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76 条记录 (耗时 0.027 秒)

    Oligosaccharide mixture
    42.
    发明授权
    Oligosaccharide mixture 有权
    寡糖混合物

    公开(公告)号：US07939118B2

    公开(公告)日：2011-05-10

    申请号：US10148193

    申请日：2000-12-07

    申请人： Bernd Stahl ,  Günther Böhm ,  Berndt Finke ,  Gilda Georgi ,  Jürgen Jelinek ,  Joachim J. Schmitt

    发明人： Bernd Stahl ,  Günther Böhm ,  Berndt Finke ,  Gilda Georgi ,  Jürgen Jelinek ,  Joachim J. Schmitt

    IPC分类号： C13K1/06

    CPC分类号： A61K45/06 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23V2002/00 ,  A61K31/702 ,  A61K35/20 ,  A61K2300/00 ,  A23V2250/28

    摘要： An oligosaccharide mixture based on oligosaccharides from one or several animal milks composed of two or more monosaccharide units. The oligosaccharide mixture comprises at least two oligosaccharide fractions which are each composed of at least two different oligosaccharides. Lactose does not pertain thereto and the total spectrum of the oligosaccharides in the oligosaccharide mixture differs from those present in animal milk or animal milks, wherefrom the oligosaccharide fractions are extracted and that a) if the oligosaccharides are extracted from only one animal milk, the proportion of neutral oligosaccharides to acidic oligosaccharides is 90-60:10-40 weight %, or b) if the oligosaccharides are extracted from at least two animal milks, the oligosaccharides extracted from two different animal milks each make up 10 weight % of the total amount of oligosaccharides present in the oligosaccharide mixture. The oligosaccharide mixture approximates human milk with respect to its positive properties.

    摘要翻译： 基于由两个或更多个单糖单元组成的一个或几个动物奶的寡糖的寡糖混合物。 寡糖混合物包含至少两种各自由至少两种不同寡糖组成的寡糖部分。 乳糖与其无关，低聚糖混合物中寡糖的总光谱与动物乳或动物奶中存在的低聚糖的总光谱不同，其中提取寡糖部分，并且a）如果寡糖仅从一种动物乳提取，则比例 的中性寡糖与酸性寡糖的比例为90-60：10-40重量％，或b）如果从至少两只动物奶中提取低聚糖，则从两种不同动物奶中提取的寡糖各自占总量的10重量％ 的寡糖混合物中存在的寡糖。 寡糖混合物相对于其正性质接近人乳。

    Carbohydrate mixtures
    43.
    发明授权
    Carbohydrate mixtures 有权
    碳水化合物混合物

    公开(公告)号：US07601364B2

    公开(公告)日：2009-10-13

    申请号：US11649879

    申请日：2007-01-05

    申请人： Gunther Sawatzki ,  Bernd Stahl

    发明人： Gunther Sawatzki ,  Bernd Stahl

    IPC分类号： A61K47/00 ,  A01N43/04 ,  A61K31/715

    CPC分类号： A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L33/21 ,  A23L33/40 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/715 ,  A61K31/733 ,  A61K31/7004 ,  A61K2300/00

    摘要： A carbohydrate mixture for dietetic foods and pharmaceuticals containing several carbohydrates is provided. The carbohydrate mixture comprises two different, substantially soluble carbohydrate components A and B, which remain undigested in the gastrointestinal tract and enter the large intestine without being resorbed. Component A comprises at least one monosaccharide, at least one oligosaccharide (disaccharide to hexasaccharide), or a mixture thereof. Component B comprises a polysaccharide or a mixture of two or more polysaccharides. Component A constitutes 5 to 95 wt-% and Component B constitutes 5 to 95 wt-% of the sum of the Components; and at least 80 wt-% of the carbohydrates/saccharides of Components A and B have a prebiotic effect. The inventive carbohydrate mixture exhibits not only a nutritive effect, but also stimulates health-promoting microorganisms present in the natural flora of the large intestine.

    摘要翻译： 提供饮食食品和含有几种碳水化合物的药物的碳水化合物混合物。 碳水化合物混合物包含两种不同的，基本上可溶的碳水化合物组分A和B，其在胃肠道中未消化并进入大肠而不被再吸收。 组分A包含至少一种单糖，至少一种寡糖（二糖与六糖）或其混合物。 组分B包含多糖或两种或多种多糖的混合物。 组分A占5至95重量％，组分B占组分总和的5至95重量％; 并且组分A和B的至少80wt％的碳水化合物/糖具有益生元效应。 本发明的碳水化合物混合物不仅显示营养作用，而且还刺激存在于大肠的天然菌群中的健康促进微生物。

    Carbohydrate mixture
    44.
    发明授权
    Carbohydrate mixture 有权
    碳水化合物混合物

    公开(公告)号：US06576251B1

    公开(公告)日：2003-06-10

    申请号：US09341775

    申请日：1999-11-09

    申请人： Bernd Stahl ,  Gunther Sawatzki

    发明人： Bernd Stahl ,  Gunther Sawatzki

    IPC分类号： A61K4736

    CPC分类号： A61K31/702 ,  A23L29/30 ,  A23L33/125

    摘要： The invention relates to a carbohydrate mixture for dietetic foods administered by the enteral or parenteral route and pharmaceuticals, characterized in that said mixture consists of (a) monosaccharide(s), (b) oligosaccharide(s) (at most hexasaccharides) and (c) polysaccharide(s) (at least heptasaccharides), where the mixing ratio a, b, c, in respect of weight, is: &agr;=1, b=40 to 1000, and c=1 to 50, and in that it contains at least 1 weight percent of fucose occurring either freely and/or bound to an oligosaccharide and/or a polysaccharide. According to the invention, the carbohydrate mixture has both a nutritional and a biological effect which is considerably greater than the corresponding action of the individual constituents.

    摘要翻译： 本发明涉及通过肠内或肠胃外途径和药物施用的饮食食品的碳水化合物混合物，其特征在于所述混合物由（a）单糖，（b）寡糖（至多六糖）和（c ）多糖（至少七糖），其中混合比a，b，c在重量方面为：α= 1，b = 40至1000，c = 1至50，并且其含有 至少1重量％的岩藻糖自由地和/或与寡糖和/或多糖结合。 根据本发明，碳水化合物混合物具有营养和生物效应，其显着大于各个成分的相应作用。

    Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
    47.
    发明授权
    Therapeutic use of antibodies directed against repulsive guidance molecule (RGM) 有权
    针对排斥指导分子（RGM）的抗体的治疗用途

    公开(公告)号：US07981420B2

    公开(公告)日：2011-07-19

    申请号：US10451586

    申请日：2001-12-21

    申请人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Anderson

    发明人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Anderson

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K14/47 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/465 ,  C07K14/4702 ,  C07K16/28

    摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardio-vascular system. Furthermore, the invention provides for the use of a modulator of a polypeptide having or comprising said amino acid sequence of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with angiogenic disorders or disorders of the cardio-vascular system. In addition the invention provides for the use of said polypeptide or said functional fragment or derivative thereof for the preparation of a pharmaceutical composition for preventing or treating tumor growth or formation of tumor metastases or as a marker of stem cells.

    摘要翻译： 本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途 预防，减轻或治疗与癫痫相关的脊椎动物神经组织的退化或损伤相关的疾病或病症或与心血管系统的血管生成障碍或病症有关。 此外，本发明提供了具有或包含其功能片段或其衍生物的所述氨基酸序列或编码所述多肽或片段或衍生物的多核苷酸的多肽的调节剂用于制备用于预防，缓解的药物组合物 或治疗与脊髓动物神经组织的变性或损伤相关的疾病或病症，与血管生成障碍或心血管系统的病症有关。 此外，本发明提供了所述多肽或其功能片段或其衍生物用于制备用于预防或治疗肿瘤生长或肿瘤转移形成或作为干细胞标记的药物组合物的用途。

    USE OF RGM AND ITS MODULATORS
    48.
    发明申请
    USE OF RGM AND ITS MODULATORS 审中-公开
    RGM及其调制器的使用

    公开(公告)号：US20110112280A1

    公开(公告)日：2011-05-12

    申请号：US12939823

    申请日：2010-11-04

    申请人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Andersen

    发明人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Andersen

    IPC分类号： C07K16/00 ,  C07K14/00 ,  C07H21/04

    CPC分类号： C07K14/47 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/465 ,  C07K14/4702 ,  C07K16/28

    摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardiovascular system. Furthermore, the invention provides for the use of a modulator of a polypeptide having or comprising said amino acid sequence of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with angiogenic disorders or disorders of the cardiovascular system. In addition, the invention provides for the use of said polypeptide or said functional fragment or derivative thereof for the preparation of a pharmaceutical compositions for preventing or treating tumor growth or formation of tumor metastases or as a marker of stem cells.

    摘要翻译： 本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途 预防，减轻或治疗与癫痫相关的脊髓动物神经组织的退化或损伤相关的疾病或病症，或与心血管系统的血管生成障碍或病症有关。 此外，本发明提供了具有或包含其功能片段或其衍生物的所述氨基酸序列或编码所述多肽或片段或衍生物的多核苷酸的多肽的调节剂用于制备用于预防，缓解的药物组合物 或治疗与血管生成障碍或心血管系统疾病相关的脊椎动物神经组织的退化或损伤相关的疾病或病症。 此外，本发明提供了所述多肽或其功能片段或衍生物用于制备用于预防或治疗肿瘤生长或肿瘤转移形成或作为干细胞标志物的药物组合物的用途。