公开(公告)号：US08841278B2

公开(公告)日：2014-09-23

申请号：US14045717

申请日：2013-10-03

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Eda Canales ,  Aesop Cho ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Michael Graupe ,  Hongyan Guo ,  Randall L. Halcomb ,  Darryl Kato ,  Choung U. Kim ,  Thorsten A. Kirschberg ,  Evan S. Krygowski ,  Scott E. Lazerwith ,  John O. Link ,  Hongtao Liu ,  Qi Liu ,  Richard L. Mackman ,  Michael L. Mitchell ,  Jay P. Parrish ,  Hyung-Jung Pyun ,  Joseph H. Saugier ,  Scott D. Schroeder ,  Jianyu Sun ,  James G. Taylor ,  James D. Trenkle ,  Winston C. Tse ,  Randall W. Vivian ,  William J. Watkins ,  Lianhong Xu

IPC: C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04 ,  A61K31/4178 ,  A61K31/7068 ,  A61K31/7052 ,  A61K31/4184 ,  A61P1/16 ,  A61P31/14

CPC classification number: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  A61P31/12 ,  C07D207/16 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D491/113 ,  C07D495/04 ,  C07F5/025

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US12227520B2

公开(公告)日：2025-02-18

申请号：US18050650

申请日：2022-10-28

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Scott D. Schroeder ,  Gregg M. Schwarzwalder ,  Nathan D. Shapiro ,  Devleena M. Shivakumar ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D498/18 ,  A61P31/18 ,  C07D471/18

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US12180197B2

公开(公告)日：2024-12-31

申请号：US17690851

申请日：2022-03-09

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas J. Brizgys ,  Chienhung Chou ,  Jeromy J. Cottell ,  Chao-I Hung ,  Michael L. Mitchell ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Suzanne M. Szewczyk ,  James G. Taylor ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D405/14 ,  A61K31/4545 ,  A61K31/4725 ,  A61K45/06 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US20240376077A1

公开(公告)日：2024-11-14

申请号：US18632593

申请日：2024-04-11

Applicant: Gilead Sciences, Inc.

Inventor： Michael Graupe ,  Steven J. Henry ,  John O. Link ,  Charles William Rowe ,  Roland D. Saito ,  Scott D. Schroeder ,  Dimitrios Stefanidis ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61K31/4439 ,  A61K31/537 ,  A61K31/675 ,  A61K31/7076 ,  A61K45/06 ,  C07C317/08 ,  C07D231/54 ,  C07F5/02

Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US12110294B2

公开(公告)日：2024-10-08

申请号：US17243911

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/28

CPC classification number: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/2818 ,  C07K16/2827

Abstract: The present disclosure provides pyrimidine dione compounds of Formula I






and pharmaceutical compositions thereof, for treating cancer, including solid tumors either-used alone or in combination with other anti-cancer agents.

公开(公告)号：US12077537B2

公开(公告)日：2024-09-03

申请号：US18110126

申请日：2023-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Chienhung Chou ,  Scott E. Lazerwith ,  John O. Link ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D513/06 ,  A61K31/4365 ,  A61K31/437 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04 ,  C07D471/06 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K45/06 ,  C07D403/12 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

公开(公告)号：US11905299B2

公开(公告)日：2024-02-20

申请号：US17317041

申请日：2021-05-11

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D401/12 ,  C07D498/04 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D401/14 ,  C07B59/00

CPC classification number: C07D498/04 ,  C07B59/002 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07B2200/05

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US11858918B2

公开(公告)日：2024-01-02

申请号：US17724212

申请日：2022-04-19

Applicant: Gilead Sciences, Inc.

Inventor： Megan K. Armstrong ,  James S. Cassidy ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Chao-I Hung ,  Kavoos Kolahdouzan ,  David W. Lin ,  Michael L. Mitchell ,  Ezra Roberts ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  James G. Taylor ,  Rhiannon Thomas-Tran ,  Nathan E. Wright ,  Zheng-Yu Yang

IPC: C07D405/14 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/675 ,  C07D401/08 ,  C07D401/10 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D493/08 ,  C07D493/10 ,  C07F9/6558

CPC classification number: C07D405/14 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/675 ,  C07D401/08 ,  C07D401/10 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D493/08 ,  C07D493/10 ,  C07F9/65586

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US20230039553A1

公开(公告)日：2023-02-09

申请号：US17243911

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07K16/28

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

公开(公告)号：US20230038823A1

公开(公告)日：2023-02-09

申请号：US17357376

申请日：2021-06-24

Applicant: Gilead Sciences, Inc.

Inventor： Chienhung Chou ,  Darryl Kato ,  Scott E. Lazerwith ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D471/04 ,  C07D498/04 ,  C07D519/00 ,  C07D513/04 ,  C07D403/12 ,  A61K45/06

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.