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公开(公告)号：US20150238631A1
公开(公告)日：2015-08-27
申请号：US14432065
申请日：2014-10-15
申请人： Chanhyuk Kim , Travis Young , Yu Cao , Jennifer Ma , Minsoo Kim , Stephanie A. Pinkerton , Peter G. Schultz
发明人： Chanhyuk Kim , Travis Young , Yu Cao , Jennifer Ma , Minsoo Kim , Stephanie A. Pinkerton , Peter G. Schultz
IPC分类号： A61K47/48 , C07K16/40 , A61K31/4188 , A61K39/385 , A61K31/352 , C07K16/28 , A61K39/395
CPC分类号： A61K47/6849 , A61K31/352 , A61K31/4188 , A61K39/385 , A61K39/3955 , A61K47/6835 , A61K49/0041 , A61K49/0058 , C07K16/2803 , C07K16/2863 , C07K16/2878 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K16/40 , C07K16/44 , C07K2317/522 , C07K2317/567 , C07K2317/622
摘要： Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain (TID). The switch may further comprise a linker. Further disclosed herein are methods of using the switches for the treatment of one or more conditions or diseases in a subject in need thereof.
摘要翻译： 本文公开了用于调节嵌合抗原受体效应细胞（CAR-EC）的活性的开关。 开关通常包含嵌合抗原受体相互作用区域（CAR-ID）和靶相互作用区域（TID）。 该开关还可以包括接头。 本文进一步公开的是使用开关来治疗有需要的受试者中的一种或多种病症或疾病的方法。
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42.发明授权Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells 有权在哺乳动物细胞中将5-羟色氨酸选择性掺入蛋白质公开(公告)号：US08658395B2
公开(公告)日：2014-02-25
申请号：US13546582
申请日：2012-07-11
申请人： Zhiwen Zhang , Lital Alfonta , Peter G. Schultz
发明人： Zhiwen Zhang , Lital Alfonta , Peter G. Schultz
摘要： This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
摘要翻译： 本发明提供了使用正交氨酰基tRNA合成酶/ tRNA对将非天然氨基酸并入肽的方法和组合物。 特别地，提供了正交对以在由蛋白石突变编码的位置中并入5-羟基-L-色氨酸。
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公开(公告)号：US08445446B2
公开(公告)日：2013-05-21
申请号：US13135129
申请日：2011-06-23
申请人： Alexander Deiters , Ashton T. Cropp , Jason W. Chin , Christopher J. Anderson , Peter G. Schultz
发明人： Alexander Deiters , Ashton T. Cropp , Jason W. Chin , Christopher J. Anderson , Peter G. Schultz
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸对。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：US08357532B2
公开(公告)日：2013-01-22
申请号：US13443800
申请日：2012-04-10
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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45.发明授权Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine 有权含有非天然氨基酸苯基硒代半胱氨酸的蛋白质的遗传程序表达公开(公告)号：US08217145B2
公开(公告)日：2012-07-10
申请号：US12225261
申请日：2007-03-13
申请人： Jiangyun Wang , Peter G. Schultz
发明人： Jiangyun Wang , Peter G. Schultz
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid phenylselenocysteine and translation systems. The invention further provides methods for producing modified proteins (e.g., lipidated proteins) through targeted modification of the phenylselenocysteine residue in a protein.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸苯硒代半胱氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。 本发明提供了例如但不限于新型正交氨酰-tRNA合成酶，编码新合成酶分子的多核苷酸，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸苯基硒半胱氨酸的蛋白质的翻译方法和翻译系统。 本发明还提供了通过蛋白质中的苯基硒代半胱氨酸残基的靶向修饰产生修饰的蛋白质（例如，脂质化蛋白质）的方法。
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公开(公告)号：US20120157457A1
公开(公告)日：2012-06-21
申请号：US13356079
申请日：2012-01-23
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A61K31/426 , A61K31/5377 , A61K31/427 , C07D277/42 , C07D417/12
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译： 本发明提供用于诱导神经元细胞分化的组合物和方法。
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公开(公告)号：US08114652B2
公开(公告)日：2012-02-14
申请号：US12311169
申请日：2007-09-20
申请人： Chang C. Liu , Peter G. Schultz
发明人： Chang C. Liu , Peter G. Schultz
CPC分类号： C12N9/93 , C07K14/815 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid sulfotyrosine and translation systems.
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公开(公告)号：US08114648B2
公开(公告)日：2012-02-14
申请号：US11978188
申请日：2007-10-26
申请人： Peter G. Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter G. Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
摘要翻译： 本发明提供用于体内掺入非天然氨基酸的方法和组合物。 还提供了包含具有非天然氨基酸的蛋白质的组合物。
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公开(公告)号：US08114628B2
公开(公告)日：2012-02-14
申请号：US11978121
申请日：2007-10-26
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：US08105581B2
公开(公告)日：2012-01-31
申请号：US12095723
申请日：2006-12-01
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译： 本发明提供用于诱导神经元细胞分化的组合物和方法。
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