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    Band
    41.
    外观设计
    Band 有权

    公开(公告)号：USD848893S1

    公开(公告)日：2019-05-21

    申请号：US29610215

    申请日：2017-07-10

    Applicant: Lin Yu

    Designer： Lin Yu

    VEHICLE INTERIOR ENVIRONMENT CONTROL
    42.
    发明申请
    VEHICLE INTERIOR ENVIRONMENT CONTROL 审中-公开

    公开(公告)号：US20190077217A1

    公开(公告)日：2019-03-14

    申请号：US16131489

    申请日：2018-09-14

    Applicant: Lin Yu ,  Mary Clover Apelian

    Inventor： Lin Yu ,  Mary Clover Apelian

    IPC: B60H1/00

    Abstract: A computer-implemented process for controlling a vehicle interior includes detecting a previously defined situation that relates to an undesirable environmental condition of the vehicle interior, and assessing both a risk level and an urgency level, based on a vehicle sensor input and vehicle historical records. The process also includes generating a vehicle command based upon the detected previously defined situation, the assessed risk level, and assessed urgency level, and executing the generated vehicle command to control at least one of an engine, a window, and a heating, ventilation and air conditioning (HVAC) unit to modify an environmental condition of the vehicle interior. The process also comprises performing in a cyclically recurring manner, until the detected previously defined situation is resolved, re-assessing the risk level, the urgency level, or both, re-generating a vehicle command, and executing the re-generated vehicle command.

    Depolymerized glycosaminoglycan from Thelenota ananas and preparation method thereof
    44.
    发明授权
    Depolymerized glycosaminoglycan from Thelenota ananas and preparation method thereof 有权
    来自Thelenota ananas的解聚糖胺聚糖及其制备方法

    公开(公告)号：US08809300B2

    公开(公告)日：2014-08-19

    申请号：US13512142

    申请日：2010-10-25

    Applicant: Jinhua Zhao ,  Hui Kang ,  Mingyi Wu ,  Weizhen Zeng ,  Zi Li ,  Yuan Gao ,  Jing Cui ,  Zhiguo Wang ,  Hanlin Feng ,  Lin Yu

    Inventor： Jinhua Zhao ,  Hui Kang ,  Mingyi Wu ,  Weizhen Zeng ,  Zi Li ,  Yuan Gao ,  Jing Cui ,  Zhiguo Wang ,  Hanlin Feng ,  Lin Yu

    IPC: A61K31/726 ,  A61K31/715 ,  C08B37/00 ,  C07H5/06 ,  A61P7/02 ,  A61K31/737

    CPC classification number: A61K31/737 ,  A61K31/726 ,  C08B37/0063

    Abstract: Disclosed is a depolymerized glycosaminoglycan from Thelenota ananas (dTHG), weight average molecular weight of which is about 8000˜20000 Da, and monosaccharide components of which are acetylgalactosamine (GalNAc), glucuronic acid (GlcUA), fucose (Fuc) or their sulfates (expressed as —OSO3−), in which molar ratio of GalNAc:GlcUA:Fuc:—OSO3− is about 1:(1±0.3):(1±0.3):(3.5±0.5). Said dTHG is a potent endogenous inhibitor of factor X, which has good anticoagulant and antithrombotic activity, and can be used for the prevention and/or treatment of thrombotic diseases. Also provided is a method for preparing said dTHG, which comprises steps of 1) extracting and obtaining fucosylated glycosaminoglycan (THG) from the body wall of Thelenota ananas; 2) depolymerizing THG to obtain dTHG by method of peroxide depolymerization or method of peroxide depolymerization catalyzed by catalyst of the fourth period transition metal ions; 3) removing impurities with lower and/or higher molecular weight in dTHG.

    Abstract translation: 公开了来自Thelenota ananas（dTHG）的解聚糖胺聚糖（dTHG），其重均分子量为约8000-20000Da，其单糖组分为乙酰半乳糖胺（GalNAc），葡糖醛酸（GlcUA），岩藻糖（Fuc）或其硫酸盐 表达为-OSO3-），其中GalNAc：GlcUA：Fuc：-OSO3-的摩尔比为约1：（1±0.3）：（1±0.3）：（3.5±0.5）。 所述dTHG是一种有效的因子X的内源性抑制剂，其具有良好的抗凝血和抗血栓形成活性，可用于预防和/或治疗血栓性疾病。 还提供了一种制备所述dTHG的方法，其包括以下步骤：1）从Thelenota ananas的体壁提取并获得岩藻糖基化的糖胺聚糖（THG）; 2）解聚THG，通过过氧化物解聚法或第四周期过渡金属离子催化剂催化的过氧化物解聚方法得到dTHG; 3）去除dTHG中具有较低和/或更高分子量的杂质。

    Cyclic polypeptides comprising a thioether linkage and methods for their preparation
    47.
    发明授权
    Cyclic polypeptides comprising a thioether linkage and methods for their preparation 失效
    包含硫醚键的环状多肽及其制备方法

    公开(公告)号：US6031073A

    公开(公告)日：2000-02-29

    申请号：US974297

    申请日：1997-11-19

    Applicant: Lin Yu

    Inventor： Lin Yu

    IPC: A61K38/00 ,  C07K1/12 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  A61K38/12 ,  C07K7/00

    CPC classification number: C07K7/06 ,  C07K1/12 ,  C07K14/001 ,  C07K7/08 ,  A61K38/00

    Abstract: This invention relates generally to cyclic polypeptides comprising a thioether linkage and methods for their preparation. More particularly, this invention relates to halogenated polypeptides having at least one haloalanine-like amino acid, and methods for their preparation which involve converting the hydroxyl group (i.e., --OH) of a serine-like amino acid to a halo group (i.e., --X where X is Cl, Br, or I) with the aid of a phosphorus-based halogenation reagent such as a triphenylphosphine dihalide (i.e., (C.sub.6 H.sub.5).sub.3 PX.sub.2, wherein X is Cl, Br, or I), a triphenylphosphite dihalide (i.e., (C.sub.6 H.sub.5 O).sub.3 PX.sub.2, wherein X is Cl, Br, or I), or a mixture of triphenylphosphine or triphenylphosphite with a halohydrocarbon (i.e., "halo-conversion"). This invention also relates to cyclic polypeptides having at least one polypeptide loop comprising a thioether linkage, and methods for their preparation which employ halogenated polypeptides and which involve intramolecular alkylation of the thiol group of a cysteine-like amino acid by the halo group of a haloalanine-like amino acid under suitable basic conditions to form a thioether linkage (i.e., "cyclization").

    Abstract translation: 本发明一般涉及包含硫醚键的环状多肽及其制备方法。 更具体地，本发明涉及具有至少一个卤代丙氨酸样氨基酸的卤代多肽及其制备方法，其涉及将丝氨酸样氨基酸的羟基（即，-OH）转化为卤基（即， -X，其中X是Cl，Br或I），借助于磷基卤化试剂如三苯基膦二卤化物（即，（C 6 H 5）3 PX 2，其中X是Cl，Br或I），亚磷酸三苯酯二卤化物 即（C6H5O）3PX2，其中X是Cl，Br或I），或三苯基膦或三苯基亚磷酸酯与卤代烃的混合物（即“卤代转化”）。 本发明还涉及具有至少一个包含硫醚键的多肽环的环状多肽及其制备方法，其使用卤代多肽，其涉及通过卤代丙氨酸的卤素基团对半胱氨酸样氨基酸的硫醇基进行分子内烷基化 类似氨基酸在合适的碱性条件下形成硫醚键（即“环化”）。

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