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公开(公告)号：US20160097938A1
公开(公告)日：2016-04-07
申请号：US14967733
申请日：2015-12-14
Applicant: Novartis AG
Inventor： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
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公开(公告)号：US20160091734A1
公开(公告)日：2016-03-31
申请号：US14962354
申请日：2015-12-08
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20150092156A1
公开(公告)日：2015-04-02
申请号：US14564660
申请日：2014-12-09
Applicant: Novartis AG
Inventor： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
Abstract translation: 本发明涉及具有层状结构构型的水合硅氧水凝胶隐形眼镜：完全被完全或基本上不含有硅酮的较高水含量水凝胶层覆盖的较低水含量的硅氧烷水凝胶核（或本体材料）。 本发明的水合硅氧水凝胶隐形眼镜具有高的透氧性，用于维持角膜健康和柔软，富水，润滑的表面，用于穿戴舒适。
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44.发明申请公开(公告)号：US20140356965A1
公开(公告)日：2014-12-04
申请号：US14289046
申请日：2014-05-28
Applicant: Novartis AG
Inventor： Xinming Qian , Frank Chang , Troy Vernon Holland , Yongxing Qiu , Venkat Shankar
IPC: G01N33/44
CPC classification number: B29D11/00865 , B29D11/00951 , G02B1/043 , C08L83/04 , C08L101/14 , C08L33/26
Abstract: The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.
Abstract translation: 本发明涉及硅胶水凝胶隐形眼镜表面上的羧基的合格和定量的方法。 本发明的方法包括以下步骤：（a）获得硅酮水凝胶隐形眼镜，每个硅胶水凝胶隐形眼镜包括硅酮水凝胶镜片主体（即散装材料）及其上的涂层，其中硅酮水凝胶镜片主体由透镜制剂 不含任何包含一个或多个羧基的可聚合组分，其中该涂层包含具有羧基的聚合物; （b）将给定数量的硅酮水凝胶隐形眼镜浸入固定体积的具有乙酸盐作为抗衡阴离子的带正电荷的染料的C1-C4醇溶液中，所述正电荷染料在给定的初始浓度下持续一段足以染色硅酮水凝胶 隐形眼镜; 和（c）确定每个硅氧水凝胶隐形眼镜的羧基浓度和/或硅氧水凝胶隐形眼镜上涂层的厚度。
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45.发明授权公开(公告)号：US08637071B2
公开(公告)日：2014-01-28
申请号：US13648379
申请日：2012-10-10
Applicant: Novartis AG
Inventor： Michael F. Rubner , Sung Yun Yang , Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
CPC classification number: A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
Abstract: The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO− groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
Abstract translation: 本发明提供了一种在医疗装置上制备具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包括至少一层带负电荷的聚离子材料层， 通过还原与带负电荷的聚离子材料的-COO-基团相关联的Ag +离子形成的-COOAg基团和/或银纳米颗粒。 此外，本发明提供了根据本发明的方法制备的医疗装置。
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Patent Agency Ranking
公开(公告)号：US20130224309A1
公开(公告)日：2013-08-29
申请号：US13847164
申请日：2013-03-19
Applicant: NOVARTIS AG
Inventor： Yongxing Qiu , John Martin Lally , Manal M. Gabriel , Xinming Qian
CPC classification number: G02B1/043 , A01N59/16 , A61L12/088 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/442 , A61L2300/624 , B29D11/00038 , B82Y30/00
Abstract: The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.
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公开(公告)号：US20130095235A1
公开(公告)日：2013-04-18
申请号：US13648522
申请日：2012-10-10
Applicant: NOVARTIS AG
Inventor： Harald Bothe , Yongxing Qiu , Peter Hagmann
IPC: B05D5/06
CPC classification number: B05D5/06 , B29D11/00125 , B29D11/00634 , B29D11/00865 , G02B1/043
Abstract: Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves dipping a contact lens in a solution of UV-absorbing polymer comprising carboxyl-containing monomeric units and UV-absorbing monomeric units to form a UV-absorbing coating on the contact lens.
Abstract translation: 本文描述了制造紫外线吸收隐形眼镜的成本效益和时间有效的方法。 与用于制备包含紫外线吸收性乙烯基单体的透镜形成组合物共聚的紫外线吸收隐形眼镜的常规方法相反，本发明的方法包括将隐形眼镜浸入含有羧基的紫外线吸收聚合物的溶液中 单体单元和紫外线吸收单体单元，以在隐形眼镜上形成紫外线吸收涂层。
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公开(公告)号：US11029447B2
公开(公告)日：2021-06-08
申请号：US16204705
申请日：2018-11-29
Applicant: Novartis AG
Inventor： Yongxing Qiu , John Dallas Pruitt , Newton T. Samuel , Chung-Yuan Chiang , Angela Driver-Scott , Ciara Dauenhauer , Rita Anand
IPC: G02B1/04 , C08L83/04 , C08L33/02 , C08L79/04 , C09D133/02 , B05D5/00 , B29D11/00 , G02C7/04 , G02B1/18 , B65B55/22 , B05D3/00 , B05D5/10 , B05D1/38 , B05D3/02 , B05D1/18 , B29K83/00 , B29K105/00
Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.
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公开(公告)号：US11029446B2
公开(公告)日：2021-06-08
申请号：US16204664
申请日：2018-11-29
Applicant: Novartis AG
Inventor： Yongxing Qiu , John Dallas Pruitt , Newton T. Samuel
IPC: G02B1/04 , C08L83/04 , C08L33/02 , C08L79/04 , C09D133/02 , B05D5/00 , B29D11/00 , G02C7/04 , G02B1/18 , B65B55/22 , B05D3/00 , B05D5/10 , B05D1/38 , B05D3/02 , B05D1/18 , B29K83/00 , B29K105/00
Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a 30-days lens care regime.
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公开(公告)号：US20200157378A1
公开(公告)日：2020-05-21
申请号：US16720932
申请日：2019-12-19
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , C09D171/02 , C09D133/26 , C09D133/14 , C09D133/02 , C09D5/16 , C08J5/00 , C08G77/388 , C08L83/04 , C08J7/04 , G02B1/18 , G02B1/10 , G02C7/04 , G02B1/04 , B29D11/00
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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