体特异性RNA合成水平 类型，以及与野生型重组甲病毒颗粒相比，从病毒连接区启动子转录的RNA编码的相同或更高水平的蛋白质。 还公开了RNA载体复制子，甲病毒载体构建体和含有上述核酸分子的真核分子载体启动系统。
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公开(公告)号：US09671395B2
公开(公告)日：2017-06-06
申请号：US13091548
申请日：2011-04-21
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/554 , G01N33/543 , G01N33/569 , C07K1/22 , C07K16/12 , C12N13/00 , G01N24/08 , G01R33/465 , A61B5/055
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.
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7.发明申请公开(公告)号：US20110263833A1
公开(公告)日：2011-10-27
申请号：US13091506
申请日：2011-04-21
申请人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
发明人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号： C07K16/12
CPC分类号： G01N33/54333 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/6806 , G01N33/56911 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen.
摘要翻译： 本发明一般涉及包括一组磁性颗粒的组合物，每组的成员与特异于病原体的抗体缀合。
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公开(公告)号：US20110262925A1
公开(公告)日：2011-10-27
申请号：US13091510
申请日：2011-04-21
申请人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
发明人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号： C12Q1/68 , G01N33/577 , G01N33/569
CPC分类号： G01N33/5434 , B01L3/502738 , B01L2300/0636 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/68 , C12Q1/6806 , G01N21/64 , G01N33/53 , G01N33/54333 , G01N2446/90 , Y10T436/25 , Y10T436/25375 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.
摘要翻译： 本发明一般涉及使用组合物的方法，所述组合物包括一组磁性颗粒，每组的成员与特异于病原体的抗体缀合，以及磁体，用于将病原体与体液样品分离。
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9.发明授权公开(公告)号：US09428547B2
公开(公告)日：2016-08-30
申请号：US13091506
申请日：2011-04-21
申请人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
发明人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号： C12Q1/70 , C12M3/00 , G01N33/53 , G01N33/567 , C07K1/22 , C07K16/12 , C12N13/00 , C12Q1/68 , G01N33/543
CPC分类号： G01N33/54333 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/6806 , G01N33/56911 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen.
摘要翻译： 本发明一般涉及包括一组磁性颗粒的组合物，每组的成员与特异于病原体的抗体缀合。
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公开(公告)号：US20110262932A1
公开(公告)日：2011-10-27
申请号：US13091518
申请日：2011-04-21
IPC分类号： G01N33/569 , C01G49/10 , C01G49/08 , C12N1/20 , C07K16/12
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to compositions that include magnetic particles bound to pathogens in a body fluid.
摘要翻译： 本发明一般涉及包含与体液中的病原体结合的磁性颗粒的组合物。
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