摘要:
The present invention relates to methods for the detection of substances capable of modulating or inhibiting pathological tau-tau protein association. The methods of the present invention are particularly useful in screening substances for the prophylaxis and treatment of Alzheiemer's disease.
摘要:
A composition, which comprises (a) a compound containing at least one epoxy group in inner position per molecule, obtained by epoxidation of a natural unsaturated oil or of its derivative; (b) an epoxy compound selected from the group consisting of glycidyl ethers, glycidyl esters and cycloaliphatic epoxides; (c) a polycarboxylic acid anhydride; (d) a compound of formula I, I, III or IV or an acid adduct of a compound of formula I, II, III or IV wherein R1 to R4 are each independently of one another hydrogen; C1-C18alkyl which is unsubstituted or substituted by one or more than one hydroxyl group amino group, halogen atom, cyano group, C1-C6alkoxy group or C1-C6cyanalkoxy group; C5-C14aryl, C6-C24aralkyl, C3-C14heteroaryl or C4-C14heteroaralkyl which are unsubstituted or substituted by one or more than one C1-C6alkyl group, C1-C6alkoxy group or halogen atom, n is an integer from 1 to 3, and R5 and R6 are each independently of the other C1-C6alkyl or, together with the nitrogen atom, form a five- or six-membered ring, and (e) 20-90% by weight, based on the entire composition, of a filler, the average diameter of the filler particles being from 0.1 &mgr;m to 5.0 mm, can be cured to products having a high Tg and are suitable in particular as encapsulating material for electrical and electronic components.
摘要:
A release element for a holddown device, on a solar generator, for example, with a retaining bolt which is under pretension in the direction of its lengthwise axis, releases the retaining bolt from its pretensioned position. Pretensioning force is exerted on the retaining bolt through thread located at the end of retaining bolt into a corresponding internal thread in the release device. Internal thread is located half in a housing of release device and half in an opener. Opener is inserted pivotably in a cutout of housing and held in place by a wire coil wound around housing and opener. To release retaining bolt, the wire coil is released by fuse elements and expands to a larger diameter, releasing the retaining bolt.
摘要:
A joint for deploying and locking a solar panel or a reflector has a fork which is pivotable through 180.degree. about a common pivot axis with a fixed bearing support. A disk mounted on the fixed bearing support has a sliding curve that terminates in a groove. A latching fork mounted rotatably on pivotable fork has a latching bolt and sliding roller which runs on the sliding curve when the pivotable fork deploys, and together with a latching bolt, engages the groove. A leg spring engages the latching bolt. The sliding curve has a shape such that during the first half of a deployment angle of the fork that is pivoted by the force of a coil spring, a decreasing portion of the coil spring moment is stored in leg spring. In the second half of the deployment angle, a moment 16 stored in leg spring 9 is again added increasingly to the movement, so that during deployment, an approximately constant corrected deployment moment is provided.
摘要:
A joint is provided for the unfolding and locking of space elements, such as solar generator panels. On one joint half, a detent lever is swivellably connected having a clamping nose as well as a finger as the guiding element. During the unfolding operation, the finger slides on a guiding contour of the other joint half. Shortly before the fully unfolded condition is reached, the finger engages in a depression, and the clamping nose runs up onto a cam and clamps down on the latter under the effect of the spring tension directed to the common axis of rotation. A movable stop element, e.g. universal ball joint, simultaneously presses against a stop surface so that both joint halves are braced with respect to one another. An arrangement of high stiffness which is as free from play as possible results.
摘要:
The invention relates to copolymers consisting of 30-100 mol %, relative to the total polymer, of structural units of the formulae I and II, the proportion of structural units of the formula I, relative to the proportion of I and II, being 5 to 95 mol %, ##STR1## in which R.sup.1 is C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 alkoxy or halogen, R.sup.2 is hydrogen or --COR.sup.3 and R.sup.3 is C.sub.1 -C.sub.20 alkyl, m is 1, 2 or 3, n is 0, 1, 2, 3 or 4 and the sum of m and n is not more than 5, and A is selected from the group of radicals consisting of halogen, cyano or structural units of the formulae III to VIII ##STR2## in which R.sup.4 and R.sup.6 independently of one another are hydroxyl, ##STR3## or glycidyl groups of the formula IXa or IXb ##STR4## R.sup.5 and R.sup.7 independently of one another are C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen, o and q independently of one another are 0, 1, 2 or 3, p and r independently of one another are 0, 1,2,3, 4 or 5, it being necessary for the totals o+p and q+4 to be not more than 5, R.sup.8 is hydrogen, C.sub.1 -C.sub.20 -alkyl, a glycidyl radical of formula IXa or a radical of formula VI, R.sup.9 is hydrogen, C.sub.1 -C.sub.20 -alkyl, cycloalkyl having 5-7 ring C atoms, phenyl, naphthyl or benzyl, R.sup.10 is hydrogen, C.sub.1 -C.sub.20 - or a glycidyl radical of the formula IXa, and the groups R.sup.11 and R.sup.12 independently of one another are hydrogen, C.sub.1 -C.sub.20 -alkyl, cycloalkyl having 5-7 ring C atoms, aryl or aralkyl which is substituted or unsubstituted or a glycidyl radical of the formula IXa, or, together with the common nitrogen atom, form a five-membered or six-membered, non-aromatic, heterocyclic ring, and R.sup.13 and R.sup.14 independently of one another are hydrogen or methyl, it being possible for the radicals R.sup.1 to R.sup.14 and A of a polymer molecule to be different, within the definitions given.The compounds are distinguished by high glass transition temperatures and good flexibility and can be employed as binders in photoresist systems. The representatives containing glycidyl groups can also be used as self-crosslinking epoxide resins.
摘要:
Thioxanthone carboxylic acid esters, thioesters and amides with reactive functional groups of the formula ##STR1## in which X, Y, Z, n and Q are as defined in the patent claim and Q is, for example, --OCH.dbd.CH.sub.2, --OCH.sub.2 CH.dbd.CH.sub.2, --SCH.sub.2 CH.dbd.CH.sub.2 or --NHCH.sub.2 CH.dbd.CH.sub.2 (n=1), --OH, --SH, --NH.sub.2, --COOH, --COCl or --OCO--C(R").dbd.CH.sub.2, in which R" is methyl or hydrogen (n=2), are suitable for the preparation of polymers with thioxanthone radicals in side chains. The compounds (I) and also the polymers which can be prepared therefrom can be employed as sensitizers for photocrosslinkable polymers or as initiators, if desired in a mixture with amines, for the photopolymerization of ethylenically unsaturated compounds or for the photochemical crosslinking of polyolefines.
摘要:
Thioxanthonecarboxylic acid esters, thioesters or amides of the formula I ##STR1## in which X and Z are hydrogen or one of the substituents defined in more detail in claim 1 and Y is --OR.sub.1, --SR.sub.1 or --N(R.sub.1)(R.sub.2), in which R.sub.1 is C.sub.1-24 alkyl and R.sub.2 is H or R.sub.1, are suitable, if desired together with amines, as initiators for the photopolymerization of ethylenically unsaturated compounds or for photochemical crosslinking of polyolefines. They are also used an sensitizers for photocrosslinkable polymers. They can be prepared by methods known per se, for example by cyclization of phenylthio-phthalic, -isophthalic or -terephthalic acids, which can be correspondingly substituted, and subsequent reaction with suitable alcohols, thiols or amines.
摘要:
A process for the manufacture of iso-imides or mixtures of iso-imides and imides by reacting corresponding amide-acids with ketene at temperatures of about -10.degree. C. to +80.degree. C. is described. According to the process of the invention, the iso-imides or mixtures of iso-imides and imides can be manufactured in a simple, economical manner and in good to very good yields. The acetic anhydride formed during the reaction with the ketene can easily be recovered.
摘要:
The imidyl compounds, according to the invention, of the formula I are suitable for the manufacture of polymers which can be crosslinked by light, which polymers can be, for example, polyesters, polyamides, polyamide-imides, polyimides, polyester-polyamides, polyester-amide-imides, polyethers, polyamines, polysaccharides and polysiloxanes. Polymers of this type are suitable for carrying out photochemical processes. Compared with known polymers, the polymers based on the imidyl compounds according to the invention have the advantage that they are photochemically substantially more sensitive. In addition, this sensitivity can also be further increased effectively by a combination with sensitizers.