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    Wireless Actuators
    42.
    发明申请
    Wireless Actuators 有权

    公开(公告)号：US20210355972A1

    公开(公告)日：2021-11-18

    申请号：US17284243

    申请日：2019-10-10

    Applicant: Massachusetts Institute of Technology

    Inventor： Seyed M. Mirvakili ,  Ian W. Hunter

    IPC: F15B15/10 ,  F15B15/14 ,  F15B21/06 ,  H01F1/44

    Abstract: A method of performing wireless actuation by inductive heating of magnetic particles. The method provides a bladder having an inner surface and an outer surface, the inner surface forming an interior area, the bladder configured to expand or retract so as to change an area of the interior area, (ii) a plurality of magnetic particles suspended in a fluid medium and disposed within the interior area, and (iii) a sleeve disposed on the outer surface of the bladder. The method excites the plurality of magnetic particles by application of an alternating magnetic field to which the particles reaction. The method causes, by the excited magnetic particles, a phase transition to the fluid medium within the interior area which causes the bladder to expand, such that the sleeve confining the bladder generates actuation from the expansion or retraction of the bladder.

    Miniature stochastic nuclear magnetic resonance
    43.
    发明授权
    Miniature stochastic nuclear magnetic resonance 有权

    公开(公告)号：US11143727B2

    公开(公告)日：2021-10-12

    申请号：US17055747

    申请日：2020-05-06

    Applicant: Massachusetts Institute of Technology

    Inventor： Ashley Brown Raynal ,  Ian W. Hunter

    IPC: G01R33/46 ,  G01R33/3875 ,  G01R33/383 ,  G01N24/08

    Abstract: A nuclear magnet resonance (NMR) system probes samples using a stochastically pulsed radio-frequency magnetic field. The NMR system uses active shims to compensate for spatial inhomogeneity in the bias magnetic field applied by a small permanent magnet. The active shim, made of a flexible conductor, creates a magnetic field when current is passed through it. The magnetic field created by the active shim can compensate for a first, second or third order spherical harmonic spatial inhomogeneity. The NMR system may have an array of active shims, with each active shim compensating for a spherical harmonic spatial inhomogeneity. The array of active shims may be arranged within the NMR system so as to increase power efficiency. The NMR system can accommodate a standard NMR sample tube and can be used to measure nuclear spin density or acquire an NMR spectrum.

    Methods, apparatus, and system for mass spectrometry
    44.
    发明授权
    Methods, apparatus, and system for mass spectrometry 有权

    公开(公告)号：US10658169B2

    公开(公告)日：2020-05-19

    申请号：US16351700

    申请日：2019-03-13

    Applicant: Massachusetts Institute of Technology

    Inventor： Ian W. Hunter ,  Brian D. Hemond ,  Harold F. Hemond

    IPC: H01J49/30 ,  H01J49/02 ,  H01J49/00 ,  H01J49/14 ,  H01J49/24

    Abstract: A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.

    Controlled needle-free transport
    45.
    发明授权
    Controlled needle-free transport 有权

    公开(公告)号：US10326347B2

    公开(公告)日：2019-06-18

    申请号：US15066868

    申请日：2016-03-10

    Applicant: Massachusetts Institute of Technology

    Inventor： Ian W. Hunter ,  Andrew J. Taberner ,  Brian D. Hemond ,  Dawn M. Wendell ,  Nora Catherine Hogan ,  Nathan B. Ball

    IPC: H02K33/18 ,  H02K33/00 ,  H02K41/02 ,  A61B17/20 ,  A61M5/30 ,  A61D7/00 ,  A61M5/19

    Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

    Injection Methods Using A Servo-Controlled Needle-Free Injector
    48.
    发明申请
    Injection Methods Using A Servo-Controlled Needle-Free Injector 审中-公开
    使用伺服控制的无针注射器的注射方法

    公开(公告)号：US20170065769A1

    公开(公告)日：2017-03-09

    申请号：US15338038

    申请日：2016-10-28

    Applicant: Massachusetts Institute of Technology

    Inventor： Brian D. Hemond ,  Ian W. Hunter ,  Andrew J. Taberner ,  Dawn M. Wendell ,  N. Catherine Hogan

    IPC: A61M5/30 ,  A61M5/48

    CPC classification number: A61M5/30 ,  A61M5/24 ,  A61M5/46 ,  A61M5/486 ,  A61M2205/3331 ,  A61M2205/3358 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/8287

    Abstract: A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

    Abstract translation: 通过生物体表面注入物质的方法包括提供构造成通过所述表面注入物质的无针透皮输送装置。 当感测到注射的参数并且使用伺服控制器基于所感测的参数来动态地调整至少一个喷射特性时，将物质与输送装置一起注入生物体。 注射物质（i）在第一时间段期间，以第一注射压力注射物质的体积的第一部分，和（ii）第二时间段，其中物质的剩余体积为 在第二注射压力下注射。 可以确定物质的粘度，并计算基于粘度注入物质的压力。 物质可以通过使用计算的压力与输送装置一起注入。

    METHODS, APPARATUS, AND SYSTEM FOR MASS SPECTROMETRY
    49.
    发明申请
    METHODS, APPARATUS, AND SYSTEM FOR MASS SPECTROMETRY 有权
    方法，装置和大容量光谱系统

    公开(公告)号：US20160172180A1

    公开(公告)日：2016-06-16

    申请号：US15045883

    申请日：2016-02-17

    Applicant: The Massachusetts Institute of Technology

    Inventor： Ian W. Hunter ,  Brian Hemond ,  Harold F. Hemond

    IPC: H01J49/30 ,  H01J49/02 ,  H01J49/24 ,  H01J49/00 ,  H01J49/14

    CPC classification number: H01J49/30 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/147 ,  H01J49/24

    Abstract: A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.

    Abstract translation: 一种小型，低成本的质谱仪，能够在10至50 AMU的质量范围内进行单位分辨率。 质谱仪结合了几个功能，可以提高设计的性能，而不是可比较的仪器。 高效的离子源能够在不牺牲测量分辨率的情况下实现相对较低的功耗。 可变几何机械滤镜允许可变分辨率。 机载离子泵不需要外部泵浦源。 磁轭和磁轭产生具有不同磁通密度的磁场区域以运行离子泵和磁性扇区质量分析器。 真空室内的数字控制器和电源转换电路允许在质谱仪的操作上具有很大的灵活性，同时不需要高压电气馈通。 微型质谱仪感测入口气体百分比的分数，并将质谱数据返回到计算机。

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