Process for the coating of objects with hyaluronic acid, derivatives
thereof, and semisynthetic polymers
    41.
    发明授权
    Process for the coating of objects with hyaluronic acid, derivatives thereof, and semisynthetic polymers 失效
    用透明质酸涂覆物体的方法,其衍生物和半合成聚合物

    公开(公告)号:US6129956A

    公开(公告)日:2000-10-10

    申请号:US930858

    申请日:1997-10-07

    摘要: Processes are provided for coating the surfaces of objects with hyaluronic acid, its derivatives or other natural or semisynthetic polymers, for applications in the fields of surgery, health care and diagnostics. The processes make it possible to bind such polymers in a stable manner to the surfaces of objects made of a wide range of materials. Surfaces treated according to the processes are characterized by a high degree of wettability, and are able to inhibit the adhesion of cells or bacteria present in the biological fluids.

    摘要翻译: PCT No.PCT / EP96 / 00509 Sec。 371 1999年10月7日第 102(e)1999年10月7日PCT PCT 1996年2月7日PCT公布。 第WO96 / 24392号公报 日期1996年8月15日提供用于在物体表面涂覆透明质酸,其衍生物或其他天然或半合成聚合物的工艺,用于手术,保健和诊断领域的应用。 这些方法使得可以以稳定的方式将这些聚合物结合到由各种材料制成的物体的表面上。 根据该方法处理的表面的特征在于高润湿性,并且能够抑制存在于生物流体中的细胞或细菌的粘附。

    Method of using low molecular weight hyaluronic acid for stimulating
bone formation
    43.
    发明授权
    Method of using low molecular weight hyaluronic acid for stimulating bone formation 失效
    使用低分子量透明质酸刺激骨形成的方法

    公开(公告)号:US5646129A

    公开(公告)日:1997-07-08

    申请号:US318804

    申请日:1995-01-17

    CPC分类号: C08B37/0072

    摘要: The present invention is drawn to hyaluronic acid fractions having molecular weights in the range of from about 20,000 to about 60,000 daltons, wherein these hyaluronic acid fractions possess osteoinductive activity. The present invention further includes pharmaceutical compositions comprising such hyaluronic acid fractions to be used in the treatment of various types of bone disorders, as well as methods of treating such disorders using the pharmaceutical compositions.

    摘要翻译: PCT No.PCT / EP93 / 00932 Sec。 371日期1995年1月17日 102(e)日期1995年1月17日PCT 1993年4月16日PCT公布。 出版物WO93 / 20827 日期:1993年10月28日本发明涉及分子量在约20,000至约60,000道尔顿范围内的透明质酸部分,其中这些透明质酸部分具有骨诱导活性。 本发明还包括药物组合物,其包含用于治疗各种类型的骨骼疾病的这种透明质酸组分,以及使用该药物组合物治疗此类病症的方法。

    Enzyme immobilization in cellulosic hollow fibres
    46.
    发明授权
    Enzyme immobilization in cellulosic hollow fibres 失效
    酶固定在纤维素中空纤维中

    公开(公告)号:US4356267A

    公开(公告)日:1982-10-26

    申请号:US233702

    申请日:1981-02-12

    摘要: Enzymes are immobilized in a bundle of cellulosic hollow fibres for use as a fibre-bundle dialyzer for purifying blood. Immobilization is carried out by circulating through the lumen of the fibres to activate the fibres an aqueous solution of sodium periodate at a concentration of 0.7-21 mg/ml, a circulation rate of 300-500 mm.sup.3 /minute/mm.sup.2, a temperature of 15.degree.-30.degree. C. and for a period not exceeding 70 minutes, removing excess sodium periodate by washing the fibres, and directly or indirectly anchoring an enzyme to the activated fibres. Washing is preferably carried out by circulating through the lumen of the fibres dionized water followed by a dilute aqueous solution of glycerol. The fibres containing an immobilized enzyme may be sterilized with a sterilizing agent.

    摘要翻译: 将酶固定在一束纤维素中空纤维中,用作纤维束透析器以净化血液。 通过循环通过纤维内腔进行固定,使纤维活化浓度为0.7-21mg / ml的高碘酸钠水溶液,循环速率为300-500mm 3 /分/ mm 2,温度为15℃ 在-30℃下进行不超过70分钟的时间,通过洗涤纤维除去过量的高碘酸钠,并直接或间接地将酶固定在活化的纤维上。 洗涤优选通过纤维的内腔循环,除去水,然后稀释的甘油水溶液进行。 含有固定化酶的纤维可以用灭菌剂灭菌。