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50 条记录 (耗时 0.061 秒)

    COMPOSITIONS AND METHODS FOR TREATING COAGULATION RELATED DISORDERS
    47.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING COAGULATION RELATED DISORDERS 审中-公开
    用于治疗凝血相关疾病的组合物和方法

    公开(公告)号：US20090136501A1

    公开(公告)日：2009-05-28

    申请号：US12036188

    申请日：2008-02-22

    申请人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

    发明人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

    IPC分类号： A61K39/395

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55

    摘要： Disclosed are methods for preventing or treating sepsis, a sepsis-related condition or an inflammatory disease in a mammal. In one embodiment, the method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to tissue factor (TF) to form a complex in which factor X or factor IX binding to the complex is inhibited and the administration is sufficient to prevent or treat the sepsis in the mammal. The invention has a wide spectrum of useful applications including treating sepsis, disorders related to sepsis, and inflammatory diseases such as arthritis.

    摘要翻译： 公开了用于预防或治疗哺乳动物中败血症，败血症相关病症或炎性疾病的方法。 在一个实施方案中，所述方法包括向哺乳动物施用治疗有效量的至少一种特异性结合组织因子（TF）的人源化抗体，嵌合抗体或其片段，以形成其中因子X或因子IX与 复合物被抑制，并且给药足以预防或治疗哺乳动物的败血症。 本发明具有广泛的有用应用，包括治疗败血症，与败血症有关的疾病，以及诸如关节炎的炎性疾病。

    P53 BINDING T CELL RECEPTOR MOLECULES
    48.
    发明申请
    P53 BINDING T CELL RECEPTOR MOLECULES 有权
    P53结合T细胞受体分子

    公开(公告)号：US20080269113A1

    公开(公告)日：2008-10-30

    申请号：US10163084

    申请日：2002-06-05

    申请人： Linda A. Sherman ,  Kimberlyn F. Card ,  Jon A. Weidanz ,  Hing C. Wong ,  Elizabeth L. Thomson

    发明人： Linda A. Sherman ,  Kimberlyn F. Card ,  Jon A. Weidanz ,  Hing C. Wong ,  Elizabeth L. Thomson

    IPC分类号： A61K38/17 ,  C07K14/715 ,  C12N5/06 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/7051 ,  A61K38/00

    摘要： The invention provides T-cell receptor (TCR) molecules comprising a Vα chain and a Vβ chain that bind peptides derived from the p53 protein, preferably, the human p53 protein. The TCR molecules include both heterodimeric molecules and single chain molecules which specifically bind a sequence preferably spanning about amino acid positions 264-272 of the p53 protein displayed in the context of an HLA molecule, preferably, HLA-A2.1. Also disclosed are methods for making and using such TCR molecules. The invention has a wide spectrum of useful application including therapeutic uses and use in the detection of cells expressing p53 protein.

    摘要翻译： 本发明提供了包含Valpha链和结合来源于p53蛋白的肽优选人p53蛋白的Vbeta链的T细胞受体（TCR）分子。 TCR分子包括异源二聚体分子和单链分子，其特异性结合优选跨越在HLA分子，优选HLA-A2.1上下文中显示的p53蛋白的氨基酸位置264-272的序列。 还公开了制备和使用这种TCR分子的方法。 本发明具有广泛的有用应用，包括治疗用途和用于检测表达p53蛋白的细胞。

    Soluble MHC complexes and methods of use thereof
    49.
    发明授权
    Soluble MHC complexes and methods of use thereof 失效

    公开(公告)号：US07074905B2

    公开(公告)日：2006-07-11

    申请号：US09766378

    申请日：2001-01-19

    申请人： Peter R. Rhode ,  Jorge Acevedo ,  Martin Burkhardt ,  Jin-an Jiao ,  Hing C. Wong

    发明人： Peter R. Rhode ,  Jorge Acevedo ,  Martin Burkhardt ,  Jin-an Jiao ,  Hing C. Wong

    IPC分类号： C07K16/00 ,  C07K14/74

    CPC分类号： C07K14/70539 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II β2 chain modification, e.g., deletion of essentially the entire class II β2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.

    Soluble MHC complexes and methods of use thereof
    50.
    发明授权
    Soluble MHC complexes and methods of use thereof 失效
    可溶性MHC复合物及其使用方法

    公开(公告)号：US06232445B1

    公开(公告)日：2001-05-15

    申请号：US08960190

    申请日：1997-10-29

    申请人： Peter R. Rhode ,  Jorge Acevedo ,  Martin Burkhardt ,  Jin-an Jiao ,  Hing C. Wong

    发明人： Peter R. Rhode ,  Jorge Acevedo ,  Martin Burkhardt ,  Jin-an Jiao ,  Hing C. Wong

    IPC分类号： C12P2108

    CPC分类号： C07K14/70539 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II &bgr;2 chain modification, e.g., deletion of essentially the entire class II &bgr;2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.

    摘要翻译： 本发明涉及主要组氨酸复合物（MHC）分子的新型复合物和这种复合物的用途。 一方面，本发明涉及包含II类β2链修饰的单链MHC II类复合物，例如基本上缺失整个II类β2链。 另一方面，本发明的特征在于包含免疫球蛋白恒定链或片段的单链MHC II类。 还提供了包含至少一种单链MHC II类分子的多特异性MHC复合物。 本发明的MHC复合物可用于多种应用，包括：1）用于鉴定和分离调节所选T细胞活性的肽的体外筛选，包括作为T细胞受体拮抗剂和部分激动剂的肽，以及2） 抑制或诱导哺乳动物的免疫应答。