摘要:
An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.
摘要:
Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.
摘要:
Vascular valve systems for treating calcified vascular vessel valves by delivery of one or more calcium chelating agents are described. Methods of making the vascular valve systems are also described.
摘要:
A bioerodible, implantable medical device that includes a supersaturated magnesium alloy. The magnesium alloy includes magnesium and at least one alloying element present in a concentration in excess of the equilibrium solid solubility concentration of the alloying element in hexagonal close-packed magnesium [at 25° C.].
摘要:
Methods, systems, and uses of bucky paper are provided in the present invention. These embodiments include covering medical implants with single or multiple layers of bucky paper, treating bucky paper with various therapeutics to be released through the bucky paper to a target site, shaping bucky paper into non-conventional configurations for improved therapeutic deliver, and using bucky paper alone or in conjunction with other materials to treat a target site.
摘要:
A catheter assembly comprises a catheter shaft having a proximal region a distal region and a rotational seal therebetween. The rotational seal comprises a first component fixedly engaged to the proximal region and a second component fixedly engaged to the distal region. The components engaged in an overlapping arrangement. The rotational seal is actuatable between a non-activated and activated states. In the non-activated state the first component and the second component are separated by a gap which provides for the distal region of the catheter shaft to be rotatable relative to the proximal region. In the activated state at least a portion of the first component and the second component being sealingly engaged together such that distal region is made static relative to the proximal region.
摘要:
A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要:
Methods, devices, and systems for extracting vessel occluding material are provided. An embodiment of a vessel occluding material extractor includes a host structure, a plurality of expandable members, a slide mechanism, and a circumferential member. The host structure has an elongate axis. The expandable members are connected to the host structure arrayed radially around the elongate axis. The slide mechanism is connected to the expandable members and adjacent the host structure, and is slidable in the direction of the elongate axis. The circumferential member is connected to the expandable members between the connection of the slide mechanism and the host structure to the expandable members.