公开(公告)号：US20080226606A1

公开(公告)日：2008-09-18

申请号：US11928369

申请日：2007-10-30

申请人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

发明人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

IPC分类号： A61K39/00 ,  C07K14/00 ,  C07K4/00 ,  C07H21/04 ,  C12N15/00 ,  A61K35/00 ,  C12N5/00 ,  C07K16/00 ,  G01N33/574 ,  C12N5/02

CPC分类号： C07K14/005 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US07202342B1

公开(公告)日：2007-04-10

申请号：US09570737

申请日：2000-05-12

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler

IPC分类号： C07K16/00 ,  A61K39/395

CPC分类号： C07K14/4748 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US07048931B1

公开(公告)日：2006-05-23

申请号：US10129909

申请日：2000-11-09

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Steven G. Reed ,  Michael D. Kalos ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Yasir A. W. Skeiky ,  Aijun Wang

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Steven G. Reed ,  Michael D. Kalos ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Yasir A. W. Skeiky ,  Aijun Wang

IPC分类号： A61K39/00 ,  A61K38/00 ,  C12Q1/68 ,  C07H21/02 ,  A01N43/04

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07H21/02 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/80

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06894146B1

公开(公告)日：2005-05-17

申请号：US09657279

申请日：2000-09-06

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  C07K14/11 ,  C07K14/47 ,  C07K14/705 ,  C12N9/64 ,  C07K5/00 ,  C07K14/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2035/124 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。

公开(公告)号：US06613515B1

公开(公告)日：2003-09-02

申请号：US09640173

申请日：2000-08-15

申请人： Jiangchun Xu ,  John A. Stolk

发明人： Jiangchun Xu ,  John A. Stolk

IPC分类号： G01N3353

CPC分类号： C07K14/4748 ,  A61K38/00 ,  Y10S436/813 ,  Y10T436/143333

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Polypeptides and polynucleotides as provided herein may further be used for the detection and monitoring of ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其部分，编码这种部分的多核苷酸或对这种蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 本文提供的多肽和多核苷酸还可用于检测和监测卵巢癌。

公开(公告)号：US06590076B1

公开(公告)日：2003-07-08

申请号：US09285480

申请日：1999-04-02

申请人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

发明人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

IPC分类号： C07K1400

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/118

摘要： Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor antigen. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are provided, together with polynucleotides for preparing the inventive polypeptides. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer.

摘要翻译： 提供了用于治疗和诊断乳腺癌的化合物和方法。 本发明的化合物包括含有至少一部分乳腺肿瘤抗原的多肽。 提供包含此类多肽的乳腺癌免疫治疗用疫苗和药物组合物，或编码此类多肽的多核苷酸，以及用于制备本发明多肽的多核苷酸。 本发明的多肽可用于产生可用于诊断和监测乳腺癌的抗体。

公开(公告)号：US06586572B2

公开(公告)日：2003-07-01

申请号：US09604287

申请日：2000-06-22

申请人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler

发明人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler

IPC分类号： C07K1100

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K2319/00 ,  Y10S977/907 ,  Y10S977/911 ,  Y10S977/912

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06528054B1

公开(公告)日：2003-03-04

申请号：US09620405

申请日：2000-07-20

申请人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler

发明人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler

IPC分类号： A61K39395

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K14/4748 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S977/924

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06379951B1

公开(公告)日：2002-04-30

申请号：US09118627

申请日：1998-07-17

申请人： Steven G. Reed ,  Jiangchun Xu

发明人： Steven G. Reed ,  Jiangchun Xu

IPC分类号： C07H2104

CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K39/00

摘要： Compounds and methods for treating breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

摘要翻译： 提供了治疗乳腺癌的化合物和方法。 本发明化合物包括含有至少一部分乳腺肿瘤蛋白质的多肽。 还提供了包含此类多肽的乳腺癌免疫治疗用疫苗和药物组合物，或编码此类多肽的DNA分子，以及用于制备本发明多肽的DNA分子。

公开(公告)号：US08182823B2

公开(公告)日：2012-05-22

申请号：US12895274

申请日：2010-09-30

申请人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

发明人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

IPC分类号： A61K47/00 ,  A61K38/00 ,  C07K1/00 ,  C07H21/02

CPC分类号： C07K16/3015 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/4748 ,  C07K2317/34 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N2500/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。