-
公开(公告)号：US20180360952A9
公开(公告)日：2018-12-20
申请号：US15673126
申请日：2017-08-09
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K39/385 , A61K47/69 , A61K9/127 , A61K38/20 , A61K39/21
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
-
公开(公告)号：US09750803B2
公开(公告)日：2017-09-05
申请号：US15230736
申请日：2016-08-08
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K39/385 , A61K9/127 , A61K39/015 , A61K39/39 , A61K39/21 , A61K47/48 , C07K14/005 , C12N15/88 , A61K39/12 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/45 , A61K39/395 , A61K39/00
CPC分类号： A61K39/385 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/217 , A61K38/45 , A61K39/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/39 , A61K39/39533 , A61K47/6811 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6018 , C07K14/005 , C12N15/88 , C12N2740/15034 , C12N2740/16234 , C12Y207/10001 , Y02A50/412
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
-
公开(公告)号：US09339462B2
公开(公告)日：2016-05-17
申请号：US14581004
申请日：2014-12-23
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K9/127 , A61K38/20 , A61K45/06 , A61K39/21 , A61K39/39 , C07K14/005 , A61K39/12 , A61K39/35 , C07K16/28 , A61K39/395 , A61K39/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
-
公开(公告)号：US20150315562A9
公开(公告)日：2015-11-05
申请号：US13667775
申请日：2012-11-02
IPC分类号： C12N11/08
CPC分类号： C12N11/08 , C12N5/0068 , C12N2533/30 , C12N2533/80
摘要： Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs).
-
公开(公告)号：US20140271827A1
公开(公告)日：2014-09-18
申请号：US14265924
申请日：2014-04-30
发明人： Darrell J. Irvine , Jaehyun Moon
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
摘要翻译： 本发明提供由稳定的多层泡囊组成的递送系统，以及组合物，合成方法及其使用方法。 稳定的多层囊泡可以包含预防性，治疗和/或诊断剂。
-
公开(公告)号：US20140017170A1
公开(公告)日：2014-01-16
申请号：US13910937
申请日：2013-06-05
IPC分类号： A61K9/127 , A61K47/46 , A61K39/00 , A61K38/20 , A61K39/395
CPC分类号： A61K9/127 , A61K9/146 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/7105 , A61K31/711 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/2086 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/46 , A61K47/6901 , A61K47/6911 , A61K47/6937 , A61K2035/124 , B82Y5/00 , C07K16/00 , C12N5/0006 , C12N5/0636 , C12N5/0647 , C12N15/113 , C12N15/87 , C12N2310/14 , A61K2300/00
摘要： The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
摘要翻译： 本发明提供了通过将负载载体的纳米颗粒与具有归巢能力的细胞结合来将药剂递送到体内的局部区域，组织或器官的组合物和方法。 这些试剂可以分别是治疗剂或诊断剂，例如癌症化学治疗剂和成像剂。
-
公开(公告)号：US11717548B2
公开(公告)日：2023-08-08
申请号：US16739407
申请日：2020-01-10
发明人： Darrell J. Irvine , Karl Dane Wittrup , Ron Weiss , Yingzhong Li , Noor Momin , Yizhou Dong
IPC分类号： A61K35/768 , A61P35/00 , A61K9/00 , C07K14/54 , C12N7/00
CPC分类号： A61K35/768 , A61K9/0019 , A61P35/00 , C07K14/5434 , C12N7/00 , C12N2770/36132
摘要： The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
-
公开(公告)号：US20220096601A1
公开(公告)日：2022-03-31
申请号：US17540477
申请日：2021-12-02
IPC分类号： A61K38/20 , A61P35/00 , A61K39/00 , A61K39/39 , A61K39/395
摘要： The present disclosure provides a method of treating cancer with a priming dose of combination immunotherapy comprising IL-2 (e.g., extended-PK IL-2), an immune checkpoint inhibitor, a tumor targeting antibody or integrin-binding polypeptide, and optional cancer vaccine, administered prior to maintenance doses of immune checkpoint inhibitor therapy. The methods of the disclosure can be used to treat a broad range of cancer types.
-
公开(公告)号：US20220064584A1
公开(公告)日：2022-03-03
申请号：US17394125
申请日：2021-08-04
发明人： Armon R. Sharei , Shirley Mao , George Hartoularos , Sophia Liu , Megan Heimann , Pamela Basto , Gregory Szeto , Siddharth Jhunjhunwala , Darrell J. Irvine , Robert S. Langer , Klavs F. Jensen , Ulrich H. Von Andrian
IPC分类号： C12M1/42 , C12N15/87 , A61K39/00 , A61K45/06 , A61K49/00 , C12M3/06 , C12N5/0781 , C12N5/0783 , C12N5/0784 , G01N33/50
摘要： A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
-
50.发明申请公开(公告)号：US20210324413A1
公开(公告)日：2021-10-21
申请号：US17231588
申请日：2021-04-15
发明人： Darrell J. Irvine , Ron Weiss , Yingzhong Li , Jan Lonzaric , Parisa Yousefpour
IPC分类号： C12N15/86 , A61K31/713 , A61K31/505
摘要： Genetic circuits have been developed to regulate behaviors of replicon RNA in responses to small molecules, which has broader applications, such as for quantitative expression of cargo genes, temporary expression of immunomodulatory cytokines or antigens for better cancer immunotherapy or vaccination, and for increased safety in use of self-replicating vectors or in combination with other viral-delivery vectors. Described herein are genetic circuits suitable for systems that either require a tight off state or a slow off state, which can serve for instance where either a kill switch or prolonged protein expression (e.g., of vaccine antigens) are needed.
-
-
-
-
-
-
-
-
-
搜索结果
77 条记录 (耗时 0.034 秒)
